LOCUS       NM_021744               1591 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus CD14 molecule (Cd14), mRNA.
ACCESSION   NM_021744
VERSION     NM_021744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1591)
  AUTHORS   Al-Aalim,A.M., Al-Iedani,A.A. and Hamad,M.A.
  TITLE     Study of the effects of Escherichia coli lipopolysaccharide on
            innate immunity: The expression profile of TLR4 and CD14 genes in
            rat liver
  JOURNAL   Open Vet J 11 (4), 771-779 (2021)
   PUBMED   35070875
  REMARK    GeneRIF: Study of the effects of Escherichia coli
            lipopolysaccharide on innate immunity: The expression profile of
            TLR4 and CD14 genes in rat liver.
REFERENCE   2  (bases 1 to 1591)
  AUTHORS   Fehrenbach,D.J., Abais-Battad,J.M., Dasinger,J.H., Lund,H.,
            Keppel,T., Zemaj,J., Cherian-Shaw,M., Gundry,R.L., Geurts,A.M.,
            Dwinell,M.R. and Mattson,D.L.
  TITLE     Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in
            Salt-Sensitive Hypertension and Renal Injury
  JOURNAL   Hypertension 77 (1), 228-240 (2021)
   PUBMED   33249861
  REMARK    GeneRIF: Sexual Dimorphic Role of CD14 (Cluster of Differentiation
            14) in Salt-Sensitive Hypertension and Renal Injury.
REFERENCE   3  (bases 1 to 1591)
  AUTHORS   Kim,J., Yang,Y.L., Jeong,Y. and Jang,Y.S.
  TITLE     Middle East Respiratory Syndrome-Coronavirus Infection into
            Established hDPP4-Transgenic Mice Accelerates Lung Damage Via
            Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis
  JOURNAL   J Microbiol Biotechnol 30 (3), 427-438 (2020)
   PUBMED   31838832
REFERENCE   4  (bases 1 to 1591)
  AUTHORS   Overhagen,S., Blumensatt,M., Fahlbusch,P., Herzfeld de Wiza,D.,
            Muller,H., Maxhera,B., Akhyari,P. and Ouwens,D.M.
  TITLE     Soluble CD14 inhibits contractile function and insulin action in
            primary adult rat cardiomyocytes
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (2), 365-374 (2017)
   PUBMED   27816522
  REMARK    GeneRIF: This study shows that sCD14 impairs contractile function
            and insulin action in primary adult rat cardiomyocytes.
REFERENCE   5  (bases 1 to 1591)
  AUTHORS   Tsai,C.H., Yeh,C.H., Sheen-Chen,S.M., Huang,C.Y., Liu,Y.W.,
            Huang,C.C., Shen,S.C. and Tang,R.P.
  TITLE     The kinetic expression of lipopolysaccharide-binding protein and
            CD14 gene in obstructive jaundice
  JOURNAL   J Invest Surg 28 (1), 18-23 (2015)
   PUBMED   25093541
  REMARK    GeneRIF: CD 14 mRNA expression increased significantly after five
            days of bile duct ligation in liver, lung, spleen, and ileum.
REFERENCE   6  (bases 1 to 1591)
  AUTHORS   Liu,S., Khemlani,L.S., Shapiro,R.A., Johnson,M.L., Liu,K.,
            Geller,D.A., Watkins,S.C., Goyert,S.M. and Billiar,T.R.
  TITLE     Expression of CD14 by hepatocytes: upregulation by cytokines during
            endotoxemia
  JOURNAL   Infect Immun 66 (11), 5089-5098 (1998)
   PUBMED   9784508
REFERENCE   7  (bases 1 to 1591)
  AUTHORS   Takai,N., Kataoka,M., Higuchi,Y., Matsuura,K. and Yamamoto,S.
  TITLE     Primary structure of rat CD14 and characteristics of rat CD14,
            cytokine, and NO synthase mRNA expression in mononuclear phagocyte
            system cells in response to LPS
  JOURNAL   J Leukoc Biol 61 (6), 736-744 (1997)
   PUBMED   9201265
REFERENCE   8  (bases 1 to 1591)
  AUTHORS   Haziot,A., Ferrero,E., Kontgen,F., Hijiya,N., Yamamoto,S.,
            Silver,J., Stewart,C.L. and Goyert,S.M.
  TITLE     Resistance to endotoxin shock and reduced dissemination of
            gram-negative bacteria in CD14-deficient mice
  JOURNAL   Immunity 4 (4), 407-414 (1996)
   PUBMED   8612135
REFERENCE   9  (bases 1 to 1591)
  AUTHORS   Galea,E., Reis,D.J., Fox,E.S., Xu,H. and Feinstein,D.L.
  TITLE     CD14 mediate endotoxin induction of nitric oxide synthase in
            cultured brain glial cells
  JOURNAL   J Neuroimmunol 64 (1), 19-28 (1996)
   PUBMED   8598386
REFERENCE   10 (bases 1 to 1591)
  AUTHORS   Haziot,A., Chen,S., Ferrero,E., Low,M.G., Silber,R. and Goyert,S.M.
  TITLE     The monocyte differentiation antigen, CD14, is anchored to the cell
            membrane by a phosphatidylinositol linkage
  JOURNAL   J Immunol 141 (2), 547-552 (1988)
   PUBMED   3385210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF087943.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087943.1, FQ219480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1591
                     /gene="Cd14"
                     /note="CD14 molecule"
                     /db_xref="GeneID:60350"
                     /db_xref="RGD:620588"
     exon            1..68
                     /gene="Cd14"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1184
                     /gene="Cd14"
                     /note="monocyte differentiation antigen CD14; myeloid
                     cell-specific leucine-rich glycoprotein; CD14 antigen"
                     /codon_start=1
                     /product="monocyte differentiation antigen CD14 precursor"
                     /protein_id="NP_068512.1"
                     /db_xref="GeneID:60350"
                     /db_xref="RGD:620588"
                     /translation="MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQ
                     PNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSAR
                     VPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTD
                     TWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISAL
                     CPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAGTPSCDWPS
                     QLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLHS
                     ESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV"
     exon            69..1507
                     /gene="Cd14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagaaac tgaagccttt ctcggagcct gtctgggctg ctcccactct cagaatctac
       61 cgaccatgaa gcttatgctc ggcttgttgc tgttgccttt gacactggtg catgcctctc
      121 ccgccacacc agaaccctgt gagctggacc aggacgagga aagtgtccgc tgctactgca
      181 acttctcaga tccgcagccc aattggtcca gcgcttttct atgcgcgggg gcggaagacg
      241 tggagttcta cggcggcggt cgcagcctgg agtaccttct aaagcgtgtg gacacggaag
      301 caaatctggg gcagtacact gatattatca ggtctctgcc cttgaagagg cttactgtgc
      361 ggtccgcgcg ggttcctact cagattctat tcggaaccct gcgtgtgctc ggatattctg
      421 gcctccggga actgactctt gaaaacctcg aggtaaccgg caccgcgctt tcgccgcttc
      481 tggatgccac cggacccgat ctcaacacct tgagcctccg caacgtgtcg tgggcaacaa
      541 cggatacctg gctcgcagaa ctgcagcagt ggctaaagcc tggactcaag gtactaagta
      601 ttgcccaagc acactcactc aacttttctt gcaaacaggt cggcgtcttc cctgcccttg
      661 ccaccttaga tctgtctgac aaccctgagt tgggcgagaa aggactgatc tcggccctct
      721 gtccgcacaa attcccgacc ctccaagttt tagcgctgcg caacgcgggg atggagacga
      781 ccagcggcgt gtgctctgcg ctggccgcag caagagtgcc actgcaggca ctggatctca
      841 gtcacaattc actgcgggat actgctggca ctccgagctg tgactggccc agtcagctaa
      901 actcgctcaa tctatctttc actgggctgg agcacgtacc taaagggctg ccagccaagc
      961 ttagcgtgct tgatctcagt tacaacaggc tggataggaa acctaggcca gaggagctgc
     1021 ctgaagtggg gagcctgtca cttacaggaa atcccttttt gcactctgaa tcccagtcgg
     1081 aggcgtataa ctctggcgta gtcatagcca cagctctttc acccggatca gcgggcttgt
     1141 caggaacttt ggctttgctc ctaggacatc gcctctttgt ttaaggaacg tttgcatctt
     1201 cctggtttct gagggtcctg gtcaacaaat cctctgcttt aaatttatta aaatcttaat
     1261 ccacaatgta aggaaggaca atcaagatgg ctcaatgggt aaaagccacc aagcttgact
     1321 cctgattttg atcctcggga tccacaccaa aggaaagaac tctctcctga aagttgtcca
     1381 tcggtgctca caaataaata tatttttttt tccggagctg aggaccgaac ccagggcctt
     1441 gcgctcacta ggcaagcgct ctaccactga gctaaatccc caaccccaca aataaatatt
     1501 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
