LOCUS       NM_001401810            3353 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CD177 molecule (Cd177), transcript variant 1,
            mRNA.
ACCESSION   NM_001401810 XM_039087124
VERSION     NM_001401810.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Bai,M., Grieshaber-Bouyer,R., Wang,J., Schmider,A.B., Wilson,Z.S.,
            Zeng,L., Halyabar,O., Godin,M.D., Nguyen,H.N., Levescot,A.,
            Cunin,P., Lefort,C.T., Soberman,R.J. and Nigrovic,P.A.
  TITLE     CD177 modulates human neutrophil migration through
            activation-mediated integrin and chemoreceptor regulation
  JOURNAL   Blood 130 (19), 2092-2100 (2017)
   PUBMED   28807980
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Jerke,U., Marino,S.F., Daumke,O. and Kettritz,R.
  TITLE     Characterization of the CD177 interaction with the ANCA antigen
            proteinase 3
  JOURNAL   Sci Rep 7, 43328 (2017)
   PUBMED   28240246
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Wu,Z., Liang,R., Ohnesorg,T., Cho,V., Lam,W., Abhayaratna,W.P.,
            Gatenby,P.A., Perera,C., Zhang,Y., Whittle,B., Sinclair,A.,
            Goodnow,C.C., Field,M., Andrews,T.D. and Cook,M.C.
  TITLE     Heterogeneity of Human Neutrophil CD177 Expression Results from
            CD177P1 Pseudogene Conversion
  JOURNAL   PLoS Genet 12 (5), e1006067 (2016)
   PUBMED   27227454
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Hu,N., Mora-Jensen,H., Theilgaard-Monch,K., Doornbos-van der
            Meer,B., Huitema,M.G., Stegeman,C.A., Heeringa,P., Kallenberg,C.G.
            and Westra,J.
  TITLE     Differential expression of granulopoiesis related genes in
            neutrophil subsets distinguished by membrane expression of CD177
  JOURNAL   PLoS One 9 (6), e99671 (2014)
   PUBMED   24926686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Wang,L., Ge,S., Agustian,A., Hiss,M., Haller,H. and von
            Vietinghoff,S.
  TITLE     Surface receptor CD177/NB1 does not confer a recruitment advantage
            to neutrophilic granulocytes during human peritonitis
  JOURNAL   Eur J Haematol 90 (5), 436-437 (2013)
   PUBMED   23461681
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Jerke,U., Rolle,S., Dittmar,G., Bayat,B., Santoso,S., Sporbert,A.,
            Luft,F. and Kettritz,R.
  TITLE     Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated
            PR3-ANCA neutrophil activation
  JOURNAL   J Biol Chem 286 (9), 7070-7081 (2011)
   PUBMED   21193407
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   von Vietinghoff,S., Eulenberg,C., Wellner,M., Luft,F.C. and
            Kettritz,R.
  TITLE     Neutrophil surface presentation of the anti-neutrophil cytoplasmic
            antibody-antigen proteinase 3 depends on N-terminal processing
  JOURNAL   Clin Exp Immunol 152 (3), 508-516 (2008)
   PUBMED   18462208
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Sachs,U.J., Andrei-Selmer,C.L., Maniar,A., Weiss,T., Paddock,C.,
            Orlova,V.V., Choi,E.Y., Newman,P.J., Preissner,K.T., Chavakis,T.
            and Santoso,S.
  TITLE     The neutrophil-specific antigen CD177 is a counter-receptor for
            platelet endothelial cell adhesion molecule-1 (CD31)
  JOURNAL   J Biol Chem 282 (32), 23603-23612 (2007)
   PUBMED   17580308
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   von Vietinghoff,S., Tunnemann,G., Eulenberg,C., Wellner,M.,
            Cristina Cardoso,M., Luft,F.C. and Kettritz,R.
  TITLE     NB1 mediates surface expression of the ANCA antigen proteinase 3 on
            human neutrophils
  JOURNAL   Blood 109 (10), 4487-4493 (2007)
   PUBMED   17244676
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Caruccio,L., Bettinotti,M., Matsuo,K., Sharon,V. and Stroncek,D.
  TITLE     Expression of human neutrophil antigen-2a (NB1) is increased in
            pregnancy
  JOURNAL   Transfusion 43 (3), 357-363 (2003)
   PUBMED   12675722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 25, 2022 this sequence version replaced XM_039087124.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000001.1  89488358-89488443   c
            87-227              JAXUCZ010000001.1  89488123-89488263   c
            228-413             JAXUCZ010000001.1  89487720-89487905   c
            414-533             JAXUCZ010000001.1  89486789-89486908   c
            534-653             JAXUCZ010000001.1  89486442-89486561   c
            654-794             JAXUCZ010000001.1  89485120-89485260   c
            795-980             JAXUCZ010000001.1  89484716-89484901   c
            981-1124            JAXUCZ010000001.1  89482964-89483107   c
            1125-1244           JAXUCZ010000001.1  89482632-89482751   c
            1245-1385           JAXUCZ010000001.1  89480749-89480889   c
            1386-1574           JAXUCZ010000001.1  89480326-89480514   c
            1575-1697           JAXUCZ010000001.1  89479106-89479228   c
            1698-1829           JAXUCZ010000001.1  89478826-89478957   c
            1830-1970           JAXUCZ010000001.1  89478128-89478268   c
            1971-2156           JAXUCZ010000001.1  89477830-89478015   c
            2157-2276           JAXUCZ010000001.1  89476374-89476493   c
            2277-2396           JAXUCZ010000001.1  89476106-89476225   c
            2397-2537           JAXUCZ010000001.1  89470211-89470351   c
            2538-2723           JAXUCZ010000001.1  89469188-89469373   c
            2724-2858           JAXUCZ010000001.1  89468955-89469089   c
            2859-3353           JAXUCZ010000001.1  89467926-89468420   c
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3353
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /note="CD177 molecule"
                     /db_xref="GeneID:499099"
                     /db_xref="RGD:1562941"
     exon            1..86
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3097
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD177 antigen; CD177 antigen-like"
                     /codon_start=1
                     /product="CD177 antigen isoform 1 precursor"
                     /protein_id="NP_001388739.1"
                     /db_xref="GeneID:499099"
                     /db_xref="RGD:1562941"
                     /translation="MNPMPVLTLLGVSTLLPCVPALICQRGRIQTVRNESELPLEWGT
                     GEKACEVGEGCQDVVMLLHNGPLINLVIIKGCIKAEDQEPRVTWLSTGPGLSVVSYTH
                     VCRHGDLCNNASSTRILEDLSTPTVPGSLRCPLCLSNNDCENAPEQVCPVGSIYCYNG
                     VLRLRGEGIRTNLKVQGCMAQPGCNLLNGTTAVGTLDMSENCGLQLGPQALDCNSASL
                     DIVKDVSDLHLSWTTGWKTCEADEGCYETVMLIQNGQEIHMALTKGCTSSVNREAQLT
                     RHRTGPGISIVSYVHVCRNGDFCNDLSSTETLWIPPPDTAPSLLLLLPVPGTLRCPHC
                     LSTRDCENAPEQVCPEGTHCYNGVLRLRGGAIATNLRVQGCTSQPGCGLLNGTKTIGP
                     IGVREDCGPQSGAQALECRSGWAEGLRKVSSLPLDWTTAWETCKIGEGCQETALLIQN
                     GPLVNLVLIKGCTAEEDHKPQITRHRLSPSLSIVSYSHVCRHWDFCNDLSSTHPLWLP
                     PPPVEGLGNVSCPFCLSKDGCPQNGPKQVCPVDSSHCYSGVLSLRGGGFISDLKVQGC
                     TSQSQSQSDCNLLNGIQTIGPIKLHESCGFHLAAESLKCQHGTLEAVQHISKLPLQWT
                     AEQKTCNVGEGCQDTLVIIENGEHVNLVLTKGCTAAEDHKAKVTEHRTGPGLAVISYT
                     RVCREKDLCNDLSTTVPLWAPPPVTAPGNTRCPLCFTAQACENAPEQFCPAGSTHCYS
                     GVLSLRGGEIISKLKVQGCMSQPGCNLLNGTQKIGPVDVSEDCSPRSNSLTCHRGTML
                     KIGNGFAEKAVEWTPLSSQVCEPDEICQETLLLIDVGQKSALLGSKGCSSLGAQNDVG
                     VSIFSRPPGMVVASYTRFCSSNLCNAASSTSVLLSNLPRPEVLPPGSVKCPVCVQLFR
                     SCFQTSDFVTCPRGATHCYRGDIALRGGGLSSTLSIQGCMASPVKSLLGNSKTIGILS
                     AKESSENERGDEDDEKPLLDGASASSPASMLGLLVLLSSLCAGICPLH"
     exon            87..227
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            228..413
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            414..533
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            534..653
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            654..794
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            795..980
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1124
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1244
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1385
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1574
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1697
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1829
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1970
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2156
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2276
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2396
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2537
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2723
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2858
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3353
                     /gene="Cd177"
                     /gene_synonym="RGD1562941"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactggaga aatttccagc cacagaccag agtcatgaat cctatgccag tgctgaccct
       61 cctgggggtc agcaccttgc taccctgtgt cccagctctg atctgccaga gaggcagaat
      121 acagaccgtg aggaacgagt cagagctgcc cctcgagtgg gggacgggtg agaaagcttg
      181 cgaggtcggc gagggttgcc aagatgtggt gatgctccta cacaatggac ccctgatcaa
      241 cttggtgatc atcaagggct gcataaaggc tgaggaccaa gagcctcggg ttacctggct
      301 cagtacaggc cctgggctct ctgtcgtctc ctacacacat gtgtgtcgcc atggtgacct
      361 ctgtaacaat gcatccagca ccaggatcct tgaggaccta tccacaccca cagtcccagg
      421 gtccctgcgc tgcccgctct gcctttctaa caatgactgt gagaatgcac cagaacaggt
      481 ctgccctgta ggaagcatat actgctacaa tggagtcctc aggctcaggg gagaaggcat
      541 caggaccaat ctcaaggtcc agggctgcat ggcccagcca ggctgcaacc tgctcaatgg
      601 caccacagca gttgggacct tggatatgag tgaaaactgt ggtcttcagt taggtccgca
      661 ggctctggac tgcaacagtg cgagtttgga cattgtgaag gacgtatctg atctgcacct
      721 gagctggacg actggctgga aaacctgcga ggctgacgag gggtgttacg aaacagtcat
      781 gctaatacag aatggacaag aaattcatat ggctctcact aagggatgta ctagcagtgt
      841 aaacagagag gctcaactca ccaggcatag aacaggtccg ggaatctcca tcgtctccta
      901 cgtccatgta tgtcgcaacg gggacttctg taatgacctg tcttcaacgg aaactctctg
      961 gatcccgccc cctgacacag ccccctcact gcttctactg cttccagtcc cagggactct
     1021 gcgctgccca cactgccttt caacgcgtga ctgtgagaat gcaccggagc aggtctgtcc
     1081 tgaaggcaca cactgctaca atggagtcct caggctccgg ggaggggcca ttgccacaaa
     1141 tttgagagtg cagggctgca cttcacagcc aggctgtgga ctgctcaatg gcaccaagac
     1201 aattggacct ataggtgtgc gtgaggactg cggtccccag tcaggcgctc aggcactaga
     1261 atgccggagt gggtgggcag aaggcctaag gaaagtgtcc tcactgcccc tggactggac
     1321 aaccgcctgg gagacttgta aaatcggcga agggtgccag gaaactgcct tgctcataca
     1381 gaatggacct cttgtgaacc tggtgctcat caaaggctgc acagcagaag aagaccacaa
     1441 gccccaaatc actcggcata ggctgagtcc cagcctatcc atcgtgtctt atagccatgt
     1501 gtgccgccac tgggacttct gcaatgacct gtcctccacc caccctctct ggctcccacc
     1561 accacctgtc gaaggcctgg ggaatgtgag ctgcccattc tgcctttcta aagatggctg
     1621 tcctcagaac ggacccaagc aggtctgccc tgtagacagt tcacactgct acagtggagt
     1681 cctcagcctc aggggaggag ggttcatctc tgatctgaag gtacagggat gcacgtccca
     1741 gtcccagtcc cagtcagact gcaacctgct caacggcatc cagacaatcg gacccataaa
     1801 actacatgag agctgtggtt ttcatttagc tgcagagtct ctgaaatgcc agcatgggac
     1861 actggaggca gtgcagcata tatcgaaact tcctctccag tggacagctg agcagaaaac
     1921 ctgtaatgta ggtgaaggct gccaagacac gctggtgata atagagaacg gagagcacgt
     1981 gaatttggtt ctcacaaagg gctgcactgc cgctgaggac cacaaggcca aagtcacgga
     2041 acacaggact ggcccggggc tggctgtcat ctcctacacc cgagtatgcc gtgaaaaaga
     2101 cttatgcaat gacctgtcta ccacagtccc tctctgggct ccacctccgg tgacagcccc
     2161 agggaacaca cgttgtcctc tctgttttac tgcacaagcc tgcgagaatg ctccagagca
     2221 gttctgccct gcaggcagca cgcactgcta cagtggagtc ctcagcctca ggggaggaga
     2281 gatcatctcc aaactcaagg tgcagggctg tatgtcccag ccaggctgca acctgctcaa
     2341 tggcacacag aaaatcggac ctgtggatgt gagtgaggac tgcagccctc ggtcaaattc
     2401 tctgacctgt cacaggggga ccatgttgaa gattggcaat ggctttgctg agaaagctgt
     2461 cgagtggact ccactgtcgt ctcaggtgtg tgaacctgat gagatatgtc aggagacgct
     2521 gctgctcata gatgtaggac aaaaatcagc cctcctgggg agcaaaggct gcagcagtct
     2581 tggagcacag aacgatgttg gtgtctccat attctcccgg ccacctggga tggtggtagc
     2641 ttcctatacc cggttctgtt cctccaacct gtgcaatgca gccagcagca ccagcgtcct
     2701 tctaagcaac ctccctcgtc cagaggtcct tcccccagga agtgtgaagt gtcccgtgtg
     2761 tgtacagtta ttcagatcct gctttcagac gtctgacttt gtcacctgtc ctcggggcgc
     2821 cactcactgt tatagaggtg acatcgcgct aagaggaggt ggactgtctt ccacattgag
     2881 cattcagggg tgcatggcct cacctgtcaa atcattattg ggtaactcca aaacaattgg
     2941 gatcctctcg gcaaaggaga gctctgagaa tgagcgtggg gatgaagatg atgagaagcc
     3001 tcttcttgat ggtgcctcag cctcctcccc ggcctccatg ttagggctcc tggttcttct
     3061 cagctctttg tgtgctggaa tttgtcctct ccactgaacc cattattggc cattcttact
     3121 ccctcttggc cagccatacc cagacctcct ctgacttcat aacccaaaga cttgagactg
     3181 ggcactggca ctgtctgtcg gcctgcactg tcgggtgccc tcatccctca cccacacacc
     3241 cctgcctcct catgtttaga tatgggagcc gctgaactca ccctgctcca gagcagacaa
     3301 ccacacatca accacacatg tggaaaaaaa taaagttgct gttgtttctc aaa
//
