LOCUS       NM_181475               5829 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CD2-associated protein (Cd2ap), mRNA.
ACCESSION   NM_181475
VERSION     NM_181475.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5829)
  AUTHORS   Ke,J., Chen,M., Ma,S., Zhang,L. and Zhang,L.
  TITLE     Circular RNA VMA21 ameliorates lung injury in septic rat via
            targeting microRNA-497-5p/CD2-associated protein axis
  JOURNAL   Bioengineered 13 (3), 5453-5466 (2022)
   PUBMED   35172672
  REMARK    GeneRIF: Circular RNA VMA21 ameliorates lung injury in septic rat
            via targeting microRNA-497-5p/CD2-associated protein axis.
REFERENCE   2  (bases 1 to 5829)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5829)
  AUTHORS   Yan,X., Nykanen,N.P., Brunello,C.A., Haapasalo,A., Hiltunen,M.,
            Uronen,R.L. and Huttunen,H.J.
  TITLE     FRMD4A-cytohesin signaling modulates the cellular release of tau
  JOURNAL   J Cell Sci 129 (10), 2003-2015 (2016)
   PUBMED   27044754
REFERENCE   4  (bases 1 to 5829)
  AUTHORS   Harrison,B.J., Venkat,G., Lamb,J.L., Hutson,T.H., Drury,C.,
            Rau,K.K., Bunge,M.B., Mendell,L.M., Gage,F.H., Johnson,R.D.,
            Hill,C.E., Rouchka,E.C., Moon,L.D. and Petruska,J.C.
  TITLE     The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin
            Signaling-Mediated Axon Arbor Plasticity
  JOURNAL   J Neurosci 36 (15), 4259-4275 (2016)
   PUBMED   27076424
  REMARK    GeneRIF: CD2AP is the first signaling molecule associated with
            adult sensory axonal collateral sprouting
REFERENCE   5  (bases 1 to 5829)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5829)
  AUTHORS   Mustonen,H., Lepisto,A., Lehtonen,S., Lehtonen,E., Puolakkainen,P.
            and Kivilaakso,E.
  TITLE     CD2AP contributes to cell migration and adhesion in cultured
            gastric epithelium
  JOURNAL   Biochem Biophys Res Commun 332 (2), 426-432 (2005)
   PUBMED   15910750
  REMARK    GeneRIF: It is concluded that CD2AP interacts with E-cadherin and
            co-localizes with F-actin in the leading edge of migrating cells,
            and significantly contributes to cell migration in restituting
            gastric epithelium.
REFERENCE   7  (bases 1 to 5829)
  AUTHORS   Kobayashi,S., Sawano,A., Nojima,Y., Shibuya,M. and Maru,Y.
  TITLE     The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and
            degradation of Flt-1 (VEGFR-1)
  JOURNAL   FASEB J 18 (7), 929-931 (2004)
   PUBMED   15001553
  REMARK    GeneRIF: the c-Cbl/CD2AP complex binds to activated Flt-1 and plays
            a crucial role in its endocytosis and subsequent degradation.
REFERENCE   8  (bases 1 to 5829)
  AUTHORS   Kim,J.M., Wu,H., Green,G., Winkler,C.A., Kopp,J.B., Miner,J.H.,
            Unanue,E.R. and Shaw,A.S.
  TITLE     CD2-associated protein haploinsufficiency is linked to glomerular
            disease susceptibility
  JOURNAL   Science 300 (5623), 1298-1300 (2003)
   PUBMED   12764198
REFERENCE   9  (bases 1 to 5829)
  AUTHORS   Lehtonen,S., Ora,A., Olkkonen,V.M., Geng,L., Zerial,M., Somlo,S.
            and Lehtonen,E.
  TITLE     In vivo interaction of the adapter protein CD2-associated protein
            with the type 2 polycystic kidney disease protein, polycystin-2
  JOURNAL   J Biol Chem 275 (42), 32888-32893 (2000)
   PUBMED   10913159
REFERENCE   10 (bases 1 to 5829)
  AUTHORS   Kirsch,K.H., Georgescu,M.M., Ishimaru,S. and Hanafusa,H.
  TITLE     CMS: an adapter molecule involved in cytoskeletal rearrangements
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6211-6216 (1999)
   PUBMED   10339567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 7, 2020 this sequence version replaced NM_181475.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.33234.1,
                                           SRR26643287.22224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               JAXUCZ010000009.1  25583975-25584331
            358-518             JAXUCZ010000009.1  25614890-25615050
            519-672             JAXUCZ010000009.1  25622163-25622316
            673-773             JAXUCZ010000009.1  25629852-25629952
            774-894             JAXUCZ010000009.1  25635230-25635350
            895-1082            JAXUCZ010000009.1  25644715-25644902
            1083-1161           JAXUCZ010000009.1  25647124-25647202
            1162-1256           JAXUCZ010000009.1  25647562-25647656
            1257-1361           JAXUCZ010000009.1  25649509-25649613
            1362-1398           JAXUCZ010000009.1  25651886-25651922
            1399-1461           JAXUCZ010000009.1  25653213-25653275
            1462-1627           JAXUCZ010000009.1  25657286-25657451
            1628-1770           JAXUCZ010000009.1  25658076-25658218
            1771-1883           JAXUCZ010000009.1  25663885-25663997
            1884-1985           JAXUCZ010000009.1  25664688-25664789
            1986-2161           JAXUCZ010000009.1  25667227-25667402
            2162-2225           JAXUCZ010000009.1  25674106-25674169
            2226-5829           JAXUCZ010000009.1  25676365-25679968
FEATURES             Location/Qualifiers
     source          1..5829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5829
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /note="CD2-associated protein"
                     /db_xref="GeneID:316258"
                     /db_xref="RGD:727803"
     exon            1..357
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..2267
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /codon_start=1
                     /product="CD2-associated protein"
                     /protein_id="NP_852140.2"
                     /db_xref="GeneID:316258"
                     /db_xref="RGD:727803"
                     /translation="MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG
                     RRGMFPDNFVKEIKRETEPKDDNLPIKRERPGNVASLVQRISTYGLPAGGIQPHPQTK
                     AMKKKTKKRQCKVLFEYSPQNEDELELTVGDVIDVIEEVEEGWWSGTLNNKLGLFPSN
                     FVKELESTDDGEMHDAQEESEVSLTGPTSPMPSPGNGSEPAPGSVTQPKKIRGVGFGD
                     IFKEGSVKLRTRTSSSETEEKKSEKPLILQSLGSRTQNVEVTKPDIDGKIKAKEYCKT
                     VFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKD
                     FPKPKKPPPPAKGPAPKPDPLAGEKKTFPLKAEDRDEKSLLEQKPSKPAAPQVPPKKP
                     TPPTKANNLLRSPGTMYPKRPEKPVPPPPPTAKINGEVSTISSKIDTEPLSKPKLDPE
                     QLPVRPKSVDLDALVARNSKETDNVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGG
                     HSPTQSPEKTLKLPKDDDSGNIKPSEFKKDAGYSSKPSLSAPSSASKVNTAAFLSPLE
                     LKAKVEADDGKKSSLDELRAQIIELLCIVDALKKDHGKELEKLRRELEEEKAMRSNLE
                     VEIAKLKKAVLLS"
     exon            358..518
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            519..672
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            673..773
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            774..894
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1082
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1256
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1361
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1398
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1461
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1627
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1770
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1883
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1985
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2161
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2225
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..5829
                     /gene="Cd2ap"
                     /gene_synonym="CMS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcgagat ttcgccccag ccgggtccca attctcttca ctcttgcccg tgggttccac
       61 cttggtcacg agcttggcgc gctcagtctc agagggagtg ggtagggact gtctgtgcga
      121 gaccccgccg gtgcctcagc cagcggcgag cggaagcggt ccgggagcgt ggctgagtgc
      181 gcactgtgcg caggcgcgga ccccgctcgc ccccgcctgc cggggccgcg gccgaggccg
      241 ggcttgagga gcggccgagc gcgccgcggg cggatggagg cgtctccccg ccgcgcctga
      301 gacggtgcac agaaggggcc gcggggccac gctttcctcg ccagagccgc agcatggttg
      361 actatattgt ggagtatgac tacgatgctg tacatgatga tgagttaact atccgagttg
      421 gggaaatcat ccgaaatgtg aaaaaactac aggaagaagg atggctagaa ggagaactaa
      481 atgggagacg agggatgttc cctgacaatt ttgttaagga aattaaaaga gagacagaac
      541 ccaaggatga caatttgccc attaaacggg aaaggcctgg aaatgtcgcg agtctggtcc
      601 agcgaatcag cacctacgga cttccagctg gagggattca gccacaccca caaaccaaag
      661 ctatgaagaa gaagacaaaa aagcgtcagt gtaaagttct ttttgagtac tctccacaaa
      721 atgaagacga actggaactg accgtggggg atgtcattga tgtcattgaa gaggtagaag
      781 aaggctggtg gagtggaacc ctgaacaata agttgggact gtttccctca aactttgtga
      841 aagaattaga gtccacagat gatggtgaaa tgcacgacgc tcaggaggaa tcagaagttt
      901 ctttgactgg ccctacctca cctatgccat ctccggggaa tgggagtgaa ccagctcctg
      961 gatcagttac acagccaaag aagatccgag gagttggatt tggagacatt tttaaagaag
     1021 gctctgtgaa acttaggaca agaacttcca gtagtgaaac agaggagaag aaatcagaaa
     1081 agcctttaat tctacagtca ctgggctcta gaacccagaa tgtggaggta acaaaaccag
     1141 acatagatgg caagattaaa gctaaggaat attgcaaaac agtatttccc tatacaggaa
     1201 ccaatgaaga tgaacttacg tttagagaag gggagataat ccatttgata agtaaggaga
     1261 ctggagaagc aggctggtgg aaaggtgaac tgaatggtaa agaaggagtg tttccagata
     1321 actttgctgt tcagataagt gaactagata aagactttcc aaaaccaaag aaaccacctc
     1381 ctcctgcaaa aggtccagct ccaaaacctg acccgttagc tggagagaag aagacctttc
     1441 ctctgaaggc ggaagacaga gatgaaaaat cactgctaga acagaaacct tctaaaccag
     1501 ctgctcctca agtcccaccc aaaaagccta ctccacctac caaagccaat aatttactga
     1561 ggtctcctgg aacaatgtac ccaaagcggc cggaaaagcc agttcctcct ccacctccaa
     1621 cagccaaaat taatggagaa gtatctacaa tttcttcaaa gattgatact gagcccttat
     1681 caaaaccaaa gctagatcct gaacaattgc cagttagacc aaagtcagta gaccttgatg
     1741 ccttggtagc caggaactca aaagaaacag ataatgtaaa ttttgatgac atagcttcct
     1801 cagagaactt gttacatctc actgcaaata gacccaagat gcctggaaga agattgcctg
     1861 gccgcttcaa tggtggacat tctccaaccc agagcccaga aaaaaccttg aagctcccaa
     1921 aagatgatga tagtggcaac ataaagccgt cggagtttaa gaaggatgca ggctactctt
     1981 caaagccatc tctttcagca ccttcaagtg cttctaaagt aaatacagct gctttcctaa
     2041 gtccattaga gctcaaagct aaagtagaag ccgatgatgg gaaaaaaagc tccctggatg
     2101 aacttagagc ccagattatt gaattattgt gcattgtaga tgcactgaaa aaggatcatg
     2161 ggaaagaact ggaaaagcta cgcagagaac tagaagaaga gaaggccatg cgaagtaacc
     2221 tagaggtgga aatagcaaag ctcaagaaag ctgttctgtt gtcttgaagt ggtgtggacc
     2281 cagtggaccc taattctcta tgaacttaac tgacttgtta aaaacaacag acgttgtgtt
     2341 gtggtgaaga aataagagaa catgaactgt gatatctacc aaaaagttgg ggtgacagtt
     2401 tttttttata tatattttgt tttgccaata tgaaaaaaag aagaggcctt atttcttact
     2461 gtgctgggat tgcaaacatt tctactgttt gcttgaaaat actactgaat ctgtataaaa
     2521 aggaaagaaa gttcataata gtttttttat tgaaacttgt attattttta aagagttcta
     2581 tactataaat atcgtaatat ctttgcaaat aagctgtaag ataaactatt tgagaaggac
     2641 gggttagctt tatagtagag tcactgcttt tcctgtaatg catagggcat gaactcatat
     2701 acatacacca cacacacaca cgtacataca tacatacaca cacacacata aacacacatt
     2761 ctacacacac acacacacac acacacacac acacacacac acacacacag cttcttaccc
     2821 agggttacac tgttgtgcct gtttgtctgc agtgctgttt gtacattggg tgataaaata
     2881 ggagctccta gttaccagtt tcctcaccca tgcatattta atcgttaatg aaataataac
     2941 aataaatcca acttctagag tgttctgtaa tgatcacact ataggattca ttaaaggaag
     3001 ctagttacaa actgtactgg attaagcttg agaaaataag agctttgttc taaattcatg
     3061 tggcctaaga aatctaaaac tgtcatgcta attcttattt gtgcctagac actgcagcac
     3121 atgtggaata tgtacacatc agccatattg ttgtattctt atgctcattc tacagtcgta
     3181 aatattactc atttcattgt ctcgtattca attcattgta tccttccttt aattttcact
     3241 aatgaaaacc ttaggaagca gcctctaaac ccatatattt tcaaaattcc agaatgaggt
     3301 tctatattgg aaagctatta tgtaaacact caggttttag agacataatt tatctaatag
     3361 aacaaactaa ttcctagaga tattttggac ttttacttag gtaaagtgaa gaagagtgtt
     3421 agtatttcac aagtggtgat atacgttatg taaatcagat ataactgacc gtactgaaga
     3481 cattccctgt ggatacttag ccatttcttt agcatcccaa tcgacagtga gtgtctgagg
     3541 ctggctcgac cacatcagag tgtgtggcta cacaccaggc gcacatgcaa atgtatctgt
     3601 agggcaacat gtcccaaacc acaaaggtta attttaaaaa gtgaaacgtt tttatttgtt
     3661 taaaaaacgt caggctttaa gctttacttt agtaaatgaa tgtcaggtgt taagttatca
     3721 tgattcatta aaaaaaaaaa caaaactttt tctttacatt ttaatcttaa aatagaacaa
     3781 tgtttttaag tcagattact tgtgtgtttc aagtaaaata gaactggagt agaaagcaat
     3841 agacttgcca gcacagagtc acggccgagt aggttctggg gggagaggta actgtaaata
     3901 gagtgcgcag ttcagggtct agacacaggg cctcaacccg ggctggactc caccttgtga
     3961 cgtagtatag caaaactgct ctgaagcttc cggtttccct gcctctgcct cccaggtgct
     4021 aggatgacag gcatgcccag cgtgtccagc ctttttaacc atttcaagtc tgagctcatc
     4081 taatgagagg ttgttgatga acagaattgc tcccttttat tttcagtgat tagtcaaatg
     4141 aagtatttgt ttcttattaa tgtaataaca gtcctcagat ggcagtgacc tcaccctaaa
     4201 aaccatctct tactttcccc acgtcctaga aattatgtcc tactttcccc attggcaggc
     4261 ttgtctccac ccacactgca gggaaggaaa gcactaacag ttcagactgc gttctattcc
     4321 cagtgagcgt tattttaata aaaaagtaac atacacattc aacagtaggt gagtgatttt
     4381 ctggaccaat atgtagctca tagatattag ttagaatgta acaaattggg aaaataattc
     4441 taatagaaaa gataacagaa aaatgagttt atgtgatata aacacgaata agaaaaatag
     4501 aagcacaacc ccttattgga tactcaattt tcatttgcag tttggttcct ttctgaccta
     4561 ctgtgattca ctgacctgat tggtgatgtt ggtcccagca acacatatat tttactactt
     4621 gtacttatat tttagcatat atactttaat gctgttgaaa ggtttacttg agacatgtgt
     4681 agtgaagaca atgtgtgtaa cttggagatg gagagaggga agtcatgagt ttgaggctgg
     4741 cctgtgctgc atgggggccc tgtgtccaca agaaaggaaa caatgttcct tgggtggtgg
     4801 tgggtatttt cagcagtcca cacaagcaga atagcagtga gtacatgctt tagccttctc
     4861 aagcagaata gagaataccg cctgttttcc atgtgtctat tttctgccct ttacaaaaca
     4921 gtaaaaagca aacaaacaaa aacaaacaac aacaacaaca gcaacaacaa aaaccaagca
     4981 agcttggact tatttaaagg ggaaaagaat tcctttaaaa tagtaatttg ccagtatttg
     5041 cccttagtat gagaactttt actatttcta aagttaaagt cagaaaatga caataacaac
     5101 aacttagagg tgaatccccc ttccccaata tgagtataaa tgaatctgtc attgccaaat
     5161 tactagtgaa tgtacagttc agatttgctg gtctttgaaa cacagtacca ctaagtgtct
     5221 agtgatttca atgttatttt gctgtgtttg tgaccactaa gcttgctctt tctataaagg
     5281 tattacctct atccaactgt ccaggacttc acagaaaatc agaggatgca agaagaggat
     5341 gggttggtct gacagaggac tccttacact ccttactgtg atcacagaca agaaatccat
     5401 tctaagtgct ctgtagattt ttttgatgaa tgttttatgc ttgcatttaa acttgaaatg
     5461 tatgagcgga atgagacaat ctttgcaatc agaattgaga agtgttacaa ttgaatggcc
     5521 ttgtgctgta gcaataaatg accaagtgca atgaccttaa taaaatcatc tttcaaaagt
     5581 tgctgctatt aatatttcta gttaacaaga ttctgccctt gtttagcctg ccttgccttc
     5641 tgtttgttaa ctgatgtgat acagttgatg ttttgacaat ctaacattcc aaagtccaca
     5701 tctatatctt agaatcttag aatactgtct tcatttttta caggtgctgt taaaaaagga
     5761 aatgacagaa aatatgcttt tccctcaaaa agaaaaatta ataataaaaa agaactgtgc
     5821 tgccgctcg
//
