LOCUS       NM_001191954            3661 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CD274 molecule (Cd274), mRNA.
ACCESSION   NM_001191954 XM_006231248 XM_574652
VERSION     NM_001191954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Lin,Y.K., Hsiao,L.C., Wu,M.Y., Chen,Y.F., Lin,Y.N., Chang,C.M.,
            Chung,W.H., Chen,K.W., Lu,C.R., Chen,W.Y., Chang,S.S., Shyu,W.C.,
            Lee,A.S., Chen,C.H., Jeng,L.B. and Chang,K.C.
  TITLE     PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal Stem Cells
            Enhance Myocardial Protection by Upregulating CD25+ T Cells in
            Acute Myocardial Infarction Rat Model
  JOURNAL   Int J Mol Sci 25 (1), 134 (2023)
   PUBMED   38203304
  REMARK    GeneRIF: PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal
            Stem Cells Enhance Myocardial Protection by Upregulating CD25[+] T
            Cells in Acute Myocardial Infarction Rat Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Zhang,Q., Mu,X., Dong,H., Hu,G., Zhang,T., He,C. and Siddique,N.
  TITLE     Pulmonary endothelium-derived PD-L1 induced by the H9N2 avian
            influenza virus inhibits the immune response of T cells
  JOURNAL   Virol J 17 (1), 92 (2020)
   PUBMED   32631356
  REMARK    GeneRIF: Pulmonary endothelium-derived PD-L1 induced by the H9N2
            avian influenza virus inhibits the immune response of T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Liu,X., Choi,M.G., Kim,K., Kim,K.M., Kim,S.T., Park,S.H.,
            Cristescu,R., Peter,S. and Lee,J.
  TITLE     High PD-L1 expression in gastric cancer (GC) patients and
            correlation with molecular features
  JOURNAL   Pathol Res Pract 216 (4), 152881 (2020)
   PUBMED   32089413
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Ito,S., Masuda,T., Noda,M., Hu,Q., Shimizu,D., Kuroda,Y.,
            Eguchi,H., Tobo,T., Utsunomiya,T. and Mimori,K.
  TITLE     Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression
            Levels in Gastric Cancer
  JOURNAL   Oncology 98 (7), 501-511 (2020)
   PUBMED   32380498
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Yang,X., Yang,X.H. and Zhang,W.Z.
  TITLE     [Temporal expression of PD-1 and PD-L1 during the development of
            experimental periodontitis in rats and its implications]
  JOURNAL   Shanghai Kou Qiang Yi Xue 28 (6), 591-596 (2019)
   PUBMED   32346701
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Jun,H., Seo,S.K., Jeong,H.Y., Seo,H.M., Zhu,G., Chen,L. and
            Choi,I.H.
  TITLE     B7-H1 (CD274) inhibits the development of herpetic stromal
            keratitis (HSK)
  JOURNAL   FEBS Lett 579 (27), 6259-6264 (2005)
   PUBMED   16253242
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Sedy,J.R., Gavrieli,M., Potter,K.G., Hurchla,M.A., Lindsley,R.C.,
            Hildner,K., Scheu,S., Pfeffer,K., Ware,C.F., Murphy,T.L. and
            Murphy,K.M.
  TITLE     B and T lymphocyte attenuator regulates T cell activation through
            interaction with herpesvirus entry mediator
  JOURNAL   Nat Immunol 6 (1), 90-98 (2005)
   PUBMED   15568026
REFERENCE   8  (bases 1 to 3661)
  AUTHORS   Lee,I., Wang,L., Wells,A.D., Ye,Q., Han,R., Dorf,M.E., Kuziel,W.A.,
            Rollins,B.J., Chen,L. and Hancock,W.W.
  TITLE     Blocking the monocyte chemoattractant protein-1/CCR2 chemokine
            pathway induces permanent survival of islet allografts through a
            programmed death-1 ligand-1-dependent mechanism
  JOURNAL   J Immunol 171 (12), 6929-6935 (2003)
   PUBMED   14662900
REFERENCE   9  (bases 1 to 3661)
  AUTHORS   Brown,J.A., Dorfman,D.M., Ma,F.R., Sullivan,E.L., Munoz,O.,
            Wood,C.R., Greenfield,E.A. and Freeman,G.J.
  TITLE     Blockade of programmed death-1 ligands on dendritic cells enhances
            T cell activation and cytokine production
  JOURNAL   J Immunol 170 (3), 1257-1266 (2003)
   PUBMED   12538684
REFERENCE   10 (bases 1 to 3661)
  AUTHORS   Dong,H., Zhu,G., Tamada,K. and Chen,L.
  TITLE     B7-H1, a third member of the B7 family, co-stimulates T-cell
            proliferation and interleukin-10 secretion
  JOURNAL   Nat Med 5 (12), 1365-1369 (1999)
   PUBMED   10581077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 17, 2022 this sequence version replaced
            XM_006231248.3, NM_001191954.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2373793.1,
                                           SRR26643292.6096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000001.1  236530232-236530274
            44-109              JAXUCZ010000001.1  236535434-236535499
            110-451             JAXUCZ010000001.1  236536537-236536878
            452-736             JAXUCZ010000001.1  236543271-236543555
            737-847             JAXUCZ010000001.1  236544488-236544598
            848-907             JAXUCZ010000001.1  236546043-236546102
            908-3661            JAXUCZ010000001.1  236547203-236549956
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3661
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /note="CD274 molecule"
                     /db_xref="GeneID:499342"
                     /db_xref="RGD:1566211"
     exon            1..43
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     exon            44..109
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..930
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /note="programmed cell death 1 ligand 1"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 1 precursor"
                     /protein_id="NP_001178883.1"
                     /db_xref="GeneID:499342"
                     /db_xref="RGD:1566211"
                     /translation="MRIFAVLIVTACSHVLAAFTITAPKDLYVVEYGSNVTMECRFPV
                     EQKLDLLALVVYWEKEDKEVIQFVEGEEDLKPQHSSFRGRAFLPKDQLLKGNAVLQIT
                     DVKLQDAGVYCCMISYGGADYKRITLKVNAPYRKINQRISMDPATSEHELMCQAEGYP
                     EAEVIWTNSDHQSLSGETTVTTSQTEEKLLNVTSVLRVNATANDVFHCTFWRVHSGEN
                     HTAELIIPELPVPRLPHNRTHWVLLGSVLLFLIVGFTVFFCLRKQVRMLDVEKCGFED
                     RNSKNRNDTQFEET"
     exon            110..451
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     exon            452..736
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     exon            737..847
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     exon            848..907
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
     exon            908..3661
                     /gene="Cd274"
                     /gene_synonym="Pdcd1lg1; RGD1566211"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaggctgc agctacgcga cttgccagtc tcctcgccta caggtaagtc tcaaaccatg
       61 aggatatttg ctgtccttat agtcacagcc tgcagtcacg tgctagcggc atttaccatc
      121 acagctccaa aggacctgta cgtggtggag tatggcagca atgtcacgat ggaatgcaga
      181 ttcccagtag aacagaaatt ggacctgctt gccttagtgg tgtactggga aaaggaagac
      241 aaggaagtta ttcagtttgt ggagggagag gaggacctga agcctcaaca cagcagcttc
      301 agggggagag ccttcttgcc aaaggaccag cttttgaagg ggaacgcggt gcttcagatc
      361 acagatgtca agctgcagga cgcaggtgtc tactgctgca tgatcagcta tggtggagcg
      421 gactacaagc gaatcacatt gaaagtcaac gctccatacc gcaaaatcaa ccaaagaatt
      481 tccatggatc cagccacttc tgagcatgaa ctaatgtgcc aggctgaggg ttacccagaa
      541 gccgaagtga tctggacaaa cagtgaccac cagtccctga gtggggaaac aactgtcacc
      601 acttcccaga ctgaggagaa gcttctcaac gtgaccagcg ttctgagggt caacgcaaca
      661 gctaatgatg ttttccactg tacgttctgg agagtacact caggggagaa ccacacggct
      721 gaactgatca tcccagaact gcctgtacca cgtctcccac ataacaggac acactgggta
      781 ctcctgggat ccgtcctttt gttcctcatc gtggggttca ccgtcttctt ctgcttgaga
      841 aaacaagtga gaatgctaga tgtggaaaaa tgcggcttcg aagatagaaa ttcaaagaac
      901 cgaaatgata cacagttcga ggagacgtaa gcagtgttga accctctgag cctcgaggcg
      961 ggattggcag cttgtggtct gtgaaagaaa gggcccgtgg gacatgggtc cagggactca
     1021 aaaatggaac cggagaggag aagagaacaa agaaagtgtt ggaagaggag cctgggacga
     1081 aagacatttc tacaggagac actgctaagc aagttaccca tcagtcatct cgggcaataa
     1141 gttgagggtt cctcatttta acagctggtc ctcgcacaag tgacctttct ctctacccag
     1201 tgcctggatg agaggcagag tcacaagtgt tgaagtgtga gtgccttcta tttacttcca
     1261 gtccgtgtgt tcttgctgtg ggcatgtggt tatgactagt gacataatag gcgttaaaat
     1321 gcagtcacca aactcaactg ctgcttagca tcctctgtaa ctactggcac aagcaggaaa
     1381 cgtggaggtc acatggttcg tttgacgggc tcttgctgtc cgacttgagt aatcttcatt
     1441 ctcaggcctc aaggttctgc agtagtagtt gttctcttta aatatctgct ttacaagtgt
     1501 tgggtactat actcaaacat cttatttcat caccatggca accctcatac taacctctgt
     1561 catactccct tcatagccaa gacgctgagt gtctgagtaa cttgaccaca aaatgacagc
     1621 tatcagattt ctatttttca gacactgtcc tttcaggata gaatttgtag ctaagaattt
     1681 aataataaaa aaaaaacccc gcttattagg cacttccaca ccacaccatg ccttgtgcac
     1741 tgctctggcc tctgacagag aaggaagcca gagtgccggt cggatttgct tatgtgtgtt
     1801 caatactcaa atcaatgctc attaacatgg agtctgcatt ttaaagacac tctccagttc
     1861 tttgtctagc attatattta cctctaatct gttatccctg ccaaacaatc tcatgttctc
     1921 catgaagtgt ctagtcttgt tgagtagttc tttttttttt ttttctattt aaatgatatt
     1981 gacatctgag gagacagctc agttggtaga attctttcct tacaagtggg aaaccctgtt
     2041 ttatccccag aacccacata aaaaacagtt gcgtatatct gtgcatgctt aatccaagca
     2101 ctagggaggc agagacaggc agatctctag ctctcaccga tcagccagct ccaggtctac
     2161 aagagctgac agtgcctgag aaacatgtct acacacacac acatacacac tctcacatac
     2221 atggaccatg tactcataca cctaagtgga ctctcttagt gaacacacat acaatggtcc
     2281 ccaagacaaa acaaaacaaa aaaaaaataa accaaactag ctctattcca tcagcctagc
     2341 catgctactc ccttcccaga agcaactgct attgtttttg cacatatatt ttcttaaaga
     2401 cagttaatat gtataaatct ttgttaaagt atgtctgtct gtctgcctgc ctgcctacct
     2461 atctacctat ctatctatcc atccatccat ccatccatcc acccatctgt ccatccgtct
     2521 gtctgtccat ctgtctgtct atctacctat ctacctacct acatacctat catctgtctg
     2581 tctgtctttc ctaaatggta taggaaaact gtacgttttc tatgcacttt gcccttttca
     2641 tttagtgtat tgatacttat gctgcttcca gactgatcta aagatccata aagagaactg
     2701 cctcatttct aggttttctt tcccatccct ctaggcacct ctcacactgt ctaggccaga
     2761 cacttgctgc ctgtatctgt agacatcatt tataaagtgt gtactcaccg agtttgtgtc
     2821 tactcaaagg gaggccatgg gtccccaggg tcactgagtc aacccagtac caaggtggag
     2881 ccttgtatct ccatggcaga agcaaatctg gggccatttc tgtttcttcc ttgacttctt
     2941 ttctaaaaca cagatgctct aattacttat tacaggttgt ccctggtaat gtcagcattg
     3001 ctcctagact tctgggtgcc ctggaaaagc ccgttagctc tgtgtgaacc cttaaggcag
     3061 ctgtctctcc ttacctcata gacactgttt cctggagggt ttgagatact gtttccaaaa
     3121 ggtgttcact tgggcgagga ggggaggggg agcccagaac tttgttacta ttttctttgt
     3181 tttgtcacat gtcaaggctg aagaaagagc ctgggtatgt tggcgcatgt ctccagttgc
     3241 aggcagaggc aggtggatct ctgtgagttt gtggccagcc tggtctccat agtgaattct
     3301 aagccagcca gggctcggtt acatagtgag atcccgtctc aaaggaaaga ctggcctatc
     3361 agaaccccca gtgaaacccc ttctgttact tgttcacaca tgtttgttga tgattctcgt
     3421 gttaatgtct tgtttgtatg acgttcaaga aaagatctgg ttgggcaaca cattgtattt
     3481 attcatctta ttcaaaatct taatgccatc tcatggcatt ggattggtat ggcactttat
     3541 tcttttgtgt tctgtataac cacaaatgga aattttattt tgtgtctgat tgtcattgta
     3601 ttgcattaat ttaataagat attatttatt aaaaacattt gatttttttc ttttttaaaa
     3661 a
//
