LOCUS       NM_001108771            4991 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CD109 molecule (Cd109), mRNA.
ACCESSION   NM_001108771 XM_001060269 XM_003750546 XM_003754439 XM_343437
VERSION     NM_001108771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4991)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 4991)
  AUTHORS   Wang,Y., Inger,M., Jiang,H., Tenenbaum,H. and Glogauer,M.
  TITLE     CD109 plays a role in osteoclastogenesis
  JOURNAL   PLoS One 8 (4), e61213 (2013)
   PUBMED   23593435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4991)
  AUTHORS   Mii,S., Murakumo,Y., Asai,N., Jijiwa,M., Hagiwara,S., Kato,T.,
            Asai,M., Enomoto,A., Ushida,K., Sobue,S., Ichihara,M. and
            Takahashi,M.
  TITLE     Epidermal hyperplasia and appendage abnormalities in mice lacking
            CD109
  JOURNAL   Am J Pathol 181 (4), 1180-1189 (2012)
   PUBMED   22846721
REFERENCE   4  (bases 1 to 4991)
  AUTHORS   Su,M.A., Davini,D., Cheng,P., Giang,K., Fan,U., DeVoss,J.J.,
            Johannes,K.P., Taylor,L., Shum,A.K., Valenzise,M., Meloni,A.,
            Bour-Jordan,H. and Anderson,M.S.
  TITLE     Defective autoimmune regulator-dependent central tolerance to
            myelin protein zero is linked to autoimmune peripheral neuropathy
  JOURNAL   J Immunol 188 (10), 4906-4912 (2012)
   PUBMED   22490868
REFERENCE   5  (bases 1 to 4991)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   6  (bases 1 to 4991)
  AUTHORS   Finnson,K.W., Tam,B.Y., Liu,K., Marcoux,A., Lepage,P., Roy,S.,
            Bizet,A.A. and Philip,A.
  TITLE     Identification of CD109 as part of the TGF-beta receptor system in
            human keratinocytes
  JOURNAL   FASEB J 20 (9), 1525-1527 (2006)
   PUBMED   16754747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1 and BQ201404.1.
            
            On or before Sep 5, 2019 this sequence version replaced
            XM_003750546.4, XM_003754439.3, NM_001108771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.32666.1,
                                           SRR26643294.33726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000008.1  88334736-88335141
            407-579             JAXUCZ010000008.1  88336139-88336311
            580-608             JAXUCZ010000008.1  88361662-88361690
            609-839             JAXUCZ010000008.1  88363608-88363838
            840-965             JAXUCZ010000008.1  88368083-88368208
            966-1005            JAXUCZ010000008.1  88384994-88385033
            1006-1090           JAXUCZ010000008.1  88387846-88387930
            1091-1187           JAXUCZ010000008.1  88389587-88389683
            1188-1347           JAXUCZ010000008.1  88390202-88390361
            1348-1457           JAXUCZ010000008.1  88390990-88391099
            1458-1673           JAXUCZ010000008.1  88393719-88393934
            1674-1775           JAXUCZ010000008.1  88394910-88395011
            1776-1838           JAXUCZ010000008.1  88395101-88395163
            1839-2015           JAXUCZ010000008.1  88396766-88396942
            2016-2168           JAXUCZ010000008.1  88398644-88398796
            2169-2243           JAXUCZ010000008.1  88398936-88399010
            2244-2304           JAXUCZ010000008.1  88399449-88399509
            2305-2446           JAXUCZ010000008.1  88409364-88409505
            2447-2564           JAXUCZ010000008.1  88410864-88410981
            2565-2678           JAXUCZ010000008.1  88414261-88414374
            2679-2897           JAXUCZ010000008.1  88417221-88417439
            2898-3042           JAXUCZ010000008.1  88419028-88419172
            3043-3219           JAXUCZ010000008.1  88420333-88420509
            3220-3301           JAXUCZ010000008.1  88426696-88426777
            3302-3530           JAXUCZ010000008.1  88429380-88429608
            3531-3696           JAXUCZ010000008.1  88430749-88430914
            3697-3884           JAXUCZ010000008.1  88434493-88434680
            3885-4040           JAXUCZ010000008.1  88435141-88435296
            4041-4106           JAXUCZ010000008.1  88436527-88436592
            4107-4246           JAXUCZ010000008.1  88441530-88441669
            4247-4394           JAXUCZ010000008.1  88444565-88444712
            4395-4497           JAXUCZ010000008.1  88446839-88446941
            4498-4973           JAXUCZ010000008.1  88448987-88449462
            4974-4991           BQ201404.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4991
                     /gene="Cd109"
                     /note="CD109 molecule"
                     /db_xref="GeneID:363104"
                     /db_xref="RGD:1311287"
     exon            1..406
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..4664
                     /gene="Cd109"
                     /note="CD109 antigen"
                     /codon_start=1
                     /product="CD109 antigen precursor"
                     /protein_id="NP_001102241.2"
                     /db_xref="GeneID:363104"
                     /db_xref="RGD:1311287"
                     /translation="MRNPRLLSAAHLLSVCVVAVAAHGSRFLVTVPGIIRPGANMTIG
                     VELLQNSPPQVLVKARVLKIASNRSTTVLEAEGVFNRGHFGILVLPALPLHKANKIYE
                     LHISGKSETEIVFSNRTRLTFDSKRISVFIQTDKVIYKPKQEVKFRVLTLFSDLKPYK
                     TPVDIYIKDPKSNLIQQWLSQEGELGVVSKTFQLSSHPILGDWSIQVQVIDQLYYQSF
                     QVLDYVLPKFEVTLQTPLYCSLKAKYLRGNVTAKYTYGKPVKGSLSLTFIPLSFWGKK
                     KNITKNFEINGFTNFAFDADEMKKVMNLKKATEISDGNYDQVDPVFPGPVEIVATVTE
                     SLTGTSRKASTNVFFKQHDYVIEIFDYTTVLKPTLNFTATVKISRSDGKQLTPEEMEN
                     DLVTVVTQKKNDNPTREKAQGTDYIQMTEYSVPHNGVVKVEFPIMSDSSELQLKASFL
                     DSASSVAVHSVFTSPSNTYIQLKTRDEHITVGSPFNLTVSGNQKFKEISYMVISKGQL
                     VAVGKQSSRTFSLTPEASWAPKACIIVYYIEQDGEVISDILKIPVQLDFKNKIKLSWS
                     KPRVKPSDKVSLRISVTQSYSLVGIVAVDKSVKLIGNSNDITMENVVHELELYNTEYY
                     LGMFLNSFAVFQECGLWVLTDANLVRDNIDEVYDTQEYSERFAEENEANLVDFEDTSS
                     ASNSHVRKHFPESWIWLDFYMGSKNHEEYEVTVPDSITSWVASAFVISEDLGFGLTAT
                     PAELHAFQPFFISLNLPYSVIRGEEFALEVSIVNYLKDTTKVVVLIEESDSFDILMFS
                     NDINNTIYRKTALVPRENSVTLVFPIKPTHLGNVPITVTAASPTSSDVVTRTIVVKPE
                     GVAKSYSQSVLLELIDKKQQTEPKSLSFSFPPDTISGSERIQITAIGDILGSSINGLS
                     SLIRLPYGCGEQNMVYLAPNVYILDYLTKQKQLTVNLKEKALSFMRQGYQRELLYQRE
                     DGSFSAFGNSDSSGSTWLSAFVLRCFMEAAQYIDIDQDVLHRTYSWLEAHKKTNGEFW
                     EPGRVIHIELQGGNKSPITLTAYVVTSLLGYKKYQPNIEIQDSIKFLENEFNRGISDN
                     YTLALVTYALSAVGSPKAEEALTMLTQQAEKEGDTQFWLSSTSESSESWQSLSAQIEI
                     AAYALLAHTQHHVPEGIPIMKWLIKQRNSLGGFVSTQDTVMALKALSEFSALVYKENR
                     DMQVTIKGPNVPKPIRFWIDSQNLFKLHKEELAPLDPIAVNVSAHGSGFAICQLNVDY
                     NVKASSSFKRRRSMENPIGFDLDVDVNDEHDLRYMKLNVCTSHLGPGRTGMALLEVNL
                     LSGFTATSDSIPLSEILKKVEYEPGKLNLYLDHVNETQFCVKIPTVRDFKVSNIRDGL
                     VSIVDYYEPSRQAVRSYNTQMKLSSCYLSADPNCRSYMDRATDSLRHSSSLLVLCSTL
                     LYFVQH"
     exon            407..579
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            580..608
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            609..839
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            840..965
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1005
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1090
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1187
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1347
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1457
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1673
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1775
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1838
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2015
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2168
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2243
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2304
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2446
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2564
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2678
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2897
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3042
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3219
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3301
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3530
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3696
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3884
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..4040
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4106
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4246
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4394
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            4395..4497
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4974
                     /gene="Cd109"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccaggtt cccggtggcc gaggaagtgg gcgctctctg ttctcccttg ggagcaggga
       61 aggtggggcc aggttgtggc caccgcgtgt agagaccgct tttctcagcc acgggacgcg
      121 cgacgttagc tagggagaag ccagaagcgc cattgtgatg cagcgggatg ggtggagcca
      181 tcaagtctca atttagattc ctctgctttt aggcgcgccc atttcagttt gctaaaccct
      241 ggtgtgaagc gggacaggcc agggcaagag gtggccagcc acaccccgca gggcgcgcac
      301 ttggcgggct gcagacccca caggcagacg ccgagatgcg caatccgagg ctcctgagcg
      361 ctgcccacct tctcagcgtg tgcgtggtcg cggtggccgc ccacgggtcc cgctttctgg
      421 tgacagtccc aggaatcatc agacccggag caaatatgac tattggggtg gaactcctgc
      481 aaaatagccc cccacaggtc cttgtaaagg ctcgggtgct caagatagct tccaaccgat
      541 cgaccactgt cctggaagca gaaggagtct ttaacagagg gcatttcgga attcttgttc
      601 ttccggcact ccctctgcac aaggcaaaca agatttatga actacacata agcggaaaat
      661 cggagactga gatcgtattc tccaaccgga cacggttaac atttgacagc aagaggatct
      721 ctgtcttcat tcagacagat aaggtgatct acaagccgaa gcaggaagtg aagtttcgag
      781 tgcttacact cttctcagat ctcaagcctt acaagacgcc cgtggacatt tacattaagg
      841 atccaaagtc taatttgatc caacagtggc tttctcagga aggtgaactt ggagttgttt
      901 ccaaaacttt tcaactatcc tctcatccaa tacttggtga ctggtccatt caggttcaag
      961 tgattgatca gttgtattac cagtcatttc aggtcctaga ctatgtgtta ccgaagtttg
     1021 aagttactct gcagactccg ctgtattgtt ctttgaaggc taagtattta cgtggtaacg
     1081 tcacagcgaa gtatacatac gggaagccag tgaaggggag tctgtcactt acatttatac
     1141 ctttatcttt ttggggaaag aagaaaaata tcacaaaaaa ttttgagata aatggattca
     1201 caaacttcgc ttttgatgct gatgagatga aaaaggtaat gaatttgaaa aaggcaacgg
     1261 agatctcgga cgggaattat gatcaggtgg acccagtctt ccctgggccc gtagagatcg
     1321 tagctacggt gaccgagtcg ctcacaggta cctcaagaaa ggcaagtacc aatgtgtttt
     1381 tcaagcaaca tgactacgtc attgagattt ttgattatac tactgtcttg aagccaacgc
     1441 tcaacttcac agccactgtg aagatcagtc ggtctgatgg caagcagctg actcctgaag
     1501 aaatggaaaa cgatttagtc acagtagtga cccagaagaa aaatgacaac cccacgagag
     1561 agaaagcgca gggcacggat tatatccaga tgacagaata ttctgtcccc cacaatggag
     1621 tcgttaaggt tgaattccca atcatgtccg attccagtga gctccaacta aaggcttctt
     1681 ttctcgatag tgcaagttct gtggccgttc acagcgtgtt cacctctcca agtaatacgt
     1741 acatccagct taaaaccaga gatgaacata tcacggtggg atcacctttt aatttgacgg
     1801 ttagtggcaa ccagaaattc aaggaaataa gctatatggt aatatcaaag ggacagttgg
     1861 tggctgtagg caaacaaagt tcaagaactt tttctttaac accggaagct tcctgggccc
     1921 caaaggcctg tataattgta tattatatcg aacaggatgg ggaagtcata agcgatattc
     1981 tgaaaatccc cgttcagctt gactttaaaa ataagataaa gctgtcttgg agtaaaccta
     2041 gagtcaagcc atctgataaa gtctctctca ggatctctgt aacacagtcg tactccctgg
     2101 ttgggattgt agctgttgac aaaagtgtga aactgatagg aaactccaat gatattacaa
     2161 tggaaaatgt ggtccatgaa ctggagcttt ataacacaga atattatcta ggcatgttcc
     2221 tgaactcctt cgccgtattt caggaatgtg gtctctgggt gttgacagat gcaaaccttg
     2281 taagagataa cattgatgaa gtttacgaca ctcaagagta ttccgagcgc tttgcggagg
     2341 agaacgaggc aaacctggtt gattttgaag acacttcgtc agctagcaat tcacatgtca
     2401 ggaagcattt tccagaatca tggatttggc tagacttcta catgggatct aagaatcacg
     2461 aagagtatga agttactgtg cctgattcca tcacttcttg ggtggcttct gcttttgtca
     2521 tctctgaaga cttgggtttt gggctaacag ccactccagc agagctgcac gccttccaac
     2581 cgtttttcat ttccctgaat cttccctact ctgttatcag aggtgaagag tttgctttgg
     2641 aagtatccat agtcaattat ttgaaagata ccaccaaggt tgtggtactt attgaggaaa
     2701 gtgacagctt tgatatttta atgttttcaa atgacatcaa taacaccatc taccggaaga
     2761 ctgctctagt tcccagagag aactcggtca ctcttgtttt tcctattaag ccaacgcact
     2821 tgggaaatgt tcccatcaca gtgacagctg cctcacccac ttcctctgat gttgtcacca
     2881 ggaccattgt agtaaagcct gaaggggtag caaagtcgta ttcgcagtct gtcttactgg
     2941 aactgattga caaaaaacag caaactgaac cgaaatcttt gagtttctcg tttcctcctg
     3001 atacgatcag tggcagtgaa agaattcaga tcacagcaat tggagatatt cttggttctt
     3061 ccatcaatgg cttatcctca ctgatacggc tgccttatgg atgtggtgaa cagaacatgg
     3121 tttatttggc tccaaatgtt tacattttgg attatctcac taaacagaaa cagctgacag
     3181 ttaatctaaa agaaaaggcc ctttcattta tgaggcaagg ttaccaaagg gagcttctct
     3241 atcagaggga agatggctcc ttcagtgctt tcgggaatag tgactcttct gggagcactt
     3301 ggctgtcggc atttgtttta agatgtttta tggaagctgc tcagtatata gatattgatc
     3361 aggatgtgtt acacagaaca tattcttggc tcgaagcaca taagaaaacc aacggtgaat
     3421 tttgggagcc aggaagagtg atccacattg aacttcaagg tggcaacaaa agtccaataa
     3481 cacttacagc ctatgttgtg acttctctcc tgggatacaa aaagtatcag cccaacatcg
     3541 agatacagga ctctatcaag tttttggaaa atgaattcaa cagaggaatt tcagacaatt
     3601 ataccttagc acttgtaacc tatgccctgt ctgcagtggg gagtcctaaa gcagaggagg
     3661 ccttgaccat gctgactcag caagcagaaa aggaaggaga cacacagttc tggttgtcat
     3721 cgacatctga gtcctctgag tcctggcagt cgctctccgc gcagattgaa atcgctgctt
     3781 atgcgttgct cgcacacacg cagcaccatg ttcctgaggg aatcccaatt atgaagtggc
     3841 ttattaagca aagaaacagt ctgggaggtt ttgtatctac tcaggatact gtcatggcct
     3901 tgaaggcgct atctgaattt tcagcccttg tgtataaaga aaacagagat atgcaagtga
     3961 ccatcaaagg gcccaacgta ccgaaaccca tacggttctg gattgactca cagaacctct
     4021 ttaagcttca caaggaagag cttgccccgc tagatcccat tgcagtcaat gtttctgcac
     4081 atggttcggg attcgctatt tgccagctta atgttgatta taacgtgaaa gcttcaagtt
     4141 cttttaagag acggagatct atggaaaatc caatcggttt tgatttagac gtcgacgtga
     4201 atgatgagca tgacctcaga tacatgaaac tgaatgtgtg cacaagtcat ttaggcccag
     4261 gaaggactgg catggccctt ctggaggtga accttctcag tggatttact gcaacttcag
     4321 attcaattcc tctcagtgag atactgaaga aagtggaata tgaacccggg aagctcaacc
     4381 tttatttaga tcatgtaaat gaaacccagt tttgtgttaa aattcctact gtgagagact
     4441 tcaaagtttc aaatattcga gatggtttgg tatctatagt ggattactat gaaccaagta
     4501 gacaggctgt gagaagctac aacacccaga tgaagctgtc ctcatgttac ctcagtgctg
     4561 accccaactg cagatcatat atggacagag ccacggactc ccttcgccat tcttcgagcc
     4621 ttctcgtcct ttgttccacc cttctgtact ttgtacaaca ttgattatga tttatttttc
     4681 aaggactcca tctaaaacta gcatttccag aaagtcaagt gtgattgctt tctttctaca
     4741 gctgatgatt gcctctgaca gttctgaaaa ccaatcgttt ccctttcttg ggggggacct
     4801 gggggaaagt ctgtgatagg ccggagcttg tgttagcatg taaaacaatt cacccaatct
     4861 ttgtgtggaa gatggccaga atgaggacac tgtgtctctc ttcatttccc cttctctaag
     4921 aaagtttatt agacgcattt gttttctcta gaataaaagt gttattttcc attaaaaaaa
     4981 aaaaaaaaaa a
//
