LOCUS       NM_020542               1870 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine receptor 1 (Ccr1), mRNA.
ACCESSION   NM_020542
VERSION     NM_020542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Shi,C., Jin,J., Xu,H., Ma,J., Li,T., Xie,Y. and Li,Z.
  TITLE     CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK
            phosphorylation to promote spinal nerve ligation-induced
            neuropathic pain
  JOURNAL   Gene Ther 29 (6), 379-389 (2022)
   PUBMED   34413501
  REMARK    GeneRIF: CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK
            phosphorylation to promote spinal nerve ligation-induced
            neuropathic pain.
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Pawlik,K., Piotrowska,A., Kwiatkowski,K., Ciapala,K.,
            Popiolek-Barczyk,K., Makuch,W. and Mika,J.
  TITLE     The blockade of CC chemokine receptor type 1 influences the level
            of nociceptive factors and enhances opioid analgesic potency in a
            rat model of neuropathic pain
  JOURNAL   Immunology 159 (4), 413-428 (2020)
   PUBMED   31919846
  REMARK    GeneRIF: The data obtained provide evidence that CCR1 blockade
            reduces hypersensitivity to neuropathic pain in rats.
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Gilliland,C.T., Salanga,C.L., Kawamura,T., Trejo,J. and Handel,T.M.
  TITLE     The chemokine receptor CCR1 is constitutively active, which leads
            to G protein-independent, beta-arrestin-mediated internalization
  JOURNAL   J Biol Chem 288 (45), 32194-32210 (2013)
   PUBMED   24056371
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Matsubara,R., Kukita,T., Ichigi,Y., Takigawa,I., Qu,P.F.,
            Funakubo,N., Miyamoto,H., Nonaka,K. and Kukita,A.
  TITLE     Characterization and identification of subpopulations of
            mononuclear preosteoclasts induced by TNF-alpha in combination with
            TGF-beta in rats
  JOURNAL   PLoS One 7 (10), e47930 (2012)
   PUBMED   23110133
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Berkhout,T.A., Gohil,J., Gonzalez,P., Nicols,C.L., Moores,K.E.,
            Macphee,C.H., White,J.R. and Groot,P.H.
  TITLE     Selective binding of the truncated form of the chemokine CKbeta8
            (25-99) to CC chemokine receptor 1(CCR1)
  JOURNAL   Biochem Pharmacol 59 (5), 591-596 (2000)
   PUBMED   10660125
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Gao,J.L., Wynn,T.A., Chang,Y., Lee,E.J., Broxmeyer,H.E., Cooper,S.,
            Tiffany,H.L., Westphal,H., Kwon-Chung,J. and Murphy,P.M.
  TITLE     Impaired host defense, hematopoiesis, granulomatous inflammation
            and type 1-type 2 cytokine balance in mice lacking CC chemokine
            receptor 1
  JOURNAL   J Exp Med 185 (11), 1959-1968 (1997)
   PUBMED   9166425
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   Combadiere,C., Ahuja,S.K., Tiffany,H.L. and Murphy,P.M.
  TITLE     Cloning and functional expression of CC CKR5, a human monocyte CC
            chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and
            RANTES
  JOURNAL   J Leukoc Biol 60 (1), 147-152 (1996)
   PUBMED   8699119
REFERENCE   9  (bases 1 to 1870)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   10 (bases 1 to 1870)
  AUTHORS   Ben-Baruch,A., Xu,L., Young,P.R., Bengali,K., Oppenheim,J.J. and
            Wang,J.M.
  TITLE     Monocyte chemotactic protein-3 (MCP3) interacts with multiple
            leukocyte receptors. C-C CKR1, a receptor for macrophage
            inflammatory protein-1 alpha/Rantes, is also a functional receptor
            for MCP3
  JOURNAL   J Biol Chem 270 (38), 22123-22128 (1995)
   PUBMED   7545673
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079207.1.
            
            On Aug 8, 2004 this sequence version replaced NM_020542.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079207.1, CK598894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1870
                     /gene="Ccr1"
                     /note="C-C motif chemokine receptor 1"
                     /db_xref="GeneID:57301"
                     /db_xref="RGD:708446"
     exon            1..283
                     /gene="Ccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..1849
                     /gene="Ccr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1418
                     /gene="Ccr1"
                     /note="macrophage inflammatory protein-1 alpha receptor;
                     chemokine (C-C motif) receptor 1"
                     /codon_start=1
                     /product="C-C chemokine receptor type 1"
                     /protein_id="NP_065417.1"
                     /db_xref="GeneID:57301"
                     /db_xref="RGD:708446"
                     /translation="MEISNITETYPTTTEYDYGDSTPCQKTDVRAFGAGLLPPLYSFV
                     FIIGVVGNILVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDNWVFG
                     DAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFSLRARTVTFGIITSIIIWAL
                     AILASIPALCFFKAQWEFTHHTCSPHFPDESLKTWKRFQALKLNLLGLILPLLVMIIC
                     YAGIIRILLRRPNEKKAKAVRLIFAITLLFFLLWTPYNLTVFVSAFQDVLFTNQCEQS
                     KQLDLAIQVTEVIAYTHCCVNPIIYVFVGERFRKYLRQLFQRHVAIPLAKWLPFFSVD
                     QLERTSSLTPSTGEHELSGGF"
ORIGIN      
        1 gaactggagc agagaggaca gagaaaacac ctttaatgaa cttggacccc aggaattgac
       61 cactggtgag cactgtgatg cttcatagac agccaaccat aaaaaagaag aactttacac
      121 catttttgtc attctgaaag actataaaac cagagtccaa tctccatcat catacaggaa
      181 gccaagaact tcctactagg ttgggacctt gaaccttgaa ttcataaaga ctctcaaagg
      241 cccagaaaca aagcctctgt ggacaaagta ctctggaaac acagactcat tgtctttgat
      301 agaaaagtaa atacagaagc tattgttcct gaccagttcc tcatcaaagg atggagattt
      361 caaatatcac agaaacctac cccacaacca cagaatatga ctatggggac tctactccat
      421 gccaaaaaac tgatgtaaga gccttcgggg ctggactcct gccccccctg tactctttcg
      481 tgtttatcat tggagtggta ggcaatatcc tggtgattct ggtgctcatg cagcatagga
      541 ggcttcaaag catgaccagc atatacctgt tcaacctggc tgtctctgat ctggtcttcc
      601 ttttcacttt acctttctgg attgactaca agctgaaaga caactgggtt tttggtgatg
      661 ccatgtgtaa gcttctctct gggttttatt acctgggctt atacagtgag atcttcttta
      721 tcatcctgct gacaattgac aggtacctgg ccattgtcca tgcagtgttt tccctgaggg
      781 cccgaactgt cacttttggc atcatcacca gtattattat ttgggcccta gccatcttag
      841 cttctattcc tgccttatgc tttttcaagg cccagtggga gttcactcac catacctgta
      901 gccctcattt ccccgatgag agcctgaaga cgtggaagag gtttcaggct ctaaagctaa
      961 acctccttgg actaatttta cctctgttag tcatgataat ttgctacgca gggatcatca
     1021 gaattctgct cagacgaccc aatgagaaga aggccaaagc cgtgcgtctg atatttgcta
     1081 ttacgcttct attcttcctc ctctggaccc cctacaatct gactgtattt gtttctgctt
     1141 tccaagatgt tctattcacc aatcagtgtg agcagagcaa gcagctggac ctggccatac
     1201 aggtgactga agtgattgcc tacacccact gttgtgtcaa tccaatcatt tatgtctttg
     1261 tgggtgagcg gttccggaag taccttcggc agctgtttca aaggcatgtg gctataccgc
     1321 tggcaaaatg gctgcccttc ttctctgtgg accaactaga aaggaccagt tccttaactc
     1381 catccacagg agaacatgaa ctttctgggg gcttctgatt cagaccctag gtgtcaacca
     1441 aggtctagag gagaatgagg gggatagtat atagctctcc aagacagata ctgacagcta
     1501 ttacagtggg gattcccagt cttgtagggt caaagggaac tttgaggtcg cttaggtaca
     1561 agtcacctat tcaatggttt ccttgaactt ctctctgtta aaaatgagat gaataaacaa
     1621 agtgggacat tatagaaatg gggataatga gtggcttggg cccaacaagt gatggatctg
     1681 tagttattaa cctaaaaaca aaaccactac ttttactgaa atcaacacct aatgatgtga
     1741 tattctgaga aaaatttaaa gcattgtaat aaagaatttt gtgtattttc atattgacat
     1801 atattataaa gtagatgtta tgtcaaaatt aaaactgtag caaactaaaa aaaaaaaaaa
     1861 aaaaaaaaaa
//
