LOCUS       NM_013121               1277 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Cd28 molecule (Cd28), mRNA.
ACCESSION   NM_013121
VERSION     NM_013121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Wang,J., Zheng,S., Xin,N., Dou,C., Fu,L., Zhang,X., Chen,J.,
            Zhang,Y., Geng,D., Xiao,C., Cui,G., Shen,X., Lu,Y., Wang,J.,
            Dong,R., Qiao,Y. and Zhang,Y.
  TITLE     Identification of novel MicroRNA signatures linked to experimental
            autoimmune myasthenia gravis pathogenesis: down-regulated miR-145
            promotes pathogenetic Th17 cell response
  JOURNAL   J Neuroimmune Pharmacol 8 (5), 1287-1302 (2013)
   PUBMED   24043548
  REMARK    GeneRIF: this study identified two crucial immune-related
            molecules-CD28 and NFATc1, as putative targets of miR-145 in human
            and experimental myasthenia gravis
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Gieseke,F., Kruchen,A., Tzaribachev,N., Bentzien,F., Dominici,M.
            and Muller,I.
  TITLE     Proinflammatory stimuli induce galectin-9 in human mesenchymal
            stromal cells to suppress T-cell proliferation
  JOURNAL   Eur J Immunol 43 (10), 2741-2749 (2013)
   PUBMED   23817958
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Ammann,J.U., Cooke,A. and Trowsdale,J.
  TITLE     Butyrophilin Btn2a2 inhibits TCR activation and
            phosphatidylinositol 3-kinase/Akt pathway signaling and induces
            Foxp3 expression in T lymphocytes
  JOURNAL   J Immunol 190 (10), 5030-5036 (2013)
   PUBMED   23589618
REFERENCE   5  (bases 1 to 1277)
  AUTHORS   Shi,Q., Niu,Y., Cao,H., Zhou,X., Jiang,S., Liu,Z. and Fan,H.
  TITLE     CD28 superagonist antibody treatment attenuated obliterative
            bronchiolitis in rat allo-orthotopic tracheal transplantation by
            preferentially expanding Foxp3-expressing regulatory T cells
  JOURNAL   Transplant Proc 44 (4), 1060-1066 (2012)
   PUBMED   22564625
  REMARK    GeneRIF: CD28 superagonist antibody treatment attenuated
            obliterative bronchiolitis in rat allo-orthotopic tracheal
            transplantation by preferentially expanding Foxp3-expressing
            regulatory T cells.
REFERENCE   6  (bases 1 to 1277)
  AUTHORS   Fargeas,C.A., Truneh,A., Reddy,M., Hurle,M., Sweet,R. and
            Sekaly,R.P.
  TITLE     Identification of residues in the V domain of CD80 (B7-1)
            implicated in functional interactions with CD28 and CTLA4
  JOURNAL   J Exp Med 182 (3), 667-675 (1995)
   PUBMED   7544393
REFERENCE   7  (bases 1 to 1277)
  AUTHORS   Shahinian,A., Pfeffer,K., Lee,K.P., Kundig,T.M., Kishihara,K.,
            Wakeham,A., Kawai,K., Ohashi,P.S., Thompson,C.B. and Mak,T.W.
  TITLE     Differential T cell costimulatory requirements in CD28-deficient
            mice
  JOURNAL   Science 261 (5121), 609-612 (1993)
   PUBMED   7688139
REFERENCE   8  (bases 1 to 1277)
  AUTHORS   Clark,G.J. and Dallman,M.J.
  TITLE     Identification of a cDNA encoding the rat CD28 homologue
  JOURNAL   Immunogenetics 35 (1), 54-57 (1992)
   PUBMED   1309509
REFERENCE   9  (bases 1 to 1277)
  AUTHORS   Moretta,A., Pantaleo,G., Lopez-Botet,M. and Moretta,L.
  TITLE     Involvement of T44 molecules in an antigen-independent pathway of T
            cell activation. Analysis of the correlations to the T cell
            antigen-receptor complex
  JOURNAL   J Exp Med 162 (3), 823-838 (1985)
   PUBMED   3875683
REFERENCE   10 (bases 1 to 1277)
  AUTHORS   Hara,T., Fu,S.M. and Hansen,J.A.
  TITLE     Human T cell activation. II. A new activation pathway used by a
            major T cell population via a disulfide-bonded dimer of a 44
            kilodalton polypeptide (9.3 antigen)
  JOURNAL   J Exp Med 161 (6), 1513-1524 (1985)
   PUBMED   3159820
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013121.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55288.1, SRR26643284.12395.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000009.1  69660316-69660394
            80-436              JAXUCZ010000009.1  69678291-69678647
            437-552             JAXUCZ010000009.1  69680625-69680740
            553-1277            JAXUCZ010000009.1  69685055-69685779
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1277
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /note="Cd28 molecule"
                     /db_xref="GeneID:25660"
                     /db_xref="RGD:2299"
     exon            1..79
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..681
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /note="T-cell-specific surface glycoprotein CD28; CD28
                     antigen"
                     /codon_start=1
                     /product="T-cell-specific surface glycoprotein CD28
                     precursor"
                     /protein_id="NP_037253.2"
                     /db_xref="GeneID:25660"
                     /db_xref="RGD:2299"
                     /translation="MTLRLLFLALSFFSVQVTENKILVKQSPLLVVDNNEVSLSCRYS
                     YNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWN
                     LHVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWALVVVAGV
                     LLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP
                     "
     exon            80..436
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            437..552
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1277
                     /gene="Cd28"
                     /gene_synonym="CD28RNA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccctga ccctcatcag gacaatgaca ctcagactgc tattcttggc tctcagcttc
       61 ttctcagttc aagtaacaga aaacaagatt ttggtgaagc agtccccgct gcttgtggta
      121 gataacaatg aggtcagcct cagctgcagg tattcctaca accttcttgc aaaggagttc
      181 cgggcatccc tttacaaggg cgtgaacagt gacgtggaag tctgtgtcgg gaatgggaat
      241 tttacctatc agccccagtt ccgcccaaac gtggggttca actgtgatgg gaatttcgac
      301 aatgaaacag tgacgttccg tctctggaat ctgcatgtta atcacacaga tatttacttc
      361 tgcaaaatcg aggtcatgta tcctccgcca tacctggaca acgagaagag caacggaact
      421 attattcaca taaaagagaa acatctttgt catgctcaga cgtctcctaa gctgttttgg
      481 gcactggtcg tggttgctgg agtcctgctg tgttatggct tgctagtgac agtgactctt
      541 tgtattatct ggacaaatag cagaaggaac aggctccttc aaagtgacta catgaacatg
      601 acaccgcgga gactcgggcc cacgcgcaag cattaccaac cctatgcccc agcgagagac
      661 tttgcagcgt accgcccctg acagggacct ctatccagaa gcccgccggc tggtacccgt
      721 ctacctgctc accatcactg ctctggatag gaaaggacag cctcatcttc agccggccac
      781 cttggacctc tactgggcca ccaatgccca ctattttaag agtgtctaga tctaacatca
      841 cgatcatctc gagactctgc aatgaatgaa agaagcttct atggcaggat aaattctgtg
      901 tggcttgacc cggacgcaag cttaatatat ttattgactt gactggggaa gttagagtag
      961 agaaatcaaa aagtgaaaga attcattcag ccttggaaag tcaatttgca ggctcctaga
     1021 tgagccccgc ccctttctta tttaccggca tatttcagtc atgtgacctg tgatagccaa
     1081 agacgttttg ggtggagaag aaaggataga aaaaccttct ctttggctaa gttggtgttt
     1141 ggggtggagg taggttggag tatagtactt aactatttga aaaataatta aaacactttt
     1201 tttttactca tgaaatgagc catttagctc ctaaacagtg ttttttagtt tagaaggatg
     1261 tggccatatt tttaatg
//
