LOCUS       NM_182824               3125 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Cd276 molecule (Cd276), mRNA.
ACCESSION   NM_182824 XM_236301
VERSION     NM_182824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Vigdorovich,V., Ramagopal,U.A., Lazar-Molnar,E., Sylvestre,E.,
            Lee,J.S., Hofmeyer,K.A., Zang,X., Nathenson,S.G. and Almo,S.C.
  TITLE     Structure and T cell inhibition properties of B7 family member,
            B7-H3
  JOURNAL   Structure 21 (5), 707-717 (2013)
   PUBMED   23583036
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Hashiguchi,M., Kobori,H., Ritprajak,P., Kamimura,Y., Kozono,H. and
            Azuma,M.
  TITLE     Triggering receptor expressed on myeloid cell-like transcript 2
            (TLT-2) is a counter-receptor for B7-H3 and enhances T cell
            responses
  JOURNAL   Proc Natl Acad Sci U S A 105 (30), 10495-10500 (2008)
   PUBMED   18650384
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14744]
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Nguyen,T., Liu,X.K., Zhang,Y. and Dong,C.
  TITLE     BTNL2, a butyrophilin-like molecule that functions to inhibit T
            cell activation
  JOURNAL   J Immunol 176 (12), 7354-7360 (2006)
   PUBMED   16751379
REFERENCE   4  (bases 1 to 3125)
  AUTHORS   Suh,W.K., Wang,S.X., Jheon,A.H., Moreno,L., Yoshinaga,S.K.,
            Ganss,B., Sodek,J., Grynpas,M.D. and Mak,T.W.
  TITLE     The immune regulatory protein B7-H3 promotes osteoblast
            differentiation and bone mineralization
  JOURNAL   Proc Natl Acad Sci U S A 101 (35), 12969-12973 (2004)
   PUBMED   15317945
REFERENCE   5  (bases 1 to 3125)
  AUTHORS   Suh,W.K., Gajewska,B.U., Okada,H., Gronski,M.A., Bertram,E.M.,
            Dawicki,W., Duncan,G.S., Bukczynski,J., Plyte,S., Elia,A.,
            Wakeham,A., Itie,A., Chung,S., Da Costa,J., Arya,S., Horan,T.,
            Campbell,P., Gaida,K., Ohashi,P.S., Watts,T.H., Yoshinaga,S.K.,
            Bray,M.R., Jordana,M. and Mak,T.W.
  TITLE     The B7 family member B7-H3 preferentially down-regulates T helper
            type 1-mediated immune responses
  JOURNAL   Nat Immunol 4 (9), 899-906 (2003)
   PUBMED   12925852
REFERENCE   6  (bases 1 to 3125)
  AUTHORS   Sun,M., Richards,S., Prasad,D.V., Mai,X.M., Rudensky,A. and Dong,C.
  TITLE     Characterization of mouse and human B7-H3 genes
  JOURNAL   J Immunol 168 (12), 6294-6297 (2002)
   PUBMED   12055244
REFERENCE   7  (bases 1 to 3125)
  AUTHORS   Chapoval,A.I., Ni,J., Lau,J.S., Wilcox,R.A., Flies,D.B., Liu,D.,
            Dong,H., Sica,G.L., Zhu,G., Tamada,K. and Chen,L.
  TITLE     B7-H3: a costimulatory molecule for T cell activation and IFN-gamma
            production
  JOURNAL   Nat Immunol 2 (3), 269-274 (2001)
   PUBMED   11224528
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100064.1.
            
            On Aug 7, 2005 this sequence version replaced NM_182824.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100064.1, AY190319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3125
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /note="Cd276 molecule"
                     /db_xref="GeneID:315716"
                     /db_xref="RGD:727815"
     exon            1..79
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..212
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1084
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /note="B7 homolog 3; costimulatory molecule; CD276
                     antigen; B7-H3"
                     /codon_start=1
                     /product="CD276 antigen precursor"
                     /protein_id="NP_877976.1"
                     /db_xref="GeneID:315716"
                     /db_xref="RGD:727815"
                     /translation="MLRGWGGPSVGVSMGTALGVLCLCLTGAVEVQVSEDPVVALVDT
                     DATLRCSFSPEPGFSLRQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLVQ
                     GNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGDM
                     VTITCSSYQGYPEAEVFWKDGQGLPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTY
                     SCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLVILLVALAFVCWRKIKQ
                     SCEEENAGAEDQDGDGEGSKTALRPLKHSENKEDDGQEIA"
     exon            213..551
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..848
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..983
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1025
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1061
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..3033
                     /gene="Cd276"
                     /gene_synonym="B7h3; B7RP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctgct ctaccgacgg tggcggcgat tgtgctgcgc cccgccgcgt ccccgagtcc
       61 cgggagtcgg cgcggcgcgg caggagcagc catccgccac ggagagtcca gctgtcagct
      121 gtctcacagg aagatgcttc gaggatgggg tggccccagt gtgggtgtgt ctatgggcac
      181 ggcactggga gtgttgtgcc tctgccttac aggagctgtg gaggtccaag tctctgaaga
      241 ccctgtggtg gccctagtgg atacggatgc caccctacgc tgctccttct ccccagagcc
      301 tggcttcagc ctgagacagc tcaacctcat ctggcagctg acagacacca aacagctggt
      361 gcacagcttc actgagggcc gggaccaagg cagtgcctat gccaaccgca cggcgctctt
      421 ccctgacttg ttggtgcagg gcaatgcatc cctgaggctg cagcgtgtcc gagtaaccga
      481 cgagggcagc tacacctgct ttgtgagcat ccaggacttt gacagcgctg ctgttagcct
      541 gcaggtggcc gccccctact caaagcccag catgaccctg gagcccaaca aggacctgcg
      601 tccaggggac atggtgacca tcacgtgctc cagctaccag ggctatcccg aggctgaggt
      661 gttctggaag gacggacagg gattgccctt gactggcaat gtgaccacat cccagatggc
      721 caacgagcgg ggcctgttcg atgttcacag tgtgctgagg gtggtgctgg gtgctaatgg
      781 cacctacagc tgcctggtcc gcaacccggt gttgcagcaa gatgctcatg gctcggtcac
      841 catcacaggg cagcccatga cattcccccc tgaggctcta tgggtgactg tggggctctc
      901 tgtctgtctt gtgatactgc tggtggccct ggccttcgtg tgctggagaa agatcaagca
      961 gagctgtgaa gaggagaatg caggtgctga ggaccaggat ggggatggag aaggatccaa
     1021 gacagctctt cggcctctga aacactctga aaacaaagaa gatgacggac aagaaatagc
     1081 ttgactggaa gctgctgccc ttccctggtg ggggggccca ccctctggct gtattgagcc
     1141 tcaatgtgag ccctgccccc aatgaatggg ttttgttcca cagatctacc cattctttag
     1201 aggacgtggt ttacaggcta cccacagcct tattttccca atggacttaa ttcccatcat
     1261 cctgaagcct cctttctcca gtgacacgat acacgaacca tcctgcggcc ttatttctta
     1321 cggactcgac acaaagagtt ctccacctca gtgtccctcc agagtcatcc ggtggccttg
     1381 tgatactaca cggaccttcc ttctgcctta ctttaataga tatacacaaa ccatccccat
     1441 gtccttgtgc ctccaaagcc atgcagagac tgtattactg ctactattct ccaaggcaca
     1501 tgctattcag atgaacccct gccttattcc tctgaagaca gatgcttagt tacctcttgg
     1561 ttctttctcc catggccctg acatatctta gtcacccatc aacgatggga tcccatctct
     1621 cagcaagtcc tcaacctgac tcccctgccc tcatctggcc ctggctttgg ttttctccct
     1681 ccctaagtga gatggggcac actccccatc cacacacatg ggtcacagct gtgcgtgctg
     1741 gatcgcgtac atacttgcct tgcatggtct cctctggctg ccctgggctg tgccctttct
     1801 cgcctcagga agcaggtgct ggtcggcctg gttctcaggg cccctcaggg agtcagcctt
     1861 caaccctgtg cttcccgtgt tggaaatctt tgttactttt cctttcttag taaattaaca
     1921 tctgttgaac aaccacagcg tccaacagga ctttcacaga ccctgccagc tagattaaat
     1981 aatgatacag aagtttatta attattttaa agcttaggtt tttttgccgg gaggtatccc
     2041 aaatactcta tcccgactaa tcctggcact atgtcccacc acatggccag gcctacctct
     2101 gctccactct gaatcatcca cctctgtgtc cgccgacaaa tctcccatga ttcagttctt
     2161 ctcccagcgt ccctatctct gcccggaagt acgacctttg acttcctgac caactattgg
     2221 ccgtcaactc tttgttaaag gtgatcagat ataattttgc cttaggcacg tgaggaagaa
     2281 acatatttat aaaatacgag accagagatg ggccatggaa ataacaccag attctgacag
     2341 cctttagccc tctgctggta caaattaaca attgaatata tagagacaca ccttcacaca
     2401 gtgcacccca acaacagggg tgagcattgt gctgggtact agggtcctgc tgaaatcaga
     2461 gaccttaact ccagctgggg aatggccttg ctccctgctg tgcccacagc ttccaacact
     2521 gtccctgacc ccagggtagg ggtggaaacc tggagaaggc acagcccctt accatacctt
     2581 gagaactggg tatttttcag agtctatatg tgtgcactgg aaggcaggtg gccacagcca
     2641 tgcagacctg ggtagggtca gaagcctatg ccacgctggg acctcctcaa cagctgaagt
     2701 ctgaggacaa gaagggcctt cttactgtgg tgctattctg gagctggggt atatacctgg
     2761 cttgtctctg acagccctgg cttttggcag aacttctgat gtcctgaagg tctctctcgc
     2821 accccagtac tggagaacct ggggataatt taaacatggg accctggcag aagcaggaag
     2881 atctctgact tactttggag tcagcctggt ctacagagtg agttccagga caactggggc
     2941 tagacagaga agccatctca agggctaaaa ctaataaaca cgggacgcta aactgggaat
     3001 attttgggag aaataaatgt ctttttcttt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3121 aaaaa
//
