LOCUS       NM_199091               1964 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus chaperonin containing TCP1 subunit 3 (Cct3),
            mRNA.
ACCESSION   NM_199091 XM_215611
VERSION     NM_199091.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Knee,K.M., Sergeeva,O.A. and King,J.A.
  TITLE     Human TRiC complex purified from HeLa cells contains all eight CCT
            subunits and is active in vitro
  JOURNAL   Cell Stress Chaperones 18 (2), 137-144 (2013)
   PUBMED   23011926
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 1964)
  AUTHORS   Creutz,C.E., Liou,A., Snyder,S.L., Brownawell,A. and Willison,K.
  TITLE     Identification of the major chromaffin granule-binding protein,
            chromobindin A, as the cytosolic chaperonin CCT (chaperonin
            containing TCP-1)
  JOURNAL   J Biol Chem 269 (51), 32035-32038 (1994)
   PUBMED   7798195
REFERENCE   10 (bases 1 to 1964)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 2, 2021 this sequence version replaced NM_199091.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063178.1, SRR22399481.1582567.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000002.1  176063529-176063669
            142-203             JAXUCZ010000002.1  176065689-176065750
            204-254             JAXUCZ010000002.1  176067214-176067264
            255-317             JAXUCZ010000002.1  176067342-176067404
            318-414             JAXUCZ010000002.1  176069848-176069944
            415-532             JAXUCZ010000002.1  176071803-176071920
            533-719             JAXUCZ010000002.1  176075731-176075917
            720-869             JAXUCZ010000002.1  176078688-176078837
            870-1002            JAXUCZ010000002.1  176079677-176079809
            1003-1084           JAXUCZ010000002.1  176079984-176080065
            1085-1265           JAXUCZ010000002.1  176084686-176084866
            1266-1511           JAXUCZ010000002.1  176086830-176087075
            1512-1643           JAXUCZ010000002.1  176087420-176087551
            1644-1964           JAXUCZ010000002.1  176087860-176088180
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1964
                     /gene="Cct3"
                     /note="chaperonin containing TCP1 subunit 3"
                     /db_xref="GeneID:295230"
                     /db_xref="RGD:735038"
     exon            1..141
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1748
                     /gene="Cct3"
                     /note="CCT-gamma; TCP-1-gamma; chaperonin subunit 3
                     (gamma); chaperonin containing Tcp1, subunit 3 (gamma)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit gamma"
                     /protein_id="NP_954522.1"
                     /db_xref="GeneID:295230"
                     /db_xref="RGD:735038"
                     /translation="MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPK
                     SMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILA
                     GEMLSVAEHFLEQQMHPTVVISAYRMALDDMVSTLKKISTPVDVNNRDMMLNIINSSI
                     TTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGV
                     MINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQ
                     QLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSR
                     PEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQ
                     DAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRT
                     LIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKT
                     AVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE"
     exon            142..203
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..254
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            255..317
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..414
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..532
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            533..719
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..869
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1002
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1084
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1265
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1511
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1643
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1964
                     /gene="Cct3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtttctgt gtcagtcctg aggaggcagc gtttccttcg ctgctcttct ctccagaagg
       61 ttctgccgat ttcccccagc tctggaaagt cggctcttcg tcgtgccgcc atgatgggcc
      121 accgtccagt gctcgtgctc agtcagaata caaagcgtga gtctggaaga aaagttcaat
      181 ctggaaatat caatgctgca aagacaattg cagacatcat ccggacctgt ttgggaccta
      241 aatctatgat gaagatgctt ttggatccaa tgggaggcat cgtgatgacc aatgatggta
      301 atgccattct tcgagagatt caagtccagc atcccgcagc aaaatccatg attgaaatta
      361 gcaggaccca ggatgaagag gttggagatg ggaccacatc agtaattatt cttgctggag
      421 aaatgctgtc tgtggctgag cacttcctag agcagcagat gcacccaaca gtggtgatca
      481 gtgcttaccg catggcactg gatgatatgg tcagcactct gaagaaaatc agtacccctg
      541 ttgatgtcaa taaccgtgat atgatgttga acatcatcaa tagctctatt actacaaaag
      601 tcatcagtcg gtggtcctct ttggcatgca acattgcact ggatgctgtt aagactgttc
      661 agtttgaaga gaatggcaga aaggaaattg atatcaagaa gtatgcaagg gtggaaaaga
      721 tacccggggg catcattgaa gactcgtgtg tcttacgtgg agttatgatc aacaaggatg
      781 tgacccatcc aagaatgcgc cgctatatta agaatcctcg aattgttcta ctggattctt
      841 ctctggagta caagaaagga gaaagccaga ctgacattga gattacacga gaggaggatt
      901 tcacccgcat cctgcaaatg gaagaagagt acatccagca gttgtgtgag gatattatcc
      961 agctgaaacc tgacgtagtc atcacagaaa agggcatctc ggatttagct cagcactacc
     1021 tcatgcgggc caatgtcaca gccattcgta gagtccggaa aacagacaat aatcgcattg
     1081 ctagagcctg tggggcacgg atagtcagcc gacccgagga actgagagaa gatgatgttg
     1141 gtacaggagc aggcttattg gaaatcaaga agattggaga tgagtacttc acattcatca
     1201 ctgactgcaa agacccaaag gcctgcacca ttcttcttag aggagccagc aaagagatac
     1261 tatcggaagt agaacgcaac ctccaggatg ccatgcaagt gtgccgcaat gttctcctgg
     1321 accctcagct ggtgcctggt ggtggagcct ctgagatggc tgtggcccat gccttgacag
     1381 aaaaatctaa ggccatgact ggtgtggaac aatggccata tagggctgtg gcccaggctt
     1441 tagaggtcat ccctcggacc ttgatccaga actgtggggc cagtaccatt cgtctgctta
     1501 cctcccttcg ggccaagcac acacaggaga attgtgagac ctggggtgtg aatggtgaga
     1561 ctggtacctt agtggacatg aaagagctgg gtatttggga gccattggct gtgaagctac
     1621 aaacatacaa aacagcagtg gagactgcag ttctgcttct gcggattgat gacattgtct
     1681 ctggccacaa gaagaagggt gatgaccaga accggcaaac cggtgctcca gatgctggcc
     1741 aggagtgagt gctaagcaag gtgactgaac cacagaacca gcagtctccc ctttcctgag
     1801 ccagagttcc aggaacactg tggacatctt tgtttgcaaa ggatcaggtt gaggggcagc
     1861 ccccagtctg tcccatctcg gtttgcaaaa agcactgacg tgtatctctt ctgttgtaag
     1921 cttccattca gtttgcttcc agtgattaaa tctaagtcat ttga
//
