LOCUS       NM_023953               2427 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CD200 receptor 1 (Cd200r1), mRNA.
ACCESSION   NM_023953
VERSION     NM_023953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Qian,H., Chen,A., Lin,D., Deng,J., Gao,F., Wei,J., Wu,X., Huang,Y.,
            Cai,D., Chen,X. and Zheng,X.
  TITLE     Activation of the CD200/CD200R1 axis improves cognitive impairment
            by enhancing hippocampal neurogenesis via suppression of M1
            microglial polarization and neuroinflammation in hypoxic-ischemic
            neonatal rats
  JOURNAL   Int Immunopharmacol 128, 111532 (2024)
   PUBMED   38237226
  REMARK    GeneRIF: Activation of the CD200/CD200R1 axis improves cognitive
            impairment by enhancing hippocampal neurogenesis via suppression of
            M1 microglial polarization and neuroinflammation in
            hypoxic-ischemic neonatal rats.
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Hong,Y., Jiang,L., Tang,F., Zhang,M., Cui,L., Zhong,H., Xu,F.,
            Li,M., Chen,C. and Chen,L.
  TITLE     PPAR-gamma promotes the polarization of rat retinal microglia to M2
            phenotype by regulating the expression of CD200-CD200R1 under
            hypoxia
  JOURNAL   Mol Biol Rep 50 (12), 10277-10285 (2023)
   PUBMED   37971567
  REMARK    GeneRIF: PPAR-gamma promotes the polarization of rat retinal
            microglia to M2 phenotype by regulating the expression of
            CD200-CD200R1 under hypoxia.
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Amirteymori,H., Veisi,A., Khaleghzadeh-Ahangar,H., Mozafari,R. and
            Haghparast,A.
  TITLE     Involvement of orexin-2 receptors in the CA1 region of the
            hippocampus in the extinction and reinstatement of
            methamphetamine-induced conditioned place preference in the rats
  JOURNAL   Peptides 160, 170926 (2023)
   PUBMED   36565856
  REMARK    GeneRIF: Involvement of orexin-2 receptors in the CA1 region of the
            hippocampus in the extinction and reinstatement of
            methamphetamine-induced conditioned place preference in the rats.
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Patoine,D., Bouchard,K., Lemay,A.M., Bissonnette,E.Y. and
            Lauzon-Joset,J.F.
  TITLE     Specificity of CD200/CD200R pathway in LPS-induced lung
            inflammation
  JOURNAL   Front Immunol 13, 1092126 (2022)
   PUBMED   36591265
  REMARK    GeneRIF: Specificity of CD200/CD200R pathway in LPS-induced lung
            inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Chamera,K., Szuster-Gluszczak,M., Trojan,E. and Basta-Kaim,A.
  TITLE     Maternal Immune Activation Sensitizes Male Offspring Rats to
            Lipopolysaccharide-Induced Microglial Deficits Involving the
            Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems
  JOURNAL   Cells 9 (7), 1676 (2020)
   PUBMED   32664639
  REMARK    GeneRIF: Maternal Immune Activation Sensitizes Male Offspring Rats
            to Lipopolysaccharide-Induced Microglial Deficits Involving the
            Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Koning,N., Swaab,D.F., Hoek,R.M. and Huitinga,I.
  TITLE     Distribution of the immune inhibitory molecules CD200 and CD200R in
            the normal central nervous system and multiple sclerosis lesions
            suggests neuron-glia and glia-glia interactions
  JOURNAL   J Neuropathol Exp Neurol 68 (2), 159-167 (2009)
   PUBMED   19151626
  REMARK    Erratum:[J Neuropathol Exp Neurol. 2009 May;68(5):594]
REFERENCE   7  (bases 1 to 2427)
  AUTHORS   Meuth,S.G., Simon,O.J., Grimm,A., Melzer,N., Herrmann,A.M.,
            Spitzer,P., Landgraf,P. and Wiendl,H.
  TITLE     CNS inflammation and neuronal degeneration is aggravated by
            impaired CD200-CD200R-mediated macrophage silencing
  JOURNAL   J Neuroimmunol 194 (1-2), 62-69 (2008)
   PUBMED   18164423
  REMARK    GeneRIF: The CD200-CD200R pathway seems of critical relevance for
            macrophage-mediated damage in autoimmune inflammation of the CNS.
REFERENCE   8  (bases 1 to 2427)
  AUTHORS   Gorczynski,R.M., Chen,Z., Clark,D.A., Kai,Y., Lee,L., Nachman,J.,
            Wong,S. and Marsden,P.
  TITLE     Structural and functional heterogeneity in the CD200R family of
            immunoregulatory molecules and their expression at the
            feto-maternal interface
  JOURNAL   Am J Reprod Immunol 52 (2), 147-163 (2004)
   PUBMED   15274657
REFERENCE   9  (bases 1 to 2427)
  AUTHORS   Wright,G.J., Jones,M., Puklavec,M.J., Brown,M.H. and Barclay,A.N.
  TITLE     The unusual distribution of the neuronal/lymphoid cell surface
            CD200 (OX2) glycoprotein is conserved in humans
  JOURNAL   Immunology 102 (2), 173-179 (2001)
   PUBMED   11260322
REFERENCE   10 (bases 1 to 2427)
  AUTHORS   Wright,G.J., Puklavec,M.J., Willis,A.C., Hoek,R.M., Sedgwick,J.D.,
            Brown,M.H. and Barclay,A.N.
  TITLE     Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel
            receptor on macrophages implicated in the control of their function
  JOURNAL   Immunity 13 (2), 233-242 (2000)
   PUBMED   10981966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 5, 2022 this sequence version replaced NM_023953.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.1356860.1,
                                           SRR21887622.1753842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000011.1  69426876-69427128   c
            254-313             JAXUCZ010000011.1  69399243-69399302   c
            314-631             JAXUCZ010000011.1  69398190-69398507   c
            632-886             JAXUCZ010000011.1  69397832-69398086   c
            887-986             JAXUCZ010000011.1  69395743-69395842   c
            987-1032            JAXUCZ010000011.1  69395170-69395215   c
            1033-2427           JAXUCZ010000011.1  69392975-69394369   c
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2427
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /note="CD200 receptor 1"
                     /db_xref="GeneID:64357"
                     /db_xref="RGD:61837"
     exon            1..253
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1173
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /note="cell adhesion molecule; OX2 cell surface
                     glycoprotein receptor; CD200 receptor; antigen identified
                     by monoclonal antibody MRC OX-2 receptor; cell surface
                     glycoprotein CD200 receptor 1; OX2 receptor; OX102
                     antigen; CD200 cell surface glycoprotein receptor; cell
                     surface glycoprotein OX2 receptor 1"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 1
                     precursor"
                     /protein_id="NP_076443.1"
                     /db_xref="GeneID:64357"
                     /db_xref="RGD:61837"
                     /translation="MLCFWRTSHVAVLLIWGVFAAESSCPDKNQTMQNNSSTMTEVNT
                     TVFVQMGKKALLCCPSISLTKVILITWTITLRGQPSCIISYKADTRETHESNCSDRSI
                     TWASTPDLAPDLQISAVALQHEGRYSCDIAVPDGNFQNIYDLQVLVPPEVTHFPGENR
                     TAVCEAIAGKPAAQISWTPDGDCVAKNESHSNGTVTVRSTCHWEQSHVSVVFCVVSHL
                     TTGNQSLSIELGRGGDQLLGSYIQYIIPSIIILIIIGCICLLKISGCRKCKLPKSGAT
                     PDIEEDEMQPYASYTEKSNPLYDTVTTTEAHPASQGKVNGTDCLTLSAMGI"
     exon            254..313
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            314..631
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            632..886
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            887..986
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1032
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2427
                     /gene="Cd200r1"
                     /gene_synonym="Mox2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccaaagc acgctgagtg gaaggagagg gcagggaaga caggactgct cccggctgat
       61 gggttaagag gtgggctacc acgcagaagc caacccgaga gcggagggat cctggtcatg
      121 gtcaccgctg ctcccctacc tgtgaagaga aagagcaccg agtgagccgc tgaaaaccag
      181 aaaaccgaaa tgctctgctt ttggagaact tctcacgtag cagtactctt gatctggggg
      241 gtcttcgcgg ctgagtcaag ttgtcctgat aagaatcaaa caatgcagaa caattcatca
      301 actatgacag aagttaacac tacagtgttt gtacagatgg gtaaaaaggc tctgctctgc
      361 tgcccttcta tttcactgac aaaagtaata ttaataacat ggacaataac cctcagagga
      421 cagccttcct gcataatatc ctacaaagca gacacaaggg agacccatga aagcaactgc
      481 tcggacagaa gcatcacctg ggcctccaca cctgacctcg ctcctgacct tcagatcagt
      541 gcagtggccc tccagcatga agggcgttac tcatgtgata tagcagtacc tgacgggaat
      601 ttccaaaaca tctatgacct ccaagtgctg gtgccccctg aagtaaccca ctttccaggg
      661 gaaaatagaa ctgcagtttg tgaggcgatt gcaggcaaac ctgctgcgca gatctcttgg
      721 acgccagatg gggattgtgt cgctaagaat gaatcacaca gcaatggcac cgtgactgtc
      781 cggagcacat gccactggga gcagagccac gtgtctgtcg tgttctgtgt tgtctctcac
      841 ttgacaactg gtaaccagtc tctgtctata gaactgggta gagggggtga ccaattatta
      901 ggatcataca ttcaatacat catcccatct attattattt tgatcatcat aggatgcatt
      961 tgtcttttga aaatcagtgg ctgcagaaaa tgtaaattgc caaaatcggg agctactcca
     1021 gatattgagg aggatgaaat gcagccgtat gctagctaca cagagaagag caatccactc
     1081 tatgatactg tgaccacgac ggaggcacac ccagcgtcac aaggcaaagt caatggcaca
     1141 gactgtctta ctttgtcagc catgggaatc tagaaccaag gaaaagaagt caagagacat
     1201 cataattact gcttttcttt ctttaaactt ctccaatgga gggaaattag ctcttctgaa
     1261 gttcttagaa agcacaaatg ttctaatgga tttgccttta agttcttcta tcattggaag
     1321 tttggaatct ttgctgctac ctgttaattc taggaagaac tgatttaatt attacaaaga
     1381 aagcacattg ttatggtaaa atatcaaatt gtgcaataca atgatgaaaa ctgagtttcc
     1441 tcaagaaata actgcagaag gaacaatcat tactaaagca tttcatgtga gttcttccaa
     1501 aaaagaaaat ccctgtgtat acgacatgat tatggtatgt gtgtgccttt atatgtttgt
     1561 ttacaaatgt gtatatatgc acacatctga ttatcaagac atctctgtca aaaactcact
     1621 ggcgttccag atttatgaaa gctaataaag tgagtattgg agatgttttt atatctgtat
     1681 atgtaaaact acctcattct ttttaatggc tacataaaat tcatggtcct tggatgggca
     1741 tttagacttt gtgttgtatg tggtattaaa tgataccatg tggaatgttt cttgtggtga
     1801 atctccgcat tatttgagtg cacctgtgag ataatttctg tgagtgtaat ggtcctgtca
     1861 gttggaatgc gcttttatga tcaatagatt agtcaaactg tgtcagttta cattttctct
     1921 aattgtgttt aatgtgactt tctccatatt cttattctta tgtttttaat atcttcactt
     1981 tcacctttta tactttccat ctttaattaa ccagttgggt gatgtgtctt aaggttgtga
     2041 tattaacttt attatttaat ggaactggat tcatatcttt gggtttcatg tccacaaaag
     2101 agatagaaag catttgtaaa gacagtattt tcaactcctt gtattactac aaaaatgttg
     2161 acatctgatg cacaacagtt ttatggatgt tatgaattgt gtgtttttaa cattctattc
     2221 tgatgtactt ataagagagc aactgtcttt gaactatata tgtaggtggg agaacttgga
     2281 gtactttatg tgctaatagg atggtaatgg gatgatataa cttttccctc cagttttttg
     2341 gagggaaata ttaggaatac atgtattgat aatttttagc atatattttt taattgttaa
     2401 aaataaacct gttcccttta tatcagg
//
