LOCUS       NM_133532               1873 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), mRNA.
ACCESSION   NM_133532
VERSION     NM_133532.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Zhao,M., Li,Y., Wei,X., Zhang,Q., Jia,H., Quan,S., Cao,D., Wang,L.,
            Yang,T., Zhao,J., Pei,M., Tian,S., Yu,Y., Guo,Y. and Yang,X.
  TITLE     Negative immune factors might predominate local tumor immune status
            and promote carcinogenesis in cervical carcinoma
  JOURNAL   Virol J 14 (1), 5 (2017)
   PUBMED   28086903
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Zhebrun,D.A., Totolyan,A.A., Maslyanskii,A.L., Titov,A.G.,
            Patrukhin,A.P., Kostareva,A.A. and Gol'tseva,I.S.
  TITLE     Synthesis of some CC chemokines and their receptors in the synovium
            in rheumatoid arthritis
  JOURNAL   Bull Exp Biol Med 158 (2), 192-196 (2014)
   PUBMED   25430645
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Nakamura,K., White,A.J., Parnell,S.M., Lane,P.J., Jenkinson,E.J.,
            Jenkinson,W.E. and Anderson,G.
  TITLE     Differential requirement for CCR4 in the maintenance but not
            establishment of the invariant Vgamma5(+) dendritic epidermal
            T-cell pool
  JOURNAL   PLoS One 8 (9), e74019 (2013)
   PUBMED   24069263
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Gehad,A., Al-Banna,N.A., Vaci,M., Issekutz,A.C., Mohan,K., Latta,M.
            and Issekutz,T.B.
  TITLE     Differing requirements for CCR4, E-selectin, and alpha4beta1 for
            the migration of memory CD4 and activated T cells to dermal
            inflammation
  JOURNAL   J Immunol 189 (1), 337-346 (2012)
   PUBMED   22664869
  REMARK    GeneRIF: There is no strict relationship between CCR4 and
            E-selectin for skin homing of CD4 cells, because activation state
            and inflammatory stimulus are the critical determinants.
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Flytlie,H.A., Hvid,M., Lindgreen,E., Kofod-Olsen,E., Petersen,E.L.,
            Jorgensen,A., Deleuran,M., Vestergaard,C. and Deleuran,B.
  TITLE     Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid
            arthritis, psoriatic arthritis and osteoarthritis
  JOURNAL   Cytokine 49 (1), 24-29 (2010)
   PUBMED   19942450
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Wu,Z., Toh,K., Nagata,K., Kukita,T. and Iijima,T.
  TITLE     Effect of the resection of the sciatic nerve on the Th1/Th2 balance
            in the synovia of the ankle joint of adjuvant arthritic rats
  JOURNAL   Histochem Cell Biol 121 (2), 141-147 (2004)
   PUBMED   14727120
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   Sun,Y.X., Wang,J., Shelburne,C.E., Lopatin,D.E., Chinnaiyan,A.M.,
            Rubin,M.A., Pienta,K.J. and Taichman,R.S.
  TITLE     Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers
            (PCa) in vivo
  JOURNAL   J Cell Biochem 89 (3), 462-473 (2003)
   PUBMED   12761880
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Garcia,G.E., Xia,Y., Harrison,J., Wilson,C.B., Johnson,R.J.,
            Bacon,K.B. and Feng,L.
  TITLE     Mononuclear cell-infiltrate inhibition by blocking
            macrophage-derived chemokine results in attenuation of developing
            crescentic glomerulonephritis
  JOURNAL   Am J Pathol 162 (4), 1061-1073 (2003)
   PUBMED   12651599
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Oh,S.B., Tran,P.B., Gillard,S.E., Hurley,R.W., Hammond,D.L. and
            Miller,R.J.
  TITLE     Chemokines and glycoprotein120 produce pain hypersensitivity by
            directly exciting primary nociceptive neurons
  JOURNAL   J Neurosci 21 (14), 5027-5035 (2001)
   PUBMED   11438578
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Chvatchko,Y., Hoogewerf,A.J., Meyer,A., Alouani,S., Juillard,P.,
            Buser,R., Conquet,F., Proudfoot,A.E., Wells,T.N. and Power,C.A.
  TITLE     A key role for CC chemokine receptor 4 in
            lipopolysaccharide-induced endotoxic shock
  JOURNAL   J Exp Med 191 (10), 1755-1764 (2000)
   PUBMED   10811868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 23, 2022 this sequence version replaced NM_133532.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.35813.1,
                                           SRR26643290.31112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000008.1  123060198-123060244 c
            48-1873             JAXUCZ010000008.1  123054505-123056330 c
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1873
                     /gene="Ccr4"
                     /gene_synonym="Cmkbr4"
                     /note="C-C motif chemokine receptor 4"
                     /db_xref="GeneID:171054"
                     /db_xref="RGD:620594"
     exon            1..47
                     /gene="Ccr4"
                     /gene_synonym="Cmkbr4"
                     /inference="alignment:Splign:2.1.0"
     exon            48..1873
                     /gene="Ccr4"
                     /gene_synonym="Cmkbr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1190
                     /gene="Ccr4"
                     /gene_synonym="Cmkbr4"
                     /EC_number="3.1.13.4"
                     /note="C-C chemokine receptor 4; chemokine (C-C) receptor
                     4; chemokine (C-C motif) receptor 4"
                     /codon_start=1
                     /product="C-C chemokine receptor type 4"
                     /protein_id="NP_598216.3"
                     /db_xref="GeneID:171054"
                     /db_xref="RGD:620594"
                     /translation="MNATDVTDTTQDEAAYNSYYFDESLPKPCTKEGIKAFGEVFLPP
                     LYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQ
                     WVFGLGLCKIISWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLRARTLTYGVITSLI
                     TWSVAVFASLPGLLFSTCDTENNHTYCKTQYSVNSTTWKVLSSLEINVLGLVIPLGIM
                     LFCYSMIIRTLRHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDC
                     TLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYIAQLFRTCRGPLVLCQHCDF
                     LQISSADTSSSSYTQSTVDHDFRDAL"
ORIGIN      
        1 ggcatttctt cacagactgt cctcaggacc actttcagaa gagcaaggct gctccatcct
       61 ttttattggc ttcttctgct gccacccaga acctgtggat tccagaaatg aatgccacag
      121 atgtcacaga caccacccag gatgaagccg cgtacaatag ttactacttc gacgagagct
      181 tgccaaagcc ttgcaccaag gaaggcatca aggcattcgg cgaggtcttc ctgcctcctc
      241 tctactcctt ggtctttctg ttgggtctgt ttgggaattc tgttgtggtt ctggtgctgt
      301 tcaagtacaa gaggctcaag tccatgactg acgtgtacct gctgaaccta gccatctcgg
      361 atttactgtt tgtgctgtct ctcccgttct ggggctacta tgctgctgac cagtgggttt
      421 ttggtctagg tctgtgtaag attatctcat ggatgtacct ggtgggcttc tacagcggga
      481 tcttcttcat catgctcatg agtatagaca gatacctggc catcgtgcac gcagtgtttt
      541 ccttgagagc gaggactctg acctatgggg tcatcaccag cctcatcacg tggtctgtgg
      601 ctgtgtttgc ctccctacca ggcctcttgt tcagcacctg cgacacagag aacaaccaca
      661 catactgcaa aacccagtac tcggtcaact cgaccacgtg gaaagtcctc agctccctgg
      721 agatcaatgt cttggggctg gtcatccccc tggggatcat gttgttctgc tattccatga
      781 tcatcaggac cctgagacac tgcaagaatg agaagaagaa cagagcagtt cggatgatct
      841 tcgccgtggt ggtcctcttc ctcggcttct ggacgccgta caacgtggtg cttttcctgg
      901 agaccttggt ggagctcgaa gtccttcagg actgcacctt ggagaggtac ctagactatg
      961 ccatccaggc cacagaaacc ctggccttca ttcactgctg ccttaaccct gtcatttact
     1021 tcttccttgg ggagaaattc cgcaagtaca tcgcccaact cttcagaacg tgccggggtc
     1081 ctcttgtgct ctgccaacac tgtgacttcc ttcagatctc ctcggccgac acttccagct
     1141 cctcttacac tcagtccact gtggatcatg acttccgtga cgctttgtaa tgtgtgttca
     1201 caggtaccgt ggtgttaaca atctccacac acccagccct tactcacttt gtttcagtca
     1261 gggagtcctg aacaggtttc tgaggaaaac aagtaaacca agatcatggc aagatggctt
     1321 ctcaccctgc tggtggctcc ctctctttct gtagagaagt gtggtttgaa atgtgtttcc
     1381 ctattcattc acataccagc tgtgtctaca gggagaggac agtcaagagg gatggggggg
     1441 aacttgggag cagagttctc agggggcttc tagattgtac taaagagaac gacacccacc
     1501 cccaaccttc ccagggatgc tcgcaagagg ttcagagccc tgatgggtgg aggaaatcac
     1561 tccttcatga aaatgagtcc ttgaatggat ctctagtttt tattgaacta cctagaattc
     1621 ttggacatgc tatactccat gaagccagat gtctagagaa atgaggatct tacatcttga
     1681 ttctcttctt atagaggatg ctccattgag ggctggtgat gagtgtagag ataagggtgt
     1741 tggatcgatc ccttctccac ttgaaacaag gtgtgtagaa cacatctgtt gaaatgtgaa
     1801 tgcagggctg gagagatggc tcagcggtta agagcgctgt ctgcttttcc agaggtcctg
     1861 agttcaattc cca
//
