LOCUS       NM_001107887            4223 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD163 molecule (Cd163), mRNA.
ACCESSION   NM_001107887 XM_001061914 XM_232342
VERSION     NM_001107887.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Yip,J.L.K., Xavier,S., Balasuriya,G.K., Hill-Yardin,E.L. and
            Spencer,S.J.
  TITLE     Macrophage regulation of the 'second brain': CD163 intestinal
            macrophages interact with inhibitory interneurons to regulate
            colonic motility - evidence from the Cx3cr1-Dtr rat model
  JOURNAL   Front Immunol 14, 1269890 (2023)
   PUBMED   37868978
  REMARK    GeneRIF: Macrophage regulation of the 'second brain': CD163
            intestinal macrophages interact with inhibitory interneurons to
            regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4223)
  AUTHORS   Fischer-Riepe,L., Daber,N., Schulte-Schrepping,J., Veras De
            Carvalho,B.C., Russo,A., Pohlen,M., Fischer,J., Chasan,A.I.,
            Wolf,M., Ulas,T., Glander,S., Schulz,C., Skryabin,B., Wollbrink
            Dipl-Ing,A., Steingraeber,N., Stremmel,C., Koehle,M., Gartner,F.,
            Vettorazzi,S., Holzinger,D., Gross,J., Rosenbauer,F., Stoll,M.,
            Niemann,S., Tuckermann,J., Schultze,J.L., Roth,J. and
            Barczyk-Kahlert,K.
  TITLE     CD163 expression defines specific, IRF8-dependent,
            immune-modulatory macrophages in the bone marrow
  JOURNAL   J Allergy Clin Immunol 146 (5), 1137-1151 (2020)
   PUBMED   32199911
REFERENCE   3  (bases 1 to 4223)
  AUTHORS   Etzerodt,A., Moulin,M., Doktor,T.K., Delfini,M.,
            Mossadegh-Keller,N., Bajenoff,M., Sieweke,M.H., Moestrup,S.K.,
            Auphan-Anezin,N. and Lawrence,T.
  TITLE     Tissue-resident macrophages in omentum promote metastatic spread of
            ovarian cancer
  JOURNAL   J Exp Med 217 (4) (2020)
   PUBMED   31951251
REFERENCE   4  (bases 1 to 4223)
  AUTHORS   Dighal,A., Mukhopadhyay,D., Sengupta,R., Moulik,S., Mukherjee,S.,
            Roy,S., Chaudhuri,S.J., Das,N.K. and Chatterjee,M.
  TITLE     Iron trafficking in patients with Indian Post kala-azar dermal
            leishmaniasis
  JOURNAL   PLoS Negl Trop Dis 14 (2), e0007991 (2020)
   PUBMED   32023254
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4223)
  AUTHORS   Sun,H., Jiang,R., Han,B., Du,X., Ma,C., Xu,Y., Chen,Z., Wang,L.,
            Yang,S., Lv,X., Zhao,H. and Li,X.
  TITLE     Serum levels of soluble CD163 and soluble CD14 following antibiotic
            therapy of patients with acute brucellosis
  JOURNAL   J Infect Dev Ctries 13 (8), 714-719 (2019)
   PUBMED   32069255
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4223)
  AUTHORS   Kusi,K.A., Gyan,B.A., Goka,B.Q., Dodoo,D., Obeng-Adjei,G.,
            Troye-Blomberg,M., Akanmori,B.D. and Adjimani,J.P.
  TITLE     Levels of soluble CD163 and severity of malaria in children in
            Ghana
  JOURNAL   Clin Vaccine Immunol 15 (9), 1456-1460 (2008)
   PUBMED   18632918
REFERENCE   7  (bases 1 to 4223)
  AUTHORS   Fabriek,B.O., Polfliet,M.M., Vloet,R.P., van der Schors,R.C.,
            Ligtenberg,A.J., Weaver,L.K., Geest,C., Matsuno,K., Moestrup,S.K.,
            Dijkstra,C.D. and van den Berg,T.K.
  TITLE     The macrophage CD163 surface glycoprotein is an erythroblast
            adhesion receptor
  JOURNAL   Blood 109 (12), 5223-5229 (2007)
   PUBMED   17353345
  REMARK    GeneRIF: identify CD163 on macrophages as an adhesion receptor for
            erythroblasts in erythroblastic islands, and suggest a regulatory
            role for CD163 during erythropoiesis
REFERENCE   8  (bases 1 to 4223)
  AUTHORS   Nielsen,M.J., Madsen,M., Moller,H.J. and Moestrup,S.K.
  TITLE     The macrophage scavenger receptor CD163: endocytic properties of
            cytoplasmic tail variants
  JOURNAL   J Leukoc Biol 79 (4), 837-845 (2006)
   PUBMED   16434690
REFERENCE   9  (bases 1 to 4223)
  AUTHORS   Polfliet,M.M., Fabriek,B.O., Daniels,W.P., Dijkstra,C.D. and van
            den Berg,T.K.
  TITLE     The rat macrophage scavenger receptor CD163: expression, regulation
            and role in inflammatory mediator production
  JOURNAL   Immunobiology 211 (6-8), 419-425 (2006)
   PUBMED   16920481
  REMARK    GeneRIF: A broadly expressed macrophage scavenger receptor that may
            play a role in the activation of macrophages during hemolytic
            and/or inflammatory conditions.
REFERENCE   10 (bases 1 to 4223)
  AUTHORS   Schaer,D.J., Schleiffenbaum,B., Kurrer,M., Imhof,A., Bachli,E.,
            Fehr,J., Moller,H.J., Moestrup,S.K. and Schaffner,A.
  TITLE     Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a
            lineage-specific marker in the reactive hemophagocytic syndrome
  JOURNAL   Eur J Haematol 74 (1), 6-10 (2005)
   PUBMED   15613100
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232342.4, XM_001061914.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4223
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /note="CD163 molecule"
                     /db_xref="GeneID:312701"
                     /db_xref="RGD:1310382"
     exon            1..143
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..3460
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /note="CD163 antigen; cluster of differentiation 163"
                     /codon_start=1
                     /product="scavenger receptor cysteine-rich type 1 protein
                     M130 precursor"
                     /protein_id="NP_001101357.1"
                     /db_xref="GeneID:312701"
                     /db_xref="RGD:1310382"
                     /translation="MGKNRMVLLGGAGSPGYKGFVHLGFFVVAVSSLLSVSAVTQAPE
                     GRKKELRLAGGENNCSGRVELKIHEKWGTVCGNGWSMNEVSVVCQQLGCPTLIKAPGW
                     ANASAGSGDIWMDKVSCTGNESALWDCKHEGWGKHNCTHEQDAGVTCADGSNLEMRLV
                     NSGDNRCSGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSG
                     QIWLDDLACNGNESAIWDCKHRGWGRHNCDHAEDVGVICLDGADLSLRLVDGVSKCSG
                     RLEVRFQGEWGTVCDDSWDRRDASVVCKQLGCPTAITAIGRVNASEGSGPIWLDSISC
                     EGHEPALWECKHQEWGKHYCNHKEDAGVTCSDGADLELRLVGGGSRCAGMVEVEIQKL
                     TGKVCSRGWTLTDADVVCRQLGCGSALQTQSKIYSKTKTEATNTWLFPGSCSGNETSL
                     WQCKNWQWGGLSCDHFEEAQVTCSGHRKPRLVGGEIPCSGRVEVKHGDTWGSVCDFDL
                     SLEAAGVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDR
                     TCSHSRDVSIVCSRYIDIRLADGKSSCEGRVELKTLGAWGPLCSSHWDIEDAHVLCQQ
                     LKCGVALSTPGGAHFGKGAGQVWRHKFHCTGTEEHIGDCPMTALGTPMCSDGQVASVI
                     CSGNQSHTLLPCSSSSSVQTTSSTIAKDSDVPCIASGQLRLVGGGGRCAGRVEVYHEG
                     SWGTICDDSWDLTDANVVCKQLDCGVAINATGSAYFGEGTGDIWLDEIDCSGKESHIW
                     QCHSHGWGRHNCRHKEDAGVVCSEFMSLRLTNEAHRVNCTGRLEVFYNGTWGSIGSSN
                     MSPTTVGVVCRQLGCADNGTVKPTSSDKTPTRPMWTDSVQCPKGVDTLWQCPSSPWKQ
                     RQASPSQESWIVCDDKIRLQEGHTDCSGRVEIWHRGSWGTVCDDSWDLNDAEVACKQL
                     GCGQAVEALKEAAFGPGTGPIWLNEMKCRGNESSLWDCPARPWSHSDCGHKEDASVKC
                     LPRMTLESQHGTGHSTLTALLVCGAILLVLLIAFLLWTLKRRQTQRLTVSSRGEVLIH
                     QVQYQEMDSKTDDLDLLKSSGWHLRNLDMTAS"
     exon            144..227
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..548
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..872
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1193
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1520
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1835
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2150
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2246
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2561
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2882
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3194
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3224
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3332
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3422
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..4223
                     /gene="Cd163"
                     /gene_synonym="ED2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattatctcc ctccgtggtc gtccactttc tttggagaac acatctatga aatagtaaaa
       61 ggagacacac gagccatcgg aatcatcaga ctttggaatg ggcaagaaca gaatggttct
      121 tcttggaggt gctgggtctc ccggttataa aggatttgtc cacctaggtt tctttgttgt
      181 ggctgtgagc tcacttctca gcgtctctgc tgtcactcag gctcctgaag gaaggaagaa
      241 ggaactgaga ctggccggcg gtgaaaacaa ctgtagtggg agagtggagc tcaagatcca
      301 cgagaagtgg ggcacagtgt gcggtaacgg ctggagcatg aacgaggtgt ccgtggtttg
      361 ccagcagcta ggatgcccaa ctttgattaa agccccggga tgggctaacg ccagcgcggg
      421 ctctggggac atctggatgg acaaggtttc ttgcacaggg aatgagtcag ctctttggga
      481 ctgcaaacat gaggggtggg gaaagcacaa ctgtacccat gaacaagatg ctggagtgac
      541 ctgcgcagat ggatctaatt tggagatgag actggtgaac agcggggaca accgatgctc
      601 aggaagagta gaaataaagt tccagggaaa gtgggggaca gtgtgtgacg acaacttcag
      661 caaagatcac gcttctgtga tttgtaaaca acttggatgt ggaagtgcca tcagtttctc
      721 tggctcagct aaattaggag ctggttctgg acaaatctgg cttgatgatc tggcatgcaa
      781 tggaaatgag tcagctatct gggactgcaa acaccgggga tggggaaggc acaactgtga
      841 ccatgctgag gacgtcggtg tgatctgctt agacggagcg gatctgagcc tgagactggt
      901 ggatggggtg tccaaatgtt caggaagatt ggaagtgaga ttccaaggag agtgggggac
      961 cgtgtgtgac gacagctggg atcgccgtga cgcttctgtg gtgtgtaagc aactgggatg
     1021 tccaactgcc atcactgcca ttggccgagt taatgccagt gagggatccg gaccaatttg
     1081 gcttgacagt atctcctgcg agggacatga gccggctctt tgggagtgta agcaccagga
     1141 atgggggaag cattactgta accacaaaga agacgctggc gtgacatgtt ctgatggagc
     1201 agatctggaa cttcgactcg tcggtggagg cagtcgctgt gctgggatgg tggaggtgga
     1261 gattcagaag ctgactggga aggtgtgcag ccgaggctgg acactgacag atgccgacgt
     1321 ggtttgcaga cagcttggat gtggctctgc acttcaaaca cagtctaaga tctactctaa
     1381 aaccaaaact gaggcaacaa atacgtggct ctttcctggc tcttgcagtg gaaatgaaac
     1441 ttctctttgg caatgtaaaa actggcagtg gggcggcctt tcctgtgatc atttcgaaga
     1501 agcccaagtt acttgctcag gccacaggaa acccagactg gttggaggag aaatcccatg
     1561 ttccggtcgt gtggaagtga aacacggaga cacgtggggt tccgtctgtg atttcgactt
     1621 gtctctggaa gctgccggcg tggtgtgcag ggaattacaa tgtggaacag tcgtctctat
     1681 cctaggggga gcacattttg gagaaggaag cggacagatc tggggtgaag aattccagtg
     1741 tagtggagat gagtcccatc tttctctgtg ctcggtggcg cccccactgg acagaacttg
     1801 tagccacagc agggatgtca gcatagtctg ctcacgatac atagatatcc gtctggcaga
     1861 tggcaagtcc tcctgtgagg gaagagtgga gctcaagaca ctcggagcct ggggtcccct
     1921 ctgcagctct cactgggaca tagaagatgc tcatgtctta tgtcagcagc ttaagtgtgg
     1981 agttgccctt tctactccag gaggagcaca ttttgggaaa ggagccggtc aggtctggag
     2041 gcacaagttc cactgcactg gaactgagga gcatataggg gattgcccta tgactgctct
     2101 gggtacaccg atgtgttctg acggacaggt ggcctctgta atttgctcag gaaaccaatc
     2161 gcatacactg ttgccatgta gttcatcatc ttcggtccaa acaacaagtt ctaccattgc
     2221 aaaggacagt gacgttccct gcatagcaag tggtcaactc cgcttggtag gtggaggtgg
     2281 tcgctgcgct gggagagtag aggtctacca tgagggctct tggggcacca tctgtgatga
     2341 cagctgggat ctgacggatg ccaatgtggt gtgcaagcag ctggactgtg gcgtggctat
     2401 taatgccact ggttctgcct actttgggga agggacagga gatatctggc tagacgaaat
     2461 tgactgcagt ggaaaagagt ctcatatctg gcagtgccat tcacatggct ggggacgcca
     2521 taactgcagg cacaaggaag atgcaggtgt tgtctgctcg gagttcatgt ctctgaggct
     2581 gaccaatgaa gcccacagag tgaactgtac aggccgtctg gaagtgtttt acaatggtac
     2641 atggggcagt attggcagca gcaatatgtc tccaaccact gtgggggtgg tgtgccgtca
     2701 gctgggctgt gcagacaatg gaacagtgaa acctacatct tcagacaaga caccaaccag
     2761 gcccatgtgg acagatagtg tgcagtgtcc aaaaggagtt gacactttgt ggcagtgccc
     2821 ctcatcacct tggaaacaga gacaagccag cccctcccag gagtcctgga ttgtctgtga
     2881 cgacaaaata agactacagg aagggcatac agactgttct ggacgtgtgg agatctggca
     2941 tagaggttcc tggggaacag tgtgtgatga ctcctgggat cttaatgatg ctgaggttgc
     3001 atgtaagcag ctgggctgtg gtcaagctgt ggaggcacta aaagaagcag catttggtcc
     3061 aggaactggg cccatatggc tgaatgaaat gaagtgtaga gggaatgagt cttccctgtg
     3121 ggattgtcct gccagaccat ggagtcacag cgactgcggg cacaaagaag atgcttctgt
     3181 gaagtgcctc ccaagaatga ctttagaatc acagcatggc acaggtcatt caaccctcac
     3241 tgcactcctg gtttgtggag ccattctatt ggtccttctc attgccttcc tcttgtggac
     3301 tctgaagcga cgacagaccc aacggcttac agtttcctca agaggagagg tcttgataca
     3361 tcaagttcag taccaagaga tggattcgaa gacggatgat ctggacttgc tgaaatcctc
     3421 gggttggcat ttaagaaacc ttgacatgac agccagctaa atggacaaga gcccagtccg
     3481 tgcacggatg accacagcta catcttcacg ctgtcctttg tttgctggca ctctactgaa
     3541 cctgcagaag ccatgtttgt gaatgtgacc actgaataga tatgggagac tttcaagggt
     3601 attaaataaa cgatattgtt attgatttga cgttgcttct ttggttcttt gttttgtctg
     3661 cttgtttggg acagggtctc attatttagc cctagttgcc ctggagatgg ctatagaagg
     3721 aaggcaagtc tagaattcac agaggtctgc ttgtctctga ttcccaagtg ctgggattaa
     3781 atatatgtgc cactacatgt ggtttaacca ttttatctcg attttataaa cttccggttg
     3841 aagttttgtg acctttttaa ggtctttatg aaaaaaaatg atgtcttttc atttggcatg
     3901 ctaatattca aatattatac acttcctttt agttgagttt aagaataatt ttcttatagc
     3961 caagtcaagt aagctcattt tcacttggat tttttaataa agaaatacgg tcatcgggac
     4021 cacacggcag ttgtgactgg ctgcatgagg ccttcaaaaa aatgctttaa aaagaaaata
     4081 aaggaggggg gcatgagacg aggagagggg actggctgag aggaggtttg gagcaagtgg
     4141 agggagatga aactctagta ggggaactta tgtgatcata gtgcattgtg ttcaaatatg
     4201 acatgaccta aagtggaaag caa
//
