LOCUS       NM_001108656            3027 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus cyclin E2 (Ccne2), mRNA.
ACCESSION   NM_001108656 XM_001064075 XM_001064132 XM_001064192 XM_001064237
            XM_342804
VERSION     NM_001108656.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3027)
  AUTHORS   Zhang L, Zhang XW, Liu CH, Lu K, Huang YQ, Wang YD, Xing L, Zhang
            LJ, Liu N, Jiang H, Sun C, Yang Y, Chen SQ, Chen M and Xu B.
  TITLE     miRNA-30a functions as a tumor suppressor by downregulating cyclin
            E2 expression in castration-resistant prostate cancer
  JOURNAL   Mol Med Rep 14 (3), 2077-2084 (2016)
   PUBMED   27431942
REFERENCE   2  (bases 1 to 3027)
  AUTHORS   Wan L, Tan HL, Thomas-Ahner JM, Pearl DK, Erdman JW Jr, Moran NE
            and Clinton SK.
  TITLE     Dietary tomato and lycopene impact androgen signaling- and
            carcinogenesis-related gene expression during early TRAMP prostate
            carcinogenesis
  JOURNAL   Cancer Prev Res (Phila) 7 (12), 1228-1239 (2014)
   PUBMED   25315431
REFERENCE   3  (bases 1 to 3027)
  AUTHORS   Martinerie L, Manterola M, Chung SS, Panigrahi SK, Weisbach M,
            Vasileva A, Geng Y, Sicinski P and Wolgemuth DJ.
  TITLE     Mammalian E-type cyclins control chromosome pairing, telomere
            stability and CDK2 localization in male meiosis
  JOURNAL   PLoS Genet 10 (2), e1004165 (2014)
   PUBMED   24586195
  REMARK    Erratum:[PLoS Genet. 2014 Apr;10(4):e1004350]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3027)
  AUTHORS   Malumbres M and Barbacid M.
  TITLE     Mammalian cyclin-dependent kinases
  JOURNAL   Trends Biochem Sci 30 (11), 630-641 (2005)
   PUBMED   16236519
  REMARK    Review article
REFERENCE   5  (bases 1 to 3027)
  AUTHORS   Boylan JM and Gruppuso PA.
  TITLE     D-type cyclins and G1 progression during liver development in the
            rat
  JOURNAL   Biochem Biophys Res Commun 330 (3), 722-730 (2005)
   PUBMED   15809057
REFERENCE   6  (bases 1 to 3027)
  AUTHORS   Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S,
            Rideout WM, Bronson RT, Gardner H and Sicinski P.
  TITLE     Cyclin E ablation in the mouse
  JOURNAL   Cell 114 (4), 431-443 (2003)
   PUBMED   12941272
REFERENCE   7  (bases 1 to 3027)
  AUTHORS   Sherr CJ.
  TITLE     The Pezcoller lecture: cancer cell cycles revisited
  JOURNAL   Cancer Res 60 (14), 3689-3695 (2000)
   PUBMED   10919634
  REMARK    Review article
REFERENCE   8  (bases 1 to 3027)
  AUTHORS   Lauper N, Beck AR, Cariou S, Richman L, Hofmann K, Reith W,
            Slingerland JM and Amati B.
  TITLE     Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the
            mammalian cell cycle
  JOURNAL   Oncogene 17 (20), 2637-2643 (1998)
   PUBMED   9840927
REFERENCE   9  (bases 1 to 3027)
  AUTHORS   Hirai H, Roussel MF, Kato JY, Ashmun RA and Sherr CJ.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342804.3, XM_001064132.1, XM_001064192.1, XM_001064237.1,
            XM_001064075.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3027
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3027
                     /gene="Ccne2"
                     /note="cyclin E2"
                     /db_xref="GeneID:362485"
                     /db_xref="RGD:1307783"
     exon            1..90
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..130
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1334
                     /gene="Ccne2"
                     /codon_start=1
                     /product="G1/S-specific cyclin-E2"
                     /protein_id="NP_001102126.1"
                     /db_xref="GeneID:362485"
                     /db_xref="RGD:1307783"
                     /translation="MSRRSSRLQAKQQHARPNQPDSPQEAQIIQAKKRKTAQDVKKRT
                     EEITKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSP
                     LPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLH
                     RETFYLAQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGA
                     CSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQI
                     AQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVS
                     VVKSVSPVKLKTFKKIPMEDRHNIQTHTNYLALLNEVNYVNIFRKGGQLSPVCNGGIM
                     TPPKSTEKPPVKF"
     exon            131..230
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..284
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..436
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..572
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..719
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..815
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..950
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1062
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1220
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..3027
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgtgcgg ggcggtccgg gccaggccta tatattgagt tggcgccggc gccagctgag
       61 ccgagctgag gagggtctgg cgctgagaag aggtttcata ggcctcaaag aagagaatgt
      121 caagacgcag tagccgttta caagctaagc agcagcatgc ccggcccaac cagccagact
      181 ctccacaaga agcccagata attcaggcca agaagagaaa aacagcacag gatgtcaaaa
      241 aaagaacaga ggagatcacc aagaagcatc agtatgagat taggaattgt tggccacctg
      301 tactgtctgg aggaatcagt ccttgcatta tcattgaaac gccccataaa gaaataggaa
      361 caagtgactt ctctaggttt acaaactaca gatttaaaaa tctttttatt aatccctcac
      421 ctctgccaga cttaagctgg gcatgttcac aggaggtttg gcaaaacatg ctacaaaagg
      481 aaagcagata cgtgcatgac aaacattttg aagttctgca ttctgacctg gaaccacaaa
      541 tgaggtcaat acttttagac tggcttttag aggtctgtga agtatatact cttcataggg
      601 aaacatttta ccttgcccaa gacttttttg acagatttat gttgacacaa aaggatgtaa
      661 ataaaaatat gcttcaactc attgggatta cctcattgtt cattgcttcc aaacttgagg
      721 aaatctacgc tcccaagctc caagagtttg cttatgtcac tgatggtgct tgcagtgaag
      781 tagatatctt aaagatggaa ctcaatatat taaaggcttt aaaatgggaa ctttgtccag
      841 taacagtcat ttcctggttg aatctttttc tccaagttga tgctgttaaa gacattccta
      901 aggttcttct acctcagtat tctcaggaga cgttcatcca aatagctcag cttttagatc
      961 tgtgcattct agccattgac tctttagaat ttcaatacag aattctggcc gccgctgcct
     1021 tatgccattt tacttccatc gaagtggtta agaaagcttc aggtttggaa tgggatgaca
     1081 tctcagaatg tgtagactgg atggtgcctt ttgtcagtgt tgtaaaaagt gtaagtccag
     1141 tgaagctgaa gacttttaag aagataccca tggaggacag acacaatatc cagacacaca
     1201 caaattactt ggctttgctg aatgaagtaa actatgtgaa catcttcaga aaaggagggc
     1261 agttgtcacc agtgtgtaat ggaggcatta tgacaccacc gaagagcact gagaaaccac
     1321 cagtaaagtt ctgaggttaa cacattggaa tgatggagag tctgatacaa atgagttaca
     1381 gggaagtagt gctgtgacta tccttgccta aggagttaca ctgccattct tttatttaaa
     1441 aattatgtca atttggcact aaatgcctag gatacacaaa atcctgggtt caatccccag
     1501 cactacaaaa gaacaaaaca aaaaacttca aaaaattggc actaaagaaa tatttcctat
     1561 aaaagagaac ttgtttacaa atgtgacttc actcccaaga atagtggatg gaagccaaca
     1621 acaatgtgtg ctatagcagc tgtttgtttg tgactgtgtt tctttacaat tcagtgttac
     1681 tgtgtttgtt ttgatgaact aggaatttta tcattggaat atggactaga ctagtgctac
     1741 cttaaaggat acattagctg acacaggaac tttgaatcta gattttatat tcttaaattc
     1801 ctatactctt gaatggtgca atttgttttt tgaaaataaa atttaagctt aattacaaag
     1861 attgttttgt aataaagtgg ctaatttatc taaagctgta gcaaaacaat gataaaactt
     1921 gaatttttat gaatggtaaa gttcaatatg tttttaacta gtttgtttgc cttaatattt
     1981 cttaatcact aaggcactga accaaatgtt taaactgtgc tctaaatggg agaaccaaag
     2041 aaattatata caagataaat gctttggctt cttctactcg ggggggtttt acttgataga
     2101 aaggttgctt tataatcctt ttgtgtatca caatttgggt aaaattaaac actttttcaa
     2161 actatataag aaagtcactt tattacacta agatatccct aaggcgcttt atgtttgtaa
     2221 aactggtggt ccatttttaa tattatgaga tgaggactgt gtcaacatgg taaaacttaa
     2281 catatgacct aaacttctat tttcttatgg cagaaaaata ttaaatgtat actgactcct
     2341 agaaatttat ttatttaaac ttgctgtata tagaatagct acttatacat taaatatttt
     2401 aagttagcct ttgaaaagga aatttgggcc taaaaaatgt taatttcatt ggataaaagt
     2461 ggtaccagac tgccagatta tcagacatgt gaacctttgt ctctctttga aaaattataa
     2521 actattgtta agatatgaag tttttgtata ctttttgttt ataaactaat ttgtttcagt
     2581 ttgttttggt taaaaagaaa gcaccactaa attgtacata tgtattatat aaacttaatc
     2641 ttttaatact gtttactttt agcccatagt ttaaaaaata aaattaaaaa aaattaacta
     2701 actgcttaaa agtaaagttt tgccattgct tgtagaaact tctttttcct tctctgtgct
     2761 gccagctgta gtacttcttc agggttgctt gcattcaatt ctgtttggcc aatggctttg
     2821 atcttaaaac agaaaagtgt tattagaagt ttggaaaaat tttgtcatag tagtacacat
     2881 aagtcaaagt taaaaataac taaatcaaat taaaaactac agaaaaaatg gcattattac
     2941 attgatccac ttttaaaatt tctttaattt acagttacct gggacatttt cttacactaa
     3001 ataaatttct gtatgcttat gtgactg
//
