LOCUS       NM_001013237            2405 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus CD19 molecule (Cd19), mRNA.
ACCESSION   NM_001013237 XM_001079863 XM_344961
VERSION     NM_001013237.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Mattila,P.K., Feest,C., Depoil,D., Treanor,B., Montaner,B.,
            Otipoby,K.L., Carter,R., Justement,L.B., Bruckbauer,A. and
            Batista,F.D.
  TITLE     The actin and tetraspanin networks organize receptor nanoclusters
            to regulate B cell receptor-mediated signaling
  JOURNAL   Immunity 38 (3), 461-474 (2013)
   PUBMED   23499492
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Uckun,F.M., Ma,H., Zhang,J., Ozer,Z., Dovat,S., Mao,C.,
            Ishkhanian,R., Goodman,P. and Qazi,S.
  TITLE     Serine phosphorylation by SYK is critical for nuclear localization
            and transcription factor function of Ikaros
  JOURNAL   Proc Natl Acad Sci U S A 109 (44), 18072-18077 (2012)
   PUBMED   23071339
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Gartlan,K.H., Belz,G.T., Tarrant,J.M., Minigo,G., Katsara,M.,
            Sheng,K.C., Sofi,M., van Spriel,A.B., Apostolopoulos,V.,
            Plebanski,M., Robb,L. and Wright,M.D.
  TITLE     A complementary role for the tetraspanins CD37 and Tssc6 in
            cellular immunity
  JOURNAL   J Immunol 185 (6), 3158-3166 (2010)
   PUBMED   20709950
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   O'Connell,R.M., Chaudhuri,A.A., Rao,D.S., Gibson,W.S., Balazs,A.B.
            and Baltimore,D.
  TITLE     MicroRNAs enriched in hematopoietic stem cells differentially
            regulate long-term hematopoietic output
  JOURNAL   Proc Natl Acad Sci U S A 107 (32), 14235-14240 (2010)
   PUBMED   20660734
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Gerth,A.J., Lin,L. and Peng,S.L.
  TITLE     T-bet regulates T-independent IgG2a class switching
  JOURNAL   Int Immunol 15 (8), 937-944 (2003)
   PUBMED   12882831
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Buhl,A.M., Pleiman,C.M., Rickert,R.C. and Cambier,J.C.
  TITLE     Qualitative regulation of B cell antigen receptor signaling by
            CD19: selective requirement for PI3-kinase activation,
            inositol-1,4,5-trisphosphate production and Ca2+ mobilization
  JOURNAL   J Exp Med 186 (11), 1897-1910 (1997)
   PUBMED   9382888
REFERENCE   8  (bases 1 to 2405)
  AUTHORS   Pani,G., Siminovitch,K.A. and Paige,C.J.
  TITLE     The motheaten mutation rescues B cell signaling and development in
            CD45-deficient mice
  JOURNAL   J Exp Med 186 (4), 581-588 (1997)
   PUBMED   9254656
REFERENCE   9  (bases 1 to 2405)
  AUTHORS   Rickert,R.C., Rajewsky,K. and Roes,J.
  TITLE     Impairment of T-cell-dependent B-cell responses and B-1 cell
            development in CD19-deficient mice
  JOURNAL   Nature 376 (6538), 352-355 (1995)
   PUBMED   7543183
REFERENCE   10 (bases 1 to 2405)
  AUTHORS   Carter,R.H. and Fearon,D.T.
  TITLE     CD19: lowering the threshold for antigen receptor stimulation of B
            lymphocytes
  JOURNAL   Science 256 (5053), 105-107 (1992)
   PUBMED   1373518
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001013237.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.3798.1,
                                           SRR26643284.1373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000001.1  190424147-190424268 c
            123-389             JAXUCZ010000001.1  190423659-190423925 c
            390-584             JAXUCZ010000001.1  190423185-190423379 c
            585-863             JAXUCZ010000001.1  190422776-190423054 c
            864-974             JAXUCZ010000001.1  190421410-190421520 c
            975-1023            JAXUCZ010000001.1  190421123-190421171 c
            1024-1112           JAXUCZ010000001.1  190420792-190420880 c
            1113-1214           JAXUCZ010000001.1  190420388-190420489 c
            1215-1316           JAXUCZ010000001.1  190420169-190420270 c
            1317-1385           JAXUCZ010000001.1  190420015-190420083 c
            1386-1442           JAXUCZ010000001.1  190419860-190419916 c
            1443-1499           JAXUCZ010000001.1  190419712-190419768 c
            1500-1586           JAXUCZ010000001.1  190418971-190419057 c
            1587-1693           JAXUCZ010000001.1  190418734-190418840 c
            1694-2405           JAXUCZ010000001.1  190417853-190418564 c
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2405
                     /gene="Cd19"
                     /note="CD19 molecule"
                     /db_xref="GeneID:365367"
                     /db_xref="RGD:1309086"
     exon            1..122
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1678
                     /gene="Cd19"
                     /note="CD19 antigen; B-lymphocyte antigen CD19"
                     /codon_start=1
                     /product="B-lymphocyte antigen CD19 precursor"
                     /protein_id="NP_001013255.2"
                     /db_xref="GeneID:365367"
                     /db_xref="RGD:1309086"
                     /translation="MPSPLPVSLLLFLTLVGGRPQNSLLVEVEEGDNVVLSCLRDSSP
                     VSSEKLAWYRGNQSTPFLELSLRSPDLGLHIGPLGILLVIVNVSDHRGGFYLCQKRPS
                     FKDTWQPAWTVNVEDSGELFRWNASDLGDLDCDLGNRSSGSHRSTSGSQLYVWATDHP
                     EVWKTKPVCAPREISLNQSLINQDLTVAPGSTLWLSCGVPPVPVTKGSISWTHVHPKT
                     LNVSLLSLSLGGEHPVREMWVWGSLLLLPQAKASDEGTYYCLQGGLTIKMHVKVIARS
                     AVWLWLLRTGGWIVPVVTLVYVIFCMVSMAAFLYFRRAFILRRKRKRMTDPARRFFKV
                     TPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAASLGSGPVSYGNPRIEVQDAGAQRHE
                     TGLEEEGEAYEEPDSEEGSEFYENDSNLEQDQLSQDGSGYENPEDDPVGPEEEDSFSN
                     AESYENADEELAQPVGRTMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLQS
                     IRSGPSHEEDADSYENMDKSDDPEPAWAGEGHMGTWGAT"
     exon            123..389
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            390..584
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            585..863
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            864..974
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1023
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1112
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1214
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1316
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1385
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1442
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1499
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1586
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1693
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2405
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaagccg ggtgccccag ggagcctggc taccatgcca tctcctctcc ctgtctccct
       61 cctcctcttc cttaccttag taggaggcag gccccagaat tccttactgg tggaggtaga
      121 agagggagac aatgttgtgc tgtcatgcct ccgggactcc tcacctgtct cttctgagaa
      181 gctggcttgg tatcgaggta accagtcaac acccttcctg gagctgagcc tcaggtcccc
      241 ggacctgggt ctgcacatcg ggcccctggg catcttgcta gtgattgtca atgtctcgga
      301 ccataggggg ggcttctatc tgtgccaaaa gaggccctct ttcaaggaca cctggcagcc
      361 tgcctggacc gtaaacgtgg aggatagtgg ggagctgttc cggtggaatg cttcagactt
      421 gggggacctg gattgtgacc taggaaacag gtcctcaggg agccacaggt ccacttctgg
      481 ttcccagctg tatgtgtggg ctacagatca tcctgaggtc tggaaaacaa agcctgtatg
      541 tgccccacgg gagatcagtc tgaatcagag tctaatcaac caagatctca ctgtggcccc
      601 tggctccaca ctttggctgt cctgtggcgt accccctgtc ccagtgacca aaggctccat
      661 ctcctggacc catgtgcatc ctaagacgct taacgtttca ttactgagcc taagccttgg
      721 gggagagcac ccagtgagag agatgtgggt ttgggggtct cttttgctac tgccccaagc
      781 caaagcttca gatgaaggta cctattattg tctccaagga ggcctgacca tcaagatgca
      841 cgtgaaggtc attgcaaggt cagcagtgtg gctctggctg ttgaggactg gtggatggat
      901 agtcccagtt gtgactttag tatatgtcat cttctgtatg gtttctatgg cggcttttct
      961 ctattttcga agagccttca tcctgaggag gaagaggaag cgaatgaccg accctgctag
     1021 gagattcttc aaagtgacgc ctccctcagg aaacgggacc cagaaccagt atgggaatgt
     1081 gctctccctt cctacatcta cctctggcca ggcccatgct cagcgttggg ctgctagcct
     1141 agggagtggt cctgtgtcct atggaaatcc acgcattgaa gtccaggatg ctggagctca
     1201 gagacatgaa acaggactgg aagaagaagg ggaggcctat gaagagccag acagcgagga
     1261 gggctctgaa ttctatgaga atgactccaa ccttgagcag gatcaacttt cccaggatgg
     1321 cagtggctat gagaaccctg aggatgaccc cgtaggtcca gaggaggaag actccttctc
     1381 caatgccgag tcttatgaaa atgcagatga ggagctggcc caaccagttg gcaggacgat
     1441 ggacttcctg agcccccacg ggtctgcatg ggaccccagc cgggaagcat cctcccttgg
     1501 gtcccagtcc tacgaagaca tgagagggat cctgtatgca gctcctcagc tccaatcaat
     1561 tcggtctggt cccagtcatg aggaagatgc agactcttat gaaaacatgg ataaatctga
     1621 cgacccagag ccagcatggg caggagaggg ccacatgggg acttggggtg ccacgtgact
     1681 cccaggtgac tagcctggac ttccttaggt cccgagaacc ccatcttact ctgaaatctg
     1741 gagatcccaa gaagatggtg tcagtcagtg aaataacctt gtttaggatg tgtgtgcgca
     1801 cacacacaca cacacacact catatgcatg tacaagcaaa gcttcctttt gactcttttt
     1861 gctttcccca aataaactca acaagccact caaatactct gaagcatgcc cttgtgtggg
     1921 agaagaagga aagatgaggc tgaatccagc tctgaatcac ccagaggaag gagagctggt
     1981 ctgaatacat cctggcccta gcatgatatt tagccactaa catccaatga tgcaaatatg
     2041 ttcagccatt attccatggt gtcccacaag ggacagacag tgatgggatt ggcacccctg
     2101 cacaaactgg gaaaccctgt ctgcccttct tcccttaacc ctggctgctc tgggctagca
     2161 ggtcagtacc cctcatctct gagtttccgg caacccacct gagtgcccgc ccagggtttc
     2221 agcttctgac catatgtgga caccacccca gctctgaact tacatatcat cactccttgt
     2281 ctaagaccta taaaaccccc ttaccttagc ccaggtgtgc catttccctg ctccctcccc
     2341 tgtccttggg atctgtgaac gtactcaaga gctgctctca ataaatctgc ctctatatgt
     2401 cttaa
//
