LOCUS       NM_053960               2495 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 5 (Ccr5), mRNA.
ACCESSION   NM_053960
VERSION     NM_053960.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Miao,H., Li,X., Zhou,C., Liang,Y., Li,D. and Ji,Q.
  TITLE     NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats
            by transcriptionally suppressing CCR5 and inducing M2 polarization
            of macrophages
  JOURNAL   Microvasc Res 140, 104279 (2022)
   PUBMED   34774582
  REMARK    GeneRIF: NR4A2 alleviates cardiomyocyte loss and myocardial injury
            in rats by transcriptionally suppressing CCR5 and inducing M2
            polarization of macrophages.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Singh,S., Bruder-Nascimento,A., Belin de Chantemele,E.J. and
            Bruder-Nascimento,T.
  TITLE     CCR5 antagonist treatment inhibits vascular injury by regulating
            NADPH oxidase 1
  JOURNAL   Biochem Pharmacol 195, 114859 (2022)
   PUBMED   34843718
  REMARK    GeneRIF: CCR5 antagonist treatment inhibits vascular injury by
            regulating NADPH oxidase 1.
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Chen,C., Chu,S.F., Ai,Q.D., Zhang,Z. and Chen,N.H.
  TITLE     CKLF1/CCR5 axis is involved in neutrophils migration of rats with
            transient cerebral ischemia
  JOURNAL   Int Immunopharmacol 85, 106577 (2020)
   PUBMED   32446198
  REMARK    GeneRIF: CKLF1/CCR5 axis is involved in neutrophils migration of
            rats with transient cerebral ischemia.
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Gao,R., Fang,Q., Zhang,X., Xu,Q., Ye,H., Guo,W., He,J., Chen,Y.,
            Wang,R., Wu,Z. and Yu,J.
  TITLE     R5 HIV-1 gp120 Activates p38 MAPK to Induce Rat Cardiomyocyte
            Injury by the CCR5 Coreceptor
  JOURNAL   Pathobiology 86 (5-6), 274-284 (2019)
   PUBMED   31574524
  REMARK    GeneRIF: R5 HIV-1 gp120 activated p38 MAPK to trigger myocardial
            cell injury by the CCR5 coreceptor.
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Zhang,C., He,Y., Shan,K.R., Tan,K., Zhang,T., Wang,C.J. and
            Guan,Z.Z.
  TITLE     Correlations between polymorphisms in the uridine
            diphosphate-glucuronosyltransferase 1A and C-C motif chemokine
            receptor 5 genes and infection with the hepatitis B virus in three
            ethnic groups in China
  JOURNAL   J Int Med Res 46 (2), 739-751 (2018)
   PUBMED   29239247
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Xia,M.Q., Qin,S.X., Wu,L.J., Mackay,C.R. and Hyman,B.T.
  TITLE     Immunohistochemical study of the beta-chemokine receptors CCR3 and
            CCR5 and their ligands in normal and Alzheimer's disease brains
  JOURNAL   Am J Pathol 153 (1), 31-37 (1998)
   PUBMED   9665462
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   Jiang,Y., Salafranca,M.N., Adhikari,S., Xia,Y., Feng,L.,
            Sonntag,M.K., deFiebre,C.M., Pennell,N.A., Streit,W.J. and
            Harrison,J.K.
  TITLE     Chemokine receptor expression in cultured glia and rat experimental
            allergic encephalomyelitis
  JOURNAL   J Neuroimmunol 86 (1), 1-12 (1998)
   PUBMED   9655467
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Combadiere,C., Ahuja,S.K., Tiffany,H.L. and Murphy,P.M.
  TITLE     Cloning and functional expression of CC CKR5, a human monocyte CC
            chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and
            RANTES
  JOURNAL   J Leukoc Biol 60 (1), 147-152 (1996)
   PUBMED   8699119
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y12009.1 and BC078756.1.
            
            On Nov 23, 2005 this sequence version replaced NM_053960.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               Y12009.1           11-155
            146-2495            BC078756.1         81-2430
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2495
                     /gene="Ccr5"
                     /gene_synonym="Ckr5; Cmkbr5"
                     /note="C-C motif chemokine receptor 5"
                     /db_xref="GeneID:117029"
                     /db_xref="RGD:620596"
     exon            1..62
                     /gene="Ccr5"
                     /gene_synonym="Ckr5; Cmkbr5"
                     /inference="alignment:Splign:2.1.0"
     exon            63..2480
                     /gene="Ccr5"
                     /gene_synonym="Ckr5; Cmkbr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1138
                     /gene="Ccr5"
                     /gene_synonym="Ckr5; Cmkbr5"
                     /note="CCR-5; CC-CKR-5; C-C CKR-5; MIP-1 alpha receptor;
                     chemokine (C-C) receptor 5; chemokine (C-C motif) receptor
                     5"
                     /codon_start=1
                     /product="C-C chemokine receptor type 5"
                     /protein_id="NP_446412.2"
                     /db_xref="GeneID:117029"
                     /db_xref="RGD:620596"
                     /translation="MDFQGSIPTYIYDIDYSMSAPCQKFNVKQIAAQLLPPLYSLVFI
                     FGFVGNMMVFLILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWVFGNIM
                     CKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVFAIKARTVNFGVITSVVTWVVAVF
                     VSLPEIIFMRSQKEGSHYTCSPHFPRIQYRFWKHFQTLKMVILSLILPLLVMVICYSG
                     ILNTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFGLNNCSSSNR
                     LDQAMQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFQQVNP
                     DRVSSVYTRSTGEQEVSTGL"
ORIGIN      
        1 gatttgtact gctctcctag caagagaagg tgagacatcc gttccctcta caagaaactc
       61 tggctcttgc aggatggatt ttcaagggtc gattccaacc tatatctatg acatcgatta
      121 tagtatgtca gcaccctgcc aaaaattcaa tgtgaaacaa attgcagccc agctcctgcc
      181 cccactctac tctctggtat tcatctttgg ttttgtgggt aacatgatgg tcttcctcat
      241 cctgataagc tgcaaaaagc tgaagagcat gactgatatc tacctgttca acctggccat
      301 ctctgacctg ctcttcctgc tcacactccc attctgggct cactatgctg caaatgagtg
      361 ggtctttggg aatataatgt gcaaattatt cacagggatc tatcacattg gttattttgg
      421 tggaatcttc ttcattatcc tcctgacaat tgataggtac ttggctattg tccatgctgt
      481 gtttgctata aaagccagaa cagtcaactt tggggtaata acaagtgtag tcacttgggt
      541 ggtggctgtg tttgtctctc tcccagaaat aatctttatg agatctcaaa aagaaggttc
      601 tcattataca tgcagtcctc attttccacg tattcaatat cgtttctgga agcattttca
      661 aacattaaag atggtcatct tgagcctgat cctaccccta cttgtcatgg tcatctgcta
      721 ttcaggaatc ctcaacaccc tgtttcgctg taggaatgag aagaagaggc acagggctgt
      781 aaggctcatc tttgccatca tgattgtcta ctttctcttc tggactccct acaacattgt
      841 cctcctcctg accaccttcc aggaatactt tggactgaat aattgcagta gttctaatag
      901 actagaccag gcaatgcagg tgacagagac tcttgggatg acacactgct gcctcaaccc
      961 tgtcatctat gcctttgttg gggagaagtt ccggaattat ctctctgtgt tcttccgaaa
     1021 acacattgtc aaacgcttct gcaaacactg ttcaattttc cagcaagtca atcctgatcg
     1081 tgtaagctca gtctataccc ggtccacagg agaacaggaa gtttctactg gtttatgagc
     1141 taggttgagt tttgtgtatc acttagtttt tttatgtagc ttgagggtag agatggttct
     1201 tttagaaaag aaattaatat agagggccta aggtacgtgc attgttttaa tatttatttg
     1261 agatagattg ggtctttgaa agctgagtag ttttataaac gtgaatgaga atgtattgat
     1321 gagacagtaa tttctggctt cattcctatt taactacaat tattgccaaa ctcttcttta
     1381 gccacaaaag ttcactatta aaaaatactg agcattggga tttttttttt tagagcttga
     1441 gtatctgacc aaaaataaca tcattttttc cctatataaa gcaaaattca ggctacttaa
     1501 atcaggtctt tgtcttgccc tgagaagaaa ggatgagacc atgactagtt agggaataga
     1561 taaccaagct atatgaattg ctttatagac ttgtatgatc agtaagtgct ctgtggcctg
     1621 agaaggctgg gaacaagtct ttataaaaag agatttgaac tggatccttg ttagtaaatg
     1681 agagggaagc cattctctgg gtggtatggc tatatgagtg aagcaagggt agagctgtga
     1741 ctagttgaag aggacatgaa gagaatggtc aaggccgaat cctaaggcat catatcagca
     1801 ttgcttcttc agagttatga gcatggtggg gagcacctag acaggtttgt acaaagcttg
     1861 tttcatggct aagaaagtct ggcaatggtg agcattgagg gctagtaagt cagcagtaat
     1921 aaggttagga tgaaatcatg tcacctgggc taggcagagg agaatgttag aagaacaaat
     1981 tacatcatgc agcatgtagg tctcatgtgg gaggtttact gggaggagga gacagaagta
     2041 gattgttgtg aagtcaattc tagctgtcca cggatgtgct tgattgctaa cagggaagaa
     2101 ccacttctgc acataaaata tagagtcagc agaacttggg ataaattgca gttaaaggtg
     2161 aacaagaacc cctaggctta attaggttgg aataaccatt gaggaaacaa caaatacaaa
     2221 gtgagaataa aggaaagagc ttgtcctagg aagatggtct cattttgcag cctgaatata
     2281 atgtctcagg ctgtcatttt gttcctgcat tcagatgtaa atcctaccgt accagctttg
     2341 atcctgaagg gtcaccaggg ggctgtgaaa tacctggatt aagaatcatg agcctggggg
     2401 ttggggactt agctcagtgg tagagcgctt gcctagcaag cgcaaggccc tgggttcggt
     2461 ccccagctcc gaaaaaaaaa aaaaaaaaaa aaaaa
//
