LOCUS       NM_001205348            1514 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus Cd300a molecule (Cd300a), mRNA.
ACCESSION   NM_001205348
VERSION     NM_001205348.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Simhadri,V.R., Andersen,J.F., Calvo,E., Choi,S.C., Coligan,J.E. and
            Borrego,F.
  TITLE     Human CD300a binds to phosphatidylethanolamine and
            phosphatidylserine, and modulates the phagocytosis of dead cells
  JOURNAL   Blood 119 (12), 2799-2809 (2012)
   PUBMED   22302738
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Kim,E.J., Lee,S.M., Suk,K. and Lee,W.H.
  TITLE     CD300a and CD300f differentially regulate the MyD88 and
            TRIF-mediated TLR signalling pathways through activation of SHP-1
            and/or SHP-2 in human monocytic cell lines
  JOURNAL   Immunology 135 (3), 226-235 (2012)
   PUBMED   22043923
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Simhadri,V.R., Mariano,J.L., Zhou,Q., DeBell,K.E. and Borrego,F.
  TITLE     Differential expression of CD300a/c on human TH1 and TH17 cells
  JOURNAL   BMC Immunol 12, 62 (2011)
   PUBMED   22046970
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Silva,R., Moir,S., Kardava,L., Debell,K., Simhadri,V.R.,
            Ferrando-Martinez,S., Leal,M., Pena,J., Coligan,J.E. and Borrego,F.
  TITLE     CD300a is expressed on human B cells, modulates BCR-mediated
            signaling, and its expression is down-regulated in HIV infection
  JOURNAL   Blood 117 (22), 5870-5880 (2011)
   PUBMED   21482706
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Munitz,A., Bachelet,I., Eliashar,R., Moretta,A., Moretta,L. and
            Levi-Schaffer,F.
  TITLE     The inhibitory receptor IRp60 (CD300a) suppresses the effects of
            IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
  JOURNAL   Blood 107 (5), 1996-2003 (2006)
   PUBMED   16254138
  REMARK    Erratum:[Blood. 2006 Apr 1;107(7):2612]
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Bachelet,I., Munitz,A., Moretta,A., Moretta,L. and Levi-Schaffer,F.
  TITLE     The inhibitory receptor IRp60 (CD300a) is expressed and functional
            on human mast cells
  JOURNAL   J Immunol 175 (12), 7989-7995 (2005)
   PUBMED   16339535
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Kumagai,H., Oki,T., Tamitsu,K., Feng,S.Z., Ono,M., Nakajima,H.,
            Bao,Y.C., Kawakami,Y., Nagayoshi,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Kawakami,T. and Kitamura,T.
  TITLE     Identification and characterization of a new pair of
            immunoglobulin-like receptors LMIR1 and 2 derived from murine bone
            marrow-derived mast cells
  JOURNAL   Biochem Biophys Res Commun 307 (3), 719-729 (2003)
   PUBMED   12893283
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Yotsumoto,K., Okoshi,Y., Shibuya,K., Yamazaki,S.,
            Tahara-Hanaoka,S., Honda,S., Osawa,M., Kuroiwa,A., Matsuda,Y.,
            Tenen,D.G., Iwama,A., Nakauchi,H. and Shibuya,A.
  TITLE     Paired activating and inhibitory immunoglobulin-like receptors,
            MAIR-I and MAIR-II, regulate mast cell and macrophage activation
  JOURNAL   J Exp Med 198 (2), 223-233 (2003)
   PUBMED   12874256
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Cantoni,C., Bottino,C., Augugliaro,R., Morelli,L., Marcenaro,E.,
            Castriconi,R., Vitale,M., Pende,D., Sivori,S., Millo,R.,
            Biassoni,R., Moretta,L. and Moretta,A.
  TITLE     Molecular and functional characterization of IRp60, a member of the
            immunoglobulin superfamily that functions as an inhibitory receptor
            in human NK cells
  JOURNAL   Eur J Immunol 29 (10), 3148-3159 (1999)
   PUBMED   10540326
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230743.1, EF199812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1514
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /note="Cd300a molecule"
                     /db_xref="GeneID:501736"
                     /db_xref="RGD:1583719"
     exon            1..392
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1258
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /note="CMRF35-like molecule 8; immune inhibitory receptor
                     CD300A; CD300 antigen-like family member A"
                     /codon_start=1
                     /product="CMRF35-like molecule 8 precursor"
                     /protein_id="NP_001192277.1"
                     /db_xref="GeneID:501736"
                     /db_xref="RGD:1583719"
                     /translation="MTQLASAVWLPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVT
                     CQYEERFKMNKKYWCRGSLVLLCKDIVKTGGSEEARNGRVSIRDDRDNLTFTVTLQNL
                     TLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQG
                     SIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQN
                     LRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQ
                     NSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP"
     exon            393..731
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     exon            732..852
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     exon            853..950
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     exon            951..988
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1096
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1514
                     /gene="Cd300a"
                     /gene_synonym="CLM-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagtgac ttgacgccaa tcagaatgaa gcctggccct gcaccctgag ctagacgcaa
       61 gcaggggtca ttaggctgtg atagcagcct ggcggtcatg agatccgtgc ctcacaccag
      121 cttcctcagc tcgcctgggc tccttccgag tgtttcagtt tctctgtagc tccaggaaca
      181 gaactaagaa aagtcagaat caaaacagct agacacaaag aaaagcagaa gtgggcgtct
      241 cagagactgg ccgggtcctc ctgctgggct gaaccgtgga gcgtccagct gtggcctgcc
      301 tgccggtgac ccatgtgtgg gagaaatgac ccagctggcc tcagctgtgt ggctgcccac
      361 gctgttgctg ctgctgcttt tctgggttcc aggctgtgtc cctcttcgtg gccccagcag
      421 tgtgacagga actgtggggg agtccctgaa cgtgacttgt cagtatgagg agagattcaa
      481 gatgaataag aaatactggt gcagagggtc acttgttcta ctttgcaaag atattgtcaa
      541 gaccggaggc tcagaagaag ctaggaatgg ccgagtgtcc atcagggacg atcgagacaa
      601 cctgaccttc acagtgacct tgcagaacct cacgctggag gatgcaggca cctacatgtg
      661 tgcggtggat ataccattga tcgatcactc cttcaaggtt gaattgtctg tggtcccagg
      721 taacatccca gtttcatctc caggaacaac acgagagaca actgtggtgc ccaccagctt
      781 ctctaccaag ggtcccaccc aaggatccat cccagagggg caccatgaac attatgagcc
      841 ccagggcttg agtctcccag tgctgctgtc cgtgttagct ctcttgctgt tgctgttggt
      901 ggggacctct ctgctggcct ggaggatgtt ccagaagcgg tcagtcaaag ctgataagca
      961 cccagagatg tcccagaacc tcagacaggc cgaggagcag agtgaatccc agtatgtcaa
     1021 tctgcagctg cacacgttgc ccctgaggga agagccggtg ccaccaagtc aggtggaggt
     1081 agaatacagc acactggcat tacctcagga agagctccat tatacatccg tggtattcga
     1141 ctctcagagg cagaattctc atgccaatgg ggatccccct tgtcaatctc cggaccaaaa
     1201 aacagagtac agtgagatcc ggaagcccag agaaggtctc tctgaccctc acccgtgact
     1261 ccttgtcatc tgatcccttc aatggtgacc accaggtccc caagctccct gctggctgct
     1321 gccttcaatg tcgtgagcct ccctggcttc actaaagatg agcaggagcc agggctctgt
     1381 gggtacagag tctcatccct gtggctctct cctcttagcc tgcatttcgt tctgcccctg
     1441 gttgtgaaga tgtagatgct actcctttgg ggctctggga agtgacatgg ttcatataga
     1501 atggcacttg tgtt
//
