LOCUS       NM_170789               1741 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Cd247 molecule (Cd247), transcript variant 1,
            mRNA.
ACCESSION   NM_170789
VERSION     NM_170789.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Zhang,J., Chen,L. and Gu,Y.D.
  TITLE     Changes in Expressions of Major Histocompatibility Complex Class I,
            Paired-Immunoglobulin-Like Receptor B, and Cluster of
            Differentiation 3zeta in Motor Cortical Representations of the
            Brachial Plexus After Avulsion in Rats
  JOURNAL   World Neurosurg 106, 211-218 (2017)
   PUBMED   28669876
  REMARK    GeneRIF: In the original motor cortical representations of the
            brachial plexus, mRNA and protein expression levels of MHCI, PirB,
            and CD3zeta were down-regulated 7 days post brachial plexus injury
            compared with control. Interestingly, mRNA and protein expression
            levels of these factors were up-regulated at 3 months compared with
            7 days, excepting PirB protein, whose expression was not
            increasing.
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Fernandez-Arenas,E., Calleja,E., Martinez-Martin,N., Gharbi,S.I.,
            Navajas,R., Garcia-Medel,N., Penela,P., Alcami,A., Mayor,F. Jr.,
            Albar,J.P. and Alarcon,B.
  TITLE     beta-Arrestin-1 mediates the TCR-triggered re-routing of distal
            receptors to the immunological synapse by a PKC-mediated mechanism
  JOURNAL   EMBO J 33 (6), 559-577 (2014)
   PUBMED   24502978
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Rudemiller,N., Lund,H., Jacob,H.J., Geurts,A.M. and Mattson,D.L.
  CONSRTM   PhysGen Knockout Program
  TITLE     CD247 modulates blood pressure by altering T-lymphocyte
            infiltration in the kidney
  JOURNAL   Hypertension 63 (3), 559-564 (2014)
   PUBMED   24343121
  REMARK    GeneRIF: functional T cells are required for the full development
            of Dahl salt-sensitive hypertension and indicate that the
            association between CD247 and hypertension in humans may be related
            to altered immune cell function.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Angibaud,J., Baudouin,S.J., Louveau,A., Nerriere-Daguin,V.,
            Bonnamain,V., Csaba,Z., Dournaud,P., Naveilhan,P., Noraz,N.,
            Pellier-Monnin,V. and Boudin,H.
  TITLE     Ectopic expression of the immune adaptor protein CD3zeta in neural
            stem/progenitor cells disrupts cell-fate specification
  JOURNAL   J Mol Neurosci 46 (2), 431-441 (2012)
   PUBMED   21809042
  REMARK    GeneRIF: ectopic CD3zeta expression in neural precursor stem cells
            impaired their normal cell-fate specification. Variations of
            CD3zeta expression in the developing CNS might result in
            neurodevelopmental anomalies.
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Baudouin,S.J., Angibaud,J., Loussouarn,G., Bonnamain,V.,
            Matsuura,A., Kinebuchi,M., Naveilhan,P. and Boudin,H.
  TITLE     The signaling adaptor protein CD3zeta is a negative regulator of
            dendrite development in young neurons
  JOURNAL   Mol Biol Cell 19 (6), 2444-2456 (2008)
   PUBMED   18367546
  REMARK    GeneRIF: The transmembrane adaptor signaling protein CD3zeta, first
            described in the immune system, has a previously uncharacterized
            role in regulating neuronal development.
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Itoh,Y., Matsuura,A., Kinebuchi,M., Honda,R., Takayama,S.,
            Ichimiya,S., Kon,S. and Kikuchi,K.
  TITLE     Structural analysis of the CD3 zeta/eta locus of the rat.
            Expression of zeta but not eta transcripts by rat T cells
  JOURNAL   J Immunol 151 (9), 4705-4717 (1993)
   PUBMED   8409430
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Farber,D.L., Giorda,R., Nettleton,M.Y., Trucco,M., Kochan,J.P. and
            Sears,D.W.
  TITLE     Rat class III Fc gamma receptor isoforms differ in IgG
            subclass-binding specificity and fail to associate productively
            with rat CD3 zeta
  JOURNAL   J Immunol 150 (10), 4364-4375 (1993)
   PUBMED   8482840
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Jensen,J.P., Cenciarelli,C., Hou,D., Rellahan,B.L., Dean,M. and
            Weissman,A.M.
  TITLE     T cell antigen receptor-eta subunit. Low levels of expression and
            limited cross-species conservation
  JOURNAL   J Immunol 150 (1), 122-130 (1993)
   PUBMED   8417118
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Tucek,C.L., Godfrey,D.I. and Boyd,R.L.
  TITLE     Five novel antigens illustrate shared phenotype between mouse
            thymic stromal cells, thymocytes, and peripheral lymphocytes
  JOURNAL   Int Immunol 4 (9), 1021-1030 (1992)
   PUBMED   1390434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1 and BC097933.1.
            
            On Apr 13, 2011 this sequence version replaced NM_170789.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097933.1, D13555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000013.1  80576269-80576325
            58-1620             BC097933.1         1-1563
            1621-1741           BC097933.1         1565-1685
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..1741
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /note="Cd247 molecule"
                     /db_xref="GeneID:25300"
                     /db_xref="RGD:2305"
     exon            1..177
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..614
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell receptor CD3, subunit zeta; CD247 antigen; T-cell
                     surface glycoprotein CD3 zeta chain; CD3 antigen, zeta
                     polypeptide"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD3 zeta chain
                     isoform 1"
                     /protein_id="NP_740770.2"
                     /db_xref="GeneID:25300"
                     /db_xref="RGD:2305"
                     /translation="MKWTASVLACILQVQFPGAEAQSFGLLDPKLCYMLDGILFIYGV
                     IVTALYLRAKFSRSADAAAYLQDPNQLYNELNLGRREEYDVLDKKRPRDPEMGGKQQR
                     RRNPQEGVYNALQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQT
                     LPPR"
     exon            178..281
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            282..338
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            339..419
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            420..455
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            456..512
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            513..548
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            549..1712
                     /gene="Cd247"
                     /gene_synonym="Cd3z; TCRzeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgtcagc cacagaacaa agccaagtga gactccttca gtacctccct ttctcctcat
       61 cctcccaggc atagctgcct ctgcccctgc ctctgggcac cctcccaggg ttgcagaaga
      121 tgaagtggac ggcatcagtc ctcgcctgca tccttcaagt gcagttccca ggagcagagg
      181 cacagagctt tggtctgctg gatcccaaac tctgctatat gctagatgga atcctcttca
      241 tctacggagt catcgtcacg gccctgtacc tgagagcaaa attcagcagg agtgcagatg
      301 ctgctgctta ccttcaggac cccaaccagc tctataacga gctcaaccta gggcgaagag
      361 aggaatatga tgttttggac aagaagcggc ctcgggatcc ggagatgggg ggcaaacagc
      421 agaggaggag gaacccccag gaaggcgtgt acaatgcact gcagaaagac aagatggcag
      481 aggcctacag tgagattggc atgaaaggcg agaggcggag aggcaagggg cacgacggcc
      541 tttaccaggg tctcagcact gccaccaagg acacctatga cgccctgcat atgcagaccc
      601 tgccccctcg ctaacagcca ggggatttct cactcaaagg cttcacctgc tgacgtcact
      661 tgtgaaggac gaggacaaag catttacaac tcagtttatt aacttcacag acaccgtttc
      721 ctgaagagga tgcttctccc acttgtcaca tttgtcttct ccagtcccaa agtattgtac
      781 atagactgtc acccctggac tctctaaagg gagagctccc ctcgctcata ccccagccca
      841 gttcttgggt ctcttggcag gcccctctcc ctgcagagtc cagccctaac caggagctgg
      901 ggggtggggc atgaatacat tccctcttgc agctagcggg agttcagttt gctttgtaaa
      961 gtccccagag ccgcctcagg tactgactgt attgttccac tgatactgac tcactttgct
     1021 cctgctgtaa atttggcttc tgttgtcata cttcccagtg tcaaggtaac atgtaattag
     1081 gtcacattgt gaaaggcaga gaggcaggta caagggaacc caggcaagtg tcagccagag
     1141 gtggctcaaa caagggaagc aacatgcaag gatgttccta gcagaggaac agtaacaagg
     1201 ggcctctttc tatcaaggat accttccaca tctcccagtc catgccagat actccaggaa
     1261 tgttaagatg tcttaccttc acggagacca cgcttttaga gtgcaaataa cttgtgtatc
     1321 aactggcgca gaagataggg tatgtcataa ctgccaatga caagggggtg agagaaaagg
     1381 aagcaagtcc tgctttcttc caggaactct gttcttcccc atccagtggc aggaagaccc
     1441 agaccaccca gttctgtagt gctcccacag taatggcaca atgacagtca gtggacagct
     1501 acatcattgt gtaattaaag tgcctgctgg ggatttagct cagtggtaga gcgcttacct
     1561 aggaagcaca aggccctggg ttcggtcccc agctccggga aaaaaaaaaa aaaaaaaaaa
     1621 gtgcctgtga ccatggatgg gaaacgctct gatctccagg gttttaattt atactggctt
     1681 gctattttgc ataataaatg ctttgctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 a
//
