LOCUS       NM_199489               1215 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 7 (Ccr7), mRNA.
ACCESSION   NM_199489 XM_213486
VERSION     NM_199489.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Wurm S, Steege A, Rom-Jurek EM, van Roeyen CR, Kurtz A, Banas B and
            Banas MC.
  TITLE     CCR7 Is Important for Mesangial Cell Physiology and Repair
  JOURNAL   J Histochem Cytochem 66 (1), 7-22 (2018)
   PUBMED   29077526
  REMARK    GeneRIF: This study shows induction of renal CCR7 expression in the
            Model of Anti-Thy1.1 Mesangioproliferative Glomerulonephritis in
            rat.
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Ma T, Luan SL, Huang H, Sun XK, Yang YM, Zhang H, Han WD, Li H and
            Han Y.
  TITLE     Upregulation of CC Chemokine Receptor 7 (CCR7) Enables Migration of
            Xenogeneic Human Adipose-Derived Mesenchymal Stem Cells to Rat
            Secondary Lymphoid Organs
  JOURNAL   Med Sci Monit 22, 5206-5217 (2016)
   PUBMED   28035134
  REMARK    GeneRIF: These results suggest that upregulation of rat CCR7
            expression does not change the phenotype, differentiation, or
            proliferation capacity of human adipose-derived stem cells (hASCs),
            but does enable efficient migration of hASCs to rat secondary
            lymphoid organs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Zhang W, Tu G, Lv C, Long J, Cong L and Han Y.
  TITLE     Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7
            interaction via PI3K/Akt pathway and is involved in CCL19-driven
            BMSCs migration
  JOURNAL   Biochem Biophys Res Commun 451 (2), 222-228 (2014)
   PUBMED   25086360
  REMARK    GeneRIF: CCL19/CCR7 contributes to the migration of bone marrow
            mesenchymal stem cells by upregulating MMP9 potentially via the
            PI3K/Akt pathway.
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Nakamura K, White AJ, Parnell SM, Lane PJ, Jenkinson EJ, Jenkinson
            WE and Anderson G.
  TITLE     Differential requirement for CCR4 in the maintenance but not
            establishment of the invariant Vgamma5(+) dendritic epidermal
            T-cell pool
  JOURNAL   PLoS One 8 (9), e74019 (2013)
   PUBMED   24069263
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF and
            Yen JJ.
  TITLE     CBAP functions as a novel component in chemokine-induced
            ZAP70-mediated T-cell adhesion and migration
  JOURNAL   PLoS One 8 (4), e61761 (2013)
   PUBMED   23620790
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Debes GF, Bonhagen K, Wolff T, Kretschmer U, Krautwald S, Kamradt T
            and Hamann A.
  TITLE     CC chemokine receptor 7 expression by effector/memory CD4+ T cells
            depends on antigen specificity and tissue localization during
            influenza A virus infection
  JOURNAL   J Virol 78 (14), 7528-7535 (2004)
   PUBMED   15220427
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Gibejova A, Mrazek F, Subrtova D, Sekerova V, Szotkowska J, Kolek
            V, du Bois RM and Petrek M.
  TITLE     Expression of macrophage inflammatory protein-3 beta/CCL19 in
            pulmonary sarcoidosis
  JOURNAL   Am J Respir Crit Care Med 167 (12), 1695-1703 (2003)
   PUBMED   12626344
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Bouchon A, Hernandez-Munain C, Cella M and Colonna M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf
            E and Lipp M.
  TITLE     CCR7 coordinates the primary immune response by establishing
            functional microenvironments in secondary lymphoid organs
  JOURNAL   Cell 99 (1), 23-33 (1999)
   PUBMED   10520991
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T and Yoshie O.
  TITLE     Secondary lymphoid-tissue chemokine is a functional ligand for the
            CC chemokine receptor CCR7
  JOURNAL   J Biol Chem 273 (12), 7118-7122 (1998)
   PUBMED   9507024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY379972.1.
            
            On Aug 30, 2012 this sequence version replaced NM_199489.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY379972.1, BC089762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1215              AY379972.1         4-1218
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1215
                     /gene="Ccr7"
                     /note="C-C motif chemokine receptor 7"
                     /db_xref="GeneID:287673"
                     /db_xref="RGD:735151"
     exon            1..88
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1215
                     /gene="Ccr7"
                     /note="C-C chemokine receptor type 7; chemokine (C-C
                     motif) receptor 7"
                     /codon_start=1
                     /product="C-C chemokine receptor type 7 precursor"
                     /protein_id="NP_955783.1"
                     /db_xref="GeneID:287673"
                     /db_xref="RGD:735151"
                     /translation="MDLGKPTKNVLVVALLVIFQVCFCQDEVTDDYIGENTTVDYTLY
                     ESVCFKKDVRNFKAWFLPLMYSVICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAV
                     ADILFLMILPFWAYSEAKSWIFGAYLCKSIFGIYKLSFFSGMLLLLCISIDRYVAIVQ
                     AVSAHRHRARVLLISKLSCIGIWTLAFFLSIPELLYSGLQKNSGEDTWRCSLVSAQVE
                     ALIAIQVAQMVVGFVLPMLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFVVFQ
                     LPYNGVVLAQTVANFNITNSSCEASKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFR
                     SDLFKLFKDLGCLSQERLRQWSSCRHVRHTSVSMEAETTTTFSP"
     exon            89..138
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
     exon            139..1215
                     /gene="Ccr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaggggt aactggagac agagacaaga gacacaagcc gagccttcct gtgtgacttc
       61 aactgcccag agagcatcat ggacctgggg aagcccacga aaaacgtgct ggtggtggct
      121 ctcctggtca ttttccaggt gtgcttctgc caagatgagg tcacagacga ctacatcggc
      181 gagaacacca ccgtggacta caccctgtat gagtcggtgt gcttcaagaa ggatgtgcgg
      241 aactttaagg cctggttcct ccctctcatg tactcagtca tttgcttcgt gggcctgcta
      301 ggcaatgggc tggtggtgct gacatacatc tatttcaaga gactgaagac catgacggat
      361 acctacctgc tcaacctggc cgtggcagac atcctcttcc tcatgatcct tcccttctgg
      421 gcctacagcg aagccaagtc ctggatcttt ggtgcctacc tgtgtaagag catctttggc
      481 atctacaagt taagcttctt cagcgggatg ttgctgctcc tgtgtatcag cattgaccgc
      541 tatgtggcca tcgtccaggc cgtgtcagcc caccggcacc gcgcccgcgt gcttctcatc
      601 agcaagctgt cctgtatagg catctggacg ctggcctttt tcctttctat ccctgagctg
      661 ctctacagcg gcctccagaa gaacagcggc gaggacacgt ggagatgctc cctggtcagt
      721 gcccaagtgg aggccttgat cgccatccaa gtggcccaga tggttgttgg gtttgtactg
      781 cctatgctgg ctatgagttt ctgctacctg gttatcatcc gcactctgct ccaggcgcga
      841 aacttcgagc ggaacaaggc catcaaggtg atcatcgctg tggtcgtagt gttcgtcgtc
      901 ttccagctgc cctacaatgg ggtggtcctg gcccagaccg tggccaattt caacatcacc
      961 aatagcagct gcgaagccag caagcagctc aacattgcct atgacgtcac ctacagcctg
     1021 gcctccgtcc gctgctgtgt caaccctttc ttgtatgcct tcatcggcgt caagttccgc
     1081 agcgacctct tcaagctctt caaggacttg ggctgcctca gccaggaacg gctccggcag
     1141 tggtcttcct gccgccatgt acggcacacg tccgtgagca tggaggcgga gactaccacc
     1201 accttctccc cgtag
//
