LOCUS       NM_001005905            1930 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus chaperonin containing TCP1 subunit 2 (Cct2),
            mRNA.
ACCESSION   NM_001005905 XM_216891
VERSION     NM_001005905.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Knee,K.M., Sergeeva,O.A. and King,J.A.
  TITLE     Human TRiC complex purified from HeLa cells contains all eight CCT
            subunits and is active in vitro
  JOURNAL   Cell Stress Chaperones 18 (2), 137-144 (2013)
   PUBMED   23011926
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
REFERENCE   8  (bases 1 to 1930)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   9  (bases 1 to 1930)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   10 (bases 1 to 1930)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083650.1.
            
            On Oct 23, 2004 this sequence version replaced XM_216891.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083650.1, SRR8487230.70765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1930
                     /gene="Cct2"
                     /note="chaperonin containing TCP1 subunit 2"
                     /db_xref="GeneID:299809"
                     /db_xref="RGD:1359143"
     exon            1..58
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1663
                     /gene="Cct2"
                     /note="CCT-beta; TCP-1-beta; chaperonin containing TCP1,
                     subunit 2 (beta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit beta"
                     /protein_id="NP_001005905.1"
                     /db_xref="GeneID:299809"
                     /db_xref="RGD:1359143"
                     /translation="MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLG
                     PKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSV
                     TVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFWQDLM
                     NIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGF
                     LLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMK
                     EKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIAST
                     FDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHD
                     ALCVLAQTVKDPRTVYGGGCSEMLMAHAVTMLASRTPGKEAVAMESFAKALRMLPTII
                     ADNAGYDSADLVAQLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAA
                     EAAEVILRVDNIIKAAPRKRVPDHHPC"
     exon            59..133
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..199
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..311
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..388
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..501
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..704
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..805
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..933
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1037
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1157
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1286
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1390
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1490
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1632
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1904
                     /gene="Cct2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcccgg cgcggcttgt gagggattat cctctactct gaattcgtcg gaaccatggc
       61 ctccctttcc cttgcacctg ttaatatctt caaggctgga gctgatgaag agagggcaga
      121 gacagctcgc ctgtcatcct ttattggtgc cattgccatt ggagacttgg tgaagagcac
      181 tttgggaccg aagggcatgg ataaaattct tctaagcagt ggacgggatg cctctctgat
      241 ggtgaccaat gacggtgcca ccattctcaa aaacatcggt gttgacaacc cagcagccaa
      301 agttctagtt gatatgtcaa gagttcagga tgatgaagtt ggtgacggca ccacctctgt
      361 tactgtctta gctgcagagc tactccggga agcggaatct ttaattgcaa aaaagatcca
      421 tccacagacc atcattgcgg gttggaggga agccacaaag gcagcaagag aggccctgct
      481 gagctcagct gtggatcatg gttctgatga agtcaaattc tggcaagatt taatgaatat
      541 tgcaggaaca acattatcct caaaactcct tactcaccac aaggaccact ttactaaatt
      601 agctgtagaa gctgtgctca gactgaaagg ctctggcaat ctggaggcga tccacgtcat
      661 caagaagcta ggtgggagcc tggcagactc ctaccttgat gaaggttttc tcttggataa
      721 aaaaattgga gtaaatcaac caaagagaat tgaaaatgct aaaattctta ttgcgaatac
      781 tggcatggat acagacaaaa taaagatatt tggctctcgg gtaagagttg attccacagc
      841 caaggttgca gagatagaac atgcagaaaa ggagaagatg aaggagaaag ttgaacgtat
      901 tcttaagcat ggaataaact gctttattaa cagacagtta atttataatt accctgaaca
      961 actcttcggt gctgctggcg tcatggctat tgagcatgca gattttgcag gtgtggaacg
     1021 cctagctctt gtcacaggtg gtgaaattgc ctctaccttt gatcatccag aacttgtgaa
     1081 gcttggaagt tgcaaactta ttgaagaagt tatgattggg gaagataaac tcattcactt
     1141 ttctggggtt gcccttggtg aggcttgtac cattgtactt cgtggtgcca ctcagcaaat
     1201 tttggatgag gctgaaagat ctctgcatga tgccctttgt gttcttgccc aaactgtaaa
     1261 agatcctaga acagtttatg gaggaggttg ttctgagatg ctgatggctc atgctgtgac
     1321 aatgcttgcc agtagaaccc caggaaaaga agccgtagca atggagtcat ttgctaaggc
     1381 cctgagaatg ttgccaacga tcatagctga caatgcaggc tatgacagtg cagatctggt
     1441 ggcacagctc cgagctgctc acagtgaagg ccgtataact gctggactgg atatgaagga
     1501 aggcagcatt ggtgatatgg cagtactggg tataaccgag agctttcaag tgaagcggca
     1561 ggttcttttg agtgcggcgg aagcagcaga ggtgattcta cgagtggaca acatcatcaa
     1621 agcggcacca aggaaacgtg tccctgatca ccacccctgt taagcattcc catttgctgt
     1681 tgaactctgg accagttcat agcaaagctg tatttgaaag acttcaccct ttaaagaaga
     1741 ctatggaatt gctgtgtcca tgacagcctt aagtttgaac atttagctga ccttctgtgt
     1801 taaacatggg tctaatttat ttgctatttc attttccata cagttcagtt gatttacagg
     1861 ttcatttctc atactgtgta ttaaaataaa aaatcagtta cttaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa
//
