LOCUS       NM_001107503            3695 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD22 molecule (Cd22), mRNA.
ACCESSION   NM_001107503 XM_001079318 XM_218523
VERSION     NM_001107503.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Pfeifer,M., Zheng,B., Erdmann,T., Koeppen,H., McCord,R., Grau,M.,
            Staiger,A., Chai,A., Sandmann,T., Madle,H., Dorken,B., Chu,Y.W.,
            Chen,A.I., Lebovic,D., Salles,G.A., Czuczman,M.S.,
            Palanca-Wessels,M.C., Press,O.W., Advani,R., Morschhauser,F.,
            Cheson,B.D., Lenz,P., Ott,G., Polson,A.G., Mundt,K.E. and Lenz,G.
  TITLE     Anti-CD22 and anti-CD79B antibody drug conjugates are active in
            different molecular diffuse large B-cell lymphoma subtypes
  JOURNAL   Leukemia 29 (7), 1578-1586 (2015)
   PUBMED   25708834
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Jiang,Y., Zhou,H., Ma,D., Chen,Z.K. and Cai,X.
  TITLE     MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response
            in Sepsis
  JOURNAL   Med Sci Monit 21, 1548-1555 (2015)
   PUBMED   26017478
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Psathas,J.N., Doonan,P.J., Raman,P., Freedman,B.D., Minn,A.J. and
            Thomas-Tikhonenko,A.
  TITLE     The Myc-miR-17-92 axis amplifies B-cell receptor signaling via
            inhibition of ITIM proteins: a novel lymphomagenic feed-forward
            loop
  JOURNAL   Blood 122 (26), 4220-4229 (2013)
   PUBMED   24169826
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Jellusova,J., Wellmann,U., Amann,K., Winkler,T.H. and Nitschke,L.
  TITLE     CD22 x Siglec-G double-deficient mice have massively increased B1
            cell numbers and develop systemic autoimmunity
  JOURNAL   J Immunol 184 (7), 3618-3627 (2010)
   PUBMED   20200274
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   Tateno,H., Li,H., Schur,M.J., Bovin,N., Crocker,P.R.,
            Wakarchuk,W.W. and Paulson,J.C.
  TITLE     Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F
            reflect roles in cell signaling and innate immunity
  JOURNAL   Mol Cell Biol 27 (16), 5699-5710 (2007)
   PUBMED   17562860
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Mott,R.T., Ait-Ghezala,G., Town,T., Mori,T., Vendrame,M., Zeng,J.,
            Ehrhart,J., Mullan,M. and Tan,J.
  TITLE     Neuronal expression of CD22: novel mechanism for inhibiting
            microglial proinflammatory cytokine production
  JOURNAL   Glia 46 (4), 369-379 (2004)
   PUBMED   15095367
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Bakker,T.R., Piperi,C., Davies,E.A. and Merwe,P.A.
  TITLE     Comparison of CD22 binding to native CD45 and synthetic
            oligosaccharide
  JOURNAL   Eur J Immunol 32 (7), 1924-1932 (2002)
   PUBMED   12115612
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Galvez,A.F., Chen,N., Macasieb,J. and de Lumen,B.O.
  TITLE     Chemopreventive property of a soybean peptide (lunasin) that binds
            to deacetylated histones and inhibits acetylation
  JOURNAL   Cancer Res 61 (20), 7473-7478 (2001)
   PUBMED   11606382
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Roes,J. and Rajewsky,K.
  TITLE     Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor
            function for IgD in antigen-mediated recruitment of B cells
  JOURNAL   J Exp Med 177 (1), 45-55 (1993)
   PUBMED   8418208
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218523.4, XM_001079318.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132262, SAMD00132263
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3695
                     /gene="Cd22"
                     /note="CD22 molecule"
                     /db_xref="GeneID:308501"
                     /db_xref="RGD:1311610"
     exon            1..328
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            329..468
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            469..526
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..3048
                     /gene="Cd22"
                     /note="B-cell receptor CD22; CD22 antigen"
                     /codon_start=1
                     /product="B-cell receptor CD22 precursor"
                     /protein_id="NP_001100973.1"
                     /db_xref="GeneID:308501"
                     /db_xref="RGD:1311610"
                     /translation="MCVPCPWLLLILGHVASFRSATGWSVEHPQTLFAWEGACIQIPC
                     KYKVPKPRSRLDSILLFQNYTFDNTTRDFTGKVLYNNTKASIETELYFSQQDRVTFLG
                     NRSNNCTLKIDPIHANDSGKLGLRLISGTDKWMEHIHLNVSERPFQPYIQLPSEIRES
                     QRVSLTCGLNFTCFGYDISLRWSLDGSEVSPVTSSITSSVENVYTESKLTFQPKWTDH
                     GKSMMCQVWHFSQVLSERTVRLDVKYTPKLQITVNPTEVKEGNSVTMTCQVNSSNPSL
                     STKKVSWFKDGSFLKEQQEQEELTLHSVTKDMRGKYQCRASNNIGQGQSKEVALTVLY
                     PPEPSKVHIYPSPAEEGQSVELICDSLASPRATNYTWYHNGEMVPGASHEKLQISNVS
                     LWHAGKYSCLAENRLGCGKIEQEAELDVHYVPKAVTTVIQSVTPIREGDSVTLDCRYN
                     SSNPEVTKYEWSPQGSGSEVTPGVLRIQKATWDSPPIKCAACNYKCSWSFPVSLNVHY
                     APRAVKILKVSPASEIHAGQHVLLQCDFSGSFPTEVRFFWKKNGNLVQEGRYLNFSSI
                     SPEDSGNYNCMVRNSIGETSSQAWSLQVLYAPRRLRVSISPGDSVMEGKKATLSCESD
                     AHPPVFKYIWFDANDQDLHFSGQKLRLEPLRVQHTGSYRCQGINELGTGKSPPSTLTV
                     YYSPETIGKRVALGLGFCLAICILAIWGMKIQKKWKHNRSQQGPQDNSSGQSFFVRNK
                     KARRTRLTEGPQSQGCYNLAMDDTVSYAVLRFPESDTHGAGGARSPATQGPPPNDDDT
                     VTYSVLQKRNMGDYENVSPNCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH"
     exon            527..919
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1219
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1489
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1753
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2011
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2275
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2539
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2636
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2712
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2831
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2916
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3695
                     /gene="Cd22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatcctgaa gctcgaacac agggggaaac aggtaaaacc attttgatct tttctctcgc
       61 tctccacaaa taaatacgcg gtggcctctg tgtgctggcc acggaaggga acctgctgtg
      121 ttttttcatc tactttacaa taggcacaga cagacctcat ctccaacccc ccaaccccta
      181 tccctcagcc cccaccccca ccccctattc cccatccctg tctttcagcg ttccctttcc
      241 gggctttctg ggtcctctga ggtagaagct gttgagtgcc agggaggaaa tgatggaacc
      301 aggacgctaa cctcgaggct ctcagaaggc caaccccctc aatagaggca gaacccagcc
      361 cagctctctc agcagctgaa ctagctttcc ccacatggcc ctgatcaccc aacagtgctt
      421 actacctgtg ccctgtggcc gtggagatag atatctggag aggaggagat ctcacccaga
      481 caagccatca tgtgtgtccc ctgcccgtgg ctcctcctga tccttggaca tgtggcttcc
      541 ttccgctcag caactggatg gtctgttgaa catccccaaa ccctctttgc ctgggaggga
      601 gcctgcatcc agattccttg caagtacaaa gtaccaaagc ctaggtcgcg tttggacagc
      661 atcctccttt ttcagaacta tacgtttgac aacaccacca gggatttcac aggaaaggtc
      721 ctctataaca acacgaaggc gagcatagag actgagctgt acttttctca gcaagacaga
      781 gtaacatttc tgggaaacag atcgaacaat tgtaccctga aaatcgaccc gatacatgcc
      841 aatgacagtg ggaagctggg cttgaggttg atctcaggga ctgacaaatg gatggagcac
      901 attcacctca acgtctctga gagaccgttc caaccttaca tccagctgcc atcggaaatc
      961 cgggaatccc aaagggtttc tctgacctgt ggactgaatt tcacctgctt tgggtatgac
     1021 atcagccttc ggtggtctct ggacgggtcc gaggtcagcc ctgtcacctc ttccatcacc
     1081 tcctccgttg agaacgtcta tacagagagc aagctcacct tccagccaaa gtggacagac
     1141 cacggaaaga gcatgatgtg ccaagtctgg cacttctccc aagtgctctc tgagaggaca
     1201 gtgcgtctgg atgttaagta caccccaaaa ctgcagatca cggtcaatcc cacagaggtc
     1261 aaggagggca actctgtgac catgacatgt caggttaaca gcagcaaccc gagtctcagt
     1321 accaagaagg tatcctggtt caaggatggg agcttcctga aggaacaaca ggaacaggag
     1381 gagctaactc tgcattcagt gaccaaggac atgagaggga aataccagtg ccgggcttcc
     1441 aacaacatag gccaaggaca gtccaaagaa gtggcactca cggtgctcta tcctccggaa
     1501 ccctccaagg ttcacatcta tccctcaccg gctgaagagg gacagtcagt agagctgatc
     1561 tgcgactcac tggccagtcc aagagcaaca aactacacct ggtatcacaa tggggaaatg
     1621 gtacccggag ccagccatga gaagctccag atctctaatg tctccttgtg gcatgctggg
     1681 aaatactctt gcttggcaga gaaccgtctg ggttgtggaa agatagaaca ggaagctgag
     1741 ctggatgtcc actatgttcc caaggcggta accacagtga ttcaaagcgt cacaccaatt
     1801 cgggaaggag acagcgtgac cctagactgt agatacaact ccagcaatcc agaggtcacc
     1861 aagtatgaat ggagtcctca aggttctggg agcgaggtca cacctggagt gctaaggatt
     1921 cagaaagcga catgggattc cccgcccatc aaatgtgctg cctgtaacta caagtgctcg
     1981 tggtccttcc ctgtcagcct gaatgtccac tatgccccca gagccgtgaa gatactgaag
     2041 gtgagccccg catcggagat ccacgctggg cagcatgtcc tcctccaatg tgacttctca
     2101 gggagcttcc ccacagaggt ccgcttcttc tggaagaaga atgggaatct cgtgcaggaa
     2161 gggagatacc tgaacttcag ctccatctct ccagaagatt ctggaaatta taactgcatg
     2221 gtcagaaact ccatcggaga gacctcgtca caggcctgga gcctgcaagt gctgtatgct
     2281 cctcggaggc tgcgtgtgtc catcagccct ggggacagcg tgatggaggg gaagaaggcc
     2341 accttgtcct gtgagagtga tgcccacccg cccgtcttca agtatatctg gtttgacgcc
     2401 aatgaccaag acctccactt ctcgggccag aaactgaggc tggaacccct gagagttcaa
     2461 cacacgggtt cctaccgctg ccaagggatc aacgagctag gcacgggaaa gtcaccaccc
     2521 agcaccctca cggtttacta cagcccagag accatcggca agcgggtcgc cttgggacta
     2581 gggttctgcc tggctatctg catcctggcc atctggggga tgaaaatcca gaaaaaatgg
     2641 aagcacaacc ggagccagca ggggcctcag gacaattcca gtggccagag cttttttgtg
     2701 aggaacaaaa aggctagaag gacccgtctc acagaaggcc cccagtccca gggatgctac
     2761 aatctggcga tggatgacac cgttagttat gctgtcttgc gctttccaga gagtgacacg
     2821 cacggcgctg gaggtgcaag gagcccagca acacagggtc ctcctccaaa cgacgatgac
     2881 acagtcactt actcggtgct acagaagcgg aatatgggtg actatgagaa tgtgagtcca
     2941 aactgccccg aggatgagag catccattac tcagagctgg ttcagtttgg ggctgggaag
     3001 cggccccagg caaaggaaga cgtagactat gtgaccctca agcactgagg tgggtagtag
     3061 ctgcagtggc aggttctgga gcctaaagaa gactacaacg tcttcagctg ctgcggctca
     3121 gctgctaaga gacaggcagc tccccacatg gtcatctaaa aacctgcgca tgcccacacg
     3181 gtcatctaaa aacctgcgca tgcccacacg gtcatctaaa aacctgcgcc cggccagacc
     3241 tagcggctgg cccaacactg tgtagcacct gtttctccaa ccccaggcac caccgccatc
     3301 ttcttcattc caagcctcct catctggacg acgtgttcct gctgtgatcc gctgggaccc
     3361 tcattaacat ttcttcttct ctgacccctt gatactccac cccactcatt aatcttacta
     3421 cccacttcct ggccctgggg agaaatcccc caggaagtgc agaaatatgg aagcaagagg
     3481 cactgtcccc agctggtttt tctcctacaa agatgtctct gagtaagtcg aaccttctgt
     3541 ggagatcatg ccttccctca ggggtactgg acgctgagca gacagaacgg catagaaata
     3601 tatatatata tatatatata tatatatata tatatatata tatatttttt ttttcactaa
     3661 atgcttcgta ttaaaaatgg cacggctgcc acacg
//
