LOCUS       NM_053958               1319 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 3 (Ccr3), mRNA.
ACCESSION   NM_053958
VERSION     NM_053958.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Zhao,H., Liang,K., Yu,Z., Wen,Y., Yu,X., Xin,J., Zhang,T., Zu,X.
            and Fang,Y.
  TITLE     CCR3 knockdown attenuates prolonged underwater operations-induced
            cognitive impairment via alleviating microglia-mediated
            neuroinflammation
  JOURNAL   iScience 27 (8), 110379 (2024)
   PUBMED   39156650
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Pawlik,K., Ciechanowska,A., Ciapala,K., Rojewska,E., Makuch,W. and
            Mika,J.
  TITLE     Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and
            Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
  JOURNAL   Front Immunol 12, 781310 (2021)
   PUBMED   34795678
  REMARK    GeneRIF: Blockade of CC Chemokine Receptor Type 3 Diminishes Pain
            and Enhances Opioid Analgesic Potency in a Model of Neuropathic
            Pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Shou,J., Peng,J., Zhao,Z., Huang,X., Li,H., Li,L., Gao,X., Xing,Y.
            and Liu,H.
  TITLE     CCL26 and CCR3 are associated with the acute inflammatory response
            in the CNS in experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 333, 576967 (2019)
   PUBMED   31151084
  REMARK    GeneRIF: CCR3 levels in EAE rats were significantly increased. CCR3
            levels in brain tissues were positively correlated with the
            inflammatory scores.
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Park,J.Y., Kang,Y.W., Choi,B.Y., Yang,Y.C., Cho,B.P. and Cho,W.G.
  TITLE     CCL11 promotes angiogenic activity by activating the PI3K/Akt
            pathway in HUVECs
  JOURNAL   J Recept Signal Transduct Res 37 (4), 416-421 (2017)
   PUBMED   28279120
  REMARK    GeneRIF: our data suggest that the CCL11-CCR3 interaction mainly
            activates PI3K/Akt signal transduction pathway in HUVECs.
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Li,Y., Huang,D., Xia,X., Wang,Z., Luo,L. and Wen,R.
  TITLE     What is the role of CCR3 in choroidal neovascularization?
  JOURNAL   Adv Exp Med Biol 723, 279-284 (2012)
   PUBMED   22183343
  REMARK    GeneRIF: CCR3 plays no role in choroidal neovascularization
            development.
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Balding,C.E., Howie,A.J., Drake-Lee,A.B. and Savage,C.O.
  TITLE     Th2 dominance in nasal mucosa in patients with Wegener's
            granulomatosis
  JOURNAL   Clin Exp Immunol 125 (2), 332-339 (2001)
   PUBMED   11529927
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Ye,J., Mayer,K.L., Mayer,M.R. and Stone,M.J.
  TITLE     NMR solution structure and backbone dynamics of the CC chemokine
            eotaxin-3
  JOURNAL   Biochemistry 40 (26), 7820-7831 (2001)
   PUBMED   11425309
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Jiang,Y., Salafranca,M.N., Adhikari,S., Xia,Y., Feng,L.,
            Sonntag,M.K., deFiebre,C.M., Pennell,N.A., Streit,W.J. and
            Harrison,J.K.
  TITLE     Chemokine receptor expression in cultured glia and rat experimental
            allergic encephalomyelitis
  JOURNAL   J Neuroimmunol 86 (1), 1-12 (1998)
   PUBMED   9655467
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Arrington,E.R., Hartshorne,M.F., Eisenberg,B., Roldan,C., West,M.,
            Mettler,F.A. Jr., Shively,B.K., Pulliam,L. and Murata,G.H.
  TITLE     The two-view radionuclide ventriculogram. Advantages of the LPO
            view
  JOURNAL   Clin Nucl Med 17 (5), 371-374 (1992)
   PUBMED   1316818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_053958.3.
            
            On Nov 27, 2020 this sequence version replaced NM_053958.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y13400.1, SRR26643284.11939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000008.1  132500249-132500451
            204-1319            JAXUCZ010000008.1  132508532-132509647
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1319
                     /gene="Ccr3"
                     /gene_synonym="Cmkbr3"
                     /note="C-C motif chemokine receptor 3"
                     /db_xref="GeneID:117027"
                     /db_xref="RGD:620593"
     exon            1..203
                     /gene="Ccr3"
                     /gene_synonym="Cmkbr3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..1319
                     /gene="Ccr3"
                     /gene_synonym="Cmkbr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1294
                     /gene="Ccr3"
                     /gene_synonym="Cmkbr3"
                     /note="CKR3; CCR-3; CC-CKR-3; C-C CKR-3; chemokine (C-C)
                     receptor 3; chemokine (C-C motif) receptor 3"
                     /codon_start=1
                     /product="C-C chemokine receptor type 3"
                     /protein_id="NP_446410.1"
                     /db_xref="GeneID:117027"
                     /db_xref="RGD:620593"
                     /translation="MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPL
                     YSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNE
                     WGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSII
                     TWGLAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLI
                     MVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETS
                     CQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISF
                     LPGEKLERTSSVSPSTGEQEISVVF"
ORIGIN      
        1 tagtaaataa caaaacggaa gaactgtaac atgttggtat ctctctgaaa acttgcaaaa
       61 cctgagaagc tagcctgttt aaaacaggaa gctctgttgt ttactacctg actggtgtat
      121 gtgatcaaat gttatctctg tttcattagc agtgagacct aagttactac tggactcata
      181 aaggacttag caaaaatcat cagagacaag taaaatggca tccaacgaag aggaactcaa
      241 gactgttgtt gaaacctttg agaccacacc ctatgaatat gagtgggcac caccctgtga
      301 aaaagtcagc atcagagagc tggggtcatg gctcctgcct ccactgtatt ccctggtgtt
      361 catcgtcggc ctcctgggca acatgatggt tgtgttgatc ctcataaagt acaggaagct
      421 gcaaattatg actaatatct acctactcaa cttggcaatt tctgacctgc tctttctctt
      481 cactgtccca ttctggattc actatgttct gtggaatgag tggggttttg gccactgcat
      541 gtgtaaaatg ctctctgggc tttattacct ggccttgtac agcgagatct ttttcatcat
      601 cctgctgaca atcgacaggt acctggctat cgttcatgct gtgttggccc ttcgagcacg
      661 aactgtgact tttgctacta tcaccagcat catcacttgg ggtcttgcag tattggcagc
      721 attgcctgaa tttatcttcc atgagtccca agacaatttt ggagatcttt cctgcagtcc
      781 tcgctatcca gagggcgaag aagacagctg gaagcgtttc catgctctaa gaatgaacat
      841 ttttggttta gctcttcctc tcctcattat ggttatctgc tactcaggaa tcattaaaac
      901 tctgcttaga tgccccaata aaaaaaaaca caaggccatc cagcttattt ttgttgtcat
      961 gatagtcttt tttatttttt ggactccata caacctggtt cttcttctgt ctgctttcca
     1021 cagcacattt ttggagacca gctgtcagca gagcatacac ctggacctgg ccatgcaagt
     1081 gactgaggtg attacccaca cccactgctg tatcaatcca ataatctatg cctttgttgg
     1141 tgagaggttc cggaaacacc ttcggctctt tttccacaga aatgtggcaa tctacctgag
     1201 aaaatatatt tcattccttc ctggcgagaa actggaaaga acaagctctg tctccccatc
     1261 aactggggag caagaaatct ctgtggtgtt ttagctgggc agagaaaact gcccctcac
//
