LOCUS       NM_012766               1969 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus cyclin D3 (Ccnd3), mRNA.
ACCESSION   NM_012766
VERSION     NM_012766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Lagarrigue,S., Lopez-Mejia,I.C., Denechaud,P.D., Escote,X.,
            Castillo-Armengol,J., Jimenez,V., Chavey,C., Giralt,A., Lai,Q.,
            Zhang,L., Martinez-Carreres,L., Delacuisine,B., Annicotte,J.S.,
            Blanchet,E., Hure,S., Abella,A., Tinahones,F.J., Vendrell,J.,
            Dubus,P., Bosch,F., Kahn,C.R. and Fajas,L.
  TITLE     CDK4 is an essential insulin effector in adipocytes
  JOURNAL   J Clin Invest 126 (1), 335-348 (2016)
   PUBMED   26657864
  REMARK    Erratum:[J Clin Invest. 2022 Jul 1;132(13):. PMID: 35775487]
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Er,H., Acar,N., Kipmen-Korgun,D., Celik-Ozenci,C., Ustunel,I.,
            Asar,M. and Korgun,E.T.
  TITLE     Determination of PCNA, cyclin D3, p27, p57 and apoptosis rate in
            normal and dexamethasone-induced intrauterine growth restricted rat
            placentas
  JOURNAL   Acta Histochem 117 (2), 137-147 (2015)
   PUBMED   25596037
  REMARK    GeneRIF: Dexamethasone induced placental and embryonal
            abnormalities which could be associated with reduced expressions of
            PCNA and cyclin D3, increased expressions of p27 and p57 and
            increased rate of apoptosis in IUGR placentas
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Powers,S.E., Mandal,M., Matsuda,S., Miletic,A.V., Cato,M.H.,
            Tanaka,A., Rickert,R.C., Koyasu,S. and Clark,M.R.
  TITLE     Subnuclear cyclin D3 compartments and the coordinated regulation of
            proliferation and immunoglobulin variable gene repression
  JOURNAL   J Exp Med 209 (12), 2199-2213 (2012)
   PUBMED   23109711
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Beyret,E. and Lin,H.
  TITLE     Pinpointing the expression of piRNAs and function of the PIWI
            protein subfamily during spermatogenesis in the mouse
  JOURNAL   Dev Biol 355 (2), 215-226 (2011)
   PUBMED   21539824
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Duan,Y., He,X., Yang,H., Ji,Y., Tao,T., Chen,J., Hu,L., Zhang,F.,
            Li,X., Wang,H., Shen,A. and Lu,X.
  TITLE     Cyclin D3/CDK11(p58) complex involved in Schwann cells
            proliferation repression caused by lipopolysaccharide
  JOURNAL   Inflammation 33 (3), 189-199 (2010)
   PUBMED   20066559
  REMARK    GeneRIF: role of cyclin D3/CDK11(p58) complex in repressing the
            Schwann cells proliferation and inducing its apoptosis
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Sherr,C.J.
  TITLE     The Pezcoller lecture: cancer cell cycles revisited
  JOURNAL   Cancer Res 60 (14), 3689-3695 (2000)
   PUBMED   10919634
  REMARK    Review article
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Yang,M., Hosokawa,Y., Kaneko,S., Tanaka,M. and Nakashima,K.
  TITLE     Structure and characterization of rat cyclin D3 promoter
  JOURNAL   Gene 181 (1-2), 153-159 (1996)
   PUBMED   8973324
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Hosokawa,Y., Onga,T. and Nakashima,K.
  TITLE     Induction of D2 and D3 cyclin-encoding genes during promotion of
            the G1/S transition by prolactin in rat Nb2 cells
  JOURNAL   Gene 147 (2), 249-252 (1994)
   PUBMED   7926809
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Meyerson,M. and Harlow,E.
  TITLE     Identification of G1 kinase activity for cdk6, a novel cyclin D
            partner
  JOURNAL   Mol Cell Biol 14 (3), 2077-2086 (1994)
   PUBMED   8114739
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Gattringer,B.
  TITLE     [Retrospective study of one year of family therapy in a
            neurological practice (author's transl)]
  JOURNAL   Nervenarzt 48 (6), 326-330 (1977)
   PUBMED   70761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000213.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_012766.3.
            
            On Dec 3, 2020 this sequence version replaced NM_012766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085763.1, D16309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132306, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JACYVU010000213.1  2750517-2750878     c
            363-578             JACYVU010000213.1  2749413-2749628     c
            579-738             JACYVU010000213.1  2746791-2746950     c
            739-875             JACYVU010000213.1  2746219-2746355     c
            876-1969            JACYVU010000213.1  2744698-2745791     c
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1969
                     /gene="Ccnd3"
                     /note="cyclin D3"
                     /db_xref="GeneID:25193"
                     /db_xref="RGD:2293"
     exon            1..362
                     /gene="Ccnd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1043
                     /gene="Ccnd3"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D3"
                     /protein_id="NP_036898.2"
                     /db_xref="GeneID:25193"
                     /db_xref="RGD:2293"
                     /translation="MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASY
                     FQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLL
                     GTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDF
                     LALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGAC
                     SMSADELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTAPSPVPKAPRGSSSQ
                     GPSQTSTPTDVTAIHL"
     exon            363..578
                     /gene="Ccnd3"
                     /inference="alignment:Splign:2.1.0"
     exon            579..738
                     /gene="Ccnd3"
                     /inference="alignment:Splign:2.1.0"
     exon            739..875
                     /gene="Ccnd3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1969
                     /gene="Ccnd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagggaag cggtgcgcgc gggtggcggg cgggctgggg cttctccgca cagtgccagc
       61 gccagcgcca gacccgcccg caccccgcgc tctcactcac acgcgtcgct tctcctagga
      121 ctcgctagcc cgcactcctg ctctcacccg tgagccatag caggatggag ctgctgtgtt
      181 gcgagggcac ccggcacgcg ccccgggccg ggcccgaccc gcggctactg ggggaccagc
      241 gtgtcctgca gagtttgctc cgcttggagg agcgctacgt gccgcgagcc tcctacttcc
      301 agtgcgtgca aaaggagatc aagccgcaca tgcggaagat gctggcgtac tggatgctgg
      361 aggtgtgtga ggagcagcgc tgcgaggagg atgtcttccc tctggctatg aactacctgg
      421 atcgctacct gtcctgcgtc cccacccgaa aggcgcaact gcagcttcta ggtaccgtct
      481 gcctgttgct ggcctccaag ctgcgcgaaa ccacgcccct gactattgag aagctctgca
      541 tctatacgga ccaagctgtg gctccctggc agttgcggga atgggaggtg ctggtcctgg
      601 ggaagctcaa gtgggacctg gctgctgtga ttgcgcacga cttcctggcc ctgattctgc
      661 accgcctctc tctgcccagt gaccggcagg cactggtcaa aaagcatgct cagacctttt
      721 tggccctctg tgccacagat tacacctttg cgatgtaccc tccatccatg atcgccacgg
      781 gcagcatcgg ggctgcagtg ctaggcctgg gtgcctgctc tatgtctgca gatgagctca
      841 cagagctgct ggcgggaatc acaggcactg aagtggactg cctgcgtgcc tgccaggagc
      901 agatcgaagc tgccctcagg gagagcctca gggaagctgc tcagacagcc cccagccccg
      961 tgcccaaagc cccccggggc tctagcagcc aggggcccag tcagaccagc actcccacag
     1021 atgtcacagc catccacctg tagcttggga caggccccct caggtggcca ccaagcagag
     1081 gaggggcccc tgccaccccc tccctgcctc taggaacaat tcatgccata tctgaagccc
     1141 gaggggggct ctttttcccc tcacaaagcc caaggggcca ggtcctgcct atccccacag
     1201 tgtgcactaa ggggctgctt ggtcatgagg gtgtctacat ggccagtcag ttcctcttcc
     1261 ttcccactca accagcttgg ctgtcctggg ccatgatggt cagagagata caaacaggta
     1321 gaacccacac accagcattt cttttgagtc cctcctctgt ctggggcgcc gatcctttca
     1381 gttgccaaaa cgccccagta ccttccaaag gtgttgttgc ccctcgcagg gtcactgcat
     1441 ttggatctgg gtccttcaga aatcccgata gacgcctatg aggagccaac ctagatggct
     1501 gctgtgtaat cctactccag ctgctcttag cgggaacagc ctaggccttg gctagaagag
     1561 caagcgcccg taaactgttg ctttgcttcc tgctatgctt ctgtggttga gggtcttgag
     1621 ggtgctgatg gtcattttaa tttattgctt tgaatacaac cgtaagaggg tacagtgagg
     1681 cctgtacccc acaagtggtg gtaaccctgg cggttgctct ttccctcccc tctgctaccg
     1741 ctttgtggcc caggagctgc tacagcctgg gagggggtcc tgccttcctc tccgtagccc
     1801 tccagctcat cttcagcggg gagggtttaa tagggatgga tgccgtggag gtgactggac
     1861 tatccggaga gagggcgagc cccatggaca caggtctttc ctcaggccac aaggtttggg
     1921 ctggtggccc atttctatca tgctgcctta ataaagattt cagaataaa
//
