LOCUS       NP_001103142             589 aa            linear   ROD 23-MAR-2023
DEFINITION  cyclin-K [Rattus norvegicus].
ACCESSION   NP_001103142 XP_580110
VERSION     NP_001103142.1
DBSOURCE    REFSEQ: accession NM_001109672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 589)
  AUTHORS   Kwak H and Lis JT.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   2  (residues 1 to 589)
  AUTHORS   Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett
            SE, Griffith M, Marra MA and Morin GB.
  TITLE     Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is
            required for the phosphorylation of the C-terminal domain of RNA
            polymerase II
  JOURNAL   Mol Cell Biol 32 (22), 4691-4704 (2012)
   PUBMED   22988298
REFERENCE   3  (residues 1 to 589)
  AUTHORS   Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang
            S, Song X, Li L and Li Q.
  TITLE     Cyclin K-containing kinase complexes maintain self-renewal in
            murine embryonic stem cells
  JOURNAL   J Biol Chem 287 (30), 25344-25352 (2012)
   PUBMED   22547058
REFERENCE   4  (residues 1 to 589)
  AUTHORS   Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P,
            Luo Z, Cimermancic P, Ule J and Peterlin BM.
  TITLE     The Cyclin K/Cdk12 complex maintains genomic stability via
            regulation of expression of DNA damage response genes
  JOURNAL   Genes Dev 25 (20), 2158-2172 (2011)
   PUBMED   22012619
REFERENCE   5  (residues 1 to 589)
  AUTHORS   Khan SZ and Mitra D.
  TITLE     Cyclin K inhibits HIV-1 gene expression and replication by
            interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1
            interaction in Nef-dependent manner
  JOURNAL   J Biol Chem 286 (26), 22943-22954 (2011)
   PUBMED   21555514
REFERENCE   6  (residues 1 to 589)
  AUTHORS   Edwards MC, Wong C and Elledge SJ.
  TITLE     Human cyclin K, a novel RNA polymerase II-associated cyclin
            possessing both carboxy-terminal domain kinase and Cdk-activating
            kinase activity
  JOURNAL   Mol Cell Biol 18 (7), 4291-4300 (1998)
   PUBMED   9632813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129121.1.
            
            On Sep 7, 2008 this sequence version replaced XP_580110.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129121.1, SRR8487230.21626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..589
                     /product="cyclin-K"
                     /calculated_mol_wt=65236
     Region          40..154
                     /region_name="CYCLIN_CCNK_rpt1"
                     /note="first cyclin box found in cyclin-K (CCNK) and
                     similar proteins; cd20530"
                     /db_xref="CDD:410233"
     Site            order(90,102,105..106,108,138,141..146,148..149,152..154)
                     /site_type="other"
                     /note="CDK interface [polypeptide binding]"
                     /db_xref="CDD:410233"
     Region          158..258
                     /region_name="CYCLIN_CCNK_rpt2"
                     /note="second cyclin box found in cyclin-K (CCNK) and
                     similar proteins; cd20531"
                     /db_xref="CDD:410234"
     CDS             1..589
                     /gene="Ccnk"
                     /coded_by="NM_001109672.1:113..1882"
                     /db_xref="GeneID:500715"
                     /db_xref="RGD:1595690"
ORIGIN      
        1 mkenkenssp svtsanldht kpcwywdkkd lahtpsqleg ldpatearyr regarfifdv
       61 gtrlglhydt latgiiyfhr fymfhsfkqf pryvtgaccl flagkveetp kkckdiikta
      121 rsllndvqfg qfgddpkeev mvlerillqt ikfdlqvehp yqfllkyakq lkgdknkiqk
      181 lvqmawtfvn dslcttlslq wepeiiavav mylagrlckf eiqewtskpm yrrwweqfvq
      241 dvpvdvledi chqildlysq gkqqmphhtp hqlqqppslq ptpqvppvpq aqpsqgseaa
      301 qpqqkdaqqq qqqqqqqqqq qqqqaqqpkk pspqpspprq akravvvspk eenkateppp
      361 ppkipkleaa hpplppahpp pdrklplapa lgeaeptgpv etsdlpkvqi pppahpapvh
      421 qppplphrpp ppppssymtg msttssymsg egyqslqsmm ktegpsygal ppaygppahl
      481 tyhphvyppn pppppvpppp asfppptipp ptpgyppppp tynpnfpppp prlppthavp
      541 phpppglglp pasypppavp pggqppvppp ipppgmppvg glgraawmr
//
