LOCUS       NM_001013145            1500 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 6 (Ccr6), mRNA.
ACCESSION   NM_001013145 XM_217862
VERSION     NM_001013145.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Reboldi,A., Arnon,T.I., Rodda,L.B., Atakilit,A., Sheppard,D. and
            Cyster,J.G.
  TITLE     IgA production requires B cell interaction with subepithelial
            dendritic cells in Peyer's patches
  JOURNAL   Science 352 (6287), aaf4822 (2016)
   PUBMED   27174992
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Zhang,Y., Liu,L., Wang,S., Zhao,Y., Liu,Y., Li,J., Nie,L. and
            Cheng,L.
  TITLE     Production of CCL20 on nucleus pulposus cells recruits
            IL-17-producing cells to degenerated IVD tissues in rat models
  JOURNAL   J Mol Histol 47 (1), 81-89 (2016)
   PUBMED   26704184
  REMARK    GeneRIF: The results suggest a potential mechanism for the
            recruitment of IL-17-producing cells to degenerated intervertebral
            discs via a CCL20/CCR6 axis in vivo.
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Bunting,M.D., Comerford,I., Kara,E.E., Korner,H. and McColl,S.R.
  TITLE     CCR6 supports migration and differentiation of a subset of DN1
            early thymocyte progenitors but is not required for thymic nTreg
            development
  JOURNAL   Immunol Cell Biol 92 (6), 489-498 (2014)
   PUBMED   24638065
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Caballero-Campo,P., Buffone,M.G., Benencia,F., Conejo-Garcia,J.R.,
            Rinaudo,P.F. and Gerton,G.L.
  TITLE     A role for the chemokine receptor CCR6 in mammalian sperm motility
            and chemotaxis
  JOURNAL   J Cell Physiol 229 (1), 68-78 (2014)
   PUBMED   23765988
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Manthey,H.D., Cochain,C., Barnsteiner,S., Karshovska,E.,
            Pelisek,J., Koch,M., Chaudhari,S.M., Busch,M., Eckstein,H.H.,
            Weber,C., Koenen,R.R. and Zernecke,A.
  TITLE     CCR6 selectively promotes monocyte mediated inflammation and
            atherogenesis in mice
  JOURNAL   Thromb Haemost 110 (6), 1267-1277 (2013)
   PUBMED   24114205
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Shirane,J., Nakayama,T., Nagakubo,D., Izawa,D., Hieshima,K.,
            Shimomura,Y. and Yoshie,O.
  TITLE     Corneal epithelial cells and stromal keratocytes efficently produce
            CC chemokine-ligand 20 (CCL20) and attract cells expressing its
            receptor CCR6 in mouse herpetic stromal keratitis
  JOURNAL   Curr Eye Res 28 (5), 297-306 (2004)
   PUBMED   15287366
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Kobayashi,H., Miura,S., Nagata,H., Tsuzuki,Y., Hokari,R., Ogino,T.,
            Watanabe,C., Azuma,T. and Ishii,H.
  TITLE     In situ demonstration of dendritic cell migration from rat
            intestine to mesenteric lymph nodes: relationships to maturation
            and role of chemokines
  JOURNAL   J Leukoc Biol 75 (3), 434-442 (2004)
   PUBMED   14673014
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Ai,L.S. and Liao,F.
  TITLE     Mutating the four extracellular cysteines in the chemokine receptor
            CCR6 reveals their differing roles in receptor trafficking, ligand
            binding, and signaling
  JOURNAL   Biochemistry 41 (26), 8332-8341 (2002)
   PUBMED   12081481
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Homey,B., Dieu-Nosjean,M.C., Wiesenborn,A., Massacrier,C.,
            Pin,J.J., Oldham,E., Catron,D., Buchanan,M.E., Muller,A., deWaal
            Malefyt,R., Deng,G., Orozco,R., Ruzicka,T., Lehmann,P.,
            Lebecque,S., Caux,C. and Zlotnik,A.
  TITLE     Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and
            CC chemokine receptor 6 in psoriasis
  JOURNAL   J Immunol 164 (12), 6621-6632 (2000)
   PUBMED   10843722
REFERENCE   10 (bases 1 to 1500)
  AUTHORS   McTigue,D.M., Tani,M., Krivacic,K., Chernosky,A., Kelner,G.S.,
            Maciejewski,D., Maki,R., Ransohoff,R.M. and Stokes,B.T.
  TITLE     Selective chemokine mRNA accumulation in the rat spinal cord after
            contusion injury
  JOURNAL   J Neurosci Res 53 (3), 368-376 (1998)
   PUBMED   9698165
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091197.1.
            
            On Apr 20, 2005 this sequence version replaced XM_217862.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091197.1, CO567771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680419
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1500
                     /gene="Ccr6"
                     /note="C-C motif chemokine receptor 6"
                     /db_xref="GeneID:308163"
                     /db_xref="RGD:1308562"
     exon            1..259
                     /gene="Ccr6"
                     /inference="alignment:Splign:2.1.0"
     exon            260..1478
                     /gene="Ccr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1366
                     /gene="Ccr6"
                     /note="CC chemokine receptor 6; chemokine (C-C motif)
                     receptor 6"
                     /codon_start=1
                     /product="C-C chemokine receptor type 6"
                     /protein_id="NP_001013163.1"
                     /db_xref="GeneID:308163"
                     /db_xref="RGD:1308562"
                     /translation="MNFTEANYGMEDYTGSDYSMFPETEPCSLQEVRDFTKVFVPIAY
                     SLICVFGLLGNIMVVITFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATDTW
                     IFGNTMCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATKSFRVRSRTLTHSKVICL
                     TVWFVSIIISSPTFFFNKQYKLQGRDVCEPQYKLVSEPITWKLLGMGLELLFGFFIPL
                     LFMVFCYLFIIKTLVQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAANTGKMG
                     RSCSAEKALAYARNVAEVLAFLHCCLNPVLYAFIGQKFRSYFMKIMKDVWCMRRKSKV
                     PTFFCARVYSESYISRQTSETVENDNASSFTM"
ORIGIN      
        1 gaagacagaa cacttgtggt aagacaccca cccccgggag ggcgaagaac aagccacaca
       61 ctgctttgaa gagtccagcc ccaagcagaa ctgcaagggc agacactgtt ctggccacct
      121 gcagtttgaa gtcatcactt tcaatccccc tgtgactagg gtcagggtct tcacacctgc
      181 gagaggaagc aaagatctaa gcaatctgaa ttttaagaga gaaactgcag ctgttggttt
      241 gtgggccgga acattattgg aaacgatgaa tttcaccgag gccaactacg gaatggaaga
      301 ttatactggc tcagattact ctatgtttcc agagaccgag ccatgctctc tgcaagaggt
      361 cagagacttc accaaggtgt tcgtgccaat cgcctactcc ttaatctgtg tctttggcct
      421 ccttggcaat attatggtgg tgataacctt tgccttctac aagaaagcca ggtccatgac
      481 tgacgtctac ctattgaaca tggccatcac agacatactc tttgtcctca ccctaccatt
      541 ctgggcagtt actcatgcca ctgacacttg gatctttggc aacacgatgt gtaaactgat
      601 gaaaggcacg tatgcggtca actttaactg tgggatgctg ctcctggcct gtatcagcat
      661 ggaccggtac attgccatcg tccaggcgac caaatctttc cgggtacgct ccagaacact
      721 gacgcacagt aaggtcatct gtctgacggt gtggttcgtt tccatcatca tctcaagccc
      781 cacattcttc ttcaacaagc aatacaagct gcagggccgt gatgtctgcg agcctcagta
      841 caagctcgtc tcggagccca tcacgtggaa actgctgggc atgggactcg agctgctctt
      901 tggcttcttc atccctttgc tgtttatggt gttctgttac ctgttcatca tcaagacctt
      961 ggtgcaggcc cagaattcca agaggcacag agccatccga gtcgtgattg ctgtggttct
     1021 cgtgttcctg gcttgtcaga tccctcacaa catggtcctc ctcgtgactg cagccaacac
     1081 gggcaaaatg ggccgcagct gcagcgccga gaaagccctc gcctacgcca ggaatgtggc
     1141 tgaggtcctg gctttcctgc actgctgtct caaccccgtg ttgtatgcct tcattggaca
     1201 gaaattcaga agctacttca tgaagatcat gaaggatgtg tggtgtatga ggaggaagag
     1261 caaggtgcct accttcttct gtgcccgggt ttactcagaa agctacatct ccaggcagac
     1321 cagtgagact gtagaaaatg acaacgcatc gtcctttacc atgtaacacg agagcacaaa
     1381 gcagcatgcc ccgaaagcct ttgtgaaact tgctattaca tgtgaaaaaa taaaaaagag
     1441 agagaaaaag agagaaaaaa aaaagaaagt aaaagaaaaa aaaaaaaaaa aaaaaaaaaa
//
