LOCUS       NM_182814               2110 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus chaperonin containing TCP1 subunit 4 (Cct4),
            mRNA.
ACCESSION   NM_182814
VERSION     NM_182814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Sergeeva,O.A., Tran,M.T., Haase-Pettingell,C. and King,J.A.
  TITLE     Biochemical characterization of mutants in chaperonin proteins CCT4
            and CCT5 associated with hereditary sensory neuropathy
  JOURNAL   J Biol Chem 289 (40), 27470-27480 (2014)
   PUBMED   25124038
  REMARK    GeneRIF: C450Y CCT4 is defective in protein stability.
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Knee,K.M., Sergeeva,O.A. and King,J.A.
  TITLE     Human TRiC complex purified from HeLa cells contains all eight CCT
            subunits and is active in vitro
  JOURNAL   Cell Stress Chaperones 18 (2), 137-144 (2013)
   PUBMED   23011926
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Seo,S., Baye,L.M., Schulz,N.P., Beck,J.S., Zhang,Q., Slusarski,D.C.
            and Sheffield,V.C.
  TITLE     BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family
            chaperonins and mediate BBSome assembly
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1488-1493 (2010)
   PUBMED   20080638
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Hsu,S.H., Lee,M.J., Hsieh,S.C., Scaravilli,F. and Hsieh,S.T.
  TITLE     Cutaneous and sympathetic denervation in neonatal rats with a
            mutation in the delta subunit of the cytosolic
            chaperonin-containing t-complex peptide-1 gene
  JOURNAL   Neurobiol Dis 16 (2), 335-345 (2004)
   PUBMED   15193290
  REMARK    GeneRIF: the mutation in Cct4 underlies cutaneous nerve
            degeneration in mutilated-foot rats.
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Lee,M.J., Stephenson,D.A., Groves,M.J., Sweeney,M.G., Davis,M.B.,
            An,S.F., Houlden,H., Salih,M.A., Timmerman,V., de Jonghe,P.,
            Auer-Grumbach,M., Di Maria,E., Scaravilli,F., Wood,N.W. and
            Reilly,M.M.
  TITLE     Hereditary sensory neuropathy is caused by a mutation in the delta
            subunit of the cytosolic chaperonin-containing t-complex peptide-1
            (Cct4) gene
  JOURNAL   Hum Mol Genet 12 (15), 1917-1925 (2003)
   PUBMED   12874111
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA340557.1, AY223861.1, BQ200856.1 and CB612673.1.
            
            On Dec 18, 2003 this sequence version replaced NM_182814.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079283.1, AY223861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               CA340557.1         7-140
            135-1754            AY223861.1         1-1620
            1755-1946           BQ200856.1         18-209              c
            1947-2110           CB612673.1         190-353
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2110
                     /gene="Cct4"
                     /note="chaperonin containing TCP1 subunit 4"
                     /db_xref="GeneID:29374"
                     /db_xref="RGD:727937"
     exon            1..261
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1754
                     /gene="Cct4"
                     /note="CCT-delta; TCP-1-delta; chaperonin subunit 4
                     (delta); chaperonin containing Tcp1, subunit 4 (delta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit delta"
                     /protein_id="NP_877966.1"
                     /db_xref="GeneID:29374"
                     /db_xref="RGD:727937"
                     /translation="MPENVASRSGPPAAGPGNRGKGAYQDRDKPAQIRFSNISAAKAV
                     ADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEA
                     GDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDR
                     ETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI
                     DDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVL
                     REERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIE
                     FICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRG
                     SNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYC
                     VRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMV
                     VQPLLVSVSALTLATETVRSILKIDDVVNTR"
     exon            262..314
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..404
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            405..513
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            514..656
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            657..778
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            779..911
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1051
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1148
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1259
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1390
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1625
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1739
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2110
                     /gene="Cct4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgccttc tctcccggcg tcgctttctg gaaggttcgt ggaggcggcg gccagggaga
       61 ccgttactcc acagcaggcc ggaatccgtg tccatcggtc ctcctgaacc cgcgcagacg
      121 ccatcaaagt cgccatgccg gagaacgtag cttcccgaag cgggccgccc gcagcggggc
      181 cgggcaaccg cgggaaaggc gcctaccagg accgcgacaa accggcccag atccgcttca
      241 gcaacatttc cgcggccaaa gcggttgccg atgccattag aacaagcctt ggacctaaag
      301 gaatggacaa aatgattcaa gacggaaaag gcgatgtgac cattaccaat gatggtgcca
      361 ccattctgaa acaaatgcaa gtattacacc cagcagccag aatgctggtg gaactgtcca
      421 aagctcaaga catagaagca ggggatggca ccacgtcggt cgtcatcatt gctggctctc
      481 tcttagactc ctgtaccaag cttctgcaga aaggtataca tccaaccatc atttccgagt
      541 cattccagaa agctttggaa aagggtcttg aaatccttac cgacatgtct cggcctgtgc
      601 aactgagcga cagagaaacc ttgttaaata gtgcaaccac ttcattgaac tcaaaggttg
      661 tctctcagta ttcaagtctg ctctctccaa tgagtgtcaa tgcagtgatg aaagtgatcg
      721 atccagccac ggctaccagt gtcgatctta gagatattaa aatagttaag aagcttggtg
      781 ggacgataga tgactgtgag ctggtggaag gccttgttct cacacagaaa gtggcaaatt
      841 ctggcataac gagagttgag aaggctaaga ttgggcttat tcagttttgc ttatctgctc
      901 ctaaaacaga tatggataat cagatagtag tatctgacta cgcccagatg gatcgagtgc
      961 ttcgagaaga aagagcctat attttaaatt tggtgaagca aattaagaaa acaggatgta
     1021 atgtccttct catacagaag tctattctaa gagatgcact tagtgatctt gcgttacatt
     1081 ttctgaataa aatgaagatt atggtggtta aggacattga aagagaagac attgaattca
     1141 tctgtaagac aattggaacc aaaccagtgg ctcacattga ccagttcact cctgacatgc
     1201 tgggttctgc tgagttagca gaggaagtca gtttgaatgg ttctggaaaa ctgttcaaga
     1261 ttacaggctg tacaagccca ggcaaaacag tgacaattgt cgtccgaggc tctaacaaac
     1321 tggtgattga ggaagctgag cgctccattc acgatgctct ctgtgttatc cgatgcttgg
     1381 tgaagaagag agctcttatt gcaggaggtg gtgctccaga aatagagctg gccctcagac
     1441 tgacggagta ctcccggaca ctgagtggca tggagtccta ctgtgttcga gcttttgcag
     1501 atgccatgga agtcattcca tctacactgg ctgaaaatgc tggcctgaat cccatctcta
     1561 ctgtaacaga gctaagaaac cgccatgccc aaggagaaaa aactacaggc attaatgtcc
     1621 gaaagggtgg gatctccaac attctggagg aaatggttgt ccagcctctg ttggtgtcag
     1681 tcagtgcgtt gaccctagca actgaaactg tgcggagcat tctgaaaatt gatgatgtgg
     1741 taaatactcg ataatctgga tgaggctggc tgactggcac gagtatggag agaagtattg
     1801 tggctagagt ggaagatgat ggccttgttc cttgtctggg agcttgcttc ttcagagttt
     1861 ttggacattg tcttgcagtt ggcatttgtt gggaattgta ttgaaacaat ttaatgaaaa
     1921 tattaaatac ttggttttaa actccatatt tgtcattcca aagctatatt gtttttaata
     1981 ctttggggga aatgcctata ggtaaactac agccctcaaa atttaacatt tacctattga
     2041 tctaacccct tagtcctgtg tattcttggt tggttcatct gtggttgtat ttgtttgttg
     2101 agacattcta
//
