LOCUS       NM_013127               2803 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CD38 molecule (Cd38), mRNA.
ACCESSION   NM_013127
VERSION     NM_013127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Zhou,H., Liu,S., Zhang,N., Fang,K., Zong,J., An,Y. and Chang,X.
  TITLE     Downregulation of Sirt6 by CD38 promotes cell senescence and aging
  JOURNAL   Aging (Albany NY) 14 (23), 9730-9757 (2022)
   PUBMED   36490326
  REMARK    GeneRIF: Downregulation of Sirt6 by CD38 promotes cell senescence
            and aging.
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Tapias-Espinosa,C., Canete,T., Sampedro-Viana,D., Brudek,T.,
            Kaihoj,A., Oliveras,I., Tobena,A., Aznar,S. and Fernandez-Teruel,A.
  TITLE     Oxytocin attenuates schizophrenia-like reduced sensorimotor gating
            in outbred and inbred rats in line with strain differences in CD38
            gene expression
  JOURNAL   Physiol Behav 240, 113547 (2021)
   PUBMED   34364851
  REMARK    GeneRIF: Oxytocin attenuates schizophrenia-like reduced
            sensorimotor gating in outbred and inbred rats in line with strain
            differences in CD38 gene expression.
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Ogura,Y., Kitada,M., Xu,J., Monno,I. and Koya,D.
  TITLE     CD38 inhibition by apigenin ameliorates mitochondrial oxidative
            stress through restoration of the intracellular NAD+/NADH ratio and
            Sirt3 activity in renal tubular cells in diabetic rats
  JOURNAL   Aging (Albany NY) 12 (12), 11325-11336 (2020)
   PUBMED   32507768
  REMARK    GeneRIF: CD38 inhibition by apigenin ameliorates mitochondrial
            oxidative stress through restoration of the intracellular
            NAD(+)/NADH ratio and Sirt3 activity in renal tubular cells in
            diabetic rats.
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Boslett,J., Hemann,C., Christofi,F.L. and Zweier,J.L.
  TITLE     Characterization of CD38 in the major cell types of the heart:
            endothelial cells highly express CD38 with activation by
            hypoxia-reoxygenation triggering NAD(P)H depletion
  JOURNAL   Am J Physiol Cell Physiol 314 (3), C297-C309 (2018)
   PUBMED   29187364
  REMARK    GeneRIF: Endothelial cells have high expression of CD38 which is
            activated by hypoxia-reoxygenation triggering CD38-mediated NADP(H)
            depletion with loss of eNOS-mediated NO generation and increased
            eNOS uncoupling.
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Guan,X.H., Hong,X., Zhao,N., Liu,X.H., Xiao,Y.F., Chen,T.T.,
            Deng,L.B., Wang,X.L., Wang,J.B., Ji,G.J., Fu,M., Deng,K.Y. and
            Xin,H.B.
  TITLE     CD38 promotes angiotensin II-induced cardiac hypertrophy
  JOURNAL   J Cell Mol Med 21 (8), 1492-1502 (2017)
   PUBMED   28296029
  REMARK    GeneRIF: CD38 plays an essential role in cardiac hypertrophy
            probably via inhibition of SIRT3 expression and activation of
            Ca(2+) -NFAT signaling pathway.
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Yoder,M.C., Hiatt,K., Dutt,P., Mukherjee,P., Bodine,D.M. and
            Orlic,D.
  TITLE     Characterization of definitive lymphohematopoietic stem cells in
            the day 9 murine yolk sac
  JOURNAL   Immunity 7 (3), 335-344 (1997)
   PUBMED   9324354
REFERENCE   7  (bases 1 to 2803)
  AUTHORS   Byth,K.F., Conroy,L.A., Howlett,S., Smith,A.J., May,J.,
            Alexander,D.R. and Holmes,N.
  TITLE     CD45-null transgenic mice reveal a positive regulatory role for
            CD45 in early thymocyte development, in the selection of CD4+CD8+
            thymocytes, and B cell maturation
  JOURNAL   J Exp Med 183 (4), 1707-1718 (1996)
   PUBMED   8666928
REFERENCE   8  (bases 1 to 2803)
  AUTHORS   Matsuoka,T., Kajimoto,Y., Watada,H., Umayahara,Y., Kubota,M.,
            Kawamori,R., Yamasaki,Y. and Kamada,T.
  TITLE     Expression of CD38 gene, but not of mitochondrial
            glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic
            islets of GK rats
  JOURNAL   Biochem Biophys Res Commun 214 (1), 239-246 (1995)
   PUBMED   7669044
REFERENCE   9  (bases 1 to 2803)
  AUTHORS   Koguma,T., Takasawa,S., Tohgo,A., Karasawa,T., Furuya,Y.,
            Yonekura,H. and Okamoto,H.
  TITLE     Cloning and characterization of cDNA encoding rat ADP-ribosyl
            cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from
            islets of Langerhans
  JOURNAL   Biochim Biophys Acta 1223 (1), 160-162 (1994)
   PUBMED   8061050
REFERENCE   10 (bases 1 to 2803)
  AUTHORS   Li,Q., Yamada,Y., Yasuda,K., Ihara,Y., Okamoto,Y., Kaisaki,P.J.,
            Watanabe,R., Ikeda,H., Tsuda,K. and Seino,Y.
  TITLE     A cloned rat CD38-homologous protein and its expression in
            pancreatic islets
  JOURNAL   Biochem Biophys Res Commun 202 (1), 629-636 (1994)
   PUBMED   8037769
  REMARK    Erratum:[Biochem Biophys Res Commun 1994 Oct 28;204(2):1001]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 30, 2022 this sequence version replaced NM_013127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212353.1, D29646.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000014.1  71424199-71424505   c
            308-437             JAXUCZ010000014.1  71395689-71395818   c
            438-573             JAXUCZ010000014.1  71394310-71394445   c
            574-659             JAXUCZ010000014.1  71392262-71392347   c
            660-733             JAXUCZ010000014.1  71389668-71389741   c
            734-826             JAXUCZ010000014.1  71388244-71388336   c
            827-913             JAXUCZ010000014.1  71387847-71387933   c
            914-2803            JAXUCZ010000014.1  71384532-71386421   c
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2803
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /note="CD38 molecule"
                     /db_xref="GeneID:25668"
                     /db_xref="RGD:2303"
     exon            1..307
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..977
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /EC_number="3.2.2.6"
                     /EC_number="2.4.99.20"
                     /note="ADP-ribosyl cyclase 1; CD38H; cADPr hydrolase 1;
                     cyclic ADP-ribose hydrolase 1; CD38 antigen (ADP-ribosyl
                     cyclase / cyclic ADP-ribose hydrolase);
                     2'-phospho-ADP-ribosyl cyclase;
                     2'-phospho-cyclic-ADP-ribose transferase;
                     2'-phospho-ADP-ribosyl
                     cyclase/2'-phospho-cyclic-ADP-ribose transferase"
                     /codon_start=1
                     /product="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
                     1"
                     /protein_id="NP_037259.1"
                     /db_xref="GeneID:25668"
                     /db_xref="RGD:2303"
                     /translation="MANYEFSQVSEDRPGCRLTRKAQIGLGVGLLLLVALVVVVVIVL
                     WPRSPLVWKGKPTTKHFADIILGRCLIYTQILRPEMRDQDCKKILSTFKRGFISKNPC
                     NITNEDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDL
                     RWCGDPSTSDMNYDSCPHWSENCPNNPVAVFWNVISQKFAEDACGVVQVMLNGSLSEP
                     FYRNSTFGSVEVFNLDPNKVHKLQAWVMHDIKGTSSNACSSPSINELKSIVNKRNMIF
                     ACQDNYRPVRFLQCVKNPEHPSCRLNV"
     exon            308..437
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..573
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..659
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..733
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..826
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..913
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..2803
                     /gene="Cd38"
                     /gene_synonym="ADPRC 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctctgac ccagccagcc ctgtgctctc ttcctgccta gcctgggcca gtctccagga
       61 gcccaatggc caactatgaa ttttcccagg tgtctgagga cagacctggc tgccgcctca
      121 ctaggaaagc ccagatcggt cttggagtgg gtctcctgct cctggtcgcc ttggtagtgg
      181 tcgtggtcat agttctgtgg ccgcgctcac ccctggtgtg gaaagggaag cctaccacga
      241 agcacttcgc tgacatcatc ttgggacgct gcctgatcta tactcaaatc ctccggccgg
      301 agatgagaga tcaggactgc aagaagatac taagtacatt caaaagaggg tttatttcca
      361 agaatccttg caacatcacc aatgaagact acgcaccact ggttaaattg gttactcaaa
      421 ccataccatg taacaagact ctcttttgga gcaagtccaa acacctggcc catcagtata
      481 cttggatcca ggggaaaatg ttcaccctgg aggacacact gctgggctat attgcagatg
      541 atctcaggtg gtgtggagac cccagtactt ccgatatgaa ctatgactct tgcccacatt
      601 ggagtgaaaa ttgtcccaac aaccctgttg ctgtgttctg gaatgtgatt tcccaaaagt
      661 ttgcagaaga tgcctgtggt gtggtccaag tgatgctcaa tgggtccctc agtgagccat
      721 tttacagaaa cagcaccttt ggaagtgtgg aagtctttaa tttggaccca aataaggttc
      781 ataaactaca ggcctgggta atgcatgaca ttaaaggaac ttccagtaat gcatgttcga
      841 gcccctccat aaatgagctg aagtcgattg tgaacaaaag gaatatgata tttgcctgcc
      901 aggataacta ccgacctgta agatttcttc agtgtgtgaa gaatcctgag catccatcat
      961 gtagacttaa tgtgtgaagg acttggatct cagaatcccc acacacactc cgcagcacgc
     1021 aatgaggtga aagattcaga agcaacactg tcgggaaagc agcagttgtc agggagaggt
     1081 ctctactaca atgctaacat cagagatgga agagcttccc aatacattat gacagaacga
     1141 cacgatcagc tcagtgcgtc ctgtgtacta ccagtaatag tcaagaaaag tcactccata
     1201 aaccagagtt aaggttctat attgttattt caatgtggtg cttttatatt gtttatattt
     1261 tgctagcatc cttttttcct ctcttttaat gaggtctctc tttctctctt aatgaggctg
     1321 agaatcagac ctgagaactt gcacacatgg tggataagcc tatataccac tgagctaact
     1381 cctcagcatg gctggatttt tattgaaaaa tgccaatcca acttcccatt ggacaaagaa
     1441 aatcaaacat caagtttatc gaaatgaata accttatttt tttatgtttt tgcattctcc
     1501 ccacaaatat tcaaatggta aacatgaggt catagggtca ttatagagaa ggtgctctgt
     1561 ggaaactacc cacatgccct gtgctttagt cgatttttaa cccatccaac atgtccttgt
     1621 taactttgag ttttattggg ggggattggg gggggttaac gtgagaaaat ggagtttaga
     1681 gagataattt attttcctaa agtcacattc ttaggatcat ggttacatct gaaattaaat
     1741 cagttctgtc aaagtcaaca acataagttt ttttttttct tttctgagct tttattgcca
     1801 aattgatagt agcctgtgtt atcgtctagc aatagactct gcaatgtgat ctttatgggt
     1861 gatttcgaaa ctaattactt gcactctctt tctcttcttc ctcattcttg gtgccttctg
     1921 taggtagtca ggagttagct tacatttgtt gctgatatcg gcaatttatg ttttttatcc
     1981 tttttttctt acatctgtct tgctcggagt cactaatttg gttgttattt tgttgttgtt
     2041 ggttgtcttt ttcaaagctc cactctttac ccttcctcat ttatttattt aattgagctt
     2101 ttgtctattt ttagaaacat agaaatttct tctgtcttca atatctccat ttagcttttt
     2161 tgaggcaaat gtttagacca ttgctatttc agcctgttct cttttttctt ttttatagga
     2221 tattttatgt atttacattt caaatgttat cccctttccc agttcccccg ccctgattct
     2281 atgaggatac ttccccttcc acccacccat tcccacctca ccaccctgac attcattccc
     2341 ctacactggg aaaatgagcc ttcacaggac caagggcttc tcctcctatt gatgcctgac
     2401 aaagccatcc tctgctacat atgtgactgg agctatgggt ccctccatgt atactcctta
     2461 gttggtggtt tggaccctga gtactctggt gggtttgttt ggttgatatt gctgttcttc
     2521 ctatggggtt gcaaaccact tcagctcctt cagttctttc tctatctcct ccatttaggt
     2581 ccctgtgctc agtccgatgt ttctcactag tttccccctg ggccctgctt ttgctgtaac
     2641 actgaatttc tgtatgcctt tcctgcttac ttacgattca gttcaaaata attcctgatt
     2701 ttattgttat ttagaaatgt gatatttact tttcaacaac taaagaatgt tttctttttt
     2761 taaatgtctt tagtgggtat caataaacta aattgaaaca gca
//
