LOCUS       NM_031561               2625 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD36 molecule (Cd36), mRNA.
ACCESSION   NM_031561 XM_346685
VERSION     NM_031561.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2625)
  AUTHORS   Silhavy,J., Mlejnek,P., Simakova,M., Markova,I., Malinska,H.,
            Huttl,M., Kazdova,L., Kazantsev,D., Mancini,M., Novotny,J. and
            Pravenec,M.
  TITLE     CD36 regulates substrates utilisation in brown adipose tissue of
            spontaneously hypertensive rats: In vitro study
  JOURNAL   PLoS One 18 (4), e0283276 (2023)
   PUBMED   37053180
  REMARK    GeneRIF: CD36 regulates substrates utilisation in brown adipose
            tissue of spontaneously hypertensive rats: In vitro study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2625)
  AUTHORS   Flores,J.J., Ding,Y., Sherchan,P., Zhang,J.H. and Tang,J.
  TITLE     Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage
  JOURNAL   Exp Neurol 359, 114257 (2023)
   PUBMED   36279933
  REMARK    GeneRIF: Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage.
REFERENCE   3  (bases 1 to 2625)
  AUTHORS   Abdel-Hamid,M.S., Mansour,A.M., Hassan,M.H., Abdelhady,R.,
            Elsadek,B.E.M., El-Sayed,E.M. and Salama,S.A.
  TITLE     Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular
            Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis
  JOURNAL   Biol Pharm Bull 46 (11), 1558-1568 (2023)
   PUBMED   37914358
  REMARK    GeneRIF: Estrogen Attenuates Diethylnitrosamine-Induced
            Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis.
REFERENCE   4  (bases 1 to 2625)
  AUTHORS   Tian,R., Deng,A., Pang,X., Chen,Y., Gao,Y., Liu,H. and Hu,Z.
  TITLE     VR-10 polypeptide interacts with CD36 to induce cell apoptosis and
            autophagy in choroid-retinal endothelial cells: Identification of
            VR-10 as putative novel therapeutic agent for choroid
            neovascularization (CNV) treatment
  JOURNAL   Peptides 157, 170868 (2022)
   PUBMED   36067926
  REMARK    GeneRIF: VR-10 polypeptide interacts with CD36 to induce cell
            apoptosis and autophagy in choroid-retinal endothelial cells:
            Identification of VR-10 as putative novel therapeutic agent for
            choroid neovascularization (CNV) treatment.
REFERENCE   5  (bases 1 to 2625)
  AUTHORS   Han,B., Wang,J., Wu,J., Yan,F., Wang,Y. and Li,J.
  TITLE     High glucose-induced upregulation of CD36 promotes inflammation
            stress via NF-kappaB in H9c2 cells
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34490487
  REMARK    GeneRIF: High glucoseinduced upregulation of CD36 promotes
            inflammation stress via NFkappaB in H9c2 cells.
REFERENCE   6  (bases 1 to 2625)
  AUTHORS   Greenwalt,D.E., Scheck,S.H. and Rhinehart-Jones,T.
  TITLE     Heart CD36 expression is increased in murine models of diabetes and
            in mice fed a high fat diet
  JOURNAL   J Clin Invest 96 (3), 1382-1388 (1995)
   PUBMED   7544802
REFERENCE   7  (bases 1 to 2625)
  AUTHORS   Tandon,N.N., Rock,G. and Jamieson,G.A.
  TITLE     Anti-CD36 antibodies in thrombotic thrombocytopenic purpura
  JOURNAL   Br J Haematol 88 (4), 816-825 (1994)
   PUBMED   7529543
REFERENCE   8  (bases 1 to 2625)
  AUTHORS   Jochen,A. and Hays,J.
  TITLE     Purification of the major substrate for palmitoylation in rat
            adipocytes: N-terminal homology with CD36 and evidence for cell
            surface acylation
  JOURNAL   J Lipid Res 34 (10), 1783-1792 (1993)
   PUBMED   7504047
REFERENCE   9  (bases 1 to 2625)
  AUTHORS   Abumrad,N.A., el-Maghrabi,M.R., Amri,E.Z., Lopez,E. and
            Grimaldi,P.A.
  TITLE     Cloning of a rat adipocyte membrane protein implicated in binding
            or transport of long-chain fatty acids that is induced during
            preadipocyte differentiation. Homology with human CD36
  JOURNAL   J Biol Chem 268 (24), 17665-17668 (1993)
   PUBMED   7688729
REFERENCE   10 (bases 1 to 2625)
  AUTHORS   Yufu,Y., Ideguchi,H., Narishige,T., Suematsu,E., Toyoda,K.,
            Nishimura,J., Nawata,H. and Oda,S.
  TITLE     Familial macrothrombocytopenia associated with decreased
            glycosylation of platelet membrane glycoprotein IV
  JOURNAL   Am J Hematol 33 (4), 271-273 (1990)
   PUBMED   2316511
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072543.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_346685.1, NM_031561.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2625
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /note="CD36 molecule"
                     /db_xref="GeneID:29184"
                     /db_xref="RGD:2301"
     exon            1..47
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            48..141
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            142..353
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1652
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /note="collagen type I receptor thrombospondin receptor;
                     GPIV; PAS-4; GPIIIB; PAS IV; CD36 molecule (thrombospondin
                     receptor); platelet glycoprotein IV; Cd36 antigen-like;
                     adipocyte membrane protein; fatty acid transport protein;
                     glycoprotein IIIb; CD36 antigen (collagen type I receptor,
                     thrombospondin receptor); fatty acid translocase"
                     /codon_start=1
                     /product="platelet glycoprotein 4"
                     /protein_id="NP_113749.2"
                     /db_xref="GeneID:29184"
                     /db_xref="RGD:2301"
                     /translation="MGCDRNCGLITGAVIGAVLAVFGGILMPVGDLLIEKTIKREVVL
                     EEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKEN
                     ITQDPKDSTVSFVQPNGAIFEPSLSVGTENDNFTVLNLAVAAAPHIYTNSFVQGVLNS
                     LIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNNTVDGVYKVFNGK
                     DNISKVAIIDTYKGKRNLSYWESYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIY
                     AVFGSEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCK
                     EGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFTLQFAKRLQVNIL
                     VKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIKLLGLVEMVLLG
                     VGVVMFVAFMISYCACRSKNGK"
     exon            354..514
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            515..662
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            663..842
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            843..934
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            935..981
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1051
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1239
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1358
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1432
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1487
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1652
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..2598
                     /gene="Cd36"
                     /gene_synonym="Fat; RGD1562323"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggacttgta ctctctcctc ggatggctag ctgattactt ctgtgtagta gcttacaaat
       61 gattcgaagt gttgaaactt tctgagtctc aatgaactat ttctcacaca actcagatac
      121 tgctgttcat gcatgaatta gttgaaccag gccacataga aagcattgta attgtacctg
      181 tgagttggca agaagcaagt gctcttcctt gattctgctg cacgaggagg agaatgggct
      241 gcgatcggaa ctgtgggctc attactggag ccgttattgg tgctgtcctg gctgtgtttg
      301 gaggcattct catgccggtt ggagacctac tcattgagaa gacaatcaaa agggaagttg
      361 tccttgaaga aggaaccatt gctttcaaaa actgggtgaa aacgggcacc actgtgtaca
      421 gacagttttg gatctttgac gtgcaaaacc cagaggaagt ggcaaagaat agcagcaaga
      481 tcaaggttaa acagagaggt ccttacacat acagagttcg ttatttagcc aaggaaaata
      541 taactcagga ccccaaggac agcactgtct cttttgtaca acccaatgga gccatctttg
      601 agccttcact gtctgttgga acagagaatg acaacttcac agttctcaat ctggctgtgg
      661 cagctgcacc acatatctac acaaactcat ttgttcaagg tgtgctcaac agccttatca
      721 aaaagtccaa gtcttctatg ttccaaacac gaagtttgaa ggaactcttg tggggttaca
      781 aagatccatt cttgagtttg gttccatatc ctataagtac cacagttggt gtgttttatc
      841 cttacaataa cactgtagat ggagtttata aagttttcaa tggaaaggat aacataagca
      901 aggttgccat aattgatacc tataaaggga aaaggaattt gtcctattgg gaaagttatt
      961 gcgacatgat taatggcaca gatgcagcct cctttccacc ttttgttgag aagtctcgaa
     1021 cactgaggtt cttttcctct gacatttgca ggtccatcta tgctgtgttt ggatctgaag
     1081 tgaaccttaa aggaatcccc gtgtacagat ttgttcttcc agccaacgcc tttgcctccc
     1141 cactccagaa cccagacaac cactgtttct gcactgaaaa agtaatctca aataactgta
     1201 cgtcgtatgg tgtgctggac attggcaagt gcaaagaagg aaagcctgtg tacatttctc
     1261 ttccacattt cctacatgca agtcctgatg tctcagaacc tatcgaaggc ttgaatccta
     1321 acgaagatga gcataggaca tacttggatg tggaacccat aactggattc actctacagt
     1381 ttgcaaaacg actgcaggtc aacatactgg tcaagccagc tagaaaaata gaagcactga
     1441 agaatctgaa gagaccttac attgtaccta tactgtggct aaatgagact gggaccatcg
     1501 gcgatgagaa agcagaaatg ttcagaaacc aagtgaccgg gaaaataaag ctcctgggcc
     1561 tggttgagat ggtcttactt ggtgttggag tagtgatgtt tgttgctttt atgatttcat
     1621 actgtgcttg cagatctaag aatggaaaat aagtagtgga tgagcctaca ttatgcacta
     1681 gctacatttt tggtaaaacc aatctccaaa acgaagactt aagacatgct tgtttttata
     1741 aaacacacct atctgtagtt gaagaaacgg tggtgtgcgc gctctctctc ttattgcaga
     1801 tatatattta tttatatatt gcaataagcc acagcatatt tcgaaaagat taatatgtca
     1861 ctaagcctat attttttaat aaaatcttgt attttgttaa gtccatcatc tgcaactgag
     1921 tggacatcaa tttctgcaga actaattatc ttttttggtt ctgatttact gatttttttt
     1981 cctgttggca aatttcaaga atgtatatat tctaagaaac gctttgttcc tcatcgaagt
     2041 aaactgttat catgtctggg gtggcccttt catttatagc aaatgttcct tgtgactgtc
     2101 agcacatgat atgtcataag gattatatca ttttaaagat ttaaggatga aaaatgaaca
     2161 attcacatat gaaccattgt tgatatattg tttaatcctc tccctctctg gtgtccttgg
     2221 caacaacaag gccaggtatc acagatactt ttttcttttt actttcttac acagagctta
     2281 tatgttctgt tcctcgccat gaaatgaact atttttagca cattttagct ctttatttta
     2341 agtatgttgt caagttccat gctgcctagc tcttttgaaa actgagtagg tttttctctt
     2401 tctgctcagc cgcaactaat gtaacttcag agagctgtta tagtgttaaa agatgtaatt
     2461 tataataaat ggattatgat atagaatctt aaaaaagcta gaattggctt taaatatgta
     2521 tttgtggtaa tatattctgc ttttataatc acccagaaat aactggtttc taacattaaa
     2581 gatgttctta aattcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
