LOCUS       NM_001077646             617 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD3 gamma subunit of T-cell receptor complex
            (Cd3g), mRNA.
ACCESSION   NM_001077646 XM_001067846 XM_217136
VERSION     NM_001077646.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 617)
  AUTHORS   Sigalov,A., Aivazian,D. and Stern,L.
  TITLE     Homooligomerization of the cytoplasmic domain of the T cell
            receptor zeta chain and of other proteins containing the
            immunoreceptor tyrosine-based activation motif
  JOURNAL   Biochemistry 43 (7), 2049-2061 (2004)
   PUBMED   14967045
REFERENCE   2  (bases 1 to 617)
  AUTHORS   Torres,P.S., Alcover,A., Zapata,D.A., Arnaud,J., Pacheco,A.,
            Martin-Fernandez,J.M., Villasevil,E.M., Sanal,O. and Regueiro,J.R.
  TITLE     TCR dynamics in human mature T lymphocytes lacking CD3 gamma
  JOURNAL   J Immunol 170 (12), 5947-5955 (2003)
   PUBMED   12794121
REFERENCE   3  (bases 1 to 617)
  AUTHORS   Kastrup,J., Pedersen,L.O., Dietrich,J., Lauritsen,J.P., Menne,C.
            and Geisler,C.
  TITLE     In vitro production and characterization of partly assembled human
            CD3 complexes
  JOURNAL   Scand J Immunol 56 (5), 436-442 (2002)
   PUBMED   12410792
REFERENCE   4  (bases 1 to 617)
  AUTHORS   Torres,P.S., Zapata,D.A., Pacheco-Castro,A.,
            Rodriguez-Fernandez,J.L., Cabanas,C. and Regueiro,J.R.
  TITLE     Contribution of CD3 gamma to TCR regulation and signaling in human
            mature T lymphocytes
  JOURNAL   Int Immunol 14 (11), 1357-1367 (2002)
   PUBMED   12407027
REFERENCE   5  (bases 1 to 617)
  AUTHORS   San Jose,E., Sahuquillo,A.G., Bragado,R. and Alarcon,B.
  TITLE     Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3
            epsilon/gamma dimers associate indistinctly with both TCR alpha and
            TCR beta chains. Evidence for a double TCR heterodimer model
  JOURNAL   Eur J Immunol 28 (1), 12-21 (1998)
   PUBMED   9485181
REFERENCE   6  (bases 1 to 617)
  AUTHORS   Wiest,D.L., Ashe,J.M., Howcroft,T.K., Lee,H.M., Kemper,D.M.,
            Negishi,I., Singer,D.S., Singer,A. and Abe,R.
  TITLE     A spontaneously arising mutation in the DLAARN motif of murine
            ZAP-70 abrogates kinase activity and arrests thymocyte development
  JOURNAL   Immunity 6 (6), 663-671 (1997)
   PUBMED   9208839
REFERENCE   7  (bases 1 to 617)
  AUTHORS   Levins,B. and Colaco,C.A.
  TITLE     The CD3 gamma-chain, transmembrane signalling or recognition?
  JOURNAL   Immunogenetics 35 (2), 140-143 (1992)
   PUBMED   1531205
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S79711.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by
            NM_001077646.3.
            
            On Apr 2, 2013 this sequence version replaced NM_001077646.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S79711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00155305,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-617               S79711.1           1-617
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..617
                     /gene="Cd3g"
                     /note="CD3 gamma subunit of T-cell receptor complex"
                     /db_xref="GeneID:300678"
                     /db_xref="RGD:1307718"
     exon            1..108
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..602
                     /gene="Cd3g"
                     /note="T-cell surface glycoprotein CD3 gamma chain; CD3
                     gamma-chain; T-cell receptor T3 gamma chain; CD3 antigen,
                     gamma polypeptide; CD3 molecule, gamma polypeptide; CD3g
                     molecule"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 gamma chain
                     precursor"
                     /protein_id="NP_001071114.1"
                     /db_xref="GeneID:300678"
                     /db_xref="RGD:1307718"
                     /translation="MEQGKGLAGLFLVISLLQGTMAQQKEEKHLVKVDDSQGDGSVLL
                     TCDFNEKTITWLKDGHRISPPNATKSTWNLGNGAKDPRGMYQCRGAKKKSQLLQVYYR
                     LCENCIELNMGTVSGFIFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLQNEQVY
                     QPLKDREYEQYSRLQGNQVRKK"
     exon            109..132
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
     exon            133..360
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
     exon            361..492
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
     exon            493..536
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
     exon            537..617
                     /gene="Cd3g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggctact aaggaactct cgacacttct actggagaag caaagaaact aacatggagc
       61 aggggaaagg tttggctggc ctcttcctgg tgatctctct tcttcaaggc accatggccc
      121 agcaaaaaga agaaaagcat ttggtaaaag tggatgacag ccaaggagat ggctctgtac
      181 ttctgacttg tgacttcaat gagaagacta tcacatggct taaagatggg cacagaataa
      241 gtcctccaaa tgcaactaaa agcacgtgga atctgggcaa cggtgccaaa gaccctcgag
      301 gcatgtatca gtgccgagga gcaaagaaga agtcgcagct cctgcaagtg tactacagac
      361 tgtgtgagaa ctgcattgag ctaaatatgg gcactgtgtc cggctttatc ttcgctgaaa
      421 tcatcagcat tttcttcctt gctgttggtg tatacttcat tgctggacag gatggagttc
      481 gccagtcaag agcttcagac aagcagactc tgttgcaaaa tgaacaggtc taccagcccc
      541 tcaaggaccg ggaatatgaa cagtacagcc gtctccaagg aaaccaagtg agaaagaagt
      601 gaactcagca ggaattc
//
