LOCUS       NM_172329               2568 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 9 (Ccr9), mRNA.
ACCESSION   NM_172329
VERSION     NM_172329.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Narita,N., Morohashi,A., Tohyama,K., Takeuchi,T., Tagawa,Y.,
            Kondo,T. and Asahi,S.
  TITLE     Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C
            Motif Receptor 9 Antagonist, to Serum Albumins
  JOURNAL   Drug Metab Dispos 46 (3), 204-213 (2018)
   PUBMED   29269409
  REMARK    GeneRIF:
            N-{4-Chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2-
            yloxy)benzenesulfonamide (MLN3126) is an orally available chemokine
            C-C motif receptor 9 selective antagonist.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Xu,Z., Mei,F., Liu,H., Sun,C. and Zheng,Z.
  TITLE     C-C Motif Chemokine Receptor 9 Exacerbates Pressure
            Overload-Induced Cardiac Hypertrophy and Dysfunction
  JOURNAL   J Am Heart Assoc 5 (5), e003342 (2016)
   PUBMED   27146447
  REMARK    GeneRIF: In cardiomyoctes in vitro, CCR9 deficiency markedly
            inhibited Ang II-induced hypertrophic response, whereas CCR9
            overexpression clearly enhanced the response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Cao,X., Ma,J., Wu,G., Zhang,C., Wang,L., Dai,S. and Xu,W.
  TITLE     Thymus-expressed chemokine promotes survival of PC12 cells via PI3K
            pathway
  JOURNAL   Neurochem Int 60 (2), 163-169 (2012)
   PUBMED   21672573
  REMARK    GeneRIF: Through its receptor Ccr9, thymus-expressed chemokine TECK
            promotes survival of serum-deprived PC12 cells.
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Miles,A., Liaskou,E., Eksteen,B., Lalor,P.F. and Adams,D.H.
  TITLE     CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of
            lymphocytes to MAdCAM-1 under shear flow
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (5), G1257-G1267 (2008)
   PUBMED   18308860
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Uehara,S., Song,K., Farber,J.M. and Love,P.E.
  TITLE     Characterization of CCR9 expression and CCL25/thymus-expressed
            chemokine responsiveness during T cell development: CD3(high)CD69+
            thymocytes and gammadeltaTCR+ thymocytes preferentially respond to
            CCL25
  JOURNAL   J Immunol 168 (1), 134-142 (2002)
   PUBMED   11751956
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Norment,A.M., Bogatzki,L.Y., Gantner,B.N. and Bevan,M.J.
  TITLE     Murine CCR9, a chemokine receptor for thymus-expressed chemokine
            that is up-regulated following pre-TCR signaling
  JOURNAL   J Immunol 164 (2), 639-648 (2000)
   PUBMED   10623805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF458780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF458780.1, BC091115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2568
                     /gene="Ccr9"
                     /note="C-C motif chemokine receptor 9"
                     /db_xref="GeneID:282832"
                     /db_xref="RGD:628750"
     exon            1..80
                     /gene="Ccr9"
                     /inference="alignment:Splign:2.1.0"
     exon            81..125
                     /gene="Ccr9"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1214
                     /gene="Ccr9"
                     /note="chemokine (C-C motif) receptor 9"
                     /codon_start=1
                     /product="C-C chemokine receptor type 9"
                     /protein_id="NP_758832.1"
                     /db_xref="GeneID:282832"
                     /db_xref="RGD:628750"
                     /translation="MTPTEFTSLIPGMFDDYSYDSTASTDDYMNLNFSSFFCKKNNVR
                     QFASHFLPPLYWLVFVVGTVGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFLATLP
                     FWAIAAAGQWMFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIVQAMKAQVWRQK
                     RLLYSKMVCITIWVMAAVLCTPEILYSQISGESGIAICTMVYPKDKNAKLKSAVLILK
                     VTLGFFLPFMVMAFCYTIIIHTLVQAKKSSKHKALKVTITVLTVFIMSQFPYNCILVV
                     QAVDAYTMFISNCTISTNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKN
                     LGCISQAQWVSFTRREGSLKLSSMLLETTSGALSL"
     exon            126..2568
                     /gene="Ccr9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacccaca gaagcatact cattccagca gctgcagtgg tcttttcccc acagacccag
       61 gctctgcact tcccctcctg aagctgactg gcgtctgacc caccatgaca cccacagaat
      121 tcacaagcct tattcctggc atgtttgatg actacagcta tgattccact gcttccacag
      181 acgactacat gaatttgaac ttcagtagct tcttctgtaa gaaaaacaat gtaaggcagt
      241 ttgcgagtca tttccttccg cctctgtact ggcttgtgtt cgttgtgggt actgtgggca
      301 acagcctggt catccttgtc tactggtact gcacaagagt gaagacaatg accgacatgt
      361 tccttttgaa tttggccatt gctgatctgc tctttcttgc cactcttccc ttctgggcca
      421 ttgctgctgc tggtcagtgg atgttccaga ccttcatgtg caaggttgtg aacagcatgt
      481 acaagatgaa cttctacagc tgtgtgctac tcatcatgtg catcagtgtg gacagataca
      541 ttgccattgt acaggccatg aaggctcagg tctggaggca gaaaaggctg ctgtacagca
      601 agatggtctg cattaccatc tgggtgatgg cagctgtgct ctgcacccca gaaatcctgt
      661 acagtcaaat cagtggggaa tctggcattg ccatatgtac catggtctac cctaaggata
      721 agaatgccaa gctaaagtct gctgttttga tcctgaaggt caccttgggg tttttcctcc
      781 ccttcatggt catggctttc tgttacacca tcatcattca tactttggta caggccaaga
      841 agtcatccaa gcacaaggcc ctcaaggtga ccatcactgt tctcactgtc ttcattatgt
      901 ctcagttccc ctacaattgc attctggtag tgcaggctgt tgatgcctac accatgttca
      961 tctccaactg caccatttcc accaacattg acatctgctt ccaggttact cagactattg
     1021 cattcttcca cagttgcctg aacccagttc tctatgtttt cgtgggtgag agattccgca
     1081 gggatctggt aaagaccctg aagaacctgg gatgcattag ccaggcccag tgggtttcat
     1141 tcacaaggag agagggtagc ttgaagcttt cttctatgct actggagaca acttctggag
     1201 ctctctccct gtgagagaac ttctcactgg gcatatggtc ctttttggaa ataatgagat
     1261 atatagacac agcataatct aaagagacag caaacagaaa gaaaacgggg ggaggcggct
     1321 gggggaggca ggaaaaaaca aaacaaacaa ctggaatgaa cctaaacaac tttatcaagt
     1381 tcagttagaa tctaccaaaa gtttccaaaa ctgaccaccc cagaacggca ccagctggtt
     1441 tttggtcaca gtaactgtag ttctgaggag gatacttgag cagcagtgag gacactccag
     1501 ctttgcacag gctgatcatc agtgcagcta ggttttggag gcattgagtt tcttcagtgc
     1561 tccaagtttc tgttacttca gatctggtgc tactcctctc cagaggtgac agagtactgg
     1621 ctgccaccat accccctttc cccccaccaa aagcttagtg acatccacct caggatcttt
     1681 tctttatact cctactggtg gaaagactgt gtttgtatgt ctcattacct atagttttgt
     1741 ttttgttttt gtttttgttt ttaaatctag aacacactga aacattctga ggctgaatgc
     1801 cattctgatc tccttggtct cttctgagcc agggagaatc actgttcctc gtttgaacca
     1861 tctgtaaggt tggtcagtcc atgtatagct gaccacatca cattacctgg attcttgctc
     1921 ccagtccact tctgtgtcag gcagaagatg ccatgtccaa acctcactgc aagcacaaac
     1981 taggaaagga tctagcctgt tcctgggtgt ggtgaaagtg gccctcacag aattaagccg
     2041 gagaatatgt tgggatggtg gggacctagc ctttgggact tccttaggga agaggcactt
     2101 gctgccggtt ttcccatctt cttcttacca gtgaacttct gaggctcccg gaagggtgtc
     2161 tgcctccctg ctgcctcccc tttccctact ttgtagtctt gacagtttac aaccttttaa
     2221 tgttagatta agaagaatgg gtgggttggg catgatagtg tacacctttt atcccagcag
     2281 aggcagggtg atctctgtga gttggaggcc agcctggtct acagatggag tccaggagat
     2341 tcggggctgc ttatgcagag aaatctcatc atgaaaaaca aacaaacaaa aagtaaaaaa
     2401 agggttgaaa agatggctca atggttaaga gcactgactg ctcttcccga ggtccagggt
     2461 tcaattccca acacctacat ggcagctcac aactgtctgt aacttcagtt gcagaggatc
     2521 tgatactctc acacagacac acatgcaggc aaagcaccaa tgcacatg
//
