LOCUS       NM_031812               2836 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus CD164 molecule (Cd164), mRNA.
ACCESSION   NM_031812
VERSION     NM_031812.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2836)
  AUTHORS   Chen,W.L., Huang,A.F., Huang,S.M., Ho,C.L., Chang,Y.L. and
            Chan,J.Y.
  TITLE     CD164 promotes lung tumor-initiating cells with stem cell activity
            and determines tumor growth and drug resistance via Akt/mTOR
            signaling
  JOURNAL   Oncotarget 8 (33), 54115-54135 (2016)
   PUBMED   28903328
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2836)
  AUTHORS   Nyegaard,M., Rendtorff,N.D., Nielsen,M.S., Corydon,T.J.,
            Demontis,D., Starnawska,A., Hedemand,A., Buniello,A., Niola,F.,
            Overgaard,M.T., Leal,S.M., Ahmad,W., Wikman,F.P., Petersen,K.B.,
            Cruger,D.G., Oostrik,J., Kremer,H., Tommerup,N., Frodin,M.,
            Steel,K.P., Tranebjaerg,L. and Borglum,A.D.
  TITLE     A Novel Locus Harbouring a Functional CD164 Nonsense Mutation
            Identified in a Large Danish Family with Nonsyndromic Hearing
            Impairment
  JOURNAL   PLoS Genet 11 (7), e1005386 (2015)
   PUBMED   26197441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2836)
  AUTHORS   Mo,D., Costa,S.A., Ihrke,G., Youker,R.T., Pastor-Soler,N.,
            Hughey,R.P. and Weisz,O.A.
  TITLE     Sialylation of N-linked glycans mediates apical delivery of endolyn
            in MDCK cells via a galectin-9-dependent mechanism
  JOURNAL   Mol Biol Cell 23 (18), 3636-3646 (2012)
   PUBMED   22855528
  REMARK    GeneRIF: Data indicate that galectin-9 plays a role in apical
            sorting of endolyn.
            Erratum:[Mol Biol Cell. 2012 Oct;23(20):4142]
REFERENCE   4  (bases 1 to 2836)
  AUTHORS   Potter,B.A., Ihrke,G., Bruns,J.R., Weixel,K.M. and Weisz,O.A.
  TITLE     Specific N-glycans direct apical delivery of transmembrane, but not
            soluble or glycosylphosphatidylinositol-anchored forms of endolyn
            in Madin-Darby canine kidney cells
  JOURNAL   Mol Biol Cell 15 (3), 1407-1416 (2004)
   PUBMED   14699065
  REMARK    GeneRIF: Specific N-glycans are only essential for the apical
            sorting of transmembrane endolyn, suggesting fundamental
            differences in the mechanisms by which soluble,
            glycosylphosphatidylinositol-anchored, and transmembrane proteins
            are sorted.
REFERENCE   5  (bases 1 to 2836)
  AUTHORS   Chan,J.Y., Lee-Prudhoe,J.E., Jorgensen,B., Ihrke,G., Doyonnas,R.,
            Zannettino,A.C., Buckle,V.J., Ward,C.J., Simmons,P.J. and Watt,S.M.
  TITLE     Relationship between novel isoforms, functionally important
            domains, and subcellular distribution of CD164/endolyn
  JOURNAL   J Biol Chem 276 (3), 2139-2152 (2001)
   PUBMED   11027692
REFERENCE   6  (bases 1 to 2836)
  AUTHORS   Ihrke,G., Gray,S.R. and Luzio,J.P.
  TITLE     Endolyn is a mucin-like type I membrane protein targeted to
            lysosomes by its cytoplasmic tail
  JOURNAL   Biochem J 345 Pt 2 (Pt 2), 287-296 (2000)
   PUBMED   10620506
REFERENCE   7  (bases 1 to 2836)
  AUTHORS   Kurosawa,N., Kanemitsu,Y., Matsui,T., Shimada,K., Ishihama,H. and
            Muramatsu,T.
  TITLE     Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164
  JOURNAL   Eur J Biochem 265 (1), 466-472 (1999)
   PUBMED   10491205
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ238574.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238574.1, BC062064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2836
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /note="CD164 molecule"
                     /db_xref="GeneID:83689"
                     /db_xref="RGD:70942"
     exon            1..177
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..602
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /note="CD164 antigen; endolyn; sialomucin core protein 24;
                     MGC-24; MUC-24; multi-glycosylated core protein 24; CD164
                     molecule, sialomucin"
                     /codon_start=1
                     /product="sialomucin core protein 24 precursor"
                     /protein_id="NP_114000.1"
                     /db_xref="GeneID:83689"
                     /db_xref="RGD:70942"
                     /translation="MSGASRGLFWAATCLAALCLSAAQSNSSASPNVTDPPTTTSKVV
                     PTTLTTTKPPETCESFNSCVSCVNATLTNNITCVWLDCHEANKTYCSSELVSNCTQKT
                     STDSCSVIPTTPVPTNSTAKPTTRPSSPTPTPSVVTSAGATNTTVTPTSQPERKSTFD
                     AASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL"
     exon            178..267
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
     exon            268..339
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
     exon            340..375
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
     exon            376..432
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
     exon            433..2819
                     /gene="Cd164"
                     /gene_synonym="MGC-24v"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgagga cacgatgtcg ggcgcctccc gcggactgtt ctgggccgcc acctgcctcg
       61 ccgcgctctg cctgtcggcc gcgcagagca acagcagcgc atctcccaac gtgactgacc
      121 cgccgaccac gaccagcaaa gtggtcccga cgacgctcac caccaccaag ccgccagaaa
      181 cctgtgagag cttcaacagc tgtgtttcct gtgtcaacgc caccttgact aataatatta
      241 cctgcgtctg gctagattgc catgaagcaa ataagaccta ttgttcaagt gaattagtaa
      301 gtaattgtac ccagaagacc agtactgact cctgttctgt aatacctacc accccagtgc
      361 caaccaattc tacagctaag cctacaactc ggccttcctc tcctacacct actccctcag
      421 ttgtcacatc agcaggtgca acaaatacca ctgtgactcc aacctcacag cctgagcgga
      481 agtccacctt tgatgcagcc agcttcattg gaggaatcgt ccttgtcttg ggtgtgcagg
      541 ctgtaatttt ctttctctat aaattctgca aatctaaaga acgaaattac catactctgt
      601 aaacagaccc attaaattaa tgtggactgg cagttaactt gtgtaactca actgaaacca
      661 aaatattcca gaagtcccac atggaagacg ctgttccagg acctttacat ttccagagga
      721 tgcatacagg atattgtgga gcactatcct tgaagaaaag tcagttaaac cattttgctc
      781 aacaggaata tttaaaatat tctgcatgaa tccatatggc tgtcgtcttt tgtttaaaat
      841 ggctgctgct gtgggattgt gtttttccct ctgacatgcc aaatgtaact tcctgtaagt
      901 tatggaaagt gctgtcctgt gcaggcagct tctgactctg cagtctaaat gtagtcccta
      961 gcaacctaga gtctgttatt ttcgtcctaa cttgagatgt cacttagtgg ccagaattga
     1021 gaagagtgcc aagtgaccac ccgtcaagca gattgagggc catcgcttca gacatggatt
     1081 aaatttattt agttctaaac tacccctaga gtaaaatttt gtgcttgata aattgtattt
     1141 tatatattaa aaataagatg ccacacggca ttccagactt agaataagga aaaggataca
     1201 tagacagtaa tacgcagcag gtcttgttca tactcataaa gtaccatatt aagaaataga
     1261 acagtgcctt aagacagacc aagatgtcag cagaacggaa aatgtgttca cactgggagg
     1321 caaagcttgg tctgagaatg taatgttggt gtgagcagca gaaacctgct tttagataac
     1381 atactgttaa tatttaatta aaaccattgg tttttccaga gctgagaact agaagctaaa
     1441 gaataattct aagctgaaag gcttccttct atcaaaccat ctaacatttt cttagggcta
     1501 ttgaatagat ataaaatcga tttctctttc tctctgtaca cagtgtatcc aaatattata
     1561 ccttaaggat tcctaccagg ttttcctgag aagtagcttt tatgtgaggc aagaaagaag
     1621 taggttgtag gtagaatcat tttctagttc tttaaatgag acaatcactt tgttttctaa
     1681 tagttgtgat ctgtgtagct taaagaaacc ttagggtttg caagagattg ctatagattt
     1741 ccagtgatga tgccctggct gaataggctt gtctctcctt tagcctgtac ctcttttctt
     1801 cctccttggt ttcagtcccc atgtgctata atcatgcaaa cttttatttc aatagcttct
     1861 gtcaagcact aagtttgcag tcctggggtc gcttccccct tgcctctgac acactgcact
     1921 agtctagagg gtgtcattgg aaataggctt tggtttcctg cctcatgcaa gtgtgtgctt
     1981 gcttgtttgt ttagagtagc acagtttagc acttggtttc cagggtttta taatagaaaa
     2041 ggcagtttga tgtgaattgg ttcataaagt gaaacgaatg acgtctctat ttccttgtca
     2101 cttgctggta cagctgaagt ttgttttact tgcacatttg tacatatatc taatgttttc
     2161 aagtgcctta cttgtttaaa ctctggcttc agaggttttg ggggaaagat aggtttacct
     2221 cacagttagt ttccattata atctaggttc ctcacacaaa tctatttcag tgccatggct
     2281 gttagttttc agtgagtgct caagttcttt tgaaagtaca cagaattccc attccttaaa
     2341 aaggtggcaa aatcagtttg tcatttgctt ccatgtgact ccttgcacca tataaatgtc
     2401 agcgtatgta acaagtttta tgagaatgta acttaatttg aaggtcctgt aattttgagc
     2461 actgctctaa cactgtagga agttagtgac agtttgcagg tctctacata agctctcgcc
     2521 acagagttca cagctgccct gactctttcc catttttgtt tagcaaggta gtattttgag
     2581 ccatcagtga ttttgggttt tttaatccag aaggtatgta gaaacctttc agagttttca
     2641 tctgatttgt ccggaggctc tagttctgtc aaatacctta tttcaccttt cctatatttg
     2701 ctgcacaagc agacactgct gtacttagaa atttctattt gagttcatta aaaaactaca
     2761 aaactaatgt gtatgcgtat caaactgatt taaaataaat atgtttatta gtctcttgaa
     2821 aaaaaaaaaa aaaaaa
//
