LOCUS       NM_012923               3198 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cyclin G1 (Ccng1), mRNA.
ACCESSION   NM_012923
VERSION     NM_012923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Liu,Y., Fu,X., Wang,X., Liu,Y. and Song,X.
  TITLE     Long non-coding RNA OIP5-AS1 facilitates the progression of ovarian
            cancer via the miR-128-3p/CCNG1 axis
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760168
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Xu,G., Bu,S., Wang,X. and Ge,H.
  TITLE     Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity
            of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing
            Apoptosis
  JOURNAL   Radiat Res 195 (4), 378-384 (2021)
   PUBMED   33543294
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Guo,J.Y., Wang,X.Q. and Sun,L.F.
  TITLE     MicroRNA-488 inhibits ovarian cancer cell metastasis through
            regulating CCNG1 and p53 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (6), 2902-2910 (2020)
   PUBMED   32271408
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Xu,Y., Zhang,Q., Miao,C., Dongol,S., Li,Y., Jin,C., Dong,R., Li,Y.,
            Yang,X. and Kong,B.
  TITLE     CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3
            expression promotes high-grade serous ovarian cancer (HGSOC)
            tumorigenesis and progression
  JOURNAL   Cancer Med 8 (1), 351-362 (2019)
   PUBMED   30565428
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Ohno,S., Ikeda,J.I., Naito,Y., Okuzaki,D., Sasakura,T.,
            Fukushima,K., Nishikawa,Y., Ota,K., Kato,Y., Wang,M., Torigata,K.,
            Kasama,T., Uchihashi,T., Miura,D., Yabuta,N., Morii,E. and
            Nojima,H.
  TITLE     Comprehensive phenotypic analysis of knockout mice deficient in
            cyclin G1 and cyclin G2
  JOURNAL   Sci Rep 6, 39091 (2016)
   PUBMED   27982046
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Chen,D.S., Zhu,N.L., Hung,G., Skotzko,M.J., Hinton,D.R., Tolo,V.,
            Hall,F.L., Anderson,W.F. and Gordon,E.M.
  TITLE     Retroviral vector-mediated transfer of an antisense cyclin G1
            construct inhibits osteosarcoma tumor growth in nude mice
  JOURNAL   Hum Gene Ther 8 (14), 1667-1674 (1997)
   PUBMED   9322869
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Zhu,N.L., Wu,L., Liu,P.X., Gordon,E.M., Anderson,W.F., Starnes,V.A.
            and Hall,F.L.
  TITLE     Downregulation of cyclin G1 expression by retrovirus-mediated
            antisense gene transfer inhibits vascular smooth muscle cell
            proliferation and neointima formation
  JOURNAL   Circulation 96 (2), 628-635 (1997)
   PUBMED   9244236
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Endo,Y., Fujita,T., Tamura,K., Tsuruga,H. and Nojima,H.
  TITLE     Structure and chromosomal assignment of the human cyclin G gene
  JOURNAL   Genomics 38 (1), 92-95 (1996)
   PUBMED   8954786
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Zauberman,A., Lupo,A. and Oren,M.
  TITLE     Identification of p53 target genes through immune selection of
            genomic DNA: the cyclin G gene contains two distinct p53 binding
            sites
  JOURNAL   Oncogene 10 (12), 2361-2366 (1995)
   PUBMED   7784084
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB805791.1 and BC081852.1.
            
            On Jan 9, 2008 this sequence version replaced NM_012923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081852.1, FQ211975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CB805791.1         22-50
            30-3198             BC081852.1         1-3169
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3198
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="cyclin G1"
                     /db_xref="GeneID:25405"
                     /db_xref="RGD:2295"
     exon            1..231
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1116
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="cyclin-G"
                     /codon_start=1
                     /product="cyclin-G1"
                     /protein_id="NP_037055.1"
                     /db_xref="GeneID:25405"
                     /db_xref="RGD:2295"
                     /translation="MIEVLTTDSQKLLHQLNTLLEQESRCQPKVCGLKLIESAHDNGL
                     RMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQAKHLGCVGLSCFY
                     LAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLY
                     YSLIRETLPFERRNDLNFERLEAQLKACHCRIIFSKAKPSVLALAIIALEIQALKYVE
                     LTEGVECIQKHSKISGRDLTFWQELVSKCLTEYSSNKCSKPNGQKLKWIVSGRTARQL
                     KHSYYRITHLPTIPETMG"
     exon            232..492
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            493..746
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            747..825
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            826..924
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            925..3198
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctccccgcg gccgggcgca gtccttcacc gcacgctgaa ccggaggaag gctgcgccta
       61 gtcggggcgc tgagggaccc tccaccggga cgccggcccc tccccgggcc tctgctcact
      121 tgcccccctg cgagcccgtc cccctagtcg gcctctcgga tcggggacgt ggggcgagct
      181 gagagcaggc ccggggtggg tggtcactgt ggagaagacg tggctgtcaa gatgatagaa
      241 gtactgacaa ctgactctca gaaactgcta caccagctga acaccctgtt ggaacaggag
      301 tccagatgtc agccaaaggt ctgtggcctg aaactgattg agtctgcaca tgataatggc
      361 ctcaggatga ctgcaagact ccgggacttt gaagtcaaag atctactgag tctaactcag
      421 ttctttggct tcgacacaga aacattttcc cttgctgtga atttactgga cagattcttg
      481 tctaaaatga aggtacaggc gaagcatctc ggctgtgtcg gactgagctg cttttatttg
      541 gctgtgaaat cgattgaaga ggaaaggaac gtcccgctgg caactgattt gatccggata
      601 agtcagtata ggttcacagt ttcagacctg atgagaatgg aaaagattgt gttggagaaa
      661 gtgtgctgga aagtcaaagc tactactgcc ttccaatttc tgcagctcta ttactccctc
      721 attcgggaga ccttgccatt tgaaaggaga aacgatctga attttgaaag actagaagcc
      781 caactgaagg cgtgccactg caggatcata ttttctaagg caaagccttc tgtgctggcg
      841 ctggcaatca tcgctttgga gatccaagca ctgaagtatg tggagttaac agaaggagta
      901 gaatgtattc agaaacattc caagataagt ggccgagatc tgaccttctg gcaagagctt
      961 gtttccaagt gtttaactga atattcatca aacaagtgtt ccaagccgaa cggtcagaag
     1021 ttaaaatgga tcgtgtctgg gcgcactgca cgacaactga agcacagtta ttacaggata
     1081 acccacctcc caacaattcc cgaaaccatg ggttagttgg caaatctggt tgttatcctc
     1141 tgtgtacaga acatttccca gtgagatcgt ttttgtgcta taacttaagg attgaaatac
     1201 taccttcaat ataaagaata caggatgaaa acagtaaagg aaacgtgagt ttgttggtct
     1261 agacagagaa tactgggagg cattcactgt gtaccgcagt ctgaagagaa atgagtatca
     1321 aacctctaga cacatgctca tactgctgtc aaaggactag cgtagaaaag agagtcctcc
     1381 aaaccggaag tttaaatgta gttactaaaa tagcacttct ttaacttaca tatcccccca
     1441 ctgtggctta tttaaagtta cagaagtcca agcagaacga caaaagatgt gacccatata
     1501 tgaacacatt ttaatctgtt cattgattag gagagtgaat atgaacttgc atgatgccca
     1561 tgttaggttt ctggaaactg ccggggtatc ttaattctct agtattctcc ctctgtggca
     1621 gttgggctaa tacaaagtaa ctatacgcat gagaatataa aatcagtctc tgatacatac
     1681 acatttttac catcaaaatt tcttaatcat agcaaagact taccttttta tgattaggaa
     1741 tttttttttt aatgtatggc agcacatgcc tttaatccca acactaggga ggcagaggca
     1801 ggtggatctc tttgagttcg aagccaggct ggtctttaca gtgagttcca ggacagctgg
     1861 agagctacag aatggagaga cgctgtctca aaaacactga aaacaaacaa acaaaccata
     1921 ccagtttgta ggcagacttc tgttgggttg ggtttgtact gtttgcctat gcagtgggat
     1981 tacagcagca gcaacaaaaa ctgtccctga agtctttctc tgccactgtg acctgagttt
     2041 cctatggtac gcgatttatt ctaagaaacc tcagcccctc accacgttag ctgttggcaa
     2101 atggcctcac agttgcggaa agtcccaatt ctaggcttgg gaaagcaatg cttagatttg
     2161 aattggccca tgaagcattc aaatcaaggc taaagacata aatgtgaaat aaaactgtga
     2221 accttcattt taacattgat ctcacttccc agatttaatc aatatatact taggtggtat
     2281 taaaaatggt aaactgccta atttaaatct caaaatttaa actatgaggt ttacatcaaa
     2341 gccaacattt cacaaatgta cttttaaggt attaaaagag gtatttaagc agtaaatggt
     2401 ttcttggcac ccataaccaa gtaatagtta agttagaggt gggacttttt tattgctatg
     2461 agaattacat ttaaactttt gggtgtttta taaaaagcag atttcacaag ttttgaaaat
     2521 tgtgaccttt actgaaattt gttaccttta atatttcttc tagaggatag gtatttataa
     2581 aagaaaaatt cgtcagaatt gctgcctcaa tctagtccca tttgagaaaa tttgtttcta
     2641 ctgtctcaat aactggatga aatatcactc tgaaaacttg cctattgcac taaagctagt
     2701 ttaggcttga taaaacactc caggaggttt ttaccacaga ctgtttctat taaaactgct
     2761 gcttctcatg tacaattttg ttttaaaagg aaccgagtac atctgcaaaa cctaagtctt
     2821 aagggacgtc aggaggtacc ttcagaatta taggatcacc atggtagtgg ggattctcca
     2881 tgctggcctt gaatgtttga tcttcactgc tgaaatgtgg gtagctcctc agcgccctgt
     2941 agagcctgag tctacctaga atagctgtaa ccattttgac aagtaatgga taagaaaatt
     3001 atccattgag aagctaaaaa caaaacaaaa caaaaccaaa gaacgggtgt attttattct
     3061 taacctttgt aaaccatcac tgagaacact tcagttcttc ctaacagctg ttatgcttcg
     3121 atttgaaaaa aatactgagt ggataaccaa ctaccatcat gctttgggta cacctttcaa
     3181 taaaattact gaaatgca
//
