LOCUS       NM_001100821            1945 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin E1 (Ccne1), mRNA.
ACCESSION   NM_001100821 XM_001077331 XM_574426
VERSION     NM_001100821.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Jin,W., Tian,Y., Ding,Y., Zhou,D., Li,L., Yuan,M., Wu,Y., Ye,M.,
            Luan,J. and Yang,K.
  TITLE     Pers reverse angiotensin II -induced vascular smooth muscle cell
            proliferation by targeting cyclin E expression via inhibition of
            the MAPK signaling pathway
  JOURNAL   Chronobiol Int 40 (7), 903-917 (2023)
   PUBMED   37338051
  REMARK    GeneRIF: Pers reverse angiotensin II -induced vascular smooth
            muscle cell proliferation by targeting cyclin E expression via
            inhibition of the MAPK signaling pathway.
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Ren,S., Xing,Y., Wang,C., Jiang,F., Liu,G., Li,Z., Jiang,T., Zhu,Y.
            and Piao,D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Ehedego,H., Mohs,A., Jansen,B., Hiththetiya,K., Sicinski,P.,
            Liedtke,C. and Trautwein,C.
  TITLE     Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in
            a mouse model of chronic liver injury
  JOURNAL   Oncogene 37 (25), 3329-3339 (2018)
   PUBMED   29551768
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Korashy,H.M., Maayah,Z.H., Al Anazi,F.E., Alsaad,A.M.,
            Alanazi,I.O., Belali,O.M., Al-Atawi,F.O. and Alshamsan,A.
  TITLE     Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing
            Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting
            NF-kappaB Signaling Pathways
  JOURNAL   Anticancer Res 37 (9), 4899-4909 (2017)
   PUBMED   28870911
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Shi,S.Y., Luk,C.T., Schroer,S.A., Kim,M.J., Dodington,D.W.,
            Sivasubramaniyam,T., Lin,L., Cai,E.P., Lu,S.Y., Wagner,K.U.,
            Bazinet,R.P. and Woo,M.
  TITLE     Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from
            Hepatocellular Carcinoma in Mice
  JOURNAL   J Biol Chem 292 (9), 3789-3799 (2017)
   PUBMED   28100771
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Singer,J.D., Gurian-West,M., Clurman,B. and Roberts,J.M.
  TITLE     Cullin-3 targets cyclin E for ubiquitination and controls S phase
            in mammalian cells
  JOURNAL   Genes Dev 13 (18), 2375-2387 (1999)
   PUBMED   10500095
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Hosokawa,Y., Yang,M., Kaneko,S., Tanaka,M. and Nakashima,K.
  TITLE     Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1
            during the prolactin-induced G1/S transition in rat Nb2 pre-T
            lymphoma cells
  JOURNAL   Biochem Mol Biol Int 37 (2), 393-399 (1995)
   PUBMED   8673024
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV771022.1, DY561075.1, BU760054.1 and CK842479.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_001077331.1, XM_574426.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC162008.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-765               EV771022.1         35-799
            766-1260            DY561075.1         202-696
            1261-1820           BU760054.1         126-685             c
            1821-1945           CK842479.1         1-125               c
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1945
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /note="cyclin E1"
                     /db_xref="GeneID:25729"
                     /db_xref="RGD:2294"
     exon            1..146
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            147..192
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1405
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /note="cyclin E"
                     /codon_start=1
                     /product="G1/S-specific cyclin-E1"
                     /protein_id="NP_001094291.1"
                     /db_xref="GeneID:25729"
                     /db_xref="RGD:2294"
                     /translation="MPRERKERDSKDHSNMKEEGGSDLSVRSRKRKANVAVFLQDPDE
                     EIAKIDKTVKSQDSSQPWDDDSACVDPCSFIPTPNKEEDNELEYPKTAFQPRKIRPPR
                     ASPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVY
                     KLHRETFYLAQDFFDRYMASQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVT
                     DGACSGDEILTMELMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVF
                     VQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWCDIEKCVKWMVP
                     FAMVIREMGSSKLKHFRGVPMEDSHNIQTHTNSLDLLDKAQAKKAILSEQNRISPPPS
                     GVLTPPHSSKKQSSEQETE"
     exon            193..280
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            281..349
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            350..498
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            499..634
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            635..781
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            782..877
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1012
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1124
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1282
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1929
                     /gene="Ccne1"
                     /gene_synonym="Ccne; CYCLE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcgacag ctagcgcggt gtagggggca ggcgcggatc ccgccagcgc cgcgcgctcg
       61 gccgccgcct cccgcctcct gcttcccgcc tgccgtcggc ctcctgtccg ctcgagcgcg
      121 cctgcctgcg gcggacacag cttcgggtct gagttccaag tcctgagcca tgccaaggga
      181 gaggaaggag agagactcga aggaccacag caacatgaaa gaagaaggtg gctccgacct
      241 ctcagtccga tccagaaaaa ggaaggcaaa tgtggccgtt tttttgcaag atccggatga
      301 agaaattgcc aagattgaca agactgtgaa aagccaggat agcagtcagc cttgggatga
      361 tgattcagcg tgcgtggacc cctgctcttt catccccacc cctaacaaag aagaggacaa
      421 tgagcttgag taccccaaga ctgcatttca gcctcggaaa atcagaccgc ccagagcctc
      481 cccacttccc gtcttgaatt ggggcaatag agaagaggtc tggaggatca tgttaaacaa
      541 agagaagact tacctgagag atgagcactt tctgcagcgc caccctctcc tgcaggcgag
      601 gatgagagca gttcttctgg actggctgat ggaggtgtgt gaagtctata agctccacag
      661 agagacattc tacttggcac aggacttctt tgatcgttac atggcatcac aacagaatat
      721 cataaaaaca cttttacagc ttattgggat ttcagcctta tttattgctt ctaaacttga
      781 ggaaatctac cctccaaagt tgcaccagtt tgcttatgtt actgatggtg cttgctccgg
      841 ggatgaaatt cttaccatgg aactgatgat gatgaaggcc cttaagtggc gtttaagccc
      901 cctgaccatt gtgtcctggc tgaatgttta tgtccaagtg gcctacgtca acgacacggg
      961 agaagtgctg atgcctcagt acccacagca ggtcttcgtg cagatcgcag agcttttaga
     1021 cctgtgcgtc ctggatgttg gctgcttaga atttccttat ggtgtcctcg ctgcttctgc
     1081 tttgtatcat ttttcctcgt tggagttgat gcagaaggtc tcaggttatc agtggtgtga
     1141 tatagagaag tgtgtcaagt ggatggttcc attcgccatg gttatccggg agatgggaag
     1201 ttccaagctc aagcacttcc ggggagttcc catggaagac tcccacaaca tccagaccca
     1261 caccaacagc ttggacttgc tggacaaagc ccaagcaaag aaagccatat tgtcagaaca
     1321 aaataggatt tctcctcctc cgagtggggt cctgacaccc ccacacagca gtaagaagca
     1381 gagcagtgag caggagacag aatgaccaga cctgccatcg cctccaaaga cagtggtgtg
     1441 gaagcagctg cctggagctc cttgtgctgc cttggaggtc aggagcccct gcagatgcta
     1501 tgctctgtgg agaggtgtct cttccagagc agcaggggtc tacaagatgc cttggacgga
     1561 agtgctttga ttgaatgcta ggtgttttaa ctatagggtc gagtacacca gccacctcca
     1621 gaacaccact gagtgctcca gaagctgcta aggagggtgc tacttgaccc actggactct
     1681 tcacacagac ggcaaaagct tgaagttaag gaggccatgg tgcttgctgg cctctgctgg
     1741 gtgtcgcagg gttgctgttg atagggtacg gcgagtggtc gtgagcaagc atgggatgca
     1801 gagccacagc ctggcctgag ctgcccttct ccactgtcag ctgacagcat atcctgcctt
     1861 tcatgaactc ttgttttgta agtgctgcta cgtctatcaa tttttaataa agataatgct
     1921 atctttgaaa aaaaaaaaaa aaaaa
//
