LOCUS       NM_001109672            2552 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus cyclin K (Ccnk), mRNA.
ACCESSION   NM_001109672 XM_580110 XR_008600
VERSION     NM_001109672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Kwak H and Lis JT.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett
            SE, Griffith M, Marra MA and Morin GB.
  TITLE     Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is
            required for the phosphorylation of the C-terminal domain of RNA
            polymerase II
  JOURNAL   Mol Cell Biol 32 (22), 4691-4704 (2012)
   PUBMED   22988298
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang
            S, Song X, Li L and Li Q.
  TITLE     Cyclin K-containing kinase complexes maintain self-renewal in
            murine embryonic stem cells
  JOURNAL   J Biol Chem 287 (30), 25344-25352 (2012)
   PUBMED   22547058
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P,
            Luo Z, Cimermancic P, Ule J and Peterlin BM.
  TITLE     The Cyclin K/Cdk12 complex maintains genomic stability via
            regulation of expression of DNA damage response genes
  JOURNAL   Genes Dev 25 (20), 2158-2172 (2011)
   PUBMED   22012619
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Khan SZ and Mitra D.
  TITLE     Cyclin K inhibits HIV-1 gene expression and replication by
            interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1
            interaction in Nef-dependent manner
  JOURNAL   J Biol Chem 286 (26), 22943-22954 (2011)
   PUBMED   21555514
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Edwards MC, Wong C and Elledge SJ.
  TITLE     Human cyclin K, a novel RNA polymerase II-associated cyclin
            possessing both carboxy-terminal domain kinase and Cdk-activating
            kinase activity
  JOURNAL   Mol Cell Biol 18 (7), 4291-4300 (1998)
   PUBMED   9632813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129121.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XR_008600.1, XM_580110.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129121.1, SRR8487230.21626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2552
                     /gene="Ccnk"
                     /note="cyclin K"
                     /db_xref="GeneID:500715"
                     /db_xref="RGD:1595690"
     exon            1..30
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            31..61
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            62..309
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1882
                     /gene="Ccnk"
                     /codon_start=1
                     /product="cyclin-K"
                     /protein_id="NP_001103142.1"
                     /db_xref="GeneID:500715"
                     /db_xref="RGD:1595690"
                     /translation="MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPA
                     TEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFL
                     AGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHP
                     YQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLC
                     KFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQP
                     PSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQ
                     PSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALG
                     EAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSG
                     EGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTI
                     PPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPP
                     VPPPIPPPGMPPVGGLGRAAWMR"
     exon            310..391
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            392..523
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            524..629
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            630..687
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            688..857
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1147
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1181
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1256
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2520
                     /gene="Ccnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcgctaag ggttttgcct gaggcgaggg gttgatgttg gcctgaaaaa gatcttcaga
       61 ggattatagc attctagaga cccattgggg aagaacaagt ctacgtcaat aaatgaagga
      121 gaacaaagaa aattcaagcc cgtcagtcac atcagcaaac ctggaccaca caaaaccatg
      181 ttggtactgg gataagaagg acttggcgca tacaccctca caacttgaag gactcgatcc
      241 agccactgag gcccggtacc gccgagaggg ggctcgcttc atctttgatg tgggcacacg
      301 tttggggtta cactatgaca ccctggcaac tggaatcatt tattttcacc gattctatat
      361 gttccattcc ttcaaacaat tcccaagata cgtgacagga gcctgttgtc tctttctggc
      421 tgggaaagta gaggaaacac caaaaaagtg taaagatatc atcaaaacgg ctcgtagttt
      481 attaaatgat gtccagtttg gccagtttgg agatgaccca aaggaagaag tcatggtgct
      541 ggagaggatc ctactgcaga ccataaagtt cgacttacaa gtagagcatc cgtaccagtt
      601 cctgctcaaa tacgccaagc agctgaaagg tgataaaaac aaaattcaga agttggttca
      661 aatggcatgg acatttgtaa atgacagtct ctgcaccacc ctgtcactgc agtgggagcc
      721 agaaatcata gctgttgcag taatgtatct tgcgggacgt ttgtgcaaat ttgaaataca
      781 agagtggacc tccaagccca tgtacaggag atggtgggaa caatttgttc aagatgtccc
      841 tgttgacgtt ctggaagaca tctgccacca aatcctggac ctttattcac aagggaaaca
      901 acagatgcct caccacaccc ctcatcagct gcagcagccc ccatctcttc agcccacacc
      961 acaagtgccc ccggtgccac aggcacagcc atcccaaggt tctgaagcag cgcagccgca
     1021 gcagaaggat gcacagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca
     1081 gcaagcacaa cagcccaaga aaccatcccc tcagcccagt cctccgcgac aggccaagcg
     1141 tgccgtggtg gtgtctccca aggaagagaa caaagccaca gaaccaccac caccacctaa
     1201 aattcccaaa cttgaggctg ctcacccacc attgcctcca gcacacccgc ctccagaccg
     1261 gaagcttccc cttgctcctg ccttaggtga ggctgaaccg actggccctg tggaaacaag
     1321 tgacctccct aaagtccaga ttcctccccc agcccacccg gcccctgtgc accagccccc
     1381 accactgcca catcggcctc cacccccgcc gccctccagc tacatgactg ggatgtctac
     1441 caccagctcc tacatgtcag gagagggcta ccagagcctg cagtccatga tgaaaacaga
     1501 ggggccctcc tatggcgccc ttcccccagc ctatggccca cctgctcacc taacatacca
     1561 tccccatgtc taccccccca acccacctcc acctcctgtt cctccacccc cagcctcctt
     1621 ccctccacca accatccctc cccctacccc aggctaccct ccacctcccc ctacctacaa
     1681 ccccaatttt ccacccccgc ccccacgcct tcctccaact catgcagtcc ctcctcaccc
     1741 tcctccaggc ttgggtttgc caccagccag ctacccacct ccagctgtcc ctcctggggg
     1801 gcaaccccct gttcccccac ccatccctcc acctggcatg ccgcctgttg ggggactagg
     1861 gcgggcagcc tggatgagat agcggcaccc cccccccttt ttttttcttt taaccatttt
     1921 ccaaacaact tgaagagtag attgaggggc agcagcaggg taccttgtat atgctagaca
     1981 gttgcagtgt ggaagggctg ggccctgggg tgagctgtgt gccctgggca gtgcctgttg
     2041 tgatcacatc cagtctcagc tacactcgct gtcctgcgct gggttacttc acgagtgaga
     2101 atgttaagtg ccacattggc tcagttaata gcttcagtga ggagtgacga accctctaga
     2161 aatcagtgcc taattctcct gggaaccatt ggtatccatg tcctatctgc agtccagctg
     2221 ctgtccctct attctgtggc ttctctctgt ggcccctagt aggtgaggtg agtccccata
     2281 gagcttgtaa ctgtcctcta ttgtcacctg ggggggctgc cttgctgggt ggctgtctct
     2341 ttccctccag ggagaaaggc ggtgtgtact tggaaaataa tgtgtgttta catctctttg
     2401 caaagtcctg tacatagaga gatatttttt aaagcgtgaa tgtaacaaca tactgtgaat
     2461 tccatctcgg ttacaaagga gagtccttca gttacctaaa taaagtcagt tctgaaacta
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
