LOCUS       NM_001014228            1803 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus chaperonin containing TCP1 subunit 6B (Cct6b),
            mRNA.
ACCESSION   NM_001014228 XM_343948
VERSION     NM_001014228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Yi,X., Wang,Z., Ren,J., Zhuang,Z., Liu,K., Wang,K. and He,R.
  TITLE     Overexpression of chaperonin containing T-complex polypeptide
            subunit zeta 2 (CCT6b) suppresses the functions of active
            fibroblasts in a rat model of joint contracture
  JOURNAL   J Orthop Surg Res 14 (1), 125 (2019)
   PUBMED   31072365
  REMARK    GeneRIF: CCT6b overexpression significantly inhibited fibroblasts
            functions in a model of joint contracture.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Mukherjee,K., Conway de Macario,E., Macario,A.J. and Brocchieri,L.
  TITLE     Chaperonin genes on the rise: new divergent classes and intense
            duplication in human and other vertebrate genomes
  JOURNAL   BMC Evol Biol 10, 64 (2010)
   PUBMED   20193073
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Kubota,H., Hynes,G.M., Kerr,S.M. and Willison,K.R.
  TITLE     Tissue-specific subunit of the mouse cytosolic
            chaperonin-containing TCP-1
  JOURNAL   FEBS Lett 402 (1), 53-56 (1997)
   PUBMED   9013858
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079020.1.
            
            On Apr 1, 2005 this sequence version replaced XM_343948.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1803
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /note="chaperonin containing TCP1 subunit 6B"
                     /db_xref="GeneID:363658"
                     /db_xref="RGD:1359453"
     exon            1..218
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1677
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /note="chaperonin subunit 6b (zeta); chaperonin containing
                     Tcp1, subunit 6B (zeta 2)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit zeta-2"
                     /protein_id="NP_001014250.1"
                     /db_xref="GeneID:363658"
                     /db_xref="RGD:1359453"
                     /translation="MAAIKIANPGAEVTRSQAALAVNICAARGLQDVLRPSLGPKGAL
                     KMLVSGAGDIKLTKDGNVLLHEMQIQHPTASIIAKVAAAQDHITGDGTTSNVLIIGEL
                     LKQADLYISEGLHPRIIAEGFDVAKTKALEVLDKIKVQKEMKREMLLDVARTSLRTKV
                     HTELADILTEAVVDSVLAIRRPGIPIDLFMVEIVEMRHKSETDTQLVRGLVLDHGARH
                     PRMKKQVQDAYILICNVSLEYEKTEVSSGFFYKTVEEKEKLVKAERKFIEDRVQKIID
                     LKQKVCAESNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLERLTLACGGLAVN
                     SLEDLSEECLGHAGLVFEYTLGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQIKDALR
                     DGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHCVQGRARLGIQAFADALLIIPKV
                     LAQNSGYDLQETLIKIQTKHAESKELVGIDLNTGEPMVAAEAGIWDNYCVKKHILHSC
                     TVIATNVLLVDEIMRAGMSSLRE"
     exon            219..282
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            283..417
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            418..591
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            592..695
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            696..806
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            807..966
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1049
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1146
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1294
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1428
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1531
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1604
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1774
                     /gene="Cct6b"
                     /gene_synonym="RGD1561014"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgccgact ggttgaagct ccggagtgtg ggcgtggcgc cagggttccg agttgcgagt
       61 taggggctgg acggttgaac catggctgca atcaaaatcg ccaaccctgg ggctgaagtg
      121 acgcggagcc aagcggcctt ggctgtgaac atatgcgccg cccgaggatt gcaggatgtg
      181 ctgcgtccca gcttgggtcc taagggcgcg ctaaaaatgc ttgtttctgg ggcaggtgac
      241 atcaaactca ccaaagatgg caatgtgttg cttcacgaga tgcaaattca acacccaaca
      301 gcttccatca tagcaaaagt ggcagcagcc caagaccata tcacagggga cggcactacc
      361 tcaaatgtcc tgatcattgg agagttgcta aagcaagctg atctttacat ttctgaggga
      421 ctgcacccta gaatcatagc tgaaggattt gatgttgcaa agacgaaagc acttgaagtt
      481 ttggataaaa ttaaagtaca aaaggagatg aaaagagaaa tgctcttaga tgtggctaga
      541 acatccctaa ggacaaaagt tcatactgaa ctggccgaca tactaacaga ggctgtggtg
      601 gattctgtct tggctattag aagaccaggt atccctattg atctcttcat ggtggaaatc
      661 gtggagatga ggcacaagtc agaaacagac acgcagttgg tccgaggatt ggttctggac
      721 catggtgccc gtcacccaag gatgaagaag caggtgcaag atgcgtacat cctcatttgc
      781 aatgtgtcac tagagtatga aaaaacagaa gtgagctctg gtttctttta taagactgta
      841 gaagagaaag agaaattggt aaaagctgaa agaaaattta ttgaagatag agtgcagaaa
      901 ataatagacc taaagcagaa agtctgtgct gagtccaata aaggatttgt tgtcattaat
      961 caaaagggca tcgatccggt ttccttagaa atgcttgcaa agcataacat cgtggctctt
     1021 cgcagggcga aaagaaggaa tctcgagagg cttacccttg cttgtggagg attggctgta
     1081 aactcccttg aagacctgag tgaagaatgc ttggggcatg ctggccttgt atttgagtac
     1141 acattgggcg aagaaaagtt cacttttatt gaggactgtg taaaccctct ctctgttacc
     1201 ttgttggtca aaggaccaaa taagcacacg ctcatacaga tcaaggatgc cttaagagat
     1261 ggacttcgtg cggtcaaaaa tgctatcgaa gatggttgtg tggttccagg agctggggca
     1321 gttgaagttg ccatagcaga ggctcttgtg aactacaagc actgtgtgca gggaagagct
     1381 cgcctcggaa tccaagcctt tgctgatgcc ttactcatta tccccaaggt tcttgctcag
     1441 aattctggtt atgacctgca ggaaacactg ataaaaattc agactaagca tgctgaatca
     1501 aaagaacttg ttggcataga cctgaataca ggggagccga tggtagcagc agaagcggga
     1561 atttgggata attactgcgt gaaaaaacat attcttcact cttgcacggt gattgccacc
     1621 aacgtcctcc tggttgatga aattatgcga gctgggatgt cttctctccg agagtgattg
     1681 aattcagaat catctgcatg acaagagttc atacgtgtcg tatccagcag cgtcacatgg
     1741 ccttaactgt tacaaaataa aggtagtgca tgtcaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaa
//
