LOCUS       NM_001106405            2708 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus CD180 molecule (Cd180), mRNA.
ACCESSION   NM_001106405 XM_001072126 XM_006231871 XM_226731
VERSION     NM_001106405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Huang,W., Yang,J., He,C. and Yang,J.
  TITLE     RP105 plays a cardioprotective role in myocardial ischemia
            reperfusion injury by regulating the Toll-like receptor 2/4
            signaling pathways
  JOURNAL   Mol Med Rep 22 (2), 1373-1381 (2020)
   PUBMED   32626996
  REMARK    GeneRIF: RP105 plays a cardioprotective role in myocardial ischemia
            reperfusion injury by regulating the Tolllike receptor 2/4
            signaling pathways.
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Qin,Q., Cui,L., Zhou,Z., Zhang,Z., Wang,Y. and Zhou,C.
  TITLE     Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in
            H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K/AKT
            Signaling Pathway
  JOURNAL   Med Sci Monit 25, 7016-7025 (2019)
   PUBMED   31532760
  REMARK    GeneRIF: Inhibition of miR-141-3p reduced hypoxia-induced apoptosis
            in H9c2 cardiomyocytes in vitro by activating the RP105-dependent
            PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Guo,X., Jiang,H., Chen,J., Zhang,B.F., Hu,Q., Yang,S., Yang,J. and
            Zhang,J.
  TITLE     RP105 ameliorates hypoxiareoxygenation injury in cardiac
            microvascular endothelial cells by suppressing TLR4MAPKsNF-kappaB
            signaling
  JOURNAL   Int J Mol Med 42 (1), 505-513 (2018)
   PUBMED   29693119
  REMARK    GeneRIF: RP105 was minimally expressed in cardiac microvascular
            endothelial cells subjected to hypoxiareoxygenation injury.
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Sun,Y., Liu,L., Yuan,J., Sun,Q., Wang,N. and Wang,Y.
  TITLE     RP105 protects PC12 cells from oxygen-glucose
            deprivation/reoxygenation injury via activation of the PI3K/AKT
            signaling pathway
  JOURNAL   Int J Mol Med 41 (5), 3081-3089 (2018)
   PUBMED   29436577
  REMARK    GeneRIF: CD180 protected PC12 cells from oxygenglucose
            deprivation/reoxygenation injury through promotion of the PI3K/AKT
            pathway.
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Guo,X., Jiang,H., Yang,J., Chen,J., Yang,J., Ding,J.W., Li,S.,
            Wu,H. and Ding,H.S.
  TITLE     Radioprotective 105 kDa protein attenuates
            ischemia/reperfusion-induced myocardial apoptosis and autophagy by
            inhibiting the activation of the TLR4/NF-kappaB signaling pathway
            in rats
  JOURNAL   Int J Mol Med 38 (3), 885-893 (2016)
   PUBMED   27431018
  REMARK    GeneRIF: Data show that overexpression of radioprotective 105 kDa
            protein (RP105; CD180) led to the repression of toll-like receptor
            4 (TLR4) activity and the phosphorylation of NF-Kappa B p65.
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Li,X., Yang,J., Yang,J., Dong,W., Li,S., Wu,H. and Li,L.
  TITLE     RP105 protects against myocardial ischemia-reperfusion injury via
            suppressing TLR4 signaling pathways in rat model
  JOURNAL   Exp Mol Pathol 100 (2), 281-286 (2016)
   PUBMED   26742900
  REMARK    GeneRIF: the anti-inflammatory roles of radioprotective 105 kDa
            protein (RP105) and its potential in preventing and treating
            myocardial ischemia-reperfusion (I/R) injury.
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Ogata,H., Su,I., Miyake,K., Nagai,Y., Akashi,S., Mecklenbrauker,I.,
            Rajewsky,K., Kimoto,M. and Tarakhovsky,A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before May 11, 2021 this sequence version replaced
            XM_006231871.4, NM_001106405.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.573810.1,
                                           SRR21887622.4066443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000002.1  35589930-35590146
            218-384             JAXUCZ010000002.1  35598431-35598597
            385-2708            JAXUCZ010000002.1  35600514-35602837
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2708
                     /gene="Cd180"
                     /gene_synonym="Ly78; RP105"
                     /note="CD180 molecule"
                     /db_xref="GeneID:294706"
                     /db_xref="RGD:1308170"
     exon            1..217
                     /gene="Cd180"
                     /gene_synonym="Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2116
                     /gene="Cd180"
                     /gene_synonym="Ly78; RP105"
                     /note="lymphocyte antigen 78; CD180 antigen;
                     radioprotective 105 kDa protein"
                     /codon_start=1
                     /product="CD180 antigen precursor"
                     /protein_id="NP_001099875.1"
                     /db_xref="GeneID:294706"
                     /db_xref="RGD:1308170"
                     /translation="MALDISCFLLVALFSASCQAIGSSDQRCTEKEVNKTYNCEHLGL
                     SEIPGTLPNSTESLEFSFNALPTIQKTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQHR
                     LETLVLTANPLIFMAETALTGPKALKHLFFIQTGISSIEFIPVHSQKALESLYLGSNH
                     ISSIRLPKDFPTEKLKVLDFQNNAIHHLSKEDVSSLQQATNLSLNLNGNDITGIEPGA
                     FKSTVFQSLNFGGTQSLLVIFKGLQNSTIQSLWLGTFEDIDDDEDISSSMFEGLCEMS
                     VERINLQKHHFFNITSNTFYCFSGLQELDLTATHLTELPSGIVGLSKLKKLVLSANKF
                     ENLCQISASNFPSLTHLYIKGNTKRLELGSGCLETLEHLRELDLSHDDIETSDCCNLQ
                     LRNLSHLQSLNLSYNEPLGLRTEAFKECPQLELLDLAFTRLHVKDAQSPFQNLHLLKV
                     LNLSHCLLGSSNQHLLDGLPALRHLNLQGNRFPNGNIQKTNPLQALGSLEILILSFCD
                     LSSIDHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIPPSLLPV
                     LSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDIEDTFCANPPLLRGVKVSDVML
                     SCSMAAVGIFFLIVFLLLFAVLLIFAVKRFLRWKYQHI"
     exon            218..384
                     /gene="Cd180"
                     /gene_synonym="Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2708
                     /gene="Cd180"
                     /gene_synonym="Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctaaga ccgaccttct gaacacctca ctgcctgcca aattgccaga gctattagag
       61 tgtgattaga ttgcttggct ctgagcgtta gctaatccta tgcagctggg cttgctctgg
      121 acctgagatg gctctggaca tcagctgctt ccttttagtg gctctcttct cagccagctg
      181 ccaagccatc ggatcctcag atcagaggtg cactgagaaa gaagtcaaca aaacatacaa
      241 ctgtgaacat ttaggtctca gtgaaattcc tggcactcta ccaaactcaa cagaatcttt
      301 ggagttcagc tttaatgcct tgcctacgat tcaaaagacg actttcagca gactcgtaaa
      361 tctcaccttc ctggatttaa ccaggtgcca gatttactgg atacatgaag atactttcca
      421 aagccaacat cggttagaga cacttgtgct aactgcaaat cccctgatat ttatggcaga
      481 gacagcactt actgggccta aggcactgaa gcatctgttc ttcatccaaa caggaatatc
      541 cagtattgag tttatcccag tgcatagtca aaaagccttg gaaagcctct atcttggaag
      601 caaccatatt tcctccatta gactccccaa agatttccca acagagaagc tgaaggtcct
      661 ggattttcag aataatgcta tccatcacct gtcgaaagaa gacgtgagct ctctacagca
      721 agccactaat ctgagcctga acttaaatgg aaacgacatt acaggaatag agcccggggc
      781 tttcaagtca actgtcttcc aaagtttgaa cttcggaggg actcaaagct tgcttgttat
      841 cttcaagggt ctgcagaact ctactatcca gtctctctgg ctggggacat ttgaggacat
      901 tgatgacgac gaagatatta gttcttccat gtttgagggc ctctgtgaaa tgtctgttga
      961 gagaatcaac ctacagaagc atcacttctt caacatcact tccaacacat tctactgctt
     1021 cagcggtctc caggagctgg acctaacagc cacccacctg acagaattac cgtctgggat
     1081 tgtgggacta agcaagctca agaaattagt tcttagtgca aataagtttg agaatttgtg
     1141 ccaaatcagt gcttccaatt tcccctccct tacacacctt tacatcaaag gcaacacaaa
     1201 gagacttgaa cttggttcgg gctgtttaga aaccctagaa caccttcgtg agcttgacct
     1261 aagccatgat gacattgaaa cttctgattg ctgcaacctg caactcagaa acctgtctca
     1321 cctacagagc ctgaacctga gctacaatga acccctgggc ctcaggactg aggccttcaa
     1381 agaatgtcct cagctagaac tgctagactt ggcatttacc cgactccatg ttaaagatgc
     1441 acaaagtcct ttccagaacc tccatctctt gaaggtgcta aatctctccc actgcctcct
     1501 tggctccagc aatcagcatc tccttgatgg cctgccagca ctccggcatc tgaatttaca
     1561 gggaaatcgc tttccaaatg ggaatatcca aaagaccaac ccacttcaag cactgggaag
     1621 cctagaaatc ctgattttat cgttttgtga tctctcctcc attgaccatc aagccttcat
     1681 caatctgaag ataatgaatc atgtagacct tagtcacaac aggctgacat ccagtagtat
     1741 tgaggccctt agtcatctta aggggatcta cctcaatcta gcttccaatc gcattagcat
     1801 catcccgccc agtctcctcc ccgtgttgtc ccagcagagg accattaatt taagacaaaa
     1861 tccccttgac tgcacttgct caaacattta ctttttagaa tggtacaaag aaaacatgca
     1921 aaaactcgaa gacatagagg acactttttg cgcaaatccc ccattgttga ggggagtcaa
     1981 ggtctctgac gtcatgctgt cctgtagtat ggcagctgta ggcattttct ttctcattgt
     2041 attcttgctc ttgtttgctg ttttgttgat ttttgcagtg aaacgttttc tcaggtggaa
     2101 ataccaacac atttagcaca aggtttccag aggaggcaga tgaacgtgtt gagcagaatt
     2161 gtcctaagtg aagaaactgt cattctcgag tgaccagact tttctattgg tcccctaggc
     2221 tgggggttca ctgaacatat gtcttactca catgagtctc ccacggtgct gtggctggag
     2281 gaccagacat ggctgagaca cagggccaat tcctccagtg agaagtgacc cacattcata
     2341 gaatacccaa tagcagcccc acccatctga gaaagaagag cattgtatca caaccatcat
     2401 catctccccc acccctaccc ttctgtctca cccacccacc ctagccccaa ccctagctcc
     2461 cacccccgag cccagtctcc atctaacttg actatgctgg ggccaactct aaccatctac
     2521 tctatctctc tcacactttt gacattttgc ttgaggctga gctcattgta attgagccat
     2581 tttggaaagt taggccccag caaaatctaa tgctcgtttt aaatgacaaa agattaaaaa
     2641 aaacaaaagc caaaaaaaca atgaatttaa aagaaaagac aaagtaataa attctgctct
     2701 caactaga
//
