LOCUS       NM_053662               2128 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cyclin L1 (Ccnl1), mRNA.
ACCESSION   NM_053662
VERSION     NM_053662.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Herrmann,A., Fleischer,K., Czajkowska,H., Muller-Newen,G. and
            Becker,W.
  TITLE     Characterization of cyclin L1 as an immobile component of the
            splicing factor compartment
  JOURNAL   FASEB J 21 (12), 3142-3152 (2007)
   PUBMED   17494991
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Chen,H.H., Wang,Y.C. and Fann,M.J.
  TITLE     Identification and characterization of the CDK12/cyclin L1 complex
            involved in alternative splicing regulation
  JOURNAL   Mol Cell Biol 26 (7), 2736-2745 (2006)
   PUBMED   16537916
  REMARK    GeneRIF: CDK12 and cyclin L1/L2 are cyclin-dependent kinase and
            cyclin partners and regulate alternative splicing.
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Sgambato,V., Minassian,R., Nairn,A.C. and Hyman,S.E.
  TITLE     Regulation of ania-6 splice variants by distinct signaling pathways
            in striatal neurons
  JOURNAL   J Neurochem 86 (1), 153-164 (2003)
   PUBMED   12807435
  REMARK    GeneRIF: Ania-6 transcription is mostly regulated via cAMP response
            element binding protein (CREB), but that signaling pathways that
            converge on CREB at the transcriptional level produce different
            effects on splicing and neuronal gene expression
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Berke,J.D., Sgambato,V., Zhu,P.P., Lavoie,B., Vincent,M., Krause,M.
            and Hyman,S.E.
  TITLE     Dopamine and glutamate induce distinct striatal splice forms of
            Ania-6, an RNA polymerase II-associated cyclin
  JOURNAL   Neuron 32 (2), 277-287 (2001)
   PUBMED   11683997
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Berke,J.D., Paletzki,R.F., Aronson,G.J., Hyman,S.E. and Gerfen,C.R.
  TITLE     A complex program of striatal gene expression induced by
            dopaminergic stimulation
  JOURNAL   J Neurosci 18 (14), 5301-5310 (1998)
   PUBMED   9651213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF030091.3 and CB608234.1.
            
            On Oct 26, 2005 this sequence version replaced NM_053662.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030091.3, BC161817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AF030091.3         1-10
            11-568              CB608234.1         18-575
            569-2128            AF030091.3         569-2128
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2128
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /note="cyclin L1"
                     /db_xref="GeneID:114121"
                     /db_xref="RGD:620864"
     exon            1..395
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1673
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /note="cyclin-L; cyclin Ania-6a; cyclin-L1-like"
                     /codon_start=1
                     /product="cyclin-L1"
                     /protein_id="NP_446114.1"
                     /db_xref="GeneID:114121"
                     /db_xref="RGD:620864"
                     /translation="MASGPHPTSTAAAASASSAAPSAGGSSSGTTTTTTTTTGGILIG
                     DRLYSEVSLTIDHSVIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQ
                     VAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQL
                     RGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERN
                     QTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTE
                     EEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNLDGTPALSTLGG
                     FSPASKPSSPREVKAEEKSPVSINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRS
                     ASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLK
                     AKHTREDLKSSNRHGHKRKKSRSRSQSKTRDHSDVTKKHRHERGHHRDRRERSRSFER
                     SHKGKHHGGSRSGHGRHRR"
     exon            396..470
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            471..580
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            581..701
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            702..766
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            767..866
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            867..971
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1113
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1225
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1324
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..2120
                     /gene="Ccnl1"
                     /gene_synonym="Ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacgggaa tatccgtcgc gccgaggacg ctggttagtc tcgctttggg ttccggctgc
       61 gtcgggcgtg cgtgtagctc gctagaacta tggcgtccgg gcctcacccg acatcgaccg
      121 ctgccgccgc ctctgcctcg tccgccgccc cgagtgcggg cggctccagc tccggcacga
      181 cgaccacgac gacgacgacg accggaggga tcctgattgg cgaccgcctg tactcggagg
      241 tgtcgcttac catcgaccac tcggtgattc cggaggagcg gctctcgcct accccgtcca
      301 tgcaggacgg cctcgacctg cccagcgaga cggacctgcg catcttaggc tgcgagctca
      361 tccaggccgc cggcattctc ctccggctgc cgcaggtggc gatggctacg gggcaggtgt
      421 tgtttcatcg ttttttctac tccaagtctt tcgtcaaaca cagtttcgag attgttgcca
      481 tggcctgtat taatcttgca tcaaaaattg aagaagcacc aagaagaata agagatgtga
      541 ttaatgtatt ccaccacctc cgccagttaa gaggaaaaag gactccaagc cccctgatcc
      601 ttgatcagaa ctacattaac accaaaaatc aagttatcaa ggcagagagg agggtgctaa
      661 aggagttggg attttgtgtt catgtcaagc atccccataa gatcattgta atgtatttac
      721 aagtcttaga atgtgaacgt aaccaaaccc tggttcagac tgcctggaat tatatgaatg
      781 acagtcttcg aaccaatgtt tttgttcgct ttcaaccaga gactatagca tgtgcttgta
      841 tctaccttgc agctagagca cttcaaattc cattgccaac tcggccccat tggtttcttc
      901 tttttggtac cacagaagag gagattcaag aaatctgcat agagacactt agactttata
      961 ccaggaaaaa gcctaactat gaattgctgg aaaaggaagt agaaaaaaga aaagtagcct
     1021 tacaggaagc caagttaaag gcaaagggat tgaatcttga tggaactcca gccctttcca
     1081 ctttaggtgg tttttctcca gcctccaaac catcatcacc aagagaagta aaagctgaag
     1141 agaaatcacc agtttccatt aatgtgaaga cagtcaaaaa agaacctgag gatagacaac
     1201 aagcttccaa aagcccttat aatggtgtaa gaaaagacag caagagaagc agaaacagca
     1261 gaagtgccag tagatcaagg tcaagaacca ggtcacgctc tagatcacac accccaagaa
     1321 gacattataa taataggcga agtcgatctg gaacatacag ctcaagatca agaagcaggt
     1381 ctcgcagtca cagtgaaagt cctcgaagac atcataatca tggttctcct caccttaagg
     1441 ccaaacatac cagagaagat ttaaaaagct caaatagaca tggtcataaa aggaaaaaat
     1501 ctcggtctcg atctcagagc aagactcggg atcactcaga tgttaccaag aaacacaggc
     1561 atgaaagggg gcatcacaga gacaggcgtg aaagatctcg ctcctttgag aggtcccata
     1621 aaggcaagca ccacggtgga agtcgctcag gacatggcag gcataggcgc tgactttcat
     1681 cctctgacac tgcatcggtc cctggtgttg cccatatgca gtgtgacgat gtatggactc
     1741 aatcaaaaca tgaaaagcaa actgattagg gattgattta ttaaaattgt ctaggtttct
     1801 agaaacactg aggacatttt cttttgaaaa gaactatgtt aaggtttttt gcacattaaa
     1861 atgccctagc agtatctaat tgaaaaccat ggtcaggttc aattgtactt tattatagtt
     1921 gtgtattgtt tattgctata agaactggag cgtaaattct gtaaaaatgt atcttatttt
     1981 tatacagata aaacttgcag acactgttct atttaagtgg ttatttgttt aaatgatggt
     2041 gaatactttc ttaacactgg tttgtccgca tgtgtaaaga tttttacaag gaaataaaat
     2101 acaaatcttg tttttctaaa aaaaaaaa
//
