LOCUS       NM_001107370            2312 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CD226 molecule (Cd226), mRNA.
ACCESSION   NM_001107370 XM_001063691 XM_225664
VERSION     NM_001107370.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Zhu,Y., Paniccia,A., Schulick,A.C., Chen,W., Koenig,M.R.,
            Byers,J.T., Yao,S., Bevers,S. and Edil,B.H.
  TITLE     Identification of CD112R as a novel checkpoint for human T cells
  JOURNAL   J Exp Med 213 (2), 167-176 (2016)
   PUBMED   26755705
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Chan,C.J., Martinet,L., Gilfillan,S., Souza-Fonseca-Guimaraes,F.,
            Chow,M.T., Town,L., Ritchie,D.S., Colonna,M., Andrews,D.M. and
            Smyth,M.J.
  TITLE     The receptors CD96 and CD226 oppose each other in the regulation of
            natural killer cell functions
  JOURNAL   Nat Immunol 15 (5), 431-438 (2014)
   PUBMED   24658051
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Liu,C., Wang,G., Liu,H., Li,Y., Li,J., Dai,Y. and Hu,X.
  TITLE     CD226 Gly307Ser association with neuromyelitis optica in Southern
            Han Chinese
  JOURNAL   Can J Neurol Sci 39 (4), 488-490 (2012)
   PUBMED   22728856
  REMARK    GeneRIF: his study showed that CD226 Gly307Ser may correlate with
            risk of neuromyelitis optica in Southern Han Chinese.
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Dong,Z., Cruz-Munoz,M.E., Zhong,M.C., Chen,R., Latour,S. and
            Veillette,A.
  TITLE     Essential function for SAP family adaptors in the surveillance of
            hematopoietic cells by natural killer cells
  JOURNAL   Nat Immunol 10 (9), 973-980 (2009)
   PUBMED   19648922
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   Bachelet,I., Munitz,A., Mankutad,D. and Levi-Schaffer,F.
  TITLE     Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel
            interface in the allergic process
  JOURNAL   J Biol Chem 281 (37), 27190-27196 (2006)
   PUBMED   16831868
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   Pende,D., Castriconi,R., Romagnani,P., Spaggiari,G.M.,
            Marcenaro,S., Dondero,A., Lazzeri,E., Lasagni,L., Martini,S.,
            Rivera,P., Capobianco,A., Moretta,L., Moretta,A. and Bottino,C.
  TITLE     Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus
            receptor (CD155), on dendritic cells: relevance for natural
            killer-dendritic cell interaction
  JOURNAL   Blood 107 (5), 2030-2036 (2006)
   PUBMED   16304049
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Tahara-Hanaoka,S., Miyamoto,A., Hara,A., Honda,S., Shibuya,K. and
            Shibuya,A.
  TITLE     Identification and characterization of murine DNAM-1 (CD226) and
            its poliovirus receptor family ligands
  JOURNAL   Biochem Biophys Res Commun 329 (3), 996-1000 (2005)
   PUBMED   15752754
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Bottino,C., Castriconi,R., Pende,D., Rivera,P., Nanni,M.,
            Carnemolla,B., Cantoni,C., Grassi,J., Marcenaro,S., Reymond,N.,
            Vitale,M., Moretta,L., Lopez,M. and Moretta,A.
  TITLE     Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface
            ligands for the human DNAM-1 (CD226) activating molecule
  JOURNAL   J Exp Med 198 (4), 557-567 (2003)
   PUBMED   12913096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474021.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225664.4, XM_001063691.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680417,
                              SAMN06680423 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q13"
     gene            1..2312
                     /gene="Cd226"
                     /note="CD226 molecule"
                     /db_xref="GeneID:307199"
                     /db_xref="RGD:1311513"
     exon            1..171
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1199
                     /gene="Cd226"
                     /note="CD226 antigen"
                     /codon_start=1
                     /product="CD226 antigen precursor"
                     /protein_id="NP_001100840.1"
                     /db_xref="GeneID:307199"
                     /db_xref="RGD:1311513"
                     /translation="MWKAVQPPEPFPEMAYLTWLLAILHVHKALCEETLWDTTVRLSE
                     TMTLECVYPLTDNLTQAEWTKDTGTKKVNIAVYHPNHNMHIDPNYLHRVHFQNATVGF
                     RNMSLSFYNASEADIGIYTCLFHAFPRGSWEKKIKVVQSDSFETTAPLDSYLSAEPGQ
                     NVTLSCQLERTWLVQLVIWEKVQPHQVDILASCNLSQGTRYTSKYLRQTWSDCSQESM
                     KSALIIPYAMAADSGLYRCRSEASTGTNKTCVIRLIITDGGTNNHFILLIVGGLASLL
                     LVILITIIIILFNRKRRRQVRTPLKELRDKQSKVATNCRSPTSPIQTTDDEKEDIYVN
                     YPTFSRRPKPRF"
     exon            172..243
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     exon            244..582
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     exon            583..930
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1027
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1085
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..2312
                     /gene="Cd226"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgcctag gtcttgcact tgtattcctg taatgtactt gcaagaatac atttcctaga
       61 aaccttaaga gcatcaccac aacaacggtg aagaaaagaa ggagaaggaa agggcagtgg
      121 cgaaggcagc atggacacag agacctaggc cctgggcaat gtggaaggca gtccaacctc
      181 ctgaaccgtt tccagagatg gcttatctta cttggctttt ggctattctt catgtgcaca
      241 aagcgctgtg tgaagagaca ttgtgggaca caactgttcg tctttctgag actatgactt
      301 tggaatgtgt atatccattg acggataact taacccaggc ggagtggacc aaggacactg
      361 gcacaaagaa agtgaacata gctgtttacc accctaacca taatatgcat atagatccta
      421 actacctcca tagagtgcac tttcaaaatg caacagtggg gttccgcaac atgagccttt
      481 ccttttacaa tgcctctgaa gcagacatcg gcatctacac ctgcttgttt catgctttcc
      541 cacgtggatc ttgggaaaag aagataaaag ttgtccagtc agatagtttt gagacaacag
      601 cacccttgga tagctacctg tctgcagaac ctggacaaaa tgtcacactc agttgccagc
      661 ttgaaaggac ttggctagtg caactagtca tatgggaaaa agtccagccc catcaggtag
      721 acatcttagc ttcctgtaac ctatctcaag ggacaagata cacttcaaag tacctaagac
      781 aaacatggag cgactgtagc caggagagca tgaagagtgc tctcattata ccctatgcca
      841 tggctgctga ctcaggactt tacagatgcc gctctgaggc cagtacggga acaaacaaaa
      901 cctgtgtcat aaggctgatc ataactgatg gtggaaccaa taaccacttt atccttctca
      961 ttgtcggagg gctagcctca ctgctacttg tcatcctaat taccatcatt attatcttat
     1021 tcaacaggaa gagaaggaga caggtgagaa ctccgcttaa agagctcaga gataaacaga
     1081 gtaaggtagc caccaactgc agaagtccaa cttctcccat tcagactaca gatgatgaaa
     1141 aagaggacat ttatgttaac tatccaactt tctctcggag accaaaacca agattctaag
     1201 ccgctctttt gcctgagcac attagtaatg acttctatgg catggatttt tacccatgtc
     1261 ctcctcacca ccaggatcta cattgattaa aaagttgatt ggatttgttt tatctcatat
     1321 atagaagtac tttatgacct gggaatattc ttaacagaga tggatttgaa aacccaaatc
     1381 taattaaccg ttcaaggaac agttcaagga accatcttcc attatataac agagtaatct
     1441 agagaggact aagtaccacg tggctttctt gctctacttg aaatcagctg tgaacataag
     1501 tttatttctg gatgcttcct acagtgttgg ttctgcttat atactactgg tccaactctc
     1561 gtactgcttc tctcagatgc tcccatgagt attgccaagg acacttggta gaaagtttac
     1621 tggttaaaca caggaaacaa agtttattat tcactcacta gcaagaaggt agcattacca
     1681 caaaagatta gatgacctaa attagctgtg ggttcaagac caggacaaaa gggttacttg
     1741 ggaattctga gtattgctaa aaaggctgaa agggacctag aagttgagtt atttttaaca
     1801 aactttaact tcaaaggcat tgcttattaa ctagataaca aatgaatgta ctgtagtatc
     1861 agcataattc aaaagaatac atgccaagga atgccgagag cagagataat tgtgtaacta
     1921 tttcttccct ttctggtttc aaataaattc atttctaatt ctatagagaa gtcttgctac
     1981 ccattcagga ctggtcttct atacagtgag atggtccaat tagaaataat tcttttaata
     2041 atgctttttc tactttcgag agttatttta atatgtaaac ttgtgagttt aaaatcttca
     2101 aaatgagcac atgaaaagag attgatggtt ttaagtagta gaatacagta atgtaggaat
     2161 ctgagagcag agagtttggg agggggtgaa gaggaaaaga catcaccaaa taatgatata
     2221 tgagagaaaa tctacacttc agagtttgat caaggccata tctcccaatt tggctggcac
     2281 tgagataatg cacctgatgt ctccatttta ga
//
