LOCUS       NM_012705               1749 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus Cd4 molecule (Cd4), mRNA.
ACCESSION   NM_012705
VERSION     NM_012705.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Reuter,S., Kentrup,D., Grabner,A., Kohler,G., Buscher,K. and
            Edemir,B.
  TITLE     C4d Deposition after Allogeneic Renal Transplantation in Rats Is
            Involved in Initial Apoptotic Cell Clearance
  JOURNAL   Cells 10 (12), 3499 (2021)
   PUBMED   34944007
  REMARK    GeneRIF: C4d Deposition after Allogeneic Renal Transplantation in
            Rats Is Involved in Initial Apoptotic Cell Clearance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Li,S., Jiang,L., Li,X., Lin,F., Wang,Y., Li,B., Jiang,T., An,W.,
            Liu,S., Liu,H., Xu,P., Zhao,L., Zhang,L., Mu,J., Wang,H., Kang,J.,
            Li,Y., Huang,L., Zhu,C., Zhao,S., Lu,J., Ji,J. and Zhao,J.
  TITLE     Clinical and pathological investigation of patients with severe
            COVID-19
  JOURNAL   JCI Insight 5 (12), 138070 (2020)
   PUBMED   32427582
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Yao,Z., Zheng,Z., Wu,K. and Junhua,Z.
  TITLE     Immune environment modulation in pneumonia patients caused by
            coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2
  JOURNAL   Aging (Albany NY) 12 (9), 7639-7651 (2020)
   PUBMED   32364527
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Wang,F.J., Cui,D. and Qian,W.D.
  TITLE     Therapeutic Effect of CD4+CD25+ Regulatory T Cells Amplified In
            Vitro on Experimental Autoimmune Neuritis in Rats
  JOURNAL   Cell Physiol Biochem 47 (1), 390-402 (2018)
   PUBMED   29772575
  REMARK    GeneRIF: Adoptive transfusion of CD4+CD25+ Regulatory T Cells into
            Experimental Autoimmune Neuritis model rats has significant
            therapeutic effects.
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Vuohelainen,V., Paavonen,T., Hamalainen,M., Moilanen,E. and
            Mennander,A.A.
  TITLE     C4d Deposition Reveals Myocardial Infarction After Cardiac
            Arrest--Experimental Study
  JOURNAL   Adv Clin Exp Med 24 (3), 393-399 (2015)
   PUBMED   26467126
  REMARK    GeneRIF: Increased C4d deposition may be amenable to identify early
            myocardial infarction after cardiac arrest.
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Ayliffe,W., Alam,Y., Bell,E.B., McLeod,D. and Hutchinson,I.V.
  TITLE     Prolongation of rat corneal graft survival by treatment with
            anti-CD4 monoclonal antibody
  JOURNAL   Br J Ophthalmol 76 (10), 602-606 (1992)
   PUBMED   1358194
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Seong,R.H., Chamberlain,J.W. and Parnes,J.R.
  TITLE     Signal for T-cell differentiation to a CD4 cell lineage is
            delivered by CD4 transmembrane region and/or cytoplasmic tail
  JOURNAL   Nature 356 (6371), 718-720 (1992)
   PUBMED   1533274
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Beyers,A.D., Spruyt,L.L. and Williams,A.F.
  TITLE     Molecular associations between the T-lymphocyte antigen receptor
            complex and the surface antigens CD2, CD4, or CD8 and CD5
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2945-2949 (1992)
   PUBMED   1372996
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Nabozny,G.H., Cobbold,S.P., Waldmann,H. and Kong,Y.C.
  TITLE     Suppression in murine experimental autoimmune thyroiditis: in vivo
            inhibition of CD4+ T cell-mediated resistance by a nondepleting rat
            CD4 monoclonal antibody
  JOURNAL   Cell Immunol 138 (1), 185-196 (1991)
   PUBMED   1680568
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Sayegh,M.H., Sablinski,T., Tanaka,K., Kut,J.P., Kwok,C.A.,
            Tilney,N.L., Kupiec-Weglinski,J.W. and Milford,E.L.
  TITLE     Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized
            cardiac allografts before and after engraftment
  JOURNAL   Transplantation 51 (2), 296-299 (1991)
   PUBMED   1704648
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M15768.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M15768.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1749
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /note="Cd4 molecule"
                     /db_xref="GeneID:24932"
                     /db_xref="RGD:2306"
     exon            1..21
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            22..108
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1427
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /note="T-cell surface glycoprotein CD4; W3/25 antigen;
                     T-cell surface antigen T4/Leu-3; CD4 antigen"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD4 precursor"
                     /protein_id="NP_036837.1"
                     /db_xref="GeneID:24932"
                     /db_xref="RGD:2306"
                     /translation="MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCE
                     STSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLR
                     MEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKH
                     KSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSE
                     GESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLS
                     ETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPT
                     SPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLN
                     QTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRM
                     QKSHNLI"
     exon            109..273
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            274..432
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            433..669
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1005
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1209
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1328
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1396
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1749
                     /gene="Cd4"
                     /gene_synonym="p55; W3/25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagaaagg actggccaga gactcagatc cccatccgct caagcaggcc accatgtgcc
       61 gaggcttctc tttcaggcac ttgctgccgc tgctgctcct gcagctgtca aaactcctag
      121 ttgtcaccca aggaaagacc gtggtgctgg ggaaggaagg gggttcagca gaactgccct
      181 gtgaaagtac ctcgaggagg agtgcatcct tcgcgtggaa gtcctctgac caaaagacaa
      241 ttctgggata taagaacaag ttattgatta aaggttcact tgagctgtat agtcgttttg
      301 attccagaaa aaatgcatgg gagagaggat catttcccct catcatcaat aaacttagga
      361 tggaggactc tcagacttat gtctgcgagc tggagaacaa gaaagaggag gtggagttgt
      421 gggtcttcag agtgaccttc aatccgggta ccagactgtt gcaggggcag agcctgaccc
      481 tgatcttgga tagcaaccct aaggtctctg accccccgat agagtgcaaa cacaaaagca
      541 gtaacattgt caaggactcc aaagctttct ccacgcacag cctaaggatt caggacagtg
      601 gcatctggaa ctgcaccgtg accctgaacc agaagaagca ctcatttgac atgaaactct
      661 cagtgctggg ctttgcgagc acatccatca cggcctataa gagtgagggg gagtcagcgg
      721 agttctcctt cccactcaac cttggagagg aaagcctgca gggagagttg agatggaagg
      781 cagagaaggc tccttcttcc cagtcctgga tcaccttctc cctaaagaac caaaaggtgt
      841 ctgtgcagaa gtctactagc aaccccaagt tccagctgtc cgaaacgctc ccactcaccc
      901 ttcagatacc ccaggtctcc cttcagtttg ctggttctgg caacctgacc ctgactctgg
      961 acagagggat actgtatcag gaagtgaacc tggtggtgat gaaagtgact cagcccgaca
     1021 gcaacacttt gacctgtgag gtgatgggac ccacctcacc caagatgaga ctgatcttga
     1081 agcaggagaa tcaggaggcc agggtctcca ggcaggagaa agtgattcaa gtgcaggccc
     1141 ctgaagcagg ggtgtggcaa tgtctactga gtgaaggtga agaggtcaag atggactcca
     1201 agatccaggt tttatccaaa gggttgaacc agacaatgtt cctggctgtc gtgctgggga
     1261 gcgccttcag ctttctggtt ttcacggggc tctgcatcct attctgtgtc aggtgccggc
     1321 accaacagcg ccaggcagca cggatgtctc agatcaagag gcttctcagt gagaagaaga
     1381 cttgccagtg ctcccaccgg atgcagaaaa gccacaatct catatgaggc ctgggcccca
     1441 cctgcagccc tgcctgtgtc ctgtcgctga cccaggcctg tggaccagat gaatgtagcc
     1501 cacacagtgc ctctggcctc ctgcttttct cttccacaac tggccacggt ttctctgcct
     1561 ctgttcccaa gcccgttggc tgagcttgcg ctcggctgtg tttcagacac tcaagcacac
     1621 ccagccagct tattgatcct ccgtagctgc ctttacgcca gagcccagcc cttctctgac
     1681 taacatcctg gatcttcttt ccagctgtct gcttggatct aagggcacct gacctggatg
     1741 gtgggactg
//
