LOCUS       NM_022523               1668 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CD151 molecule (Raph blood group) (Cd151), mRNA.
ACCESSION   NM_022523 XM_346571 XM_347358
VERSION     NM_022523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Gao,C., Jia,W., Xu,W., Wu,Q. and Wu,J.
  TITLE     Downregulation of CD151 restricts VCAM-1 mediated leukocyte
            infiltration to reduce neurobiological injuries after experimental
            stroke
  JOURNAL   J Neuroinflammation 18 (1), 118 (2021)
   PUBMED   34022890
  REMARK    GeneRIF: Downregulation of CD151 restricts VCAM-1 mediated
            leukocyte infiltration to reduce neurobiological injuries after
            experimental stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Xu,W., Gao,C. and Wu,J.
  TITLE     CD151 Alleviates Early Blood-Brain Barrier Dysfunction After
            Experimental Focal Brain Ischemia in Rats
  JOURNAL   Cell Mol Neurobiol 41 (1), 151-162 (2021)
   PUBMED   32285246
  REMARK    GeneRIF: CD151 Alleviates Early Blood-Brain Barrier Dysfunction
            After Experimental Focal Brain Ischemia in Rats.
REFERENCE   3  (bases 1 to 1668)
  AUTHORS   Tao,Y., Zhang,H., Huang,S., Pei,L., Feng,M., Zhao,X., Ouyang,Z.,
            Yao,S., Jiang,R. and Wei,K.
  TITLE     miR-199a-3p promotes cardiomyocyte proliferation by inhibiting
            Cd151 expression
  JOURNAL   Biochem Biophys Res Commun 516 (1), 28-36 (2019)
   PUBMED   31186138
  REMARK    GeneRIF: Overexpression of Cd151 blocks the activating effect of
            miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a
            functional target of miR-199a-3p in cardiomyocytes.
REFERENCE   4  (bases 1 to 1668)
  AUTHORS   Yu,J., Lee,C.Y., Changou,C.A., Cedano-Prieto,D.M., Takada,Y.K. and
            Takada,Y.
  TITLE     The CD9, CD81, and CD151 EC2 domains bind to the classical
            RGD-binding site of integrin alphavbeta3
  JOURNAL   Biochem J 474 (4), 589-596 (2017)
   PUBMED   27993971
REFERENCE   5  (bases 1 to 1668)
  AUTHORS   Yue,S., Mu,W., Erb,U. and Zoller,M.
  TITLE     The tetraspanins CD151 and Tspan8 are essential exosome components
            for the crosstalk between cancer initiating cells and their
            surrounding
  JOURNAL   Oncotarget 6 (4), 2366-2384 (2015)
   PUBMED   25544774
  REMARK    GeneRIF: Data indicate that the major contribution of cellular
            tetraspanins CD151 and Tspan8 to lymphatic metastasis formation
            relies on promoting motility and invasiveness.
REFERENCE   6  (bases 1 to 1668)
  AUTHORS   Nazarenko,I., Rana,S., Baumann,A., McAlear,J., Hellwig,A.,
            Trendelenburg,M., Lochnit,G., Preissner,K.T. and Zoller,M.
  TITLE     Cell surface tetraspanin Tspan8 contributes to molecular pathways
            of exosome-induced endothelial cell activation
  JOURNAL   Cancer Res 70 (4), 1668-1678 (2010)
   PUBMED   20124479
  REMARK    Erratum:[Cancer Res.2010 Aug 15;70(16):6683]
REFERENCE   7  (bases 1 to 1668)
  AUTHORS   Liu,L., He,B., Liu,W.M., Zhou,D., Cox,J.V. and Zhang,X.A.
  TITLE     Tetraspanin CD151 promotes cell migration by regulating integrin
            trafficking
  JOURNAL   J Biol Chem 282 (43), 31631-31642 (2007)
   PUBMED   17716972
REFERENCE   8  (bases 1 to 1668)
  AUTHORS   Wright,M.D., Geary,S.M., Fitter,S., Moseley,G.W., Lau,L.M.,
            Sheng,K.C., Apostolopoulos,V., Stanley,E.G., Jackson,D.E. and
            Ashman,L.K.
  TITLE     Characterization of mice lacking the tetraspanin superfamily member
            CD151
  JOURNAL   Mol Cell Biol 24 (13), 5978-5988 (2004)
   PUBMED   15199151
REFERENCE   9  (bases 1 to 1668)
  AUTHORS   Sawada,S., Yoshimoto,M., Odintsova,E., Hotchin,N.A. and
            Berditchevski,F.
  TITLE     The tetraspanin CD151 functions as a negative regulator in the
            adhesion-dependent activation of Ras
  JOURNAL   J Biol Chem 278 (29), 26323-26326 (2003)
   PUBMED   12782641
  REMARK    GeneRIF: Expression of CD151 specifically attenuated
            adhesion-dependent activation of Ras.
REFERENCE   10 (bases 1 to 1668)
  AUTHORS   Hua,L.V., Green,M., Wong,A., Warsh,J.J. and Li,P.P.
  TITLE     Tetraspan protein CD151: a common target of mood stabilizing drugs?
  JOURNAL   Neuropsychopharmacology 25 (5), 729-736 (2001)
   PUBMED   11682256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF192547.2.
            
            On or before Dec 17, 2003 this sequence version replaced
            XM_346571.1, XM_347358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072515.1, CV110298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1668
                     /gene="Cd151"
                     /note="CD151 molecule (Raph blood group)"
                     /db_xref="GeneID:64315"
                     /db_xref="RGD:621290"
     exon            1..46
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            47..176
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            177..267
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..945
                     /gene="Cd151"
                     /note="PETA-3; platelet-endothelial tetraspan antigen 3;
                     CD151 antigen (Raph blood group); CD151 antigen-like"
                     /codon_start=1
                     /product="CD151 antigen"
                     /protein_id="NP_071968.1"
                     /db_xref="GeneID:64315"
                     /db_xref="RGD:621290"
                     /translation="MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLAL
                     KSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFL
                     LEIIAGILAYVYYQQLNTELKENLKDTMIKRYHQSGHEGVTNAVDKLQQEFHCCGSNN
                     SRDWRDSEWIRSGEADSRVVPDSCCKTVVTGCGKREHASNIYKVEGGCITKLESFIQE
                     HLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY"
     exon            268..459
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            460..534
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            535..639
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            640..798
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1642
                     /gene="Cd151"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctcctac agtggctgcc ggggctggta tttcaaagcg tggttgatct ggtggctctg
       61 agaatcattc tgattactgc ttcagacacc ataggagtgg caagatccca cctgccaggt
      121 gaagggcggg cagatcagtg actttgacct gtacctgctg gtcctgactt ccagaggccc
      181 aggatggggg aattcaacga gaagaaggca acatgtggca cagtctgcct caagtatctg
      241 ctgttcacct acaactgctg cttctggctg gctggcctgg ccgtcatggc agtgggcatt
      301 tggacactgg ccctcaagag tgactacatt agtctgctgg cttcaagcac ctacctagca
      361 acagcctaca tcttagtggt ggctggtgtt gttgtcatgg tgactggagt cctgggctgc
      421 tgtgccactt tcaaggagcg acggaacctg ttacgcttgt acttcatcct gctcctcatc
      481 atcttccttc tggagatcat tgctggcatc ctggcctatg tctactatca gcagctcaac
      541 accgagctca aggagaatct gaaggacacc atgatcaaga gataccacca gtcaggccat
      601 gagggtgtga ccaacgctgt agacaagctg cagcaagagt tccactgctg tggcagcaac
      661 aactctcgag actggagaga cagcgagtgg atccgctctg gtgaggcaga cagccgtgtg
      721 gtccctgaca gctgctgtaa gactgtggta actggctgtg gtaagcggga gcacgcctcc
      781 aacatctata aagtggaagg tggctgcatc actaagctgg agtccttcat tcaggagcac
      841 ctgcgggtca tcggggccgt gggcattggc atcgcctgtg tgcaggtctt cggcatgatc
      901 ttcacctgct gcttgtacag aagcctcaag ctggagcact actgaccatg gtgccaggcc
      961 agaaggccag cctcgcgctg tgtcccagcc ccccactact gaacactact gagttagact
     1021 gctgactgcc agagaggtag ctgccctcat gccattacca tgtcccctgg tggctccacc
     1081 tccgtggtag cttcaagtgc ctttccctgc acaccaaagt cccaaagctt gaggcagcgt
     1141 acttgcccca gcattaacaa gagggggcat gtatgccagt gttgggctag gcctggctag
     1201 tagagtaggg tttagattac ttgacagaag tgcctcttat gtagactgct tccctttggg
     1261 tagctgtgat ctgcagtaag tctggggaga atccgagcat accactacac ggtgggtaag
     1321 agcaggtggg aaggggcctt tctggttggg ctaggcacct ttcatgcctg ctgccaggaa
     1381 ccctcagata gggcaagctt aggggaactg gaatcccaca ctgtatgctg tcctttccac
     1441 acaggcctct tgctcctaac ggcctcagcc ctgggctttt cctactactg ataacactat
     1501 gtaaatgttc catgttcctg tacactgtct cttttgggaa catctctgaa tggagcatgg
     1561 ctgttttcat tcactgctgt atcccagatg cccacagatg ctcctgctgt gtgacaggtg
     1621 ctcaataaat gtataagcag tcaaaaaaaa aaaaaaaaaa aaaaaaaa
//
