LOCUS       NM_021866               3603 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 2 (Ccr2), mRNA.
ACCESSION   NM_021866 XM_039082060
VERSION     NM_021866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Puukila,S., Lawrence,M.D., De Pasquale,C.G., Bersten,A.D.,
            Bihari,S., McEvoy-May,J., Nemec-Bakk,A. and Dixon,D.L.
  TITLE     Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor (CCR2)
            are elevated in chronic heart failure facilitating lung monocyte
            infiltration and differentiation which may contribute to lung
            fibrosis
  JOURNAL   Cytokine 161, 156060 (2023)
   PUBMED   36219898
  REMARK    GeneRIF: Monocyte chemotactic protein (MCP)-1 (CCL2) and its
            receptor (CCR2) are elevated in chronic heart failure facilitating
            lung monocyte infiltration and differentiation which may contribute
            to lung fibrosis.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Jin,X., Zheng,W., Chi,S., Cui,T. and He,W.
  TITLE     miR-506-3p Relieves Neuropathic Pain following Brachial Plexus
            Avulsion via Mitigating Microglial Activation through Targeting the
            CCL2-CCR2 Axis
  JOURNAL   Dev Neurosci 45 (1), 37-52 (2023)
   PUBMED   36470227
  REMARK    GeneRIF: miR-506-3p Relieves Neuropathic Pain following Brachial
            Plexus Avulsion via Mitigating Microglial Activation through
            Targeting the CCL2-CCR2 Axis.
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Chang,G.Q., Karatayev,O., Boorgu,D.S.S.K. and Leibowitz,S.F.
  TITLE     CCL2/CCR2 system in neuroepithelial radial glia progenitor cells:
            involvement in stimulatory, sexually dimorphic effects of maternal
            ethanol on embryonic development of hypothalamic peptide neurons
  JOURNAL   J Neuroinflammation 17 (1), 207 (2020)
   PUBMED   32650794
  REMARK    GeneRIF: CCL2/CCR2 system in neuroepithelial radial glia progenitor
            cells: involvement in stimulatory, sexually dimorphic effects of
            maternal ethanol on embryonic development of hypothalamic peptide
            neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   English,S.J., Sastriques,S.E., Detering,L., Sultan,D., Luehmann,H.,
            Arif,B., Heo,G.S., Zhang,X., Laforest,R., Zheng,J., Lin,C.Y.,
            Gropler,R.J. and Liu,Y.
  TITLE     CCR2 Positron Emission Tomography for the Assessment of Abdominal
            Aortic Aneurysm Inflammation and Rupture Prediction
  JOURNAL   Circ Cardiovasc Imaging 13 (3), e009889 (2020)
   PUBMED   32164451
  REMARK    GeneRIF: CCR2 Positron Emission Tomography for the Assessment of
            Abdominal Aortic Aneurysm Inflammation and Rupture Prediction.
REFERENCE   5  (bases 1 to 3603)
  AUTHORS   Xian,H., Jiang,Y., Zhang,H., Ma,S.B., Zhao,R. and Cong,R.
  TITLE     CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate
            Neuropathic Pain Induced by Brachial Plexus Avulsion
  JOURNAL   Neuroscience 425, 29-38 (2020)
   PUBMED   31805255
  REMARK    GeneRIF: CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to
            Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
REFERENCE   6  (bases 1 to 3603)
  AUTHORS   Boring,L., Gosling,J., Chensue,S.W., Kunkel,S.L., Farese,R.V. Jr.,
            Broxmeyer,H.E. and Charo,I.F.
  TITLE     Impaired monocyte migration and reduced type 1 (Th1) cytokine
            responses in C-C chemokine receptor 2 knockout mice
  JOURNAL   J Clin Invest 100 (10), 2552-2561 (1997)
   PUBMED   9366570
REFERENCE   7  (bases 1 to 3603)
  AUTHORS   Kuziel,W.A., Morgan,S.J., Dawson,T.C., Griffin,S., Smithies,O.,
            Ley,K. and Maeda,N.
  TITLE     Severe reduction in leukocyte adhesion and monocyte extravasation
            in mice deficient in CC chemokine receptor 2
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 12053-12058 (1997)
   PUBMED   9342361
REFERENCE   8  (bases 1 to 3603)
  AUTHORS   Sarafi,M.N., Garcia-Zepeda,E.A., MacLean,J.A., Charo,I.F. and
            Luster,A.D.
  TITLE     Murine monocyte chemoattractant protein (MCP)-5: a novel CC
            chemokine that is a structural and functional homologue of human
            MCP-1
  JOURNAL   J Exp Med 185 (1), 99-109 (1997)
   PUBMED   8996246
REFERENCE   9  (bases 1 to 3603)
  AUTHORS   Kurihara,T. and Bravo,R.
  TITLE     Cloning and functional expression of mCCR2, a murine receptor for
            the C-C chemokines JE and FIC
  JOURNAL   J Biol Chem 271 (20), 11603-11607 (1996)
   PUBMED   8662823
REFERENCE   10 (bases 1 to 3603)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 22, 2022 this sequence version replaced
            XM_039082060.1, NM_021866.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.31433.1,
                                           SRR26643299.38003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000008.1  132612203-132612258
            57-153              JAXUCZ010000008.1  132613956-132614052
            154-3603            JAXUCZ010000008.1  132615657-132619106
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3603
                     /gene="Ccr2"
                     /note="C-C motif chemokine receptor 2"
                     /db_xref="GeneID:60463"
                     /db_xref="RGD:620876"
     exon            1..56
                     /gene="Ccr2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..153
                     /gene="Ccr2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..3603
                     /gene="Ccr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1286
                     /gene="Ccr2"
                     /note="CCR-2; CC-CKR-2; C-C CKR-2; chemokine receptor
                     CCR2; chemokine (C-C motif) receptor 2"
                     /codon_start=1
                     /product="C-C chemokine receptor type 2"
                     /protein_id="NP_068638.1"
                     /db_xref="GeneID:60463"
                     /db_xref="RGD:620876"
                     /translation="MEDSNMLPQFIHGILSTSHSLFPRSIQELDEGATTPYDYDDGEP
                     CHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDL
                     LFLLTLPFWAHYAANEWVFGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVF
                     ALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSEQEDDQHTCGPYFPTIWKNFQTIM
                     RNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVL
                     FLTTFQEFLGMSNCVVDMHLDQAMQVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFR
                     KHIAKNLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL"
ORIGIN      
        1 agatctgtta ctgagacgcc tgagacacca gagccatcat aaagaagcca tagtagtaaa
       61 tgccatgtga gttcagctgc ctgcaaagac cagaaaaggg cattggattc accacaagtg
      121 ctaggaactg aacttgaatc gtctgcaaaa acaaatcaaa ggaaatggaa gacagtaata
      181 tgttacctca gttcatccat ggcatactat caacatctca ttctctattt ccaagaagta
      241 tccaagagct tgatgagggg gccaccacac cgtatgacta tgatgatggt gaaccttgtc
      301 ataaaaccag tgtgaagcaa attggagctt ggatcctgcc cccactctac tccctggtat
      361 tcatctttgg ttttgtgggc aacatgttgg tcattataat tctgataagc tgtaaaaagc
      421 tgaagagcat gactgatatc tacctgttca acctggccat ctctgacctg ctcttcctgc
      481 tcacactccc attctgggct cactatgctg caaatgagtg ggtctttggg aatataatgt
      541 gcaaattatt cacagggctt tatcacattg ggtattttgg tggaatcttc ttcattatcc
      601 tcctgacaat tgatagatat ttggctattg tccatgctgt ctttgcttta aaagccagga
      661 cagttacctt tggggtaata acaagtgtag tcacttgggt ggtggctgtg tttgcctctc
      721 taccaggaat catatttact aaatctgaac aagaagatga tcagcacact tgtggccctt
      781 attttccaac aatctggaag aatttccaaa caataatgag gaatatcttg agtttgatcc
      841 tgcccctact tgtcatggtc atctgctact caggaatcct ccacaccctg tttcgctgta
      901 ggaatgagaa aaagaggcat agggctgtga ggctcatctt tgccatcatg attgtctact
      961 ttctcttctg gactccatac aatattgttc tcttcctgac caccttccag gaattcttgg
     1021 gaatgagtaa ctgtgtggtt gacatgcact tagaccaggc catgcaggtg acagagactc
     1081 ttggaatgac acactgctgc gttaatccta tcatttatgc ctttgttggt gagaagttcc
     1141 gaaggtatct ctccatattt ttcagaaagc acattgccaa aaatctctgc aaacaatgcc
     1201 cagttttcta tagggagaca gcagaccgag tgagctcaac atttacccct tctactgggg
     1261 agcaagaagt ctcagttggg ttgtaaagta agtagcagtc ccccccccct ttttttaagc
     1321 agggaaggag aggacagttt gtatatagta acaaacctca aagacaataa ttcttacttt
     1381 tggtcatgat tcctttgggg aagtcaaatg accctttcac agaggtcact taaaaccatc
     1441 agaaaacaca cacacacaca cacacacaca cattataatt catgacagta gcaatattac
     1501 agctatgaag tagcaacaaa aataatttta tggttgggga tcaccacaac atgaggaact
     1561 gtattaaagg atcacaggat taagaaggtt gtgaaccact gctcatagat atattgaaca
     1621 atagagacct ttaaatcagg ttcccagaac cttaggatta tatcacaact aaaccatatc
     1681 tcttcttgta tatataatac atgtttggaa aatattctag aataatcatt gatagattct
     1741 tcagtgtcta gtgaactctg tccctctgaa gagcctcatt gccttgtagc aatactgttt
     1801 taccagtctt catcatgttt tgccctaatc taacaagaaa gacatggaat gcatagaaag
     1861 gaaggtgtga ggctatcggg actgagtgag aaggaagaag agatatgcag ttgatcctga
     1921 gtgaagatgg agacgaaagt gaacaggggc cttctcattt ggaaagaaac gtcctggtct
     1981 tcggcttctt ctcccacctg tgtttgattt gaaggcttta tcaggttgtg ggaaatctgg
     2041 aaactaattg tttgttggga acttcatttg agtcccatgg tccttttata tataattgta
     2101 ctacacattt ttgctttgtt atttttatct atgacatgga aaatcttttc aatatcaaac
     2161 tccactgttt acatgtttct caagccatgg ctccttgcat gatgtttata aaattattgt
     2221 ttataaaata tgcattgtta gtgattcgcc taaaaataat aagggctctt gtttgatctt
     2281 cccagggaga gcagagctgg agatagtgaa tgaccaagaa tgaggagaaa aaccaatccc
     2341 tctaccaggc atagagggct acagcaaaaa ggcagggatt tgtgggacga tagaagtggt
     2401 atgtttagaa ccacatagaa tcagaagcaa aatggatgtc tcagcaccaa ggaaaggttt
     2461 ctgtctgaat ataaacttgt tttatttttt tgctgctatt tttctgcctc tcaactacct
     2521 ttgcacttgc ttcttcctca tagcctttat ctattagctt ccacctggga aaggtgtgca
     2581 tggaagagcc aaatctggaa gcctggatag tttaggaaga gaaaaaagca ctgttatgtt
     2641 atctttgtgg gtaaaacgag actggatgaa gcatggacag aaacccttgc tttgaaaata
     2701 gtacttggga acatacctta attaccagga acaataagcc tgaataaaaa cgattataga
     2761 tagaatgggg aaaagtgtgt catagactat cttccaaagc cttatttttg gatataaaca
     2821 taatttaaat atttaaaaat tgaaaataga aaaaataaaa tcaagactga aaactttaac
     2881 ttttaaatgt gatgaagtac ctctgtaact tgccaagctt gaaaatagtc cattagttat
     2941 agaaaaaaat tttgactttg agcatatgaa ctaacataga tagctcagga ttggcaggga
     3001 cttggggttt gtggcatgtg gggttaccca accatggtga tttagactct acgccatctg
     3061 gatcctagat gctgcataga tgtcacgtgt acatgaaagt ggtgtacttg ttctttcagg
     3121 cttggtttcc ccaaactcct ttggattttt tttttgtcaa tgtgatcttg gtgacagatt
     3181 gtcctttgag tgaatgggaa ctcccaagtc aaatcagcct cttatcaaag cattaaaaat
     3241 aaatttacaa aggagaaaag ttagagaaac tccttctcat aagagaaata tcttccctga
     3301 attgagccaa aaatattctt ccctgtgcac taatgcattt attatctaaa agaagcaaga
     3361 aacaaagaaa cagacaacct gggagctgag agtcattgtg gtctggcttt gctaccacgt
     3421 gatgagaaga agtttctgaa aggagtaggg gataagagta tcaccttcag atagcctaac
     3481 cgttttattt taaagacaat gagatgcaaa tatctgtaaa cctgtgattt agaaataaac
     3541 caatgctcta tctatacctc tagaaatatt aaaaagaaac aagcatatgt tttgttatac
     3601 caa
//
