LOCUS       NM_001107171            5652 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cyclin T2 (Ccnt2), mRNA.
ACCESSION   NM_001107171 XM_001054848 XM_222617
VERSION     NM_001107171.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5652)
  AUTHORS   Tian R, Guan X, Qian H, Wang L, Shen Z, Fang L and Liu Z.
  TITLE     Restoration of NRF2 attenuates myocardial ischemia reperfusion
            injury through mediating microRNA-29a-3p/CCNT2 axis
  JOURNAL   Biofactors 47 (3), 414-426 (2021)
   PUBMED   33600051
  REMARK    GeneRIF: Restoration of NRF2 attenuates myocardial ischemia
            reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis.
REFERENCE   2  (bases 1 to 5652)
  AUTHORS   Marchesi I, Nieddu V, Caracciolo V, Maioli M, Gaspa L, Giordano A
            and Bagella L.
  TITLE     Activation and function of murine Cyclin T2A and Cyclin T2B during
            skeletal muscle differentiation
  JOURNAL   J Cell Biochem 114 (3), 728-734 (2013)
   PUBMED   23060074
REFERENCE   3  (bases 1 to 5652)
  AUTHORS   Kwak H and Lis JT.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   4  (bases 1 to 5652)
  AUTHORS   Wu W, Yu X, Li W, Guo L, Liu L, Wang L and Li Q.
  TITLE     HSV-1 stimulation-related protein HSRG1 inhibits viral gene
            transcriptional elongation by interacting with Cyclin T2
  JOURNAL   Sci China Life Sci 54 (4), 359-365 (2011)
   PUBMED   21509660
REFERENCE   5  (bases 1 to 5652)
  AUTHORS   Akiyama K, Morita H, Suetsugu S, Kuraba S, Numata Y, Yamamoto Y,
            Inui K, Ideura T, Wakisaka N, Nakano K, Oniki H, Takenawa T,
            Matsuyama M and Yoshimura A.
  TITLE     Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna
            rats
  JOURNAL   Mamm Genome 19 (1), 41-50 (2008)
   PUBMED   18064521
REFERENCE   6  (bases 1 to 5652)
  AUTHORS   Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN and Ozato K.
  TITLE     The bromodomain protein Brd4 is a positive regulatory component of
            P-TEFb and stimulates RNA polymerase II-dependent transcription
  JOURNAL   Mol Cell 19 (4), 523-534 (2005)
   PUBMED   16109376
REFERENCE   7  (bases 1 to 5652)
  AUTHORS   Kurosu T, Zhang F and Peterlin BM.
  TITLE     Transcriptional activity and substrate recognition of cyclin T2
            from P-TEFb
  JOURNAL   Gene 343 (1), 173-179 (2004)
   PUBMED   15563843
REFERENCE   8  (bases 1 to 5652)
  AUTHORS   Simone C, Bagella L, Bellan C and Giordano A.
  TITLE     Physical interaction between pRb and cdk9/cyclinT2 complex
  JOURNAL   Oncogene 21 (26), 4158-4165 (2002)
   PUBMED   12037672
REFERENCE   9  (bases 1 to 5652)
  AUTHORS   Nguyen VT, Kiss T, Michels AA and Bensaude O.
  TITLE     7SK small nuclear RNA binds to and inhibits the activity of
            CDK9/cyclin T complexes
  JOURNAL   Nature 414 (6861), 322-325 (2001)
   PUBMED   11713533
REFERENCE   10 (bases 1 to 5652)
  AUTHORS   Peng J, Zhu Y, Milton JT and Price DH.
  TITLE     Identification of multiple cyclin subunits of human P-TEFb
  JOURNAL   Genes Dev 12 (5), 755-762 (1998)
   PUBMED   9499409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222617.4, XM_001054848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5652
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..5652
                     /gene="Ccnt2"
                     /note="cyclin T2"
                     /db_xref="GeneID:304758"
                     /db_xref="RGD:1309205"
     exon            1..193
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2204
                     /gene="Ccnt2"
                     /codon_start=1
                     /product="cyclin-T2"
                     /protein_id="NP_001100641.1"
                     /db_xref="GeneID:304758"
                     /db_xref="RGD:1309205"
                     /translation="MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLI
                     QDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEH
                     VIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCT
                     QLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGK
                     HWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLL
                     GSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPLPLTSGSTSVQDGRASDTGSVLAG
                     MPSSSYTVSSHQEWPHHPDSARTDPVYTQKQEATLSGSQYLSFQQGPSMALHSGLHHR
                     PDKVADHSSAKQEYTHKGGSSKHHGPIPATPGVVPQKMSLDKYREKRKLETLDLDSRD
                     HYMAAHAEQQHKHGPAQAVAGTSVTSPIKMKLPLTNSDKPEKHLAEKRERSGSLKLRI
                     PIPPPDKGPSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPANR
                     HHSSHKHLHMHSSGGSKHADGMPPTVLRSPVGLGPEGISSGPSARKKLHINDASHNHH
                     SKMSKSSKSSGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKK
                     PVEPHGPEANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM"
     exon            194..275
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..404
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..465
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..528
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..574
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..738
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..809
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..5652
                     /gene="Ccnt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggctaa gggtgcgggc ggaggaggaa gtgtcatggc gtcgggccgt ggagcttctt
       61 ctcgctggtt ctttactcga gaacagctgg agaacacgcc gagccgccgc tgcggagtgg
      121 aagcggatga agagctgtcg catcgccagc aggcggccaa cctcatccag gacatggggc
      181 aacgtcttaa tgtctctcag cttacaataa acactgcgat tgtttatatg cacaggtttt
      241 atatgcacca ttctttcacc aaattcaaca gaaatataat atcacctacc gcattgtttt
      301 tggctgcaaa agtggaagaa caggctcgaa agcttgaaca tgttatcaaa gtagcacacg
      361 cttgtcttca tcccctagag ccactgctgg atacaaaatg tgatgcatat cttcagcaga
      421 ctcaagaact ggttttactt gaaaccataa tgctacaaac actgggtttt gagatcacca
      481 ttgaacaccc acatacagat gtggtgaaat gcacccagtt agtaagagca agcaaggatt
      541 tggcacagac atcctatttc atggctacca acagtttgca tcttacgacc ttctgtcttc
      601 agtacaaacc cacagtgata gcatgtgtat gcattcattt ggcttgcaaa tggtccaatt
      661 gggagattcc tgtgtcaacg gatggaaagc actggtggga gtatgtggac cctacagtta
      721 ccctagagct gctagatgag ctaacacatg agtttctaca aatattggag aaaacgccta
      781 gtaggttgaa gaggattcga aactggaggg ctatggctaa gaaaccaaaa gtcgatggac
      841 aagtatcaga gacaccactg cttggttctt ctttggtcca gaattccatt ttagtagaca
      901 gtgtcactgg tgtgcctgcc aacccaagct ttcagaagcc atcaacgtca acgttccctg
      961 ctccactacc tctaacttca ggaagtactt ctgttcaaga tggccgtgca tctgatactg
     1021 gatcagtgct cgcagggatg cctagttcct catacactgt gtcatcacac caagagtggc
     1081 ctcaccatcc agactcagcc aggacagacc cggtatacac acagaagcag gaggccactc
     1141 tctctgggag ccagtaccta agcttccagc agggaccttc aatggcactg cattccggat
     1201 tacatcacag gccggacaaa gttgctgatc attcgtcagc taagcaagaa tatactcaca
     1261 aaggtgggag cagcaaacac catggcccca tacctgctac tcctggagtg gttcctcaga
     1321 aaatgtcttt agataagtac agagagaagc ggaagctgga aacccttgac ctggactcga
     1381 gggatcacta tatggctgcc catgcagagc agcagcacaa acatgggcca gctcaggcag
     1441 tcgcaggcac ttctgtcact tctcccatca aaatgaagct tcccctcacc aactccgaca
     1501 agcctgagaa acacttggca gagaaaaggg agaggagtgg atcactgaag ctgcggatcc
     1561 ccatcccacc gcctgataaa ggtcccagca aggaggagct gaagatgaaa atcaaagtgt
     1621 cgtcctctga gagacacagc tcttctgatg aaggcagtgg gaagagcaag cactcgagcc
     1681 cacacatcag cagagaccac aaggaaaagc acaaggagca cccggccaac cgccaccaca
     1741 gcagccacaa gcatttgcac atgcacagca gcggaggcag caagcatgct gacggcatgc
     1801 cacccactgt gctgaggagt cctgtgggcc tgggccctga aggcatctcc tccggcccca
     1861 gtgcaaggaa gaagctgcat atcaacgatg cctcccacaa ccaccactcc aaaatgagca
     1921 aaagttccaa aagttcaggt agttcatcta gttcttcctc tgttaagcag tatctatcct
     1981 ctcacagctc tgtttttaac catcccttac cccctcctcc ccctgtcaca taccaggtgg
     2041 gctacggaca tctcagcacc ctcgtgaaac tggacaagaa accagtggag ccccacggtc
     2101 ctgaggccaa tcacgagtac agtacaagca gccagcatat ggactacaaa gacacattcg
     2161 acatgctgga ctcgctgcta agtgcccaag gaatgaatat gtaacccttt gtttaggtca
     2221 acttttcctt tcctttttaa tttaaaaatg gttggaatgg aaaatgccct cctggtccag
     2281 cggtggtgcc actgcttccg tatttgtaag tgctgctttg ttcttcattc tgaaagaaga
     2341 gatgatagta aacaagccta tctccacata catagtgcta ccaggactgt aagccgcttg
     2401 gaagacgcag ctgggaacat tagggtgaat ggctggctgc tgctaggaac ccaagctgcc
     2461 tcaagcctct gttgtttagg attcgagtat cgtagctggt tttttgttgt tgcttggctt
     2521 tgaatgagtg tcaattgttt tcttttgtgt atttatactt gtatgtatgg tttgcatgtc
     2581 tcagtgataa agggataaca gtacactgac aactgtttac aagaaagtgg agaaaaatgt
     2641 acatacattt ttgtatgttt agatattacc ataaatactc aggatcggag ctgcttgtaa
     2701 gtataacaat agacagaata actttatttt ctctcgtcag agtccatcac taatctaaaa
     2761 cacaagtggc acttttttat gttaacctta aactctaggc cttactgaaa gccgctgagg
     2821 ggacacttca ctactagacg ggaatgtggt gccacgggtg gtccttaaca ctgggaagca
     2881 ctcagtttgc cctcagagat tctgaccaga gtggctgcag aatcagccac tgatttctga
     2941 aggcttgaag aggaaaaaaa aaaaaaataa agtttacata ctcttgatgt gaagtgcatt
     3001 taaatgtttg ccggcttgtt gcagtgctgt agaaaagcag ctactaatgt gtgtgaggat
     3061 ggctgacttc actcacagcc gccctcagtg aaggtcagtc catttctgca agaacgctga
     3121 cactacaggt tctgggtgag caggggtcac gtttccttta gcatttgcag tgacaccata
     3181 gtcttgaata tatattactc ttcccctggg gagagagagt atgagagagc gagagcgtga
     3241 gtgtgcgtgc gtgcgtgcgt gcgtgcgtgc gtgcgtgtat gtgtgtgtgt gtgtgtgtgt
     3301 gtgtgtgtgt gtgtgtctgt gagagagaga gagataccat atttcttttt caggtaaatg
     3361 cagtcttcct tataaaaatg aaattaaacc tatgctctct tgattctttt atattctaac
     3421 aataaataaa aaagaaaaga ttgctgactg tgcattgtac ctgtatttat agcttatggt
     3481 cattatcagg aaaatgtaag aaaaaaggcc aacctccggc aagccactgc tgggggtttt
     3541 acattggttt gcacgtctta gtaggttctc attgaggtaa tgcttgcact gtcacctgac
     3601 gcctggtcag gagatagact gactgacttg tctaactttt ggtgtaagca ccaatagtat
     3661 ggctcttgtc tcttgcctaa tcttgaattt atttctgtgg taagtcttcg ctgttgagtc
     3721 tcttaagatg ggtcggattc aacttgtatt gaatcacaag ttttcctttg tatatgaaat
     3781 gttttgttat aaagccactg atctgtgcac aattgtaatt ttattcaagt atgttgtggt
     3841 tgtaaatatt agagttgagc cttgtactct acttttattt agcagttatc taatttgcca
     3901 gtagctattt gtttgtttgt ttgttttaaa gaaaattgtt gattattttg tcaatgttat
     3961 ttgaacctgg gatgtcagga gcttctttgt ggaaactcag ccaagcaggc tagtgtcact
     4021 ctgttcttgt cttgcattgg taatctttgt cactctgatt tttgttgcta tgtggtatac
     4081 attgtatcat acacatgatt ttgatacagt ttggttttac cgtggtacaa ttccaagaac
     4141 tagcatagaa tttaaacaga gtacaaggtg agggagggaa gggttttgtt cttggtgatt
     4201 tagatgtgaa acctcaacag agcatcatgt gaactgacac gaggtgttgt gctactgtat
     4261 cattgggagt gatgccagga attctaatcc gcctttgtaa agagtatcca gagaagtagt
     4321 gaacttaatt tcagtatgac atagaaaaca atgtgaatat ttaaggtctg gggctctagt
     4381 taaacttcac taagggtttt cagaaatgtg ttgtttttcg tttgtttttg tttttttgtt
     4441 gttttggttt ttttagctat gggaataaag gtaattttgt tgaatcttta ttggtgctaa
     4501 tgatggacag ttaaacagat agtgtatatg ccgtggatca gtacacctag tgcttccaga
     4561 acggactctg aaatgctgtg tgttcacttt cactctgtaa atgtaattct ttacaatgac
     4621 tatttattaa agggcagtca gttgtgattt ttacaggatt gtgtgaactg ttcaaactct
     4681 tcaacctcag aacaagatgc taaaaccaca atgggggata atttgtgact ccttgtttcc
     4741 tttccactaa ggaaaaccct cataattcat atcaccatga atttgcttga aagatcttgt
     4801 ttgcataaca tagttctttg catggtccca ttagactcta ccaaagaaaa aagactcaat
     4861 aaatggacat tctattgcga gtcttgtaag tagccataaa taaccaaaat agtatcgaat
     4921 ttagatgtga aatttcacat gtgcatagta ctgttaaggt gatacatttt tgatgagttt
     4981 ttaatacttg aaaataatta aaaagcatta tctttacatc atcccataac agagtgattc
     5041 attcttaggg tgtgtttccc taggttttca acctttttgc aaaaaacatt gttatcagag
     5101 gcttcctgtc tacctctctc agctaatttt ctaaaatcaa gatgagcttc ctaaatattt
     5161 gccttagcta ctaacacaag ctgtcttcag aaccaaagca aaggagtgtt tatttgtggg
     5221 agccatcttg gaggcctgca ttacaaactc ggtgccagtg cccactggta gagaaggccc
     5281 ctcatgtcct ctagtagcag gtagcggtaa aggcaacagt gccagtcgtg ggtacacttt
     5341 aaagcgatgg atactggtgt tagagtcttc agctttaaag atgccttcca tggtattagg
     5401 tgttgttttg ttaggaacgt catgagtaca cacttcgtgc caatagtgat tatacagaac
     5461 tcccaaacat ttggaccaat ccgttccctt tgaagtaaaa aattgaacag gttagatttg
     5521 ctttagagaa ccagtttaaa aagtttgatt agttaccaaa taccttgcct taagatgttt
     5581 caagtatatt ttcttagaat ttaaattcta attgtattcc ttagccagcc tgaggaataa
     5641 gccgctgcct at
//
