LOCUS       NM_001108140            1254 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CD3 epsilon subunit of T-cell receptor complex
            (Cd3e), mRNA.
ACCESSION   NM_001108140 XM_001063976 XM_039081430 XM_236196
VERSION     NM_001108140.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Gieseke,F., Kruchen,A., Tzaribachev,N., Bentzien,F., Dominici,M.
            and Muller,I.
  TITLE     Proinflammatory stimuli induce galectin-9 in human mesenchymal
            stromal cells to suppress T-cell proliferation
  JOURNAL   Eur J Immunol 43 (10), 2741-2749 (2013)
   PUBMED   23817958
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Lesourne,R., Zvezdova,E., Song,K.D., El-Khoury,D., Uehara,S.,
            Barr,V.A., Samelson,L.E. and Love,P.E.
  TITLE     Interchangeability of Themis1 and Themis2 in thymocyte development
            reveals two related proteins with conserved molecular function
  JOURNAL   J Immunol 189 (3), 1154-1161 (2012)
   PUBMED   22732588
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Gartlan,K.H., Belz,G.T., Tarrant,J.M., Minigo,G., Katsara,M.,
            Sheng,K.C., Sofi,M., van Spriel,A.B., Apostolopoulos,V.,
            Plebanski,M., Robb,L. and Wright,M.D.
  TITLE     A complementary role for the tetraspanins CD37 and Tssc6 in
            cellular immunity
  JOURNAL   J Immunol 185 (6), 3158-3166 (2010)
   PUBMED   20709950
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   O'Connell,R.M., Chaudhuri,A.A., Rao,D.S., Gibson,W.S., Balazs,A.B.
            and Baltimore,D.
  TITLE     MicroRNAs enriched in hematopoietic stem cells differentially
            regulate long-term hematopoietic output
  JOURNAL   Proc Natl Acad Sci U S A 107 (32), 14235-14240 (2010)
   PUBMED   20660734
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Bouvier,G., Watrin,F., Naspetti,M., Verthuy,C., Naquet,P. and
            Ferrier,P.
  TITLE     Deletion of the mouse T-cell receptor beta gene enhancer blocks
            alphabeta T-cell development
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7877-7881 (1996)
   PUBMED   8755570
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Byth,K.F., Conroy,L.A., Howlett,S., Smith,A.J., May,J.,
            Alexander,D.R. and Holmes,N.
  TITLE     CD45-null transgenic mice reveal a positive regulatory role for
            CD45 in early thymocyte development, in the selection of CD4+CD8+
            thymocytes, and B cell maturation
  JOURNAL   J Exp Med 183 (4), 1707-1718 (1996)
   PUBMED   8666928
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Negishi,I., Motoyama,N., Nakayama,K., Nakayama,K., Senju,S.,
            Hatakeyama,S., Zhang,Q., Chan,A.C. and Loh,D.Y.
  TITLE     Essential role for ZAP-70 in both positive and negative selection
            of thymocytes
  JOURNAL   Nature 376 (6539), 435-438 (1995)
   PUBMED   7630421
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Hubbe,M. and Altevogt,P.
  TITLE     Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a
            costimulatory function
  JOURNAL   Eur J Immunol 24 (3), 731-737 (1994)
   PUBMED   8125140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 31, 2021 this sequence version replaced
            XM_039081430.1, NM_001108140.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000008.1  54211726-54211770   c
            46-147              JAXUCZ010000008.1  54211496-54211597   c
            148-165             JAXUCZ010000008.1  54209205-54209222   c
            166-180             JAXUCZ010000008.1  54207526-54207540   c
            181-204             JAXUCZ010000008.1  54204316-54204339   c
            205-420             JAXUCZ010000008.1  54203663-54203878   c
            421-588             JAXUCZ010000008.1  54202522-54202689   c
            589-635             JAXUCZ010000008.1  54201968-54202014   c
            636-1254            JAXUCZ010000008.1  54200617-54201235   c
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1254
                     /gene="Cd3e"
                     /note="CD3 epsilon subunit of T-cell receptor complex"
                     /db_xref="GeneID:315609"
                     /db_xref="RGD:1309222"
     exon            1..45
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            46..147
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..692
                     /gene="Cd3e"
                     /note="T-cell surface glycoprotein CD3 epsilon chain; CD3
                     antigen, epsilon polypeptide; CD3 molecule, epsilon
                     polypeptide; CD3e molecule"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 epsilon chain
                     precursor"
                     /protein_id="NP_001101610.2"
                     /db_xref="GeneID:315609"
                     /db_xref="RGD:1309222"
                     /translation="MQWNAFWSILGLSLLAVGTCQEDIEDTVTDDGAQKQYEVSISGT
                     SVELTCPLENEDNLKWEKNDKVLPDKNEKHLVLEDFSEVKDSGYYVCYTESSRKNTYL
                     YLKARVCENCMEVDLTAVSIIIIVDICITLGLLMVVYYWSKKRKAKAKPVTRGTGTGG
                     RPRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRAV"
     exon            148..165
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            166..180
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            181..204
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            205..420
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            421..588
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            589..635
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1254
                     /gene="Cd3e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacttgc ctccctgcct gcttctggtg ccttcttcag aaatgaagta atgagccagc
       61 cgtgtccgcc atcttagttg agagagcatt ctaagaggat gcagtggaac gctttctgga
      121 gcatcctggg cctcagcctc ctagcagttg gcacttgcca ggaagatatc gaggacactg
      181 ttacagatga tggagcacag aaacagtatg aagtctccat ctcaggaacc agtgtagagc
      241 tgacgtgccc tctagagaat gaggacaact taaagtggga gaaaaatgac aaagtcctgc
      301 ctgataagaa tgagaaacac ctggtgctag aggatttctc ggaagtcaag gacagtggtt
      361 actatgtctg ctacacagaa agctcaagga aaaacacgta cctgtacctg aaagccagag
      421 tgtgcgagaa ctgcatggag gtggacctga cagcagtatc cataatcatc attgttgaca
      481 tctgcatcac tctgggcttg ctgatggtcg tttattactg gagcaagaaa aggaaggcca
      541 aggccaagcc tgtgacccga ggaactggta ctggtggcag gcccagaggg caaaacaagg
      601 agcggccgcc acctgttccc aacccagact atgagcccat ccgaaaaggc caacgggacc
      661 tgtattctgg cctgaatcag agagcagtct gacagatagg agggacactg ccttctgtgg
      721 acccatgcta ttccttgttc tctggacaag cggcagagtc cacagcctta ttcttcagcc
      781 tcctggtgaa cacgcatcct agaaccttcc tctcccactt cctttgctag aagccagtac
      841 taggacattg ctgactcagt atcctttgaa atatcatgac tggtcagatt gtcggccagc
      901 caccttgtgg ggatactttt ctcagttgcc ctgctgccat tccctgccag ctcccccctt
      961 cttcaccaat gtcatctctg ccttcaatcc cttccctctc ctaattggcc ctcatagcca
     1021 gcactttcct atagctttct gtttttctac ctctgtattt tatgcccttc tctggggatg
     1081 gatttggtga tcattggcat aggtcctgcc ccattcatag atcctgaccc agcccctgcc
     1141 acgggcccct ttccaggctt caccttaggt ccttggatgg tcatctccat atccatcaat
     1201 ataccaagct cttctttgct aatgcaaaag caataaagta tgttggttgg aaaa
//
