LOCUS       NM_134360               1272 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD40 molecule (Cd40), mRNA.
ACCESSION   NM_134360 XM_230854
VERSION     NM_134360.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1272)
  AUTHORS   Zhang,S., Breidenbach,J.D., Khalaf,F.K., Dube,P.R., Mohammed,C.J.,
            Lad,A., Stepkowski,S., Hinds,T.D., Kumarasamy,S., Kleinhenz,A.,
            Tian,J., Malhotra,D., Kennedy,D.J., Cooper,C.J. and Haller,S.T.
  TITLE     Renal Fibrosis Is Significantly Attenuated Following Targeted
            Disruption of Cd40 in Experimental Renal Ischemia
  JOURNAL   J Am Heart Assoc 9 (7), e014072 (2020)
   PUBMED   32200719
  REMARK    GeneRIF: Renal Fibrosis Is Significantly Attenuated Following
            Targeted Disruption of Cd40 in Experimental Renal Ischemia.
REFERENCE   2  (bases 1 to 1272)
  AUTHORS   Li,Q.Q., Xi,J., Li,B.Q. and Li,N.
  TITLE     MiR-16, as a potential NF-kappaB-related miRNA, exerts
            anti-inflammatory effects on LPS-induced myocarditis via mediating
            CD40 expression: A preliminary study
  JOURNAL   J Biochem Mol Toxicol 34 (2), e22426 (2020)
   PUBMED   31777165
  REMARK    GeneRIF: CD40 was a direct target of miR-16 and was negatively
            regulated by miR-16 in H9c2 cells stimulated by LPS. The ablation
            of CD40 aggravated the biological activities of miR-16 in
            LPS-induced H9c2 cells.
REFERENCE   3  (bases 1 to 1272)
  AUTHORS   Takada,Y.K., Yu,J., Shimoda,M. and Takada,Y.
  TITLE     Integrin Binding to the Trimeric Interface of CD40L Plays a
            Critical Role in CD40/CD40L Signaling
  JOURNAL   J Immunol 203 (5), 1383-1391 (2019)
   PUBMED   31331973
REFERENCE   4  (bases 1 to 1272)
  AUTHORS   Jiang,R.H., Xu,X.Q., Wu,C.J., Lu,S.S., Zu,Q.Q., Zhao,L.B., Liu,S.
            and Shi,H.B.
  TITLE     The CD40/CD40L system regulates rat cerebral microvasculature after
            focal ischemia/reperfusion via the mTOR/S6K signaling pathway
  JOURNAL   Neurol Res 40 (9), 717-723 (2018)
   PUBMED   29843579
  REMARK    GeneRIF: Transient middle cerebral artery occlusion (MCAO) rats
            yielded an acceleration of thrombus formation that was accompanied
            by increased CD40 levels in serum. The brain infarction was
            significantly decreased in CD40 antagonist treatment group compared
            to MCAO model group. The mTOR/S6K signaling was activated in MACO
            model than that of CD40 antagonist treatment group.
            Erratum:[Neurol Res. 2019 Jan;41(1):98. doi:
            10.1080/01616412.2018.1526508. PMID: 30311854]
REFERENCE   5  (bases 1 to 1272)
  AUTHORS   Lee,A., Papangeli,I., Park,Y., Jeong,H.N., Choi,J., Kang,H.,
            Jo,H.N., Kim,J. and Chun,H.J.
  TITLE     A PPARgamma-dependent miR-424/503-CD40 axis regulates inflammation
            mediated angiogenesis
  JOURNAL   Sci Rep 7 (1), 2528 (2017)
   PUBMED   28566713
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1272)
  AUTHORS   van den Oord,J.J., Maes,A., Stas,M., Nuyts,J., Battocchio,S.,
            Kasran,A., Garmyn,M., De Wever,I. and De Wolf-Peeters,C.
  TITLE     CD40 is a prognostic marker in primary cutaneous malignant melanoma
  JOURNAL   Am J Pathol 149 (6), 1953-1961 (1996)
   PUBMED   8952530
REFERENCE   7  (bases 1 to 1272)
  AUTHORS   Chappel,M.S., Hough,M.R., Mittel,A., Takei,F., Kay,R. and
            Humphries,R.K.
  TITLE     Cross-linking the murine heat-stable antigen induces apoptosis in B
            cell precursors and suppresses the anti-CD40-induced proliferation
            of mature resting B lymphocytes
  JOURNAL   J Exp Med 184 (5), 1639-1649 (1996)
   PUBMED   8920854
REFERENCE   8  (bases 1 to 1272)
  AUTHORS   Resetkova,E., Kawai,K., Enomoto,T., Arreaza,G., Togun,R., Foy,T.M.,
            Noelle,R.J. and Volpe,R.
  TITLE     Antibody to gp39, the ligand for CD40 significantly inhibits the
            humoral response from Graves' thyroid tissues xenografted into
            severe combined immunodeficient (SCID) mice
  JOURNAL   Thyroid 6 (4), 267-273 (1996)
   PUBMED   8875745
REFERENCE   9  (bases 1 to 1272)
  AUTHORS   Byth,K.F., Conroy,L.A., Howlett,S., Smith,A.J., May,J.,
            Alexander,D.R. and Holmes,N.
  TITLE     CD45-null transgenic mice reveal a positive regulatory role for
            CD45 in early thymocyte development, in the selection of CD4+CD8+
            thymocytes, and B cell maturation
  JOURNAL   J Exp Med 183 (4), 1707-1718 (1996)
   PUBMED   8666928
REFERENCE   10 (bases 1 to 1272)
  AUTHORS   Kong,Y.Y., Kishihara,K., Sumichika,H., Nakamura,T., Kaneko,M. and
            Nomoto,K.
  TITLE     Differential requirements of CD45 for lymphocyte development and
            function
  JOURNAL   Eur J Immunol 25 (12), 3431-3436 (1995)
   PUBMED   8566034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097949.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_134360.2.
            
            On Jul 4, 2005 this sequence version replaced XM_230854.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097949.1, CV115559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1272
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /note="CD40 molecule"
                     /db_xref="GeneID:171369"
                     /db_xref="RGD:619830"
     exon            1..76
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..895
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /note="CD40 antigen, TNF receptor superfamily member 5;
                     tumor necrosis factor receptor superfamily, member 5; CD40
                     molecule, TNF receptor superfamily member 5"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 5 precursor"
                     /protein_id="NP_599187.1"
                     /db_xref="GeneID:171369"
                     /db_xref="RGD:619830"
                     /translation="MLPLPQLCALWGCLLTAVHLGQCVTCSDKQYLQGGECCDLCQPG
                     NRLVSHCTALEKTQCQPCDSGEFSAHWNREIRCHQHRHCELNQGLQVKKEGTAVSDTV
                     CTCKEGQHCASKECETCAQHTPCGPGFGVVQMATETTDTVCQPCPVGFFSNGSSLFEK
                     CHPWTSCEDQKLMVLREGTSQTDTLCGFQPRMRALLVIPVVMVILITIFVVFLYIKKV
                     VKKPKDNEVLPPEARGQDPVEIEDYPGHNTAAPVQETLHGCQPVAQEDGKESRISVQE
                     RQVTGSMALKPLV"
     exon            77..155
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            156..281
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            282..428
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            429..522
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            523..584
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            585..671
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            672..703
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1242
                     /gene="Cd40"
                     /gene_synonym="Tnfrsf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctgctc tgatctcgct ctgcaatgct gcctttgcct cagctgtgcg cgctctgggg
       61 ctgcttgttg acagcggtcc atctaggaca gtgtgttacg tgcagtgaca aacagtacct
      121 ccaaggtggc gagtgctgcg atttgtgcca gccgggaaac cgactagtta gccactgcac
      181 agctcttgag aagacccaat gccaaccgtg cgactcaggc gaattctcag ctcactggaa
      241 cagggagatc cgctgccacc agcaccgaca ctgcgaactc aatcaagggc ttcaggttaa
      301 gaaggagggc accgcggttt cagacactgt ttgtacctgc aaggaagggc agcactgcgc
      361 cagcaaggag tgcgagacgt gcgctcagca cacgccctgt ggccctggct ttggagtcgt
      421 gcagatggcc actgagacta ctgatactgt ctgccaaccc tgcccggtcg gattcttctc
      481 caatgggtca tcactttttg aaaagtgtca tccatggaca agctgtgaag atcagaagct
      541 gatggtccta cgggaaggaa caagtcagac tgataccctc tgtggtttcc agccccggat
      601 gcgagccctg ctggtcattc ccgtcgtgat ggtcatcctc atcaccatct ttgtggtttt
      661 tctctatatc aaaaaggtgg tcaagaaacc aaaggacaat gaggtcttac cccctgaggc
      721 tcgaggacaa gatcctgtgg agatagaaga ttatcccggt cacaacactg ctgctccagt
      781 gcaggagacg ttgcatgggt gtcagcctgt tgcacaggag gatggtaaag agagtcgcat
      841 ctcagtgcag gagcggcagg tgacaggcag catggccttg aagcccctgg tctgagccct
      901 ggaactgttt tggaggtgat ggttccggag caggggcctg gctctgacag ccgctgactt
      961 ttgaagtttg agaggagcca aggcagagcc cggtgcagct aactttcgtg cctgcccctg
     1021 tcatctctcg acttgctttt taaagatgga ggaaaagctt tggcgtcagg ggtccgcagt
     1081 aatatctaca gagtgcagca atgcaggccc agagatgtct tgctgcggtt ttcactgtaa
     1141 ggagtcgtgg acacgggagt ccatgacttg tggcttgtgc tgctagaagg cacctggttg
     1201 cccagcagcc ggggactggc taaataaatc tgtaattatt taaaaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aa
//
