LOCUS       NM_052981               1230 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cyclin H (Ccnh), mRNA.
ACCESSION   NM_052981
VERSION     NM_052981.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Wang,K.C., Nguyen,P., Weiss,A., Yeh,Y.T., Chien,H.S., Lee,A.,
            Teng,D., Subramaniam,S., Li,Y.S. and Chien,S.
  TITLE     MicroRNA-23b regulates cyclin-dependent kinase-activating kinase
            complex through cyclin H repression to modulate endothelial
            transcription and growth under flow
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (7), 1437-1445 (2014)
   PUBMED   24855060
  REMARK    GeneRIF: Hemodynamic forces modulate EC proliferative phenotype
            through the miR-23b/CAK/cyclin H pathway.
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Wang,Y., Liu,F., Mao,F., Hang,Q., Huang,X., He,S., Wang,Y.,
            Cheng,C., Wang,H., Xu,G., Zhang,T. and Shen,A.
  TITLE     Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7)
            stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer
            cell migration
  JOURNAL   J Biol Chem 288 (13), 9028-9034 (2013)
   PUBMED   23393140
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Fujii,W., Nishimura,T., Kano,K., Sugiura,K. and Naito,K.
  TITLE     CDK7 and CCNH are components of CDK-activating kinase and are
            required for meiotic progression of pig oocytes
  JOURNAL   Biol Reprod 85 (6), 1124-1132 (2011)
   PUBMED   21778139
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Wu,G., Cao,J., Peng,C., Yang,H., Cui,Z., Zhao,J., Wu,Q., Han,J.,
            Li,H., Gu,X. and Zhang,F.
  TITLE     Temporal and spatial expression of cyclin H in rat spinal cord
            injury
  JOURNAL   Neuromolecular Med 13 (3), 187-196 (2011)
   PUBMED   21710280
  REMARK    GeneRIF: Data suggest that cyclin H may play a proliferative role
            in spinal cord injury (SCI).
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   6  (bases 1 to 1230)
  AUTHORS   Laes,J.F., Quan,X., Ravoet,M., Stieber,D., Van Vooren,P., Van
            Reeth,T., Szpirer,J. and Szpirer,C.
  TITLE     Analysis of candidate genes included in the mammary cancer
            susceptibility 1 (Mcs1) region
  JOURNAL   Mamm Genome 12 (3), 199-206 (2001)
   PUBMED   11252168
REFERENCE   7  (bases 1 to 1230)
  AUTHORS   Jin,K., Nagayama,T., Chen,J., Stetler,A.R., Kawaguchi,K.,
            Simon,R.P. and Graham,S.H.
  TITLE     Molecular cloning of a cell cycle regulation gene cyclin H from
            ischemic rat brain: expression in neurons after global cerebral
            ischemia
  JOURNAL   J Neurochem 73 (4), 1598-1608 (1999)
   PUBMED   10501206
REFERENCE   8  (bases 1 to 1230)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   9  (bases 1 to 1230)
  AUTHORS   Drapkin,R., Le Roy,G., Cho,H., Akoulitchev,S. and Reinberg,D.
  TITLE     Human cyclin-dependent kinase-activating kinase exists in three
            distinct complexes
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6488-6493 (1996)
   PUBMED   8692842
REFERENCE   10 (bases 1 to 1230)
  AUTHORS   Reardon,J.T., Ge,H., Gibbs,E., Sancar,A., Hurwitz,J. and Pan,Z.Q.
  TITLE     Isolation and characterization of two human transcription factor
            IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996)
   PUBMED   8692841
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 1, 2021 this sequence version replaced NM_052981.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059109.1, AF154914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000002.1  17570494-17570739
            247-369             JAXUCZ010000002.1  17571826-17571948
            370-443             JAXUCZ010000002.1  17576936-17577009
            444-654             JAXUCZ010000002.1  17578091-17578301
            655-818             JAXUCZ010000002.1  17582939-17583102
            819-889             JAXUCZ010000002.1  17585939-17586009
            890-1001            JAXUCZ010000002.1  17589521-17589632
            1002-1062           JAXUCZ010000002.1  17589982-17590042
            1063-1230           JAXUCZ010000002.1  17590911-17591078
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..1230
                     /gene="Ccnh"
                     /note="cyclin H"
                     /db_xref="GeneID:84389"
                     /db_xref="RGD:69419"
     exon            1..246
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1101
                     /gene="Ccnh"
                     /codon_start=1
                     /product="cyclin-H"
                     /protein_id="NP_443213.3"
                     /db_xref="GeneID:84389"
                     /db_xref="RGD:69419"
                     /translation="MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPND
                     PLFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPR
                     IIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIV
                     HNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAIL
                     SSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAILKQK
                     LERCHSSDLALNMVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDAL"
     exon            247..369
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            370..443
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            444..654
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            655..818
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            819..889
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1001
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1062
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1230
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaccgtga cgtcacgcgc gcgcctgcgg tctgggccga gggttctcgc gttggcagtc
       61 gctcgtggct gctgtctccc ggagtgtcgc tgtttctgtc tcggccctgc ggcccgtgag
      121 ggctacagca tgtaccacaa cagcagccag aagcggcact ggaccttcgc tagcgaggag
      181 caactggcgc gtctgcgggc cgacgccaac cgcaaattca agtgcaaagc tgtggctaac
      241 gggaaggttc ttccaaatga tccgttgttt cttgagcctc atgaagaaat gacactttgc
      301 aaatactatg aaaaaagatt gttggaattt tgttcagtgt ttaaaccagc tatgccacgg
      361 tctgttgtgg gtacagcttg tatgtatttc aagcgttttt atcttaataa ctcagtaatg
      421 gaatatcacc ctcggataat aatgcttact tgtgcatttt tggcctgcaa agtagatgaa
      481 ttcaatgtgt ctagtcctca gtttgttggg aaccttcgag agagtcctct tggacaggag
      541 aaggcactgg aacagatttt ggaatatgaa ctactactta tacaacaact taattttcac
      601 ctcattgtcc acaatccata tagaccattt gaaggcttcc tcattgatat aaagactcga
      661 taccccatgt tggagaatcc agagattttg aggaaaacgg ctgatgattt tcttagtaga
      721 attgcattga cagatgctta tcttttgtac acaccctcac aaattgccct gactgccatt
      781 ttatcaagtg cctctagggc tggaattact atggaaagct atttatcaga gagtctaatg
      841 ctgaaagaaa acagaacttg cctgtcacag ctactggata taatgaaaag catgagaaat
      901 ctagtaaaaa agtatgagcc acccagatct gaagaagttg ctattctgaa acagaagttg
      961 gagcgatgtc attcttctga ccttgcactt aatatggtta caaagaagag gaaaggctac
     1021 gaagacgatg actatgtatc aaagaaaccc aaacaggaag aggaggagtg gacggacgat
     1081 gacctggtag atgctctcta accagtgtaa atgactgcag cagtacttac tgaccgacgg
     1141 aagtaggaag catgtctgac attttacttt tgtcaaaata gtgcaatgtg aaaacatcaa
     1201 aatatattaa acttttctaa ttcttatata
//
