LOCUS       NM_031518               2243 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Cd200 molecule (Cd200), mRNA.
ACCESSION   NM_031518 XM_001066772
VERSION     NM_031518.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Qian,H., Chen,A., Lin,D., Deng,J., Gao,F., Wei,J., Wu,X., Huang,Y.,
            Cai,D., Chen,X. and Zheng,X.
  TITLE     Activation of the CD200/CD200R1 axis improves cognitive impairment
            by enhancing hippocampal neurogenesis via suppression of M1
            microglial polarization and neuroinflammation in hypoxic-ischemic
            neonatal rats
  JOURNAL   Int Immunopharmacol 128, 111532 (2024)
   PUBMED   38237226
  REMARK    GeneRIF: Activation of the CD200/CD200R1 axis improves cognitive
            impairment by enhancing hippocampal neurogenesis via suppression of
            M1 microglial polarization and neuroinflammation in
            hypoxic-ischemic neonatal rats.
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Hong,Y., Jiang,L., Tang,F., Zhang,M., Cui,L., Zhong,H., Xu,F.,
            Li,M., Chen,C. and Chen,L.
  TITLE     PPAR-gamma promotes the polarization of rat retinal microglia to M2
            phenotype by regulating the expression of CD200-CD200R1 under
            hypoxia
  JOURNAL   Mol Biol Rep 50 (12), 10277-10285 (2023)
   PUBMED   37971567
  REMARK    GeneRIF: PPAR-gamma promotes the polarization of rat retinal
            microglia to M2 phenotype by regulating the expression of
            CD200-CD200R1 under hypoxia.
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Patoine,D., Bouchard,K., Lemay,A.M., Bissonnette,E.Y. and
            Lauzon-Joset,J.F.
  TITLE     Specificity of CD200/CD200R pathway in LPS-induced lung
            inflammation
  JOURNAL   Front Immunol 13, 1092126 (2022)
   PUBMED   36591265
  REMARK    GeneRIF: Specificity of CD200/CD200R pathway in LPS-induced lung
            inflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Chamera,K., Szuster-Gluszczak,M., Trojan,E. and Basta-Kaim,A.
  TITLE     Maternal Immune Activation Sensitizes Male Offspring Rats to
            Lipopolysaccharide-Induced Microglial Deficits Involving the
            Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems
  JOURNAL   Cells 9 (7), 1676 (2020)
   PUBMED   32664639
  REMARK    GeneRIF: Maternal Immune Activation Sensitizes Male Offspring Rats
            to Lipopolysaccharide-Induced Microglial Deficits Involving the
            Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Sun,H., He,X., Tao,X., Hou,T., Chen,M., He,M. and Liao,H.
  TITLE     The CD200/CD200R signaling pathway contributes to spontaneous
            functional recovery by enhancing synaptic plasticity after stroke
  JOURNAL   J Neuroinflammation 17 (1), 171 (2020)
   PUBMED   32473633
  REMARK    GeneRIF: The CD200/CD200R signaling pathway contributes to
            spontaneous functional recovery by enhancing synaptic plasticity
            after stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2243)
  AUTHORS   Wright,G.J., Puklavec,M.J., Willis,A.C., Hoek,R.M., Sedgwick,J.D.,
            Brown,M.H. and Barclay,A.N.
  TITLE     Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel
            receptor on macrophages implicated in the control of their function
  JOURNAL   Immunity 13 (2), 233-242 (2000)
   PUBMED   10981966
REFERENCE   7  (bases 1 to 2243)
  AUTHORS   Toriyama,S., Kimishima,T. and Takahashi,M.
  TITLE     The proteins encoded by rice grassy stunt virus RNA5 and RNA6 are
            only distantly related to the corresponding proteins of other
            members of the genus Tenuivirus
  JOURNAL   J Gen Virol 78 (Pt 9), 2355-2363 (1997)
   PUBMED   9292026
REFERENCE   8  (bases 1 to 2243)
  AUTHORS   Preston,S., Wright,G.J., Starr,K., Barclay,A.N. and Brown,M.H.
  TITLE     The leukocyte/neuron cell surface antigen OX2 binds to a ligand on
            macrophages
  JOURNAL   Eur J Immunol 27 (8), 1911-1918 (1997)
   PUBMED   9295026
REFERENCE   9  (bases 1 to 2243)
  AUTHORS   Clark,M.J., Gagnon,J., Williams,A.F. and Barclay,A.N.
  TITLE     MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a
            structure like a single immunoglobulin light chain
  JOURNAL   EMBO J 4 (1), 113-118 (1985)
   PUBMED   2862025
REFERENCE   10 (bases 1 to 2243)
  AUTHORS   Webb,M. and Barclay,A.N.
  TITLE     Localisation of the MRC OX-2 glycoprotein on the surfaces of
            neurones
  JOURNAL   J Neurochem 43 (4), 1061-1067 (1984)
   PUBMED   6147390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Apr 12, 2023 this sequence version replaced NM_031518.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089793.1, X01785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000011.1  68916315-68916401
            88-169              JAXUCZ010000011.1  68924817-68924898
            170-496             JAXUCZ010000011.1  68928542-68928868
            497-769             JAXUCZ010000011.1  68930859-68931131
            770-913             JAXUCZ010000011.1  68933294-68933437
            914-2243            JAXUCZ010000011.1  68942239-68943568
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2243
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /note="Cd200 molecule"
                     /db_xref="GeneID:24560"
                     /db_xref="RGD:3104"
     exon            1..87
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..912
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /note="OX-2 membrane glycoprotein; MRC OX-2 antigen; cell
                     surface protein (thymocyte antigen identified by
                     monoclonal antibody MRC-OX2); Cd200 antigen"
                     /codon_start=1
                     /product="OX-2 membrane glycoprotein precursor"
                     /protein_id="NP_113706.2"
                     /db_xref="GeneID:24560"
                     /db_xref="RGD:3104"
                     /translation="MGSPVFRRPFCHLSTYSLLWAIAAVALSTAQVEVVTQDERKLLH
                     TTASLRCSLKTTQEPLIVTWQKKKAVGPENMVTYSKAHGVVIQPTYRDRINITELGLL
                     NTSITFWNTTLDDEGCYMCLFNMFGSGKVSGTACLTLYVQPIVHLHYNYFEDHLNITC
                     SATARPAPAISWKGTGSGIENSTESHSHSNGTTSVTSILRVKDPKTQVGKEVICQVLY
                     LGNVIDYKQSLDKGFWFSVPLLLSIVSLVILLVLISILLYWKRHRNQERGESSQGMQR
                     MK"
     exon            88..169
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..496
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..769
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..913
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..2243
                     /gene="Cd200"
                     /gene_synonym="Cspmo2; Mox2; MRCOX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcggaga taccctccac agtggaagag ctcagacccg gagacgctgg tgtcttactg
       61 cggcccagag caaggatggg cagtccggta ttcaggagac ctttctgcca tctgtccacc
      121 tacagcctgc tctgggccat agcagcagta gcgctgagca cagctcaagt ggaagtggtg
      181 acccaggatg aaagaaagct gctgcacaca actgcatcct tacgctgttc tctaaaaaca
      241 acccaggaac ccttgattgt gacatggcag aaaaagaaag ccgtaggccc agaaaacatg
      301 gtcacttaca gcaaagccca tggggttgtc attcagccca cctacagaga caggataaac
      361 atcactgagc tgggactctt gaacacaagc atcaccttct ggaacacaac cctggatgat
      421 gagggttgct acatgtgtct cttcaacatg tttggatctg ggaaggtctc tgggacagct
      481 tgccttactc tctatgtaca gcccatagta caccttcact acaactattt tgaagaccac
      541 ctaaacatca cgtgctctgc aactgcccgc ccagcccctg ccatctcctg gaagggcact
      601 gggtcaggaa ttgagaatag tactgagagt cactcccatt caaatgggac tacatctgtc
      661 accagcatcc tccgggtcaa agaccccaaa actcaggttg gaaaggaagt gatctgccag
      721 gttttatact tggggaatgt gattgactac aagcagagtc tggacaaagg attttggttt
      781 tcagtcccac tgctgctgag cattgtttct ctggtaattc ttctggtctt gatctccatc
      841 ttattatact ggaaacggca ccgaaatcag gagcggggtg agtcatcaca ggggatgcaa
      901 agaatgaaat aagagctcta gagaaattat acagaaccct gaacgtgttt ccctggtcta
      961 cttgaatctg atgttaaaga aaagcaggag ggaaaaggtc attctccata ggacctaaaa
     1021 aagagcaaaa gatgcagaag gaagcctgtg agggatttga ctttttgctg ctgtcccggg
     1081 tcctcagtat ttacattcca agaggaagtt gtgtgcctcg ggtctgttgc aggacttgat
     1141 ttttgtggag caatgcagcg tcattgctgt tagaaaggca ccagacttag aatcaccagt
     1201 gccaagccgg ctcgcagacc gactagggct cccaccggag ggacaaatca tagtcaactt
     1261 acctcacaga gcttcctggt ctttatacaa agtagaaagg agtgggacca gaaaatttgc
     1321 catgtctgag atctgatgga attttaggaa gaaaactgaa gagcgatcaa aagaagaaga
     1381 gagaacacag aagggtcaaa gagcttcgga gagtaccttt tgcctttctg ttggggtccc
     1441 acctctggtt ttgttcttag gtccaccagt ttgtttccct gttgtttgag tatctaattg
     1501 actacctgct actgttccgc tgattgttgg ccttgctaaa atccctgatt cccctgccgt
     1561 tctctatgtg cttctatgag ggttactatg atgaaaatag agaagaattt agtgtgaagt
     1621 aacattggca accgtaatgt gtccatttaa cttattttta tagcacgtag gcaaataccg
     1681 ttagtcttag caagtagttc acatctttac aaaagcatgc tttccctgtc catttggccc
     1741 aggatatcac cctctttgag gccattctga atcctgtctc gtgtaacgat aatatattat
     1801 gaaaacagat gtgttaagaa tttcctgtac agcagtcagt tgtatattct ctctctctct
     1861 ctctctctct ctctctctct ctctctctct ctctcaactt ctttttctgt gactttattt
     1921 ttcacaaaga gaaggcaact ctggaataca atcgctttgt tctgaagaca tttgtggaca
     1981 tcttaaccct ttgacagaac tagtgacgtt gttttctgta tcttttgctt catctgtctc
     2041 tgtagagtga cctaggaatt caagtgtaag ttgttttcat tgtcaaactc gatatttata
     2101 tacttggtat gcttttcatg tgttatttaa ttccgtataa ttttcctata tttgtattaa
     2161 aatactgagc aattaaaagt gtcaactaaa tagttgatgt gtgacattcc cttgagaaat
     2221 atagaaataa agaataacac ttg
//
