LOCUS       NM_022259               1924 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CD244 molecule like 1 (Cd244l1), mRNA.
ACCESSION   NM_022259 XM_003752689
VERSION     NM_022259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Georgoudaki,A.M., Khodabandeh,S., Puiac,S., Persson,C.M.,
            Larsson,M.K., Lind,M., Hammarfjord,O., Nabatti,T.H., Wallin,R.P.,
            Yrlid,U., Rhen,M., Kumar,V. and Chambers,B.J.
  TITLE     CD244 is expressed on dendritic cells and regulates their functions
  JOURNAL   Immunol Cell Biol 93 (6), 581-590 (2015)
   PUBMED   25643613
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Betser-Cohen,G., Mizrahi,S., Elboim,M., Alsheich-Bartok,O. and
            Mandelboim,O.
  TITLE     The association of MHC class I proteins with the 2B4 receptor
            inhibits self-killing of human NK cells
  JOURNAL   J Immunol 184 (6), 2761-2768 (2010)
   PUBMED   20164429
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Wilson,T.J., Presti,R.M., Tassi,I., Overton,E.T., Cella,M. and
            Colonna,M.
  TITLE     FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly
            expressed by lymphocytes following HIV-1 infection
  JOURNAL   Blood 109 (9), 3786-3793 (2007)
   PUBMED   17213291
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Evans,E.J., Castro,M.A., O'Brien,R., Kearney,A., Walsh,H.,
            Sparks,L.M., Tucknott,M.G., Davies,E.A., Carmo,A.M., van der
            Merwe,P.A., Stuart,D.I., Jones,E.Y., Ladbury,J.E., Ikemizu,S. and
            Davis,S.J.
  TITLE     Crystal structure and binding properties of the CD2 and CD244
            (2B4)-binding protein, CD48
  JOURNAL   J Biol Chem 281 (39), 29309-29320 (2006)
   PUBMED   16803907
  REMARK    GeneRIF: CD48 is a CD2 and CD244 (2B4)-binding protein
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Lee,K.M., Forman,J.P., McNerney,M.E., Stepp,S., Kuppireddi,S.,
            Guzior,D., Latchman,Y.E., Sayegh,M.H., Yagita,H., Park,C.K.,
            Oh,S.B., Wulfing,C., Schatzle,J., Mathew,P.A., Sharpe,A.H. and
            Kumar,V.
  TITLE     Requirement of homotypic NK-cell interactions through
            2B4(CD244)/CD48 in the generation of NK effector functions
  JOURNAL   Blood 107 (8), 3181-3188 (2006)
   PUBMED   15905190
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Speiser,D.E., Colonna,M., Ayyoub,M., Cella,M., Pittet,M.J.,
            Batard,P., Valmori,D., Guillaume,P., Lienard,D., Cerottini,J.C. and
            Romero,P.
  TITLE     The activatory receptor 2B4 is expressed in vivo by human CD8+
            effector alpha beta T cells
  JOURNAL   J Immunol 167 (11), 6165-6170 (2001)
   PUBMED   11714776
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Kumaresan,P.R., Stepp,S.E., Verrett,P.C., Chuang,S.S., Boles,K.S.,
            Lai,W.C., Ryan,J.C., Bennett,M., Kumar,V. and Mathew,P.A.
  TITLE     Molecular characterization of the rat NK cell receptor 2B4
  JOURNAL   Mol Immunol 37 (12-13), 735-744 (2000)
   PUBMED   11275258
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Kumaresan,P.R., Stepp,S.E., Bennett,M., Kumar,V. and Mathew,P.A.
  TITLE     Molecular cloning of transmembrane and soluble forms of a novel rat
            natural killer cell receptor related to 2B4
  JOURNAL   Immunogenetics 51 (4-5), 306-313 (2000)
   PUBMED   10803843
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Moriggl,R., Topham,D.J., Teglund,S., Sexl,V., McKay,C., Wang,D.,
            Hoffmeyer,A., van Deursen,J., Sangster,M.Y., Bunting,K.D.,
            Grosveld,G.C. and Ihle,J.N.
  TITLE     Stat5 is required for IL-2-induced cell cycle progression of
            peripheral T cells
  JOURNAL   Immunity 10 (2), 249-259 (1999)
   PUBMED   10072077
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Valiante,N.M. and Trinchieri,G.
  TITLE     Identification of a novel signal transduction surface molecule on
            human cytotoxic lymphocytes
  JOURNAL   J Exp Med 178 (4), 1397-1406 (1993)
   PUBMED   8376943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 12, 2023 this sequence version replaced NM_022259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN06680429
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000013.1  86552449-86552627
            180-500             JAXUCZ010000013.1  86561057-86561377
            501-776             JAXUCZ010000013.1  86561466-86561741
            777-881             JAXUCZ010000013.1  86565366-86565470
            882-1036            JAXUCZ010000013.1  86565938-86566092
            1037-1924           JAXUCZ010000013.1  86568139-86569026
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1924
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /note="CD244 molecule like 1"
                     /db_xref="GeneID:64025"
                     /db_xref="RGD:68400"
     exon            1..179
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1054
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /note="natural killer cell receptor 2B4; NKR2B4; NK cell
                     type I receptor protein 2B4; non-MHC restricted killing
                     associated; CD244 natural killer cell receptor 2B4;
                     transmembrane NK cell receptor 2B4; Cd244 molecule,
                     natural killer cell receptor 2B4"
                     /codon_start=1
                     /product="natural killer cell receptor 2B4 precursor"
                     /protein_id="NP_071595.2"
                     /db_xref="GeneID:64025"
                     /db_xref="RGD:68400"
                     /translation="MLQQTVLLSLFLLLRAHQGQDCADSSEEVLGVSGKPVRLRPSNI
                     QTKHVSIEWKKKTGHQQTPQIVTWDTTDNKNFNMCCSDIYGFESENFALSIKSAKLND
                     SGHYLLEITNQRGIVCTKNFQMLIFDPVETPHLTVQGTLWANGTCQLSLSCFVPKDDN
                     VSYALYRGSMLISNQRYGTHWENRTDASSLHTYTCNVSNKASWANHTLTSPQSCQSVP
                     SKFNYLPFVVSIGILVKFFHGAIDCFCVWNRKRKQSQSIAKESLTIHEYVKNAQVSRD
                     QRGHFRASGSSSDVRGDERGQRESDRRLFQFINRS"
     exon            180..500
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
     exon            501..776
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
     exon            777..881
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1036
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1924
                     /gene="Cd244l1"
                     /gene_synonym="2B4; Cd244; Nmrk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggctggac aggcagggag gtagttctgc tgtgtcctgc tggctgttag ctgcagagtc
       61 tagacatcag agcacctgga ggagacaggg gccccttagc ctgctctgtt ctgtggggat
      121 gttgcagcaa actgtcctgt tgtcactctt cctgctcctc agagctcatc agggccaaga
      181 ttgtgcagat tcttctgaag aagtgcttgg tgtctcagga aagcctgtcc ggctgcggcc
      241 ttccaacata caaacaaaac atgtttctat tgaatggaag aagaagacag gacatcaaca
      301 gactccccag atcgtgactt gggatactac ggataacaaa aactttaata tgtgttgtag
      361 tgatatctat ggttttgagt ctgagaattt tgctcttagt atcaagtcag ctaagctaaa
      421 tgacagtggt cactacctgc tggagatcac caaccaaaga ggaatagtgt gcactaaaaa
      481 cttccagatg cttatatttg atcctgttga gacacctcac ctgactgtcc aggggacgct
      541 ctgggctaac gggacttgtc aactgtcttt gtcctgcttt gtgcccaagg atgacaatgt
      601 aagctatgct ttgtacagag ggagcatgct gatctcgaat caaaggtatg gcacccactg
      661 ggagaaccgg actgatgcca gcagcctgca cacatatacc tgcaatgtta gcaacaaggc
      721 cagctgggca aaccacaccc tgacctcccc gcagagctgt cagagtgtcc cttcgaaatt
      781 caattatctg ccctttgtgg tatccatcgg tatcctcgtc aaattttttc atggggccat
      841 cgattgcttc tgtgtgtgga ataggaagag aaagcagtca cagtccatcg ctaaggaatc
      901 tttgaccata catgaatacg tcaagaacgc acaagtcagc agggaccaac gaggacattt
      961 tagggcctct ggatcttcct cagatgttcg gggagatgag aggggacaaa gagaatcgga
     1021 cagacgtctt ttccagttca tcaacaggtc ttaggtttca tgaagagtga agcaagttgc
     1081 tagattggaa agaagaactt cctgcaagct gaagacagct caagacatgg atctgttact
     1141 acttagattc aactgatttc tacctcagct ttgtatccag taaaaaacgt tccctttcat
     1201 cttctgataa ctgatcttca gctgtagttt agactttcta cctaaacatt ctctcacctg
     1261 gagaaaagaa cgtctttctc ctcgtgtttc atctctctga acctcagtat tcacaccaaa
     1321 catttacaac aagctctacc taagggaagg ctgaggagtg agcgatgcag agcaagaagt
     1381 gaaagcactc actgataagt ggagcccaga agctcagaaa aaccacgata caactcacag
     1441 accatctgaa gcttaagagg aaggaagacc aaagtgtgaa aatgcttcag tccttcttag
     1501 aagggagaac aaaataatca tgggagatag agggagggag agatgtggga aggagagagg
     1561 agtgggaagg ataaaggggg ggggaccaga tatgggaaga ggcaggagag aagtacagat
     1621 ggccaggaaa gtgtacagtg gggaatgggg aatggggata gccactagaa agtcccagat
     1681 gtcagggaag caagaggttc ccaggaccca acagggatga cattagccaa aatacccaac
     1741 aaagggaagc tgtagggaac acctccagta catagatacg acccctggtt gagagatagg
     1801 gccacctacc catctcaaga attttaaccc agaatttttc ctatctaaag gaaatgcaga
     1861 gacagaaaat ggagcagaga ctgaaggaaa ggccattcag agacatcccc acctagggat
     1921 ccat
//
