LOCUS       NM_001105904            1467 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CD209a molecule (Cd209a), mRNA.
ACCESSION   NM_001105904 XM_001058705 XM_221778
VERSION     NM_001105904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE,
            Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC and
            Stadecker MJ.
  TITLE     CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17
            Cell-Mediated Schistosome Egg-Induced Immunopathology
  JOURNAL   Cell Rep 22 (5), 1288-1300 (2018)
   PUBMED   29386115
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Bradford BM, Brown KL and Mabbott NA.
  TITLE     Prion pathogenesis is unaltered following down-regulation of
            SIGN-R1
  JOURNAL   Virology 497, 337-345 (2016)
   PUBMED   27522473
REFERENCE   3  (bases 1 to 1467)
  AUTHORS   Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM,
            Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C,
            Bunnell SC, Hacohen N and Stadecker MJ.
  TITLE     CD209a expression on dendritic cells is critical for the
            development of pathogenic Th17 cell responses in murine
            schistosomiasis
  JOURNAL   J Immunol 192 (10), 4655-4665 (2014)
   PUBMED   24729611
REFERENCE   4  (bases 1 to 1467)
  AUTHORS   Lu XJ, Chen J, Yu CH, Shi YH, He YQ, Zhang RC, Huang ZA, Lv JN,
            Zhang S and Xu L.
  TITLE     LECT2 protects mice against bacterial sepsis by activating
            macrophages via the CD209a receptor
  JOURNAL   J Exp Med 210 (1), 5-13 (2013)
   PUBMED   23254286
REFERENCE   5  (bases 1 to 1467)
  AUTHORS   Powlesland AS, Ward EM, Sadhu SK, Guo Y, Taylor ME and Drickamer K.
  TITLE     Widely divergent biochemical properties of the complete set of
            mouse DC-SIGN-related proteins
  JOURNAL   J Biol Chem 281 (29), 20440-20449 (2006)
   PUBMED   16682406
  REMARK    Erratum:[J Biol Chem. 2006 Sep 1;281(35):25868]
REFERENCE   6  (bases 1 to 1467)
  AUTHORS   Caminschi I, Corbett AJ, Zahra C, Lahoud M, Lucas KM, Sofi M,
            Vremec D, Gramberg T, Pohlmann S, Curtis J, Handman E, van Dommelen
            SL, Fleming P, Degli-Esposti MA, Shortman K and Wright MD.
  TITLE     Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN
  JOURNAL   Int Immunol 18 (5), 741-753 (2006)
   PUBMED   16569675
REFERENCE   7  (bases 1 to 1467)
  AUTHORS   Lanoue A, Clatworthy MR, Smith P, Green S, Townsend MJ, Jolin HE,
            Smith KG, Fallon PG and McKenzie AN.
  TITLE     SIGN-R1 contributes to protection against lethal pneumococcal
            infection in mice
  JOURNAL   J Exp Med 200 (11), 1383-1393 (2004)
   PUBMED   15583012
REFERENCE   8  (bases 1 to 1467)
  AUTHORS   Katz LC.
  TITLE     Somatosensory development. A new level of refinement
  JOURNAL   Curr Biol 4 (9), 831-834 (1994)
   PUBMED   7820555
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474084.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001058705.1, XM_221778.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..1467
                     /gene="Cd209a"
                     /note="CD209a molecule"
                     /db_xref="GeneID:288375"
                     /db_xref="RGD:1308239"
     exon            1..124
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..801
                     /gene="Cd209a"
                     /note="CD209a antigen"
                     /codon_start=1
                     /product="CD209a molecule"
                     /protein_id="NP_001099374.1"
                     /db_xref="GeneID:288375"
                     /db_xref="RGD:1308239"
                     /translation="MSESKETGKQQLGPLDEELLTSSHTRYSMKGFGFQPNSGFSSFT
                     GYLVHSHVPLALKALFLTVFSVLLVVILVKVYKIPSSHEQEESNQKNFYQELIQLKAG
                     VDRLCRSCPWDWTAFQGNCYFFSVAQKSWNDSATACHNVGAQLVVIKSEEEQNFLQKT
                     SKKRGYTWMGLIDINKESTWHWVDGSPLTLTFMKYWNKGEPNNVGDKDCAEFREDGWN
                     DTKCDNKKFWICKKPETSCSSK"
     exon            125..211
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     exon            212..301
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     exon            302..388
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     exon            389..540
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     exon            541..650
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
     exon            651..1467
                     /gene="Cd209a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaagtaaga ttcaaggagg aggcaaataa aagctgttgt ctccatcagg ttctggcact
       61 gagaagtggc tgtgaagcat gagtgaatct aaggaaacag ggaagcagca gcttggccct
      121 ctggatgagg aactgctgac atccagccac accaggtact ctatgaaagg ttttggcttc
      181 caaccaaatt ctggattcag tagcttcaca ggatacctgg tccacagcca tgttcccttg
      241 gcactgaagg cgctcttcct cactgtgttc tctgtgctgc tggttgtcat ccttgttaaa
      301 gtctataaga tccccagttc tcatgaacag gaggagtcca atcagaagaa tttctaccag
      361 gaactgatcc agttgaaggc tggggtagat cgcctgtgcc gctcctgccc ctgggactgg
      421 acagccttcc aaggaaactg ctactttttc tctgttgccc agaagtcctg gaatgattct
      481 gccactgcct gccacaatgt gggggctcaa cttgtagtca tcaagagtga agaagaacag
      541 aactttctac aaaaaacttc taagaagaga ggctacactt ggatggggct catagacatc
      601 aacaaggaat ctacatggca ctgggtagat ggttcacctc tgaccctcac ttttatgaag
      661 tattggaata aaggggaacc taacaacgtc ggagacaaag actgtgcaga gttcagagaa
      721 gacggctgga atgacaccaa atgtgacaac aagaaattct ggatctgcaa aaaacctgaa
      781 acgtcctgct ctagcaagtg atgaccaact ccctccactg cctccacagt tcccaaaccg
      841 tgccacatgg cagaacttta cccatagcca tgccagttta ttctccttgt ctgtggccac
      901 tgataccttg acaaggtctg tgagacattt ctctggcagg taccttgccc cctgccttgc
      961 tcctggacca gcatgtctcc ttgacctctg ctgaggtctt ctgaggtctg caggttctct
     1021 ttgggttagt ggttgtggct ctgatttacc tttgccattt aatgaagtga acagacatga
     1081 ggtgtgtaca ggcccttaag tgggtccctt tcatctcctc tgtcttcctt tctgaggtca
     1141 aaccatgtac agccatgtgc aatcgatgat acatcctatg tggcttcata acatttctaa
     1201 gtattttact cccacctact aaattttcat ccatccaccc tgcacccctt tctatgggac
     1261 ccttctctga ttcaggagct caacctgtag gctataagca aaccaattcc tcacctatta
     1321 gtcataatct aaaattattt tgttaatatg tggatatgga gccagggtat taacacaata
     1381 atttttattg aatctgctca ttgacaattt tatacatatt tacatataaa tatgtctaaa
     1441 taaacatttt tattattgcc atccttt
//
