LOCUS       NP_001093944             780 aa            linear   ROD 31-MAR-2024
DEFINITION  cyclin-F [Rattus norvegicus].
ACCESSION   NP_001093944 XP_001054372 XP_340764
VERSION     NP_001093944.1
DBSOURCE    REFSEQ: accession NM_001100474.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   D'Angiolella,V., Donato,V., Vijayakumar,S., Saraf,A., Florens,L.,
            Washburn,M.P., Dynlacht,B. and Pagano,M.
  TITLE     SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity
            through CP110 degradation
  JOURNAL   Nature 466 (7302), 138-142 (2010)
   PUBMED   20596027
REFERENCE   2  (residues 1 to 780)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   3  (residues 1 to 780)
  AUTHORS   Tetzlaff,M.T., Bai,C., Finegold,M., Wilson,J., Harper,J.W.,
            Mahon,K.A. and Elledge,S.J.
  TITLE     Cyclin F disruption compromises placental development and affects
            normal cell cycle execution
  JOURNAL   Mol Cell Biol 24 (6), 2487-2498 (2004)
   PUBMED   14993286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 14, 2007 this sequence version replaced
            XP_001054372.1, XP_340764.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF410816.1, SRR26643292.39421.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..780
                     /product="cyclin-F"
                     /calculated_mol_wt=86659
     Region          20..28
                     /region_name="Nuclear localization signal 1.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          31..82
                     /region_name="F-box_FBXO1"
                     /note="F-box domain found in F-box only protein 1 (FBXO1)
                     and similar proteins; cd22082"
                     /db_xref="CDD:438854"
     Site            order(35,39,42..43,46..47,51,53..54,58..60,62)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438854"
     Region          <88..138
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          307..401
                     /region_name="CYCLIN_CCNF_rpt1"
                     /note="first cyclin box found in G2/mitotic-specific
                     cyclin-F (CCNF) and similar proteins; cd20521"
                     /db_xref="CDD:410225"
     Region          310..313
                     /region_name="D box 1.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          343..346
                     /region_name="D box 2.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          349..352
                     /region_name="D box 3.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          429..540
                     /region_name="CYCLIN_SF"
                     /note="Cyclin box fold superfamily; cl40454"
                     /db_xref="CDD:477360"
     Region          544..594
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          568..574
                     /region_name="Nuclear localization signal 2.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          582..761
                     /region_name="PEST"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          651..733
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          745..780
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     Region          762..765
                     /region_name="D box 4.
                     /evidence=ECO:0000250|UniProtKB:P41002"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F8.2)"
     CDS             1..780
                     /gene="Ccnf"
                     /coded_by="NM_001100474.1:32..2374"
                     /db_xref="GeneID:117524"
                     /db_xref="RGD:67401"
ORIGIN      
        1 mgsggvihcr cakcfcyptk rrikrrprnl tilslpedvl fhilkwlsvg dilavravhs
       61 hlkylvdnha svwasasfqe lwpspqnlkl feraaekgnf eaavklgiay lyneglsvsd
      121 eacaevnglk asrffsmaer lntgsdpfiw lfirppwsvs gscckavvhd slraecqlqr
      181 shkasilhcl grvlnlfede ekrkqahnlf eesahqgcla ssyllwesdr kvdmsdpgrc
      241 lhsfrklrdy aakgcweaql alakacaggs qlglegkacs esvcqlfqas qavnkqqifs
      301 vqkglsdtmr yilidwlvev atmkdftslc lhltvecvdr ylrrrlvpry klqllgiacm
      361 victrfiske iltireavwl tdntykyedl vrvmgeiisa legkiriptv vdykevlltl
      421 vpvaprtqhl csflceltll htslsvyapa rlasaallla rlmhghtqpw ttqlwdltgf
      481 sysdltpcvl slhkkcfhdd apkdyrqvsl tavkqrfedk cyeeisqeev lsyaelcsal
      541 gvkqespepp sfpssgeiht flsspsgrrs krkrenslqe drgsfvttpt aelsnqeetl
      601 lgslldwsld ccsgyegdqe segekegdvt apsglldvtv vylnpeehcc qessdeevwp
      661 edkshptpgt qappasapwp lpcnrgdpgk dvttsgyssv sssspissld ggmvgsprst
      721 svlsvgshss tkpcyhqakk sclqcrppnp pesgahqqpv krqnlsvhsd edtnlgflkl
//
