LOCUS       NM_012830               1159 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus Cd2 molecule (Cd2), mRNA.
ACCESSION   NM_012830 XM_346638
VERSION     NM_012830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Kanatsu-Shinohara,M., Chen,G., Morimoto,H. and Shinohara,T.
  TITLE     CD2 is a surface marker for mouse and rat spermatogonial stem cells
  JOURNAL   J Reprod Dev 66 (4), 341-349 (2020)
   PUBMED   32213736
  REMARK    GeneRIF: CD2 is a surface marker for mouse and rat spermatogonial
            stem cells.
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Motomura,Y., Kitamura,H., Hijikata,A., Matsunaga,Y., Matsumoto,K.,
            Inoue,H., Atarashi,K., Hori,S., Watarai,H., Zhu,J., Taniguchi,M.
            and Kubo,M.
  TITLE     The transcription factor E4BP4 regulates the production of IL-10
            and IL-13 in CD4+ T cells
  JOURNAL   Nat Immunol 12 (5), 450-459 (2011)
   PUBMED   21460847
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Ebert,E.C., Panja,A. and Praveen,R.
  TITLE     Human intestinal intraepithelial lymphocytes and epithelial cells
            coinduce interleukin-8 production through the CD2-CD58 interaction
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 296 (3), G671-G677 (2009)
   PUBMED   19109405
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Hoffmann,J.C., Peters,K., Pawlowski,N.N., Grollich,K., Henschke,S.,
            Herrmann,B., Zeitz,M. and Westermann,J.
  TITLE     In vivo proliferation of rat lamina propria T lymphocytes: general
            hyporesponsiveness but increased importance of the CD2 and CD28
            pathways
  JOURNAL   Immunol Invest 38 (6), 466-482 (2009)
   PUBMED   19811406
  REMARK    GeneRIF: CD2/CD28 costimulation is the strongest T cell stimulus in
            vivo in rat lamina propria.
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Bell,G.M., Fargnoli,J., Bolen,J.B., Kish,L. and Imboden,J.B.
  TITLE     The SH3 domain of p56lck binds to proline-rich sequences in the
            cytoplasmic domain of CD2
  JOURNAL   J Exp Med 183 (1), 169-178 (1996)
   PUBMED   8551220
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Hubbe,M. and Altevogt,P.
  TITLE     Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a
            costimulatory function
  JOURNAL   Eur J Immunol 24 (3), 731-737 (1994)
   PUBMED   8125140
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Bell,G.M., Bolen,J.B. and Imboden,J.B.
  TITLE     Association of Src-like protein tyrosine kinases with the CD2 cell
            surface molecule in rat T lymphocytes and natural killer cells
  JOURNAL   Mol Cell Biol 12 (12), 5548-5554 (1992)
   PUBMED   1280324
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Kato,K., Koyanagi,M., Okada,H., Takanashi,T., Wong,Y.W.,
            Williams,A.F., Okumura,K. and Yagita,H.
  TITLE     CD48 is a counter-receptor for mouse CD2 and is involved in T cell
            activation
  JOURNAL   J Exp Med 176 (5), 1241-1249 (1992)
   PUBMED   1383383
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Williams,A.F., Barclay,A.N., Clark,S.J., Paterson,D.J. and
            Willis,A.C.
  TITLE     Similarities in sequences and cellular expression between rat CD2
            and CD4 antigens
  JOURNAL   J Exp Med 165 (2), 368-380 (1987)
   PUBMED   3102667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 2, 2020 this sequence version replaced NM_012830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088164.1, SRR26643292.10091.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000002.1  191412529-191412659 c
            132-437             JAXUCZ010000002.1  191412114-191412419 c
            438-668             JAXUCZ010000002.1  191406850-191407080 c
            669-791             JAXUCZ010000002.1  191403624-191403746 c
            792-1159            JAXUCZ010000002.1  191399510-191399877 c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1159
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /note="Cd2 molecule"
                     /db_xref="GeneID:497761"
                     /db_xref="RGD:2297"
     exon            1..131
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1111
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /note="T-cell surface antigen CD2; CD2 antigen; OX-34
                     antigen; LFA-3 receptor; T-cell surface antigen T11/Leu-5;
                     OX-45 surface antigen homolog to human T lymphocyte CD2
                     antigen"
                     /codon_start=1
                     /product="T-cell surface antigen CD2 precursor"
                     /protein_id="NP_036962.2"
                     /db_xref="GeneID:497761"
                     /db_xref="RGD:2297"
                     /translation="MRCKFLGSFFLLFSLSSKGADCRDSGTVWGALGHGINLNIPNFQ
                     MTDDIDEVRWERGSTLVAEFKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTV
                     YSTNGTRILNKALDLRILEMVSKPMIYWECSNATLTCEVLEGTDVELKLYQGKEHLRS
                     LRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVNCPEKGLPLYLIVGVSAGGLLLVF
                     FGALFIFCICKRKKRNRRRKGEELEIKASRMSTVERGPKPHSTQASAPASQNPVASQA
                     PPPPGHHLQTPGHRPLPPSHRNREHQPKKRPPPSGTQVHQQKGPPLPRPRVQPKPPCG
                     SGDVSLPPPN"
     exon            132..437
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /inference="alignment:Splign:2.1.0"
     exon            438..668
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /inference="alignment:Splign:2.1.0"
     exon            669..791
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1159
                     /gene="Cd2"
                     /gene_synonym="CD2R; LFA-2; LFA2; OX-34; OX34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcttctg ccagcctcac cacagccctg gcagaaagaa gaactcagag ccaccactgg
       61 gaaaagaatt gtaaagatga gatgtaaatt cctagggagt ttctttctgc tcttcagcct
      121 gtccagcaaa ggagcagact gcagagacag tgggaccgtc tggggtgccc tgggtcatgg
      181 catcaacctg aacatcccta actttcaaat gactgatgat attgatgagg tgcgatggga
      241 gagggggagc accctggttg ccgagtttaa aaggaagatg aagccttttt tgaaatcggg
      301 agcatttgag atcttagcaa atggagactt gaagataaag aatctgacaa gagatgacag
      361 tggcacctat aatgtaacgg tatacagcac aaatgggaca cgtatcctga acaaggcact
      421 ggacttgagg attctagaga tggtctcaaa gccgatgatc tactgggagt gcagcaacgc
      481 aaccctgacc tgtgaagtct tggaaggaac agatgttgaa ctaaagctgt accaaggaaa
      541 ggagcatctc aggagcctcc gtcagaagac catgagttac cagtggacca acctgagagc
      601 accgtttaag tgcaaggcag taaacagggt cagccaggag tctgagatgg aagttgtcaa
      661 ctgtccagag aaaggtctgc ccctctatct catagtgggg gtcagtgcag gaggactcct
      721 cttggtgttc tttggggcgc tgtttatttt ctgtatctgc aagaggaaaa aacggaacag
      781 gaggagaaaa ggtgaagagc tggagataaa agcttccaga atgagcactg tggaaagggg
      841 acccaagcca cactcaaccc aggcctcagc accagcatca cagaatccag tggcttccca
      901 agctcctcct ccacctggcc atcatctcca gacacctggc catcgtcccc tgcctccaag
      961 ccaccgtaac cgtgagcacc agccgaagaa gagacctcct ccatcaggca cacaggttca
     1021 ccagcagaaa ggccctcctt tgcccagacc ccgagttcag ccaaagcctc cctgtgggag
     1081 tggagatgtt tcgttgccac cccctaatta aaaaggcaga atctgccatt tccaataaaa
     1141 agctgtgtgg atataactt
//
