LOCUS       NM_001399780            1825 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cyclin O (Ccno), mRNA.
ACCESSION   NM_001399780 XM_006231947
VERSION     NM_001399780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Gasa,L., Sanchez-Botet,A., Quandt,E., Hernandez-Ortega,S.,
            Jimenez,J., Carrasco-Garcia,M.A., Simonetti,S., Kron,S.J.,
            Ribeiro,M.P., Nadal,E., Villanueva,A. and Clotet,J.
  TITLE     A systematic analysis of orphan cyclins reveals CNTD2 as a new
            oncogenic driver in lung cancer
  JOURNAL   Sci Rep 7 (1), 10228 (2017)
   PUBMED   28860486
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Wallmeier,J., Al-Mutairi,D.A., Chen,C.T., Loges,N.T., Pennekamp,P.,
            Menchen,T., Ma,L., Shamseldin,H.E., Olbrich,H., Dougherty,G.W.,
            Werner,C., Alsabah,B.H., Kohler,G., Jaspers,M., Boon,M., Griese,M.,
            Schmitt-Grohe,S., Zimmermann,T., Koerner-Rettberg,C., Horak,E.,
            Kintner,C., Alkuraya,F.S. and Omran,H.
  TITLE     Mutations in CCNO result in congenital mucociliary clearance
            disorder with reduced generation of multiple motile cilia
  JOURNAL   Nat Genet 46 (6), 646-651 (2014)
   PUBMED   24747639
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Kavli,B., Sundheim,O., Akbari,M., Otterlei,M., Nilsen,H.,
            Skorpen,F., Aas,P.A., Hagen,L., Krokan,H.E. and Slupphaug,G.
  TITLE     hUNG2 is the major repair enzyme for removal of uracil from U:A
            matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1
            as a broad specificity backup
  JOURNAL   J Biol Chem 277 (42), 39926-39936 (2002)
   PUBMED   12161446
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Vinson,R.K. and Hales,B.F.
  TITLE     Expression and activity of the DNA repair enzyme uracil DNA
            glycosylase during organogenesis in the rat conceptus and following
            methotrexate exposure in vitro
  JOURNAL   Biochem Pharmacol 64 (4), 711-721 (2002)
   PUBMED   12167490
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Muller,S.J. and Caradonna,S.
  TITLE     Cell cycle regulation of a human cyclin-like gene encoding
            uracil-DNA glycosylase
  JOURNAL   J Biol Chem 268 (2), 1310-1319 (1993)
   PUBMED   8419333
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 14, 2022 this sequence version replaced XM_006231947.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.10536.1,
                                           SRR26643429.6985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               JAXUCZ010000002.1  46364074-46364529
            457-642             JAXUCZ010000002.1  46365087-46365272
            643-1825            JAXUCZ010000002.1  46365931-46367113
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..1825
                     /gene="Ccno"
                     /gene_synonym="RGD1565217"
                     /note="cyclin O"
                     /db_xref="GeneID:499528"
                     /db_xref="RGD:1565217"
     exon            1..456
                     /gene="Ccno"
                     /gene_synonym="RGD1565217"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1128
                     /gene="Ccno"
                     /gene_synonym="RGD1565217"
                     /codon_start=1
                     /product="cyclin-O"
                     /protein_id="NP_001386709.1"
                     /db_xref="GeneID:499528"
                     /db_xref="RGD:1565217"
                     /translation="MVTPCPASPASPASGAGRQDNHQNLRAPVKKSRRPRLRRKEPLR
                     PLNACSLPGDSGVCDLFESPSSSSDGADSPAVSAVRDCSSLLSSAQPLTALDLQTFRE
                     YGQSCYDFRKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTV
                     NTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRMKQLLALCGGAFSRQQLCNL
                     ECIVLHKLHFSLGAPTINFFLEHFTHSRVEAGQVEVTEALAAQTLARGVAELSLTDYA
                     FTTYTPSLLAICCLALADRMLRHQRLMDLRLGEHPEATLLDCLGKLQKLVSINSSSLT
                     HMLPAHIWEKCSLPQSWK"
     exon            457..642
                     /gene="Ccno"
                     /gene_synonym="RGD1565217"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1825
                     /gene="Ccno"
                     /gene_synonym="RGD1565217"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttcctcc tagccctcgc gccgacgctc cgggcgttgt agacgctagg gcggctactc
       61 gattgtaaca tggtgacccc ttgtcctgcc agcccggcca gccccgcctc gggagccggg
      121 aggcaggaca accatcagaa cctccgcgcc ccagtgaaga agagcagacg cccgcgcctc
      181 cggaggaagg agccgctgcg gccgctgaac gcgtgttcgc tcccgggaga ctcgggcgtc
      241 tgtgaccttt tcgagtcccc cagttccagc tcggacggtg ccgacagccc cgcagtgtct
      301 gcggtgcggg actgcagctc cctactcagc tctgcccagc ccttgacagc gctagatctc
      361 cagaccttcc gagaatatgg ccagagctgc tacgacttcc gaaaggcgca ggagaacctt
      421 ttccacccac gggagtcgct ggcgcgccag ccacaagtga ctgctgaatc ccgctgtaag
      481 ctgctcagtt ggctcctcca agtccaccgc cagttcggcc tctctttcga gtcgctgtgc
      541 ctgaccgtga atactctgga ccgtttcctc ctcacgaccc ctgtagctgc agactgcttc
      601 cagctgctcg gggtcacctg tctgctcatc gcttgcaagc aggtagaagt gcacccacct
      661 cgcatgaaac agctcctggc cctgtgcggc ggggctttct cccggcagca gctgtgtaac
      721 ctcgagtgca tcgtgctaca caagctgcac ttcagcttgg gcgcgcccac catcaacttc
      781 ttcctggagc acttcacaca ttcgcgcgtg gaggccggtc aggttgaggt cacggaagct
      841 ttagcagctc aaaccttggc ccggggagtg gcggagctga gcctgaccga ttatgcgttc
      901 accacctaca caccctccct gctagctatc tgctgcctgg cgctggctga tcgaatgctg
      961 aggcaccagc gcctgatgga ccttcgcctg ggagagcacc cagaggcgac actgctagac
     1021 tgcctgggca aactgcagaa gctagtgtcc atcaacagta gctccctgac tcacatgttg
     1081 cctgcccaca tctgggagaa gtgcagcctg ccccagagtt ggaaataaaa gcacaccctt
     1141 gagctccttt taaaattttc ctggcccctg ctccgtgcct tcaggagaat atgcagtact
     1201 gatccaaagc gaagttcagg tctcctacct gtaaatagtg tacaataacg gaatcttagt
     1261 ttatttattt tgcagtacac atgggcaggg tgacagttct ggcttgtcta aatgctgctg
     1321 ttggtgtgcc cgcctttccc aggcgaagtc agtcacgagg ttgtccgttt ctgcggctct
     1381 tccttgctcc cacaatttta ctctgtagtt cgctgtgaaa acagtctggc aagatgccac
     1441 tgttccagta agcagacaaa tcgaggatgc ttgtctgtat cttaaccccc tccagtcagg
     1501 aggctgagtc ccctcctcca taccagtggc ccaaagagaa tgagacagag ttagaagtca
     1561 tagtagtctg tgtttggaag ggcagtggct gctctcattg atgtgtagct gggaagtttt
     1621 ggggaccagg cagccgtact agcagtgggc aaagcaagag acaatccctg gtgcaacacg
     1681 caaaatgctg gaaggttttt gagtattgtt atagctgttg caacgtgagc catttcctct
     1741 gcagttaaac acggtttagt ttatgctgca gcgcgagccc agggtaacta tggtataaag
     1801 taataaatat tacatgcttg caaca
//
